Pyruvate kinase deletion as an effective phenotype to enhance lysine production in Corynebacterium glutamicum ATCC13032: Redirecting the carbon flow to a precursor metabolite

Journal of Bioscience and Bioengineering

Volumn 122, Issue 2, 2016, Pages 160-167

  Yanase, Masaki ^a   Aikoh, Tohru ^a   Sawada, Kazunori ^a   Ogura, Kotaro ^a   Hagiwara, Takuya ^a   Imai, Keita ^a   Wada, Masaru ^a   Yokota, Atsushi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Citrate synthase; Corynebacterium glutamicum; Feedback inhibition; Lysine; Phosphoenolpyruvate carboxylase; Pyruvate kinase

Indexed keywords

BIOCHEMISTRY; CARBON; DEFECTS; ENZYMES; METABOLITES;

CITRATE SYNTHASE; CORYNEBACTERIUM GLUTAMICUM; FEEDBACK INHIBITION; LYSINE; PHOSPHOENOLPYRUVATE CARBOXYLASE; PYRUVATE KINASE;

AMINO ACIDS;

ASPARTATE KINASE; ASPARTIC ACID; CARBON; CITRATE SYNTHASE; LYSINE; MALIC ACID; OXALOACETIC ACID; OXIDOREDUCTASE; PHOSPHOENOLPYRUVATE CARBOXYLASE; PYRUVATE KINASE; QUINONE DERIVATIVE; BENZOQUINONE DERIVATIVE; MALIC ACID DERIVATIVE; MUTANT PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BACTERIAL METABOLISM; BACTERIAL STRAIN; BIOMASS PRODUCTION; CELL MUTANT; CORYNEBACTERIUM GLUTAMICUM; DENATURATION; DESENSITIZATION; DNA SEQUENCE; ESCHERICHIA COLI; GENE DELETION; GENETIC ENGINEERING; GLUCOSE INTAKE; LIMIT OF DETECTION; NEGATIVE FEEDBACK; PH; PHENOTYPE; BIOSYNTHESIS; DEFICIENCY; DRUG EFFECTS; ENZYMOLOGY; FEEDBACK SYSTEM; GENETICS; METABOLISM;

ASPARTIC ACID; BENZOQUINONES; CARBON; CITRATE (SI)-SYNTHASE; CORYNEBACTERIUM GLUTAMICUM; FEEDBACK, PHYSIOLOGICAL; GENE DELETION; LYSINE; MALATES; MUTANT PROTEINS; OXALOACETIC ACID; OXIDOREDUCTASES; PHENOTYPE; PHOSPHOENOLPYRUVATE CARBOXYLASE; PYRUVATE KINASE;

EID: 84960415501     PISSN: 13891723     EISSN: 13474421     Source Type: Journal    
DOI: 10.1016/j.jbiosc.2015.12.023     Document Type: Article

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