메뉴 건너뛰기




Volumn 102, Issue , 2016, Pages 51-63

Dermal quercetin smartCrystals®: Formulation development, antioxidant activity and cellular safety

Author keywords

Antioxidative effect; Cellular toxicity; Flavonoids; Hydrogen peroxide induced toxicity; Nanocrystals; Nanosuspensions; Nonionic gel; Quercetin; SmartCrystals

Indexed keywords

CELLULOSE; HYDROGEN PEROXIDE; HYDROXYTHYLCELLULOSE; NANOCRYSTAL; POLOXAMER; QUERCETIN; UNCLASSIFIED DRUG; ANTIOXIDANT; NANOPARTICLE; POWDER; SUSPENSION;

EID: 84960153126     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2016.03.004     Document Type: Article
Times cited : (78)

References (65)
  • 1
    • 36949063535 scopus 로고
    • Antioxidant determinations by the use of a stable free radical
    • M.S. Blois Antioxidant determinations by the use of a stable free radical Nature 181 1958 1199 1200
    • (1958) Nature , vol.181 , pp. 1199-1200
    • Blois, M.S.1
  • 3
    • 33749031288 scopus 로고    scopus 로고
    • Characterization of different samples of quercetin in solid-state: Indication of polymorphism occurrence
    • G.S. Borghetti, I.M. Costa, P.R. Petrovick, V.P. Pereira, and V.L. Bassani Characterization of different samples of quercetin in solid-state: Indication of polymorphism occurrence Pharmazie 61 9 2006 802 804
    • (2006) Pharmazie , vol.61 , Issue.9 , pp. 802-804
    • Borghetti, G.S.1    Costa, I.M.2    Petrovick, P.R.3    Pereira, V.P.4    Bassani, V.L.5
  • 5
    • 75549084961 scopus 로고    scopus 로고
    • Nanotechnology and the transdermal route: A state of the art review and critical appraisal
    • G. Cevc, and U. Vierl Nanotechnology and the transdermal route: A state of the art review and critical appraisal J. Control. Release 141 2010 277 299
    • (2010) J. Control. Release , vol.141 , pp. 277-299
    • Cevc, G.1    Vierl, U.2
  • 8
    • 14744294057 scopus 로고    scopus 로고
    • In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappaB pathway
    • M. Comalada, D. Camuesco, S. Sierra, I. Ballester, J. Xaus, J. Galvez, and A. Zarzuelo In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappaB pathway Eur. J. Immunol. 35 2005 584 592
    • (2005) Eur. J. Immunol. , vol.35 , pp. 584-592
    • Comalada, M.1    Camuesco, D.2    Sierra, S.3    Ballester, I.4    Xaus, J.5    Galvez, J.6    Zarzuelo, A.7
  • 9
    • 0031004436 scopus 로고    scopus 로고
    • Bioavailability and metabolism of cidofovir following topical administration to rabbits
    • K.C. Cundy, G. Lynch, and W.A. Lee Bioavailability and metabolism of cidofovir following topical administration to rabbits Antivir. Res. 35 1997 113 122
    • (1997) Antivir. Res. , vol.35 , pp. 113-122
    • Cundy, K.C.1    Lynch, G.2    Lee, W.A.3
  • 10
    • 84899620674 scopus 로고    scopus 로고
    • Protective effect of quercetin against acetic acid induced inflammatory bowel disease (IBD) like symptoms in rats: Possible morphological and biochemical alterations
    • D. Dodda, R. Chhajed, and J. Mishra Protective effect of quercetin against acetic acid induced inflammatory bowel disease (IBD) like symptoms in rats: Possible morphological and biochemical alterations Pharmacol. Rep. 66 2014 169 173
    • (2014) Pharmacol. Rep. , vol.66 , pp. 169-173
    • Dodda, D.1    Chhajed, R.2    Mishra, J.3
  • 11
    • 0034730560 scopus 로고    scopus 로고
    • Effect of ethylene oxide and propylene oxide block copolymers on the permeability of bilayer lipid membranes to small solutes including doxorubicin
