Permethrin is a potential thyroid-disrupting chemical: In vivo and in silico envidence

Aquatic Toxicology

Volumn 175, Issue , 2016, Pages 39-46

  Tu, Wenqing ^a,b   Xu, Chao ^b   Jin, Yuanxiang ^b   Lu, Bin ^b   Lin, Chunmian ^b   Wu, Yongming ^a   Liu, Weiping ^c  

^a INSTITUTE OF APPLIED CHEMISTRY   (China)

^b ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

Modeling; Permethrin; Thyroid hormone; Transthyretin; Zebrafish

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; ENDOCRINE DISRUPTOR; LEUCINE; LIOTHYRONINE; MESSENGER RNA; PERMETHRIN; PREALBUMIN; SODIUM IODIDE SYMPORTER; THREONINE; THYROID HORMONE; THYROID HORMONE DISRUPTING CHEMICAL; THYROID HORMONE RECEPTOR; THYROID HORMONE RECEPTOR ALPHA; THYROID HORMONE RECEPTOR BETA; THYROID PEROXIDASE; THYROTROPIN BETA SUBUNIT; THYROXINE; THYROXINE DEIODINASE; UNCLASSIFIED DRUG; VALINE; IODIDE PEROXIDASE; PYRETHROID; THYROTROPIN; WATER POLLUTANT;

CHEMICAL POLLUTANT; CYPRINID; EMBRYO; FERTILIZATION (REPRODUCTION); PERMETHRIN; PROTEIN;

ADULT; ANIMAL EXPERIMENT; ARTICLE; BIOACCUMULATION; COMPUTER MODEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRH GENE; DIO1 GENE; DIO2 GENE; ECOTOXICOLOGY; EMBRYO; FERTILIZATION; GENE; GENE EXPRESSION REGULATION; HORMONE DETERMINATION; HYPOTHALAMUS HYPOPHYSIS THYROID SYSTEM; IN VIVO STUDY; LARVAL DEVELOPMENT; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NIS GENE; NONHUMAN; PAX8 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; RECEPTOR GENE; THYROID FUNCTION; TPO GENE; TR ALPHA GENE; TR BETA GENE; TRANSCRIPTION REGULATION; TSH BETA GENE; TTR GENE; UPREGULATION; WESTERN BLOTTING; ZEBRA FISH; ANIMAL; CHEMISTRY; DRUG EFFECTS; EMBRYOLOGY; ENDOCRINE SYSTEM; GENETICS; GROWTH, DEVELOPMENT AND AGING; LARVA; METABOLISM; THYROID GLAND; TOXICITY; WATER POLLUTANT;

DANIO RERIO; MAMMALIA;

ANIMALS; BLOTTING, WESTERN; ENDOCRINE DISRUPTORS; ENDOCRINE SYSTEM; IODIDE PEROXIDASE; LARVA; MOLECULAR DOCKING SIMULATION; PERMETHRIN; PYRETHRINS; THYROID GLAND; THYROID HORMONES; THYROTROPIN; THYROXINE; TRIIODOTHYRONINE; WATER POLLUTANTS, CHEMICAL; ZEBRAFISH;

EID: 84960905612     PISSN: 0166445X     EISSN: 18791514     Source Type: Journal    
DOI: 10.1016/j.aquatox.2016.03.006     Document Type: Article

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