Identification and biological consequences of the O-GlcNAc modification of the human innate immune receptor, Nod2

Glycobiology

Volumn 26, Issue 1, 2015, Pages 13-18

  Hou, Ching Wen ^a   Mohanan, Vishnu ^a   Zachara, Natasha E ^b   Grimes, Catherine Leimkuhler ^a  

^a UNIVERSITY OF DELAWARE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Crohn's disease; NF ?B; Nod2; O GlcNAcylation; OGT

Indexed keywords

N ACETYLGLUCOSAMINE; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN 2; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN PROTEIN; SERINE; THREONINE; UNCLASSIFIED DRUG; CASPASE RECRUITMENT DOMAIN PROTEIN 15; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NOD2 PROTEIN, HUMAN;

ACYLATION; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INNATE IMMUNITY; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; GENETICS; GLYCOSYLATION; HCT 116 CELL LINE; HEK293 CELL LINE; METABOLISM; MUTATION;

ACETYLGLUCOSAMINE; GLYCOSYLATION; HCT116 CELLS; HEK293 CELLS; HUMANS; MUTATION; NF-KAPPA B; NOD2 SIGNALING ADAPTOR PROTEIN; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 84960409522     PISSN: 09596658     EISSN: 14602423     Source Type: Journal    
DOI: 10.1093/glycob/cwv076     Document Type: Article

References (31)

1. Abbott DW, Wilkins A, Asara JM, Cantley LC. 2004. The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO. Curr Biol. 14:2217-2227.
2. Belle A, Tanay A, Bitincka L, Shamir R, O'Shea EK. 2006. Quantification of protein half-lives in the budding yeast proteome. Proc Natl Acad Sci USA. 103:13004-13009.
3. Chu CS, Lo PW, Yeh YH, Hsu PH, Peng SH, Teng YC, Kang ML, Wong CH, Juan LJ. 2014. O-GlcNAcylation regulates EZH2 protein stability and function. Proc Natl Acad Sci USA. 111:1355-1360.
4. Dong DL, Hart GW. 1994. Purification and characterization of an O-GlcNAc selective N-acetyl-beta-D-glucosaminidase from rat spleen cytosol. J Biol Chem. 269:19321-19330.
5. Grimes CL, Ariyananda Lde Z, Melnyk JE, O'Shea EK. 2012. The innate immune protein Nod2 binds directly to MDP, a bacterial cell wall fragment. J Am Chem Soc. 134:13535-13537.
6. Groves JA, Lee A, Yildirir G, Zachara NE. 2013. Dynamic O-GlcNAcylation and its roles in the cellular stress response and homeostasis. Cell Stress Chaperon. 18:535-558.
7. Hart GW, Housley MP, Slawson C. 2007. Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins. Nature. 446:1017-1022.
8. Holt GD, Haltiwanger RS, Torres CR, Hart GW. 1987. Erythrocytes contain cytoplasmic glycoproteins. O-linked GlcNAc on Band 4.1. J Biol Chem. 262:14847-14850.
9. Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, Almer S, Tysk C, O'Morain CA, Gassull M, et al. 2001. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature. 411:599-603.
10. Janeway CA Jr, Medzhitov R. 2002. Innate immune recognition. Annu Rev Immunol. 20:197-216.
11. Lovering AL, Safadi SS, Strynadka NC. 2012. Structural perspective of peptidoglycan biosynthesis and assembly. Annu Rev Biochem. 81:451-478.
12. Macia L, Thorburn AN, Binge LC, Marino E, Rogers KE, Maslowski KM, Vieira AT, Kranich J, Mackay CR. 2012. Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases. Immunol Rev. 245:164-176.
13. Magalhaes JG, Sorbara MT, Girardin SE, Philpott DJ. 2011. What is new with Nods? Curr Opin Immunol. 23:29-34.
14. Martinon F, Tschopp J. 2005. NLRs join TLRs as innate sensors of pathogens. Trends Immunol. 26:447-454.
15. Mo J, Boyle JP, Howard CB, Monie TP, Davis BK, Duncan JA. 2012. Pathogen sensing by nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is mediated by direct binding to muramyl dipeptide and ATP. J Biol Chem. 287:23057-23067.
16. Mohanan V, Grimes CL. 2014. The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease. J Biol Chem. 289:18987-18998.
17. Mohanan V, Temburni MK, Kappes JC, Galileo DS. 2013. L1CAM stimulates glioma cell motility and proliferation through the fibroblast growth factor receptor. Clin Exp Metastasis. 30:507-520.
18. Naseem S, Parrino SM, Buenten DM, Konopka JB. 2012. Novel roles for GlcNAc in cell signaling. Commun Integr Biol. 5:156-159.
19. Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH, et al. 2001. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature. 411:603-606.
20. Ogura Y, Inohara N, Benito A, Chen FF, Yamaoka S, Nunez G. 2001. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J Biol Chem. 276:4812-4818.
21. Park JT, Uehara T. 2008. How bacteria consume their own exoskeletons (turnover and recycling of cell wall peptidoglycan). Microbiol Mol Biol Rev. 72:211-227, table of contents.
22. Raetz CR, Whitfield C. 2002. Lipopolysaccharide endotoxins. Annu Rev Biochem. 71:635-700.
23. Schneider-Poetsch T, Ju J, Eyler DE, Dang Y, Bhat S, Merrick WC, Green R, Shen B, Liu JO. 2010. Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. Nat Chem Biol. 6:209-217.
24. Torres CR, Hart GW. 1984. Topography and polypeptide distribution of terminal N-acetylglucosamine residues on the surfaces of intact lymphocytes. Evidence for O-linked GlcNAc. J Biol Chem. 259: 3308-3317.
25. Tosi MF. 2005. Innate immune responses to infection. J Allergy Clin Immunol. 116:241-249; quiz 250.
26. van Heijenoort J. 2001. Formation of the glycan chains in the synthesis of bacterial peptidoglycan. Glycobiology. 11:25R-36R.
27. Wells L, Vosseller K, Hart GW. 2001. Glycosylation of nucleocytoplasmic proteins: Signal transduction and O-GlcNAc. Science. 291:2376-2378.
28. Yang YR, Suh PG. 2014. O-GlcNAcylation in cellular functions and human diseases. Adv Biol Regul. 54:68-73.
29. Yuzwa SA, Macauley MS, Heinonen JE, Shan X, Dennis RJ, He Y, Whitworth GE, Stubbs KA, McEachern EJ, Davies GJ, et al. 2008. A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat Chem Biol. 4:483-490.
30. Zachara NE, Vosseller K, Hart GW. 2011. Detection and analysis of proteins modified by O-linked N-acetylglucosamine. Cur Protoc Mol Biol . Chapter 12:Unit12 18.
31. Zhu Y, Liu TW, Cecioni S, Eskandari R, Zandberg WF, Vocadlo DJ. 2015. O-GlcNAc occurs cotranslationally to stabilize nascent polypeptide chains. Nat Chem Biol. 11:319-325.