Structure of ThiM from Vitamin B1 biosynthetic pathway of Staphylococcus aureus - Insights into a novel pro-drug approach addressing MRSA infections

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Drebes, Julia ^a,b   Künz, Madeleine ^a   Windshügel, Björn ^c   Kikhney, Alexey G ^d   Müller, Ingrid B ^b   Eberle, Raphael J ^a,g   Oberthür, Dominik ^a,d   Cang, Huaixing ^e   Svergun, Dmitri I ^d   Perbandt, Markus ^a   Betzel, Christian ^a   Wrenger, Carsten ^f  

^a UNIVERSITY OF HAMBURG   (Germany)

^b BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

^c FRAUNHOFER INSTITUTE FOR MOLECULAR BIOLOGY AND APPLIED ECOLOGY IME   (Germany)

^d DESY   (Germany)

^e NORTHWESTERN POLYTECHNICAL UNIVERSITY   (China)

^f UNIVERSITY OF SÃO PAULO   (Brazil)

^g SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

2-(4-METHYL-1,3-THIAZOL-5-YL)ETHANOL; ANTIINFECTIVE AGENT; PHOSPHOTRANSFERASE; PRODRUG; THIAMINE; THIAZOLE DERIVATIVE;

BIOSYNTHESIS; CHEMICAL DATABASE; CHEMISTRY; ENZYME ACTIVE SITE; ENZYMOLOGY; MOLECULAR MODEL; PENICILLIN RESISTANCE; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; BIOSYNTHETIC PATHWAYS; CATALYTIC DOMAIN; DATABASES, CHEMICAL; METHICILLIN RESISTANCE; MODELS, MOLECULAR; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PRODRUGS; STAPHYLOCOCCUS AUREUS; THIAMINE; THIAZOLES;

EID: 84960911847     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep22871     Document Type: Article

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