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Volumn 21, Issue 1, 2016, Pages 103-110

Exploration of individuality in drug metabolism by high-throughput metabolomics: The fast line for personalized medicine

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLISM; GENETIC SCREENING; HIGH THROUGHPUT METABOLOMICS; HIGH THROUGHPUT SCREENING; HUMAN; INDIVIDUALITY; METABOLOMICS; PERSONALIZED MEDICINE; REVIEW; METABOLISM; PROCEDURES;

EID: 84960303719     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2015.07.011     Document Type: Review
Times cited : (17)

References (41)
  • 1
    • 77954827460 scopus 로고    scopus 로고
    • The path to personalized medicine
    • M.A. Hamburg, and F.S. Collins The path to personalized medicine N. Engl. J. Med. 363 2010 301 304
    • (2010) N. Engl. J. Med. , vol.363 , pp. 301-304
    • Hamburg, M.A.1    Collins, F.S.2
  • 2
    • 84895928974 scopus 로고    scopus 로고
    • Systems diagnostics: Anticipating the next generation of diagnostic tests based on mechanistic insight into disease
    • D.A. Fryburg, and et al. Systems diagnostics: anticipating the next generation of diagnostic tests based on mechanistic insight into disease Drug Discov. Today 19 2014 108 112
    • (2014) Drug Discov. Today , vol.19 , pp. 108-112
    • Fryburg, D.A.1
  • 3
    • 84873801934 scopus 로고    scopus 로고
    • High-throughput sequencing for biology and medicine
    • W.W. Soon, and et al. High-throughput sequencing for biology and medicine Mol. Syst. Biol. 9 2013 640
    • (2013) Mol. Syst. Biol. , vol.9 , pp. 640
    • Soon, W.W.1
  • 4
    • 84888027867 scopus 로고    scopus 로고
    • Next-generation sequencing: from understanding biology to personalized medicine
    • K.S. Frese, and et al. Next-generation sequencing: from understanding biology to personalized medicine Biology (Basel) 2 2013 378 398
    • (2013) Biology (Basel) , vol.2 , pp. 378-398
    • Frese, K.S.1
  • 5
    • 0035793373 scopus 로고    scopus 로고
    • Metabolic activation in drug allergies
    • B.K. Park, and et al. Metabolic activation in drug allergies Toxicology 158 2001 11 23
    • (2001) Toxicology , vol.158 , pp. 11-23
    • Park, B.K.1
  • 6
    • 79952083050 scopus 로고    scopus 로고
    • Genetic polymorphism and toxicology - with emphasis on cytochrome p450
    • I. Johansson, and M. Ingelman-Sundberg Genetic polymorphism and toxicology - with emphasis on cytochrome p450 Toxicol. Sci. 120 2011 1 13
    • (2011) Toxicol. Sci. , vol.120 , pp. 1-13
    • Johansson, I.1    Ingelman-Sundberg, M.2
  • 7
    • 77950354310 scopus 로고    scopus 로고
    • Drug-induced hypersensitivity reactions and pharmacogenomics: Past, present and future
    • A. Alfirevic, and M. Pirmohamed Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future Pharmacogenomics 11 2010 497 499
    • (2010) Pharmacogenomics , vol.11 , pp. 497-499
    • Alfirevic, A.1    Pirmohamed, M.2
  • 8
    • 77951778977 scopus 로고    scopus 로고
    • Personalized medicine in oncology: The future is now
    • R.L. Schilsky Personalized medicine in oncology: the future is now Nat. Rev. Drug Discov. 9 2010 363 366
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 363-366
    • Schilsky, R.L.1
  • 9
    • 79955485361 scopus 로고    scopus 로고
    • Tamoxifen metabolite concentrations, CYP2D6 genotype, and breast cancer outcomes
    • L. Madlensky, and et al. Tamoxifen metabolite concentrations, CYP2D6 genotype, and breast cancer outcomes Clin. Pharmacol. Ther. 89 2011 718 725
    • (2011) Clin. Pharmacol. Ther. , vol.89 , pp. 718-725
    • Madlensky, L.1
  • 10
    • 66349133649 scopus 로고    scopus 로고
    • Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan
    • E. Cecchin, and et al. Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan J. Clin. Oncol. 27 2009 2457 2465
    • (2009) J. Clin. Oncol. , vol.27 , pp. 2457-2465
    • Cecchin, E.1
  • 11
    • 84888092572 scopus 로고    scopus 로고
    • Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11)