    • V.Y. Erukova, O.O. Krylova, Y.N. Antonenko, and N.S. Melik-Nubarov Effect of ethylene oxide and propylene oxide block copolymers on the permeability of bilayer lipid membranes to small solutes including doxorubicin Biochim. et Biophys. Acta (BBA)-Biomembr. 1468 2000 73 86
    • (2000) Biochim. et Biophys. Acta (BBA)-Biomembr. , vol.1468 , pp. 73-86
    • Erukova, V.Y.1    Krylova, O.O.2    Antonenko, Y.N.3    Melik-Nubarov, N.S.4
  • 12
    • 78650679438 scopus 로고    scopus 로고
    • Preparation of a chemically stable quercetin formulation using nanosuspension technology
    • L. Gao, G. Liu, X. Wang, F. Liu, Y. Xu, and J. Ma Preparation of a chemically stable quercetin formulation using nanosuspension technology Int. J. Pharm. 404 2011 231 237
    • (2011) Int. J. Pharm. , vol.404 , pp. 231-237
    • Gao, L.1    Liu, G.2    Wang, X.3    Liu, F.4    Xu, Y.5    Ma, J.6
  • 13
    • 0034962062 scopus 로고    scopus 로고
    • Trehalose-hydroxyethylcellulose microspheres containing vancomycin for topical drug delivery
    • G. Giandalia, V. De Caro, L. Cordone, and L.I. Giannola Trehalose-hydroxyethylcellulose microspheres containing vancomycin for topical drug delivery Eur. J. Pharm. Biopharm. 52 2001 83 89
    • (2001) Eur. J. Pharm. Biopharm. , vol.52 , pp. 83-89
    • Giandalia, G.1    De Caro, V.2    Cordone, L.3    Giannola, L.I.4
  • 15
    • 49249107085 scopus 로고    scopus 로고
    • Physicochemical characterisation of a novel thermogelling formulation for percutaneous penetration of 5-aminolevulinic acid
    • N. Gruning, and C.C. Muller-Goymann Physicochemical characterisation of a novel thermogelling formulation for percutaneous penetration of 5-aminolevulinic acid J. Pharm. Sci. 97 2008 2311 2323
    • (2008) J. Pharm. Sci. , vol.97 , pp. 2311-2323
    • Gruning, N.1    Muller-Goymann, C.C.2
  • 16
    • 79951882026 scopus 로고    scopus 로고
    • Quercetin inhibits diethylnitrosamine-induced hepatic preneoplastic lesions in rats
    • C. Gupta, D.N. Tripathi, A. Vikram, P. Ramarao, and G.B. Jena Quercetin inhibits diethylnitrosamine-induced hepatic preneoplastic lesions in rats Nutr. Cancer 63 2011 234 241
    • (2011) Nutr. Cancer , vol.63 , pp. 234-241
    • Gupta, C.1    Tripathi, D.N.2    Vikram, A.3    Ramarao, P.4    Jena, G.B.5
  • 19
    • 54249096899 scopus 로고    scopus 로고
    • Cytoprotective effect of fucoxanthin isolated from brown algae sargassum siliquastrum against h2o2-induced cell damage
    • S.J. Heo, S.C. Ko, S.M. Kang, H.S. Kang, J.P. Kim, S.H. Kim, and Y.J. Jeon Cytoprotective effect of fucoxanthin isolated from brown algae sargassum siliquastrum against h2o2-induced cell damage Eur. Food Res. Technol. 228 1 2008 145 151
    • (2008) Eur. Food Res. Technol. , vol.228 , Issue.1 , pp. 145-151
    • Heo, S.J.1    Ko, S.C.2    Kang, S.M.3    Kang, H.S.4    Kim, J.P.5    Kim, S.H.6    Jeon, Y.J.7
  • 20
    • 0028904605 scopus 로고
    • Antioxidative activity of quercetin and quercetin monoglucosides in solution and phospholipid bilayers
    • K. Ioku, T. Tsushida, Y. Takei, N. Nakatani, and J. Terao Antioxidative activity of quercetin and quercetin monoglucosides in solution and phospholipid bilayers Biochim. Biophys. Acta 1234 1995 99 104
    • (1995) Biochim. Biophys. Acta , vol.1234 , pp. 99-104
    • Ioku, K.1    Tsushida, T.2    Takei, Y.3    Nakatani, N.4    Terao, J.5
  • 21
    • 69749103682 scopus 로고    scopus 로고
    • Nanocrystal technology, drug delivery and clinical applications
    • J.-U.A.H. Junghanns, and R.H. Müller Nanocrystal technology, drug delivery and clinical applications Int. J. Nanomed. 3 2008 295 310
