An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation

Annals of the Rheumatic Diseases

Volumn 75, Issue 12, 2016, Pages 2150-2156

  Roberts, Amity R ^a   Vecellio, Matteo ^a   Chen, Liye ^a   Ridley, Anna ^a   Cortes, Adrian ^a,b   Knight, Julian C ^b   Bowness, Paul ^a   Cohen, Carla J ^a   Wordsworth, B Paul ^a,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c NUFFIELD ORTHOPAEDIC CENTRE   (United Kingdom)

Author keywords

Ankylosing Spondylitis; Gene Polymorphism; T Cells

Indexed keywords

GAMMA INTERFERON; HISTONE H3; INTERLEUKIN 12 RECEPTOR BETA2; INTERLEUKIN 17; INTERLEUKIN 23 RECEPTOR; MESSENGER RNA; NONSTEROID ANTIINFLAMMATORY AGENT; IL12RB2 PROTEIN, HUMAN; IL23R PROTEIN, HUMAN; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN RECEPTOR; SPACER DNA;

ADULT; ANKYLOSING SPONDYLITIS; ARTICLE; CD4+ T LYMPHOCYTE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; EMBRYO; ENHANCER REGION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HISTONE METHYLATION; HOMOZYGOSITY; HOMOZYGOTE; HUMAN; HUMAN CELL; IL12RB2 GENE; IL23R GENE; LYMPHOCYTE DIFFERENTIATION; MAJOR CLINICAL STUDY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTECTION; SINGLE NUCLEOTIDE POLYMORPHISM; TH1 CELL; ALLELE; CELL DIFFERENTIATION; FEMALE; FLOW CYTOMETRY; GENETIC ASSOCIATION STUDY; GENETIC VARIATION; GENETICS; HEK293 CELL LINE; MALE; PHYSIOLOGY;

ADULT; ALLELES; CELL DIFFERENTIATION; DNA, INTERGENIC; FEMALE; FLOW CYTOMETRY; GENETIC ASSOCIATION STUDIES; GENETIC VARIATION; GENOTYPE; HEK293 CELLS; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-12; SPONDYLITIS, ANKYLOSING; TH1 CELLS;

EID: 84960155602     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2015-208640     Document Type: Article

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