    • S. Chen, and et al. Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11) Proc. Natl. Acad. Sci. U. S. A. 110 2013 19143 19148
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 19143-19148
    • Chen, S.1
  • 12
    • 33947587274 scopus 로고    scopus 로고
    • Simulation and prediction of in vivo drug metabolism in human populations from in vitro data
    • A. Rostami-Hodjegan, and G.T. Tucker Simulation and prediction of in vivo drug metabolism in human populations from in vitro data Nat. Rev. Drug Discov. 6 2007 140 148
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 140-148
    • Rostami-Hodjegan, A.1    Tucker, G.T.2
  • 13
    • 75449140776 scopus 로고
    • Studies on the metabolism and mechanism of action of methyldopa
    • A. Sjoerdsma, and et al. Studies on the metabolism and mechanism of action of methyldopa Circulation 28 1963 492 502
    • (1963) Circulation , vol.28 , pp. 492-502
    • Sjoerdsma, A.1
  • 14
    • 84881369390 scopus 로고    scopus 로고
    • Identification of urinary metabolites of imperatorin with a single run on an LC/Triple TOF system based on multiple mass defect filter data acquisition and multiple data mining techniques
    • S. Qiao, and et al. Identification of urinary metabolites of imperatorin with a single run on an LC/Triple TOF system based on multiple mass defect filter data acquisition and multiple data mining techniques Anal. Bioanal. Chem. 405 2013 6721 6738
    • (2013) Anal. Bioanal. Chem. , vol.405 , pp. 6721-6738
    • Qiao, S.1
  • 15
    • 0842327199 scopus 로고    scopus 로고
    • Integration of knowledge-based metabolic predictions with liquid chromatography data-dependent tandem mass spectrometry for drug metabolism studies: Application to studies on the biotransformation of indinavir
    • M.R. Anari, and et al. Integration of knowledge-based metabolic predictions with liquid chromatography data-dependent tandem mass spectrometry for drug metabolism studies: application to studies on the biotransformation of indinavir Anal. Chem. 76 2004 823 832
    • (2004) Anal. Chem. , vol.76 , pp. 823-832
    • Anari, M.R.1
  • 16
    • 43349100561 scopus 로고    scopus 로고
    • Towards high-throughput metabolomics using ultrahigh-field Fourier transform ion cyclotron resonance mass spectrometry
    • J. Han, and et al. Towards high-throughput metabolomics using ultrahigh-field Fourier transform ion cyclotron resonance mass spectrometry Metabolomics 4 2008 128 140
    • (2008) Metabolomics , vol.4 , pp. 128-140
    • Han, J.1
  • 17
    • 80052785690 scopus 로고    scopus 로고
    • High-throughput, accurate mass metabolome profiling of cellular extracts by flow injection-time-of-flight mass spectrometry
    • T. Fuhrer, and et al. High-throughput, accurate mass metabolome profiling of cellular extracts by flow injection-time-of-flight mass spectrometry Anal. Chem. 83 2011 7074 7080
    • (2011) Anal. Chem. , vol.83 , pp. 7074-7080
    • Fuhrer, T.1
  • 18
    • 84890894398 scopus 로고    scopus 로고
    • Mass spectrometry in high-throughput clinical biomarker assays: Multiple reaction monitoring
    • C.E. Parker, and et al. Mass spectrometry in high-throughput clinical biomarker assays: multiple reaction monitoring Top. Curr. Chem. 336 2014 117 137
    • (2014) Top. Curr. Chem. , vol.336 , pp. 117-137
    • Parker, C.E.1
  • 19
    • 84929459697 scopus 로고    scopus 로고
    • Applications of mass spectrometry in drug metabolism: 50 years of progress
    • B. Wen, and M. Zhu Applications of mass spectrometry in drug metabolism: 50 years of progress Drug Metab. Rev. 47 2015 71 87
    • (2015) Drug Metab. Rev. , vol.47 , pp. 71-87
    • Wen, B.1    Zhu, M.2
  • 20
    • 84887039295 scopus 로고    scopus 로고
    • Postgenomics diagnostics: Metabolomics approaches to human blood profiling
    • O. Trifonova, and et al. Postgenomics diagnostics: metabolomics approaches to human blood profiling OMICS 17 2013 550 559
    • (2013) OMICS , vol.17 , pp. 550-559
    • Trifonova, O.1
  • 21
    • 84865687710 scopus 로고    scopus 로고
