A Binding Site on IL-17A for Inhibitory Macrocycles Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry

Journal of Medicinal Chemistry

Volumn 59, Issue 5, 2016, Pages 2255-2260

  Espada, Alfonso ^a   Broughton, Howard ^a   Jones, Spencer ^b   Chalmers, Michael J ^b   Dodge, Jeffrey A ^b  

^a ELI LILLY AND COMPANY   (Spain)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 17; MACROCYCLIC COMPOUND; MACROCYCLIC PEPTIDE; RECOMBINANT INTERLEUKIN 17; UNCLASSIFIED DRUG; CYCLOPEPTIDE; IL17A PROTEIN, HUMAN;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DEUTERIUM HYDROGEN EXCHANGE; DRUG BINDING SITE; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; MASS SPECTROMETER; MASS SPECTROMETRY; MOLECULE; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DOSE RESPONSE; DRUG EFFECTS; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

BINDING SITES; DEUTERIUM EXCHANGE MEASUREMENT; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INTERLEUKIN-17; MACROCYCLIC COMPOUNDS; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PEPTIDES, CYCLIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84960915474     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01693     Document Type: Article

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