    • (2008) Int. J. Nanomed. , vol.3 , pp. 295-310
    • Junghanns, J.-U.A.H.1    Müller, R.H.2
  • 22
    • 84859848502 scopus 로고    scopus 로고
    • Fabrication of quercetin nanoparticles by anti-solvent precipitation method for enhanced dissolution
    • M. Kakran, N.G. Sahoo, L. Li, and Z. Judeh Fabrication of quercetin nanoparticles by anti-solvent precipitation method for enhanced dissolution Powder Technol. 223 2012 59 64
    • (2012) Powder Technol. , vol.223 , pp. 59-64
    • Kakran, M.1    Sahoo, N.G.2    Li, L.3    Judeh, Z.4
  • 25
    • 76149089279 scopus 로고    scopus 로고
    • Second generation of drug nanocrystals for delivery of poorly soluble drugs: SmartCrystal technology
    • C. Keck, S. Kobierski, R. Mauludin, and H.R. Müller Second generation of drug nanocrystals for delivery of poorly soluble drugs: SmartCrystal technology Dosis 24 2008 124 128
    • (2008) Dosis , vol.24 , pp. 124-128
    • Keck, C.1    Kobierski, S.2    Mauludin, R.3    Müller, H.R.4
  • 26
    • 84906079253 scopus 로고    scopus 로고
    • Formulation of solid lipid nanoparticles (SLN): The value of different alkyl polyglucoside surfactants
    • C.M. Keck, A. Kovačević, R.H. Müller, S. Savić, G. Vuleta, and J. Milić Formulation of solid lipid nanoparticles (SLN): The value of different alkyl polyglucoside surfactants Int. J. Pharm. 474 2014 33 41
    • (2014) Int. J. Pharm. , vol.474 , pp. 33-41
    • Keck, C.M.1    Kovačević, A.2    Müller, R.H.3    Savić, S.4    Vuleta, G.5    Milić, J.6
  • 27
    • 78049446251 scopus 로고    scopus 로고
    • Subcritical water extraction of flavonol quercetin from onion skin
    • M.J. Ko, C.I. Cheigh, S.W. Cho, and M.S. Chung Subcritical water extraction of flavonol quercetin from onion skin J. Food Eng. 102 2011 327 333
    • (2011) J. Food Eng. , vol.102 , pp. 327-333
    • Ko, M.J.1    Cheigh, C.I.2    Cho, S.W.3    Chung, M.S.4
  • 28
    • 57249103373 scopus 로고    scopus 로고
    • A new method for determination of myricetin and quercetin using solid phase microextraction-high performance liquid chromatography-ultra violet/visible system in grapes, vegetables and red wine samples
    • A. Kumar, A.K. Malik, and D.K. Tewary A new method for determination of myricetin and quercetin using solid phase microextraction-high performance liquid chromatography-ultra violet/visible system in grapes, vegetables and red wine samples Anal. Chim. Acta 631 2009 177 181
    • (2009) Anal. Chim. Acta , vol.631 , pp. 177-181
    • Kumar, A.1    Malik, A.K.2    Tewary, D.K.3
  • 29
    • 58549089321 scopus 로고    scopus 로고
    • Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles
    • H. Li, X. Zhao, Y. Ma, G. Zhai, L. Li, and H. Lou Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles J. Control. Release 133 2009 238 244
    • (2009) J. Control. Release , vol.133 , pp. 238-244
    • Li, H.1    Zhao, X.2    Ma, Y.3    Zhai, G.4    Li, L.5    Lou, H.6
  • 30
    • 84868711105 scopus 로고    scopus 로고
    • Anti-inflammatory activity and percutaneous absorption of quercetin and its polymethoxylated compound and glycosides: The relationships to chemical structures
    • C.F. Lin, Y.L. Leu, S.A. Al-Suwayeh, M.C. Ku, T.-L. Hwang, and J.-Y. Fang Anti-inflammatory activity and percutaneous absorption of quercetin and its polymethoxylated compound and glycosides: The relationships to chemical structures Eur. J. Pharm. Sci. 47 2012 857 864
    • (2012) Eur. J. Pharm. Sci. , vol.47 , pp. 857-864
    • Lin, C.F.1    Leu, Y.L.2    Al-Suwayeh, S.A.3    Ku, M.C.4    Hwang, T.-L.5    Fang, J.-Y.6
  • 31
