DHA Suppresses Primary Macrophage Inflammatory Responses via Notch 1/ Jagged 1 Signaling

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Ali, Mehboob ^a   Heyob, Kathryn ^a   Rogers, Lynette K ^a,b  

^a NATIONWIDE CHILDREN S HOSPITAL   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTACOID; DOCOSAHEXAENOIC ACID; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOSUPPRESSIVE AGENT; JAG1 PROTEIN, MOUSE; NOTCH1 PROTEIN, MOUSE; NOTCH1 RECEPTOR; PROTEIN JAGGED 1;

ADVERSE EFFECTS; ANIMAL; C3H MOUSE; CELL CULTURE; COCULTURE; DRUG EFFECTS; EPITHELIUM CELL; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HYPEROXIA; IMMUNOLOGY; LUNG; MACROPHAGE; MALE; MATERNAL EXPOSURE; METABOLISM; MOUSE; PHYSIOLOGY; PREVENTION AND CONTROL; SIGNAL TRANSDUCTION;

ANIMALS; CELLS, CULTURED; COCULTURE TECHNIQUES; DOCOSAHEXAENOIC ACIDS; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION; HMGB1 PROTEIN; HYPEROXIA; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATION MEDIATORS; JAGGED-1 PROTEIN; LUNG; MACROPHAGES; MALE; MATERNAL EXPOSURE; MICE; MICE, INBRED C3H; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION;

EID: 84960539498     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep22276     Document Type: Article

References (42)

