CRISPR-Cas9 can inhibit HIV-1 replication but NHEJ repair facilitates virus escape

Molecular Therapy

Volumn 24, Issue 3, 2016, Pages 522-526

  Wang, Gang ^a   Zhao, Na ^a   Berkhout, Ben ^a   Das, Atze T ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 9; CRISPR ASSOCIATED PROTEIN; BACTERIAL PROTEIN; CAS9 ENDONUCLEASE STREPTOCOCCUS PYOGENES; ENDONUCLEASE; GUIDE RNA; PROTEIN BINDING;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; CODON; DNA END JOINING REPAIR; GENE DELETION; GENE INSERTION; GENOME ANALYSIS; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; OPEN READING FRAME; PROTEIN CLEAVAGE; RNA CLEAVAGE; VIRAL PHENOMENA AND FUNCTIONS; VIRUS ESCAPE; VIRUS GENOME; VIRUS INHIBITION; VIRUS REPLICATION; BINDING SITE; CELL LINE; CRISPR CAS SYSTEM; GENE TARGETING; GENETICS; HUMAN; METABOLISM; MUTATION; PHYSIOLOGY; PROVIRUS; RNA EDITING;

BACTERIAL PROTEINS; BINDING SITES; CELL LINE; CRISPR-CAS SYSTEMS; DNA END-JOINING REPAIR; ENDONUCLEASES; GENE TARGETING; GENOME, VIRAL; HIV-1; HUMANS; MUTATION; PROTEIN BINDING; PROVIRUSES; RNA EDITING; RNA, GUIDE; VIRUS REPLICATION;

EID: 84960380460     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2016.24     Document Type: Article

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