    • 84863839992 scopus 로고    scopus 로고
    • Protective role of quercetin against lead-induced inflammatory response in rat kidney through the ROS-mediated MAPKs and NF-κB pathway
    • C.M. Liu, Y.Z. Sun, J.M. Sun, J.Q. Ma, and C. Cheng Protective role of quercetin against lead-induced inflammatory response in rat kidney through the ROS-mediated MAPKs and NF-κB pathway Biochim. et Biophys. Acta (BBA)-Gen. Sub. 1820 2012 1693 1703
    • (2012) Biochim. et Biophys. Acta (BBA)-Gen. Sub. , vol.1820 , pp. 1693-1703
    • Liu, C.M.1    Sun, Y.Z.2    Sun, J.M.3    Ma, J.Q.4    Cheng, C.5
  • 32
    • 84881190336 scopus 로고    scopus 로고
    • Quercetin deformable liposome: Preparation and efficacy against ultraviolet B induced skin damages in vitro and in vivo
    • D. Liu, H. Hu, Z. Lin, D. Chen, Y. Zhu, S. Hou, and X. Shi Quercetin deformable liposome: Preparation and efficacy against ultraviolet B induced skin damages in vitro and in vivo J. Photochem. Photobiol., B 127 2013 8 17
    • (2013) J. Photochem. Photobiol., B , vol.127 , pp. 8-17
    • Liu, D.1    Hu, H.2    Lin, Z.3    Chen, D.4    Zhu, Y.5    Hou, S.6    Shi, X.7
  • 34
    • 84960159694 scopus 로고    scopus 로고
    • G.G. Liversidge, K.C. Cundy, J.F. Bishop, D.A. Czekai, S.D. Inc., Dispersion, Bioavailability, U.S. Patent No. 5,145,684. U.S. Patent and Trademark Office, Washington, DC, 1992.
    • G.G. Liversidge, K.C. Cundy, J.F. Bishop, D.A. Czekai, S.D. Inc., Dispersion, Bioavailability, U.S. Patent No. 5,145,684. U.S. Patent and Trademark Office, Washington, DC, 1992.
  • 35
    • 28944454312 scopus 로고    scopus 로고
    • Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro
    • S.Y. Lyu, J.Y. Rhim, and W.B. Park Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro Arch. Pharm. Res. 28 2005 1293 1301
    • (2005) Arch. Pharm. Res. , vol.28 , pp. 1293-1301
    • Lyu, S.Y.1    Rhim, J.Y.2    Park, W.B.3
  • 36
    • 62749150964 scopus 로고    scopus 로고
    • Production and characterization of Hesperetin nanosuspensions for dermal delivery
    • P.R. Mishra, L.A. Shaal, R.H. Müller, and C.M. Keck Production and characterization of Hesperetin nanosuspensions for dermal delivery Int. J. Pharm. 371 2009 182 189
    • (2009) Int. J. Pharm. , vol.371 , pp. 182-189
    • Mishra, P.R.1    Shaal, L.A.2    Müller, R.H.3    Keck, C.M.4
  • 37
    • 79959739491 scopus 로고    scopus 로고
    • Lipid nanocarriers for dermal delivery of lutein: Preparation, characterization, stability and performance
    • K. Mitri, R. Shegokar, S. Gohla, C. Anselmi, and R.H. Müller Lipid nanocarriers for dermal delivery of lutein: Preparation, characterization, stability and performance Int. J. Pharm. 414 2011 267 275
    • (2011) Int. J. Pharm. , vol.414 , pp. 267-275
    • Mitri, K.1    Shegokar, R.2    Gohla, S.3    Anselmi, C.4    Müller, R.H.5
  • 38
    • 0029070782 scopus 로고
    • Percutaneous absorption of indomethacin from pluronic F127 gels in rats
    • S. Miyazaki, T. Tobiyama, M. Takada, and D. Attwood Percutaneous absorption of indomethacin from pluronic F127 gels in rats J. Pharm. Pharmacol. 47 1995 455 457
    • (1995) J. Pharm. Pharmacol. , vol.47 , pp. 455-457
    • Miyazaki, S.1    Tobiyama, T.2    Takada, M.3    Attwood, D.4
  • 41
    • 84960159695 scopus 로고    scopus 로고
    • R.H. Müller, R. Becker, B. Kruss, K. Peters, Pharmaceutical Nanosuspensions for Medicament Administration as Systems With Increased Saturation Solubility and Rate of Solution, United States Patent 5,858,410, Medac Gesellschaft für Klinische Spezialpraparate mbH, 1999.
    • R.H. Müller, R. Becker, B. Kruss, K. Peters, Pharmaceutical Nanosuspensions for Medicament Administration as Systems With Increased Saturation Solubility and Rate of Solution, United States Patent 5,858,410, Medac Gesellschaft für Klinische Spezialpraparate mbH, 1999.
  • 42
    • 0037177516 scopus 로고    scopus 로고
    • Buparvaquone mucoadhesive nanosuspension: Preparation, optimisation and long-term stability
    • R.H. Müller, and C. Jacobs Buparvaquone mucoadhesive nanosuspension: Preparation, optimisation and long-term stability Int. J. Pharm. 237 2002 151 161
    • (2002) Int. J. Pharm. , vol.237 , pp. 151-161
    • Müller, R.H.1    Jacobs, C.2
  • 43
    • 78650677364 scopus 로고    scopus 로고
    • Second generation of drug nanocrystals for delivery of poorly soluble drugs: SmartCrystal technology
    • R.H. Müller, and C.M. Keck Second generation of drug nanocrystals for delivery of poorly soluble drugs: SmartCrystal technology Eur. J. Pharm. Sci. 34 2008 S20 S21
    • (2008) Eur. J. Pharm. Sci. , vol.34 , pp. S20-S21
    • Müller, R.H.1    Keck, C.M.2
  • 44
    • 71549124967 scopus 로고    scopus 로고
    • Influence of ball milling parameters on the particle size of barium titanate nanocrystalline powders
    • A.K. Nath, C. Jiten, and K.C. Singh Influence of ball milling parameters on the particle size of barium titanate nanocrystalline powders Physica B 405 2010 430 434
    • (2010) Physica B , vol.405 , pp. 430-434
    • Nath, A.K.1    Jiten, C.2    Singh, K.C.3
  • 45
    • 84892594944 scopus 로고    scopus 로고
    • On the role of specific interactions in the diffusion of nanoparticles in aqueous polymer solutions
    • E.A. Mun, C. Hannell, S.E. Rogers, P. Hole, A.C. Williams, and V.V. Khutoryanskiy On the role of specific interactions in the diffusion of nanoparticles in aqueous polymer solutions Langmuir 30 1 2014 308 317
    • (2014) Langmuir , vol.30 , Issue.1 , pp. 308-317
    • Mun, E.A.1    Hannell, C.2    Rogers, S.E.3    Hole, P.4    Williams, A.C.5    Khutoryanskiy, V.V.6
  • 46
    • 0033965872 scopus 로고    scopus 로고
    • Preparation of a clofazimine nanosuspension for intravenous use and evaluation of its therapeutic efficacy in murine Mycobacterium avium infection
    • K. Peters, S. Leitzke, J.E. Diederichs, K. Borner, H. Hahn, R.H. Müller, and S. Ehlers Preparation of a clofazimine nanosuspension for intravenous use and evaluation of its therapeutic efficacy in murine Mycobacterium avium infection J. Antimicrob. Chemother. 45 2000 77 83
    • (2000) J. Antimicrob. Chemother. , vol.45 , pp. 77-83
    • Peters, K.1    Leitzke, S.2    Diederichs, J.E.3    Borner, K.4    Hahn, H.5    Müller, R.H.6    Ehlers, S.7
  • 47
    • 84960159696 scopus 로고    scopus 로고
    • R. Petersen, Nanocrystals for Use in Topical Cosmetic Formulations and Method of Production Thereof, US Patent, 2006.
    • R. Petersen, Nanocrystals for Use in Topical Cosmetic Formulations and Method of Production Thereof, US Patent 60/8866233, 2006.
  • 48
    • 84896739800 scopus 로고    scopus 로고
    • Quercetin improves hypoxia-ischemia induced cognitive deficits via promoting remyelination in neonatal rat
    • X. Qu, D. Qi, F. Dong, B. Wang, R. Guo, M. Luo, and R. Yao Quercetin improves hypoxia-ischemia induced cognitive deficits via promoting remyelination in neonatal rat Brain Res. 1553 2014 31 40
    • (2014) Brain Res. , vol.1553 , pp. 31-40
    • Qu, X.1    Qi, D.2    Dong, F.3    Wang, B.4    Guo, R.5    Luo, M.6    Yao, R.7
  • 49
    • 84899428460 scopus 로고    scopus 로고
    • Synthesis, antioxidant and photoprotection activities of hybrid derivatives useful to prevent skin cancer
    • J.S. Reis, M.A. Correâ, M.C. Chung, and J.L. dos Santos Synthesis, antioxidant and photoprotection activities of hybrid derivatives useful to prevent skin cancer Bioorg. Med. Chem. 22 2014 2733 2738
    • (2014) Bioorg. Med. Chem. , vol.22 , pp. 2733-2738
    • Reis, J.S.1    Correâ, M.A.2    Chung, M.C.3    Dos Santos, J.L.4
  • 52
    • 84922710442 scopus 로고    scopus 로고
    • Combinative particle size reduction technologies for the production of drug nanocrystals
    • J. Salazar, R.H. Müller, and J.P. Möschwitzer Combinative particle size reduction technologies for the production of drug nanocrystals J. Pharm. 2014 2014 265 754
    • (2014) J. Pharm. , vol.2014 , pp. 265-754
    • Salazar, J.1    Müller, R.H.2    Möschwitzer, J.P.3
  • 53
    • 0036244921 scopus 로고    scopus 로고
    • Elution order of quercetin glycosides from apple pomace extracts on a new HPLC stationary phase with hydrophilic endcapping
    • A. Schieber, P. Hilt, J. Conrad, U. Beifuss, and R. Carle Elution order of quercetin glycosides from apple pomace extracts on a new HPLC stationary phase with hydrophilic endcapping J. Sep. Sci. 25 2002 361 364
    • (2002) J. Sep. Sci. , vol.25 , pp. 361-364
    • Schieber, A.1    Hilt, P.2    Conrad, J.3    Beifuss, U.4    Carle, R.5
  • 54
    • 84865410633 scopus 로고    scopus 로고
    • Nanocarriers for dermal drug delivery: Influence of preparation method, carrier type and rheological properties
    • J.C. Schwarz, A. Weixelbaum, E. Pagitsch, M. Löw, G.P. Resch, and C. Valenta Nanocarriers for dermal drug delivery: Influence of preparation method, carrier type and rheological properties Int. J. Pharm. 437 2012 83 88
    • (2012) Int. J. Pharm. , vol.437 , pp. 83-88
    • Schwarz, J.C.1    Weixelbaum, A.2    Pagitsch, E.3    Löw, M.4    Resch, G.P.5    Valenta, C.6
  • 55
    • 77956882799 scopus 로고    scopus 로고
    • Nanocrystals: Industrially feasible multifunctional formulation technology for poorly soluble actives
    • R. Shegokar, and R.H. Müller Nanocrystals: Industrially feasible multifunctional formulation technology for poorly soluble actives Int. J. Pharm. 399 2010 129 139
    • (2010) Int. J. Pharm. , vol.399 , pp. 129-139
    • Shegokar, R.1    Müller, R.H.2
  • 56
    • 0000468690 scopus 로고
    • Phenolics of apple, pear, and white grape juices and their changes with processing and storage. A review
    • G.A. Spanos, and R.E. Wrolstad Phenolics of apple, pear, and white grape juices and their changes with processing and storage. A review J. Agric. Food Chem. 40 1992 1478 1487
    • (1992) J. Agric. Food Chem. , vol.40 , pp. 1478-1487
    • Spanos, G.A.1    Wrolstad, R.E.2
  • 57
  • 58
    • 84918799193 scopus 로고    scopus 로고
    • The "real environment" quantification of surface hydrophobicity of differently stabilized nanocrystals as key parameter for organ distribution
    • S. Staufenbiel, C.M. Keck, and R.H. Müller The "real environment" quantification of surface hydrophobicity of differently stabilized nanocrystals as key parameter for organ distribution Macromol. Sym. 345 1 2014 32 41
    • (2014) Macromol. Sym. , vol.345 , Issue.1 , pp. 32-41
    • Staufenbiel, S.1    Keck, C.M.2    Müller, R.H.3
  • 59
    • 40949138845 scopus 로고    scopus 로고
    • Development of ascorbyl palmitate nanocrystals applying the nanosuspension technology
    • V. Teeranachaideekul, V.B. Junyaprasert, E.B. Souto, and R.H. Müller Development of ascorbyl palmitate nanocrystals applying the nanosuspension technology Int. J. Pharm. 354 2008 227 234
    • (2008) Int. J. Pharm. , vol.354 , pp. 227-234
    • Teeranachaideekul, V.1    Junyaprasert, V.B.2    Souto, E.B.3    Müller, R.H.4
  • 60
    • 0027292287 scopus 로고
    • Molecular pharmacology of Vitamin E: Structural aspects of antioxidant activity
    • S.A.B.E. van Acker, L.M.H. Koymans, and A. Bast Molecular pharmacology of vitamin E: Structural aspects of antioxidant activity Free Rad. Biol. Med. 15 1993 311 328
    • (1993) Free Rad. Biol. Med. , vol.15 , pp. 311-328
    • Van Acker, S.A.B.E.1    Koymans, L.M.H.2    Bast, A.3
  • 62
    • 20744447048 scopus 로고    scopus 로고
    • Electrokinetic properties of noncharged lipid nanocapsules: Influence of the dipolar distribution at the interface
    • A. Vonarbourg, P. Saulnier, C. Passirani, and J.P. Benoit Electrokinetic properties of noncharged lipid nanocapsules: Influence of the dipolar distribution at the interface Electrophoresis 26 11 2005 2066 2075
    • (2005) Electrophoresis , vol.26 , Issue.11 , pp. 2066-2075
    • Vonarbourg, A.1    Saulnier, P.2    Passirani, C.3    Benoit, J.P.4
  • 63
    • 79957691069 scopus 로고    scopus 로고
    • Physical and chemical stability of drug nanoparticles
    • L. Wu, J. Zhang, and W. Watanabe Physical and chemical stability of drug nanoparticles Adv. Drug Deliv. Rev. 63 2011 456 469
    • (2011) Adv. Drug Deliv. Rev. , vol.63 , pp. 456-469
    • Wu, L.1    Zhang, J.2    Watanabe, W.3
  • 64
    • 67649159521 scopus 로고    scopus 로고
    • Time resolved UV-VIS absorption spectra of quercetin reacting with various concentrations of sodium hydroxide
    • L.J. Yang, P. Li, Y.J. Gao, H.F. Li, D.C. Wu, and R.X. Li Time resolved UV-VIS absorption spectra of quercetin reacting with various concentrations of sodium hydroxide Guang Pu Xue Yu Guang Pu Fen Xi 29 6 2009 1632 1635
    • (2009) Guang Pu Xue Yu Guang Pu Fen Xi , vol.29 , Issue.6 , pp. 1632-1635
    • Yang, L.J.1    Li, P.2    Gao, Y.J.3    Li, H.F.4    Wu, D.C.5    Li, R.X.6
  • 65
    • 84862777378 scopus 로고    scopus 로고
    • Antitumor activities of quercetin and quercetin-5′,8-disulfonate in human colon and breast cancer cell lines
    • H. Zhang, M. Zhang, L. Yu, Y. Zhao, N. He, and X. Yang Antitumor activities of quercetin and quercetin-5′,8-disulfonate in human colon and breast cancer cell lines Food Chem. Toxicol. 50 2012 1589 1599
    • (2012) Food Chem. Toxicol. , vol.50 , pp. 1589-1599
    • Zhang, H.1    Zhang, M.2    Yu, L.3    Zhao, Y.4    He, N.5    Yang, X.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.