Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination

Neuron

Volumn 89, Issue 6, 2016, Pages 1208-1222

  Olmos Serrano, Jose Luis ^a   Kang, Hyo Jung ^b,c   Tyler, William A ^a   Silbereis, John C ^b   Cheng, Feng ^b,d   Zhu, Ying ^b   Pletikos, Mihovil ^b   Jankovic Rapan, Lucija ^b   Cramer, Nathan P ^e   Galdzicki, Zygmunt ^e   Goodliffe, Joseph ^a   Peters, Alan ^a   Sethares, Claire ^a   Delalle, Ivana ^a   Golden, Jeffrey A ^f   Haydar, Tarik F ^a   Sestan, Nenad ^b,g  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Chung Ang University   (South Korea)

^d UNIVERSITY OF SOUTH FLORIDA   (United States)

^e Uniformed Services University of the Health Sciences   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

^g YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Brain development; Gene expression; Genomics; Glia; Neocortex; Neurodevelopmental disorders; White matter

Indexed keywords

TRANSCRIPTOME; MBP PROTEIN, MOUSE; MYELIN BASIC PROTEIN;

ADOLESCENT; ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN FUNCTION; CHILD; CONTROLLED STUDY; DOWN REGULATION; DOWN SYNDROME; FEMALE; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INFANT; MALE; MOUSE; MYELINATION; NEOCORTEX; NERVE CELL DIFFERENTIATION; NERVE POTENTIAL; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; SYNAPTIC TRANSMISSION; TRANSCRIPTOMICS; WHITE MATTER; ACTION POTENTIAL; ANIMAL; BRAIN; CELL DIFFERENTIATION; CHROMOSOME 17; DISEASE MODEL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOSAICISM; MYELIN SHEATH; NERVE CONDUCTION; NEWBORN; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; POSTMORTEM CHANGE; PRESCHOOL CHILD; TRANSGENIC MOUSE; TRISOMY; ULTRASTRUCTURE; YOUNG ADULT;

ACTION POTENTIALS; ADOLESCENT; ADULT; ANIMALS; BRAIN; CELL DIFFERENTIATION; CHILD; CHILD, PRESCHOOL; CHROMOSOMES, HUMAN, PAIR 17; DISEASE MODELS, ANIMAL; DOWN SYNDROME; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; INFANT; INFANT, NEWBORN; MALE; MICE; MICE, TRANSGENIC; MOSAICISM; MYELIN BASIC PROTEIN; MYELIN SHEATH; NEURAL CONDUCTION; OLIGODENDROGLIA; POSTMORTEM CHANGES; TRISOMY; WHITE MATTER; YOUNG ADULT;

EID: 84960802950     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2016.01.042     Document Type: Article

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