    • Targeted therapies: The toxic reality of new drugs
    • R. Kirk Targeted therapies: the toxic reality of new drugs Nat. Rev. Clin. Oncol. 9 2012 488
    • (2012) Nat. Rev. Clin. Oncol. , vol.9 , pp. 488
    • Kirk, R.1
  • 22
    • 79956129310 scopus 로고    scopus 로고
    • Characterization of isotopic abundance measurements in high resolution FT-ICR and Orbitrap mass spectra for improved confidence of metabolite identification
    • R.J. Weber, and et al. Characterization of isotopic abundance measurements in high resolution FT-ICR and Orbitrap mass spectra for improved confidence of metabolite identification Anal. Chem. 83 2011 3737 3743
    • (2011) Anal. Chem. , vol.83 , pp. 3737-3743
    • Weber, R.J.1
  • 23
    • 42949111593 scopus 로고    scopus 로고
    • Direct introduction of biological samples into a LTQ-Orbitrap hybrid mass spectrometer as a tool for fast metabolome analysis
    • G. Madalinski, and et al. Direct introduction of biological samples into a LTQ-Orbitrap hybrid mass spectrometer as a tool for fast metabolome analysis Anal. Chem. 80 2008 3291 3303
    • (2008) Anal. Chem. , vol.80 , pp. 3291-3303
    • Madalinski, G.1
  • 24
    • 79551507196 scopus 로고    scopus 로고
    • Metabolomics: from small molecules to big ideas
    • M. Baker Metabolomics: from small molecules to big ideas Nat. Methods 8 2011 117 121
    • (2011) Nat. Methods , vol.8 , pp. 117-121
    • Baker, M.1
  • 25
    • 78650186960 scopus 로고    scopus 로고
    • Mass spectrometry-based technologies for high-throughput metabolomics
    • J. Han, and et al. Mass spectrometry-based technologies for high-throughput metabolomics Bioanalysis 1 2009 1665 1684
    • (2009) Bioanalysis , vol.1 , pp. 1665-1684
    • Han, J.1
  • 26
    • 84922426336 scopus 로고    scopus 로고
    • Metabolic profiling of bile acids in human and mouse blood by LC-MS/MS in combination with phospholipid-depletion solid-phase extraction
    • J. Han, and et al. Metabolic profiling of bile acids in human and mouse blood by LC-MS/MS in combination with phospholipid-depletion solid-phase extraction Anal. Chem. 87 2015 1127 1136
    • (2015) Anal. Chem. , vol.87 , pp. 1127-1136
    • Han, J.1
  • 27
    • 0033982936 scopus 로고    scopus 로고
    • KEGG: Kyoto encyclopedia of genes and genomes
    • M. Kanehisa, and S. Goto KEGG: Kyoto encyclopedia of genes and genomes Nucleic Acids Res. 28 2000 27 30
    • (2000) Nucleic Acids Res. , vol.28 , pp. 27-30
    • Kanehisa, M.1    Goto, S.2
  • 28
    • 62149124281 scopus 로고    scopus 로고
    • TICL - a web tool for network-based interpretation of compound lists inferred by high-throughput metabolomics
    • A.V. Antonov, and et al. TICL - a web tool for network-based interpretation of compound lists inferred by high-throughput metabolomics FEBS J. 276 2009 2084 2094
    • (2009) FEBS J. , vol.276 , pp. 2084-2094
    • Antonov, A.V.1
  • 29
    • 84900624571 scopus 로고    scopus 로고
    • Systematic screening for novel lipids by shotgun lipidomics
    • C. Papan, and et al. Systematic screening for novel lipids by shotgun lipidomics Anal. Chem. 86 2014 2703 2710
    • (2014) Anal. Chem. , vol.86 , pp. 2703-2710
    • Papan, C.1
  • 30
    • 33749163985 scopus 로고    scopus 로고
    • Ab initio prediction of metabolic networks using Fourier transform mass spectrometry data
    • R. Breitling, and et al. Ab initio prediction of metabolic networks using Fourier transform mass spectrometry data Metabolomics 2 2006 155 164
    • (2006) Metabolomics , vol.2 , pp. 155-164
    • Breitling, R.1
  • 31
    • 46849091191 scopus 로고    scopus 로고
    • Mass defect profiles of biological matrices and the general applicability of mass defect filtering for metabolite detection
    • H. Zhang, and et al. Mass defect profiles of biological matrices and the general applicability of mass defect filtering for metabolite detection Rapid Commun. Mass Spectrom. 22 2008 2082 2088
    • (2008) Rapid Commun. Mass Spectrom. , vol.22 , pp. 2082-2088
    • Zhang, H.1