1. Calder, P. C. Immunomodulation by omega-3 fatty acids. Prostaglandins Leukot Essent Fatty Acids 77, 327-335 (2007).
2. Calder, P. C. Polyunsaturated fatty acids and inflammatory processes: New twists in an old tale. Biochimie 91, 791-795 (2009).
3. Calder, P. C., Bond, J. A., Harvey, D. J., Gordon, S. & Newsholme, E. A. Uptake and incorporation of saturated and unsaturated fatty acids into macrophage lipids and their effect upon macrophage adhesion and phagocytosis. Biochem J 269, 807-814 (1990).
4. Lee, J. Y. et al. Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids. J Lipid Res 44, 479-486 (2003).
5. Wong, S. W. et al. Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner. J Biol Chem 284, 27384-27392 (2009).
6. Simons, K. & Ikonen, E. Functional rafts in cell membranes. Nature 387, 569-572 (1997).
7. Velten, M. et al. Prenatal inflammation exacerbates hyperoxia-induced functional and structural changes in adult mice. Am J Physiol Regul Integr Comp Physiol 303, R279-290 (2012).
8. Velten, M., Heyob, K. M., Rogers, L. K. & Welty, S. E. Deficits in lung alveolarization and function after systemic maternal inflammation and neonatal hyperoxia exposure. J Appl Physiol (1985) 108, 1347-1356 (2010).
9. Velten, M., Britt, R. D., Jr., Heyob, K. M., Tipple, T. E. & Rogers, L. K. Maternal dietary docosahexaenoic acid supplementation attenuates fetal growth restriction and enhances pulmonary function in a newborn mouse model of perinatal inflammation. J Nutr 144, 258-266 (2014).
10. Ali, M., Heyob, K. M., Velten, M., Tipple, T. E. & Rogers, L. K. DHA suppresses chronic apoptosis in the lung caused by perinatal inflammation. Am J Physiol Lung Cell Mol Physiol 309, L441-448 (2015).
11. Italiani, P. & Boraschi, D. New Insights Into Tissue Macrophages: From Their Origin to the Development of Memory. Immune network 15, 167-176 (2015).
12. Sitapara, R. A. et al. The alpha7 nicotinic acetylcholine receptor agonist GTS-21 improves bacterial clearance in mice by restoring hyperoxia-compromised macrophage function. Molecular medicine 20, 238-247 (2014).
13. Wang, M. et al. The compromise of macrophage functions by hyperoxia is attenuated by ethacrynic acid via inhibition of NF-kappaBmediated release of high-mobility group box-1. American journal of respiratory cell and molecular biology 52, 171-182 (2015).
14. Gladine, C. et al. The omega-3 fatty acid docosahexaenoic acid favorably modulates the inflammatory pathways and macrophage polarization within aorta of LDLR(- /- ) mice. Genes & nutrition 9, 424 (2014).
15. Chang, H. Y., Lee, H. N., Kim, W. & Surh, Y. J. Docosahexaenoic acid induces M2 macrophage polarization through peroxisome proliferator-activated receptor gamma activation. Life Sci 120, 39-47 (2015).
16. Titos, E. et al. Resolvin D1 and its precursor docosahexaenoic acid promote resolution of adipose tissue inflammation by eliciting macrophage polarization toward an M2-like phenotype. Journal of immunology 187, 5408-5418 (2011).
17. Xu, J. et al. NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation. J Clin Invest 125, 1579-1590 (2015).
18. Xu, K., Moghal, N. & Egan, S. E. Notch signaling in lung development and disease. Adv Exp Med Biol 727, 89-98 (2012).
19. Wang, Y. C. et al. Notch signaling determines the M1 versus M2 polarization of macrophages in antitumor immune responses. Cancer research 70, 4840-4849 (2010).
20. Singla, R. D., Wang, J. & Singla, D. K. Regulation of Notch 1 signaling in THP-1 cells enhances M2 macrophage differentiation. American journal of physiology. Heart and circulatory physiology 307, H1634-1642 (2014).
21. Rittirsch, D. et al. Acute lung injury induced by lipopolysaccharide is independent of complement activation. Journal of immunology 180, 7664-7672 (2008).
22. Mantovani, A. & Locati, M. Orchestration of macrophage polarization. Blood 114, 3135-3136 (2009).
23. Jones, C. V. et al. M2 macrophage polarisation is associated with alveolar formation during postnatal lung development. Respir Res 14, 41 (2013).
24. Bowman, C. M., Harada, R. N. & Repine, J. E. Hyperoxia stimulates alveolar macrophages to produce and release a factor which increases neutrophil adherence. Inflammation 7, 331-338 (1983).
25. Danielson, D. S., Heagy, W., Nieman, K. M. & West, M. A. Relative hyperoxia augments lipopolysaccharide-stimulated cytokine secretion by murine macrophages. Surgery 133, 538-546 (2003).
26. Boorsma, C. E., Draijer, C. & Melgert, B. N. Macrophage heterogeneity in respiratory diseases. Mediators of inflammation 2013, 769214 (2013).
27. Artavanis-Tsakonas, S., Rand, M. D. & Lake, R. J. Notch signaling: cell fate control and signal integration in development. Science 284, 770-776 (1999).
28. Syed, M. A. & Bhandari, V. Hyperoxia exacerbates postnatal inflammation-induced lung injury in neonatal BRP-39 null mutant mice promoting the M1 macrophage phenotype. Mediators of inflammation 2013, 457189 (2013).
29. Monsalve, E. et al. Notch-1 up-regulation and signaling following macrophage activation modulates gene expression patterns known to affect antigen-presenting capacity and cytotoxic activity. Journal of immunology 176, 5362-5373 (2006).
30. Ali, M., Heyob, K. M., Velten, M., Tipple, T. E. & Rogers, L. K. DHA Suppresses Chronic Apoptosis in the Lung Caused by Perinatal Inflammation. American journal of physiology. Lung cellular and molecular physiology, ajplung 00137 02015 (2015).
31. Chou, D. K., Evans, J. E. & Jungalwala, F. B. Identity of nuclear high-mobility-group protein, HMG-1, and sulfoglucuronyl carbohydrate-binding protein, SBP-1, in brain. Journal of neurochemistry 77, 120-131 (2001).
32. Bianchi, M. E. & Agresti, A. HMG proteins: dynamic players in gene regulation and differentiation. Current opinion in genetics & development 15, 496-506 (2005).
33. Klune, J. R., Dhupar, R., Cardinal, J., Billiar, T. R. & Tsung, A. HMGB1: endogenous danger signaling. Molecular medicine 14, 476-484 (2008).
34. Patel, V. S. et al. High Mobility Group Box-1 mediates hyperoxia-induced impairment of Pseudomonas aeruginosa clearance and inflammatory lung injury in mice. Am J Respir Cell Mol Biol 48, 280-287 (2013).
35. Bonaldi, T. et al. Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion. The EMBO journal 22, 5551-5560 (2003).
36. Martin, T. R., Pistorese, B. P., Chi, E. Y., Goodman, R. B. & Matthay, M. A. Effects of leukotriene B4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in protein permeability. J Clin Invest 84, 1609-1619 (1989).
37. Woo, C. H. et al. Transepithelial migration of neutrophils in response to leukotriene B4 is mediated by a reactive oxygen speciesextracellular signal-regulated kinase-linked cascade. Journal of immunology 170, 6273-6279 (2003).
38. Riediger, N. D., Othman, R. A., Suh, M. & Moghadasian, M. H. A systemic review of the roles of n-3 fatty acids in health and disease. J Am Diet Assoc 109, 668-679 (2009).
39. Rogers, L. K. et al. Maternal docosahexaenoic acid supplementation decreases lung inflammation in hyperoxia-exposed newborn mice. J Nutr 141, 214-222 (2011).
40. Farrell, M. R., Rogers, L. K., Liu, Y., Welty, S. E. & Tipple, T. E. Thioredoxin-interacting protein inhibits hypoxia-inducible factor transcriptional activity. Free radical biology & medicine 49, 1361-1367 (2010).
41. Tipple, T. E. & Rogers, L. K. Methods for the determination of plasma or tissue glutathione levels. Methods in molecular biology 889, 315-324 (2012).
42. Rogers, L. K., Gupta, S., Welty, S. E., Hansen, T. N. & Smith, C. V. Nuclear and nucleolar glutathione reductase, peroxidase, and transferase activities in livers of male and female Fischer-344 rats. Toxicological sciences: an official journal of the Society of Toxicology 69, 279-285 (2002).