Bioavailability and metabolism of cidofovir following topical administration to rabbits

Antiviral Research

Volumn 35, Issue 2, 1997, Pages 113-122

  Cundy, Kenneth C ^a   Lynch, Geoffrey ^a   Lee, William A ^a  

^a GILEAD SCIENCES   (United States)

Author keywords

Antiviral; Cidofovir; Formulation; Pharmacokinetics; Rabbit; Topical

Indexed keywords

ANTIVIRUS AGENT; CIDOFOVIR; HYDROXYETHYLCELLULOSE; NUCLEOTIDE DERIVATIVE; PROPYLENE GLYCOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG TISSUE LEVEL; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RADIOACTIVITY; SKIN; SKIN ABRASION; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ANIMALS; ANTIVIRAL AGENTS; BIOLOGICAL AVAILABILITY; CARBON RADIOISOTOPES; CYTOSINE; ISOTOPE LABELING; MALE; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHONIC ACIDS; RABBITS; TISSUE DISTRIBUTION;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0031004436     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(97)00022-3     Document Type: Article

References (18)

1. Aspe, E., Guy, R.H., Lee, W.A., Kennedy, J.A., Visor, G.C., Ennis, R.D., 1995. Optimization of in vitro flux through hairless mouse skin of cidofovir, a potent nucleotide analog. J. Pharm. Sci. 84, 750-754.
2. Bischofberger, N., Hitchcock, M.J.M., Chen, M.S., Barkhimer, D.B., Cundy, K.C., Kent, K.M., Lacy, S.A., Lee, W.A., Li, Z.-H., Louie, M., Mendel, D.B., Smee, D.S., Smith, J.L., 1994. Cyclic HPMPC: An intracellular prodrug for HPMPC with improved therapeutic index in vivo. Antimicrob. Agents Chemother. 38, 2387-2391.
3. Bronson, J.J., Ghazzouli, I., Hitchcock, M.J.M., Webb, R.R., Kern, E.R., Martin, J.C., 1989. Synthesis and antiviral activity of nucleotide analogs bearing the (S)-(3-hydroxy-2-phosphonylmethoxy)propyl moiety attached to adenine, guanine and cytosine. In: Martin, J.C. (Ed.), Nucleotide Analogues as Antiviral Agents, American Chemical Society, Washington, DC, pp. 88-102.
4. Bronson, J.J., Ferrara, L.M., Hitchcock, M.J.M., Ho, H.-T., Woods, K.L., Ghazzouli, I., Kern, E.R., Soike, K.F., Martin, J.C., 1990a. (S)-1-(3-Hydroxy-2-(phosphonylmethoxy)propyl) cytosine (HPMPC): A potent antiherpesvirus agent. In: Lopez, C. et al. (Eds.), Immunobiology and Prophylaxis of Human Herpesvirus Infections, Plenum Press, New York, pp. 277-283.
5. Bronson, J.J., Ho, H.-T., De Boeck, H., Woods, K.L., Ghazzouli, I., Martin, J.C., Hitchcock, M.J.M., 1990b. Biochemical pharmacology of acyclic nucleotide analogs. Annal. New York Acad. Sci. 616, 398-407.
6. Cundy, K.C., Petty, B.P., Flaherty, J., Fisher, P.E., Polis, M.A., Wachsmann, M., Lietman, P.S., Hitchcock, M.J.M., Jaffe, H.S., 1995. Clinical pharmacokinetics of cidofovir in HIV-infected patients. Antimicrob. Agents Chemother. 39, 1247-1252.
7. Cundy, K.C., Bidgood, A., Lynch, G., Shaw, J.-P., Griffin, L., Lee, W.A., 1996a. Pharmacokinetics, bioavailability, metabolism and tissue distribution of cidofovir (HPMPC) and cyclic HPMPC in rats. Drug Metab. Disposit. 24, 745-752.
8. Cundy, K.C., Li, Z.-H., Lee, W.A., 1996b. Effect of probenecid on the metabolism, distribution and excretion of cidofovir in rabbits. Drug Met. Disposit. 24, 315-321.
9. Cundy, K.C., Lynch, G., Shaw, J.-P., Hitchcock, M.J.M., Lee, W.A., 1996c. Distribution and metabolism of intravitreal cidofovir and cyclic HPMPC in rabbits. Current Eye Res. 15, 569-576.
10. De Clercq, E., Holy, A., 1991. Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine in various models of herpes simplex virus infection in mice. Antimicrob. