Improved L-lysine production with Corynebacterium glutamicum and systemic insight into citrate synthase flux and activity

Biotechnology and Bioengineering

Volumn 109, Issue 8, 2012, Pages 2070-2081

  van Ooyen, Jan ^a   Noack, Stephan ^a   Bott, Michael ^a   Reth, Alexander ^b   Eggeling, Lothar ^a  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

^b EVONIK DEGUSSA GMBH   (Germany)

Author keywords

Citrate synthase; Fluxes; In vivo kinetics; Metabolite pools; Metabolite production

Indexed keywords

ACETYL-COA; BIOSYNTHESIS PATHWAYS; CITRATE SYNTHASE; CORYNEBACTERIUM GLUTAMICUM; FLUX ANALYSIS; IN-VIVO; L-LYSINE; L-LYSINE PRODUCTION; METABOLITE PRODUCTION; METABOLOMES; MULTI-FACETED APPROACH; RESIDUAL ACTIVITY; TRANSCRIPTOMES; YIELD INCREASE;

BIOCHEMISTRY; FLUXES; GENE EXPRESSION; STRAIN;

AMINO ACIDS;

ACETYL COENZYME A; CITRATE SYNTHASE; LYSINE; OXALOACETIC ACID; TRANSCRIPTOME;

AMINO ACID SYNTHESIS; ARTICLE; BACTERIAL METABOLISM; BACTERIAL STRAIN; BACTERIUM MUTANT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORYNEBACTERIUM GLUTAMICUM; ENZYME ACTIVITY; FLUXOME; GENE DELETION; GENE EXPRESSION; METABOLOME; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; REDUCTION; TRANSPORT KINETICS;

CITRATE (SI)-SYNTHASE; CORYNEBACTERIUM GLUTAMICUM; GENE EXPRESSION; LYSINE; METABOLOME; TRANSCRIPTOME;

CORYNEBACTERIUM GLUTAMICUM;

EID: 84862689750     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.24486     Document Type: Article

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