Reciprocal regulation by hypoxia-inducible factor-2α and the NAMPT-NAD+-SIRT axis in articular chondrocytes is involved in osteoarthritis

Osteoarthritis and Cartilage

Volumn 23, Issue 12, 2015, Pages 2288-2296

  Oh, H ^a   Kwak, J S ^a   Yang, S ^a   Gong, M K ^a   Kim, J H ^a,b   Rhee, J ^a   Kim, S K ^a   Kim, H E ^a   Ryu, J H ^a,c   Chun, J S ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b Seoul National University   (South Korea)

^c Chonnam National University   (South Korea)

Author keywords

Chondrocytes; Hypoxia inducible factor (HIF); NAD+ biosynthesis; Osteoarthritis; Sirtuin

Indexed keywords

COLLAGENASE 3; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MACROPHAGE ELASTASE; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PROTEASOME; SIRTUIN; STROMELYSIN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CYTOKINE; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; MATRIX METALLOPEPTIDASE 12, MOUSE; MMP13 PROTEIN, MOUSE; MMP3 PROTEIN, MOUSE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE, MOUSE; SIRT1 PROTEIN, MOUSE; SIRT2 PROTEIN, MOUSE; SIRTUIN 1; SIRTUIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE CELL; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; HYDROXYLATION; MALE; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; REPORTER GENE; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; ARTICULAR CARTILAGE; EXPERIMENTAL ARTHRITIS; GENETICS; IMMUNOPRECIPITATION; KNEE OSTEOARTHRITIS; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; ARTHRITIS, EXPERIMENTAL; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BLOTTING, WESTERN; CARTILAGE, ARTICULAR; CHONDROCYTES; CYTOKINES; IMMUNOPRECIPITATION; MATRIX METALLOPROTEINASE 12; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 3; MICE; NAD; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; OSTEOARTHRITIS, KNEE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIRTUIN 1; SIRTUIN 2; SIRTUINS; UP-REGULATION;

EID: 84960220520     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2015.07.009     Document Type: Article

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