  • 32
    • 67650494794 scopus 로고    scopus 로고
    • Mass defect filter technique and its applications to drug metabolite identification by high-resolution mass spectrometry
    • H. Zhang, and et al. Mass defect filter technique and its applications to drug metabolite identification by high-resolution mass spectrometry J. Mass Spectrom. 44 2009 999 1016
    • (2009) J. Mass Spectrom. , vol.44 , pp. 999-1016
    • Zhang, H.1
  • 33
    • 27144529964 scopus 로고    scopus 로고
    • Principles and applications of LC-MS in new drug discovery
    • W.A. Korfmacher Principles and applications of LC-MS in new drug discovery Drug Discov. Today 10 2005 1357 1367
    • (2005) Drug Discov. Today , vol.10 , pp. 1357-1367
    • Korfmacher, W.A.1
  • 34
    • 84906861310 scopus 로고    scopus 로고
    • High-throughput discovery metabolomics
    • T. Fuhrer, and N. Zamboni High-throughput discovery metabolomics Curr. Opin. Biotechnol. 31C 2015 73 78
    • (2015) Curr. Opin. Biotechnol. , vol.31 C , pp. 73-78
    • Fuhrer, T.1    Zamboni, N.2
  • 35
    • 11144355178 scopus 로고    scopus 로고
    • Tamoxifen and metabolite concentrations in serum and breast cancer tissue during three dose regimens in a randomized preoperative trial
    • E.R. Kisanga, and et al. Tamoxifen and metabolite concentrations in serum and breast cancer tissue during three dose regimens in a randomized preoperative trial Clin. Cancer Res. 10 2004 2336 2343
    • (2004) Clin. Cancer Res. , vol.10 , pp. 2336-2343
    • Kisanga, E.R.1
  • 36
    • 1842607090 scopus 로고    scopus 로고
    • Association of tamoxifen (TAM) and TAM metabolite concentrations with self-reported side effects of TAM in women with breast cancer
    • L. Gallicchio, and et al. Association of tamoxifen (TAM) and TAM metabolite concentrations with self-reported side effects of TAM in women with breast cancer Breast Cancer Res. Treat. 85 2004 89 97
    • (2004) Breast Cancer Res. Treat. , vol.85 , pp. 89-97
    • Gallicchio, L.1
  • 37
    • 2342459714 scopus 로고    scopus 로고
    • Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan
    • F. Innocenti, and et al. Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan J. Clin. Oncol. 22 2004 1382 1388
    • (2004) J. Clin. Oncol. , vol.22 , pp. 1382-1388
    • Innocenti, F.1
  • 38
    • 0020003085 scopus 로고
    • Tamoxifen and metabolites in MCF7 cells: Correlation between binding to estrogen receptor and inhibition of cell growth
    • E. Coezy, and et al. Tamoxifen and metabolites in MCF7 cells: correlation between binding to estrogen receptor and inhibition of cell growth Cancer Res. 42 1982 317 323
    • (1982) Cancer Res. , vol.42 , pp. 317-323
    • Coezy, E.1
  • 39
    • 0020402019 scopus 로고
    • Metabolites of tamoxifen in animals and man: Identification, pharmacology, and significance
    • V.C. Jordan Metabolites of tamoxifen in animals and man: identification, pharmacology, and significance Breast Cancer Res. Treat. 2 1982 123 138
    • (1982) Breast Cancer Res. Treat. , vol.2 , pp. 123-138
    • Jordan, V.C.1
  • 40
    • 84896775029 scopus 로고    scopus 로고
    • DRUGSURV: A resource for repositioning of approved and experimental drugs in oncology based on patient survival information
    • I. Amelio, and et al. DRUGSURV: a resource for repositioning of approved and experimental drugs in oncology based on patient survival information Cell Death Dis. 5 2014 e1051
    • (2014) Cell Death Dis. , vol.5 , pp. e1051
    • Amelio, I.1
  • 41
    • 84896830559 scopus 로고    scopus 로고
    • Large scale integration of drug-target information reveals poly-pharmacological drug action mechanisms in tumor cell line growth inhibition assays
    • R.A. Knight, and et al. Large scale integration of drug-target information reveals poly-pharmacological drug action mechanisms in tumor cell line growth inhibition assays Oncotarget 5 2014 659 666
    • (2014) Oncotarget , vol.5 , pp. 659-666
    • Knight, R.A.1


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