Molecular mechanisms linking autonomic dysfunction and impaired cardiac contractility in critical illness

Critical Care Medicine

Volumn 44, Issue 8, 2016, Pages e614-e624

  Ackland, Gareth L ^a,b   Whittle, John ^a   Toner, Andrew ^a   Machhada, Asif ^a   Del Arroyo, Ana Gutierrez ^a   Sciuso, Alberto ^a   Jenkins, Nicholas ^a   Dyson, Alex ^a   Struthers, Richard ^c   Sneyd, J Robert ^c   Minto, Gary ^c   Singer, Mervyn ^a   Shah, Ajay M ^d   Gourine, Alexander V ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c PENINSULA MEDICAL SCHOOL   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

autonomic dysfunction; cardiac contractility; G protein coupled receptor; G protein coupled receptor kinase; multiple organ dysfunction syndrome; sepsis

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN RECEPTOR; BETA 1 ADRENERGIC RECEPTOR; BETA ARRESTIN 1; CYCLIC AMP DEPENDENT PROTEIN KINASE; G PROTEIN COUPLED RECEPTOR KINASE 2; MESSENGER RNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; TROPONIN I; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTONOMIC DYSFUNCTION; CARDIOPULMONARY EXERCISE TEST; CAROTID SINUS NERVE; COMORBIDITY; CONTROLLED STUDY; CRITICAL ILLNESS; DIABETES MELLITUS; ENZYME ACTIVITY; EXERCISE; FEMALE; GENOTYPE; HEART DENERVATION; HEART FAILURE; HEART MUSCLE CONTRACTILITY; HEART OUTPUT; HEART PERFORMANCE; HEART RATE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INOTROPISM; INTENSIVE CARE; MAJOR CLINICAL STUDY; MALE; MOLECULAR PATHOLOGY; MONONUCLEAR CELL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PARASYMPATHETIC FUNCTION; PARASYMPATHETIC TONE; PHENOTYPE; POSTOPERATIVE COMPLICATION; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; TRANSTHORACIC ECHOCARDIOGRAPHY; UPREGULATION; VAGUS NERVE STIMULATION; ANIMAL; BLOOD PRESSURE; C57BL MOUSE; CARDIAC MUSCLE CELL; ECHOCARDIOGRAPHY; HEART; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; POSTOPERATIVE COMPLICATIONS; PROCEDURES; RANDOMIZATION; SPRAGUE DAWLEY RAT; SURGERY;

ANIMALS; BAROREFLEX; BLOOD PRESSURE; CRITICAL ILLNESS; ECHOCARDIOGRAPHY; FEMALE; G-PROTEIN-COUPLED RECEPTOR KINASE 2; HEART; HEART RATE; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MICE; MICE, INBRED C57BL; MYOCYTES, CARDIAC; NADPH OXIDASE; POSTOPERATIVE COMPLICATIONS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SURGICAL PROCEDURES, OPERATIVE; UP-REGULATION;

EID: 84960156992     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000001606     Document Type: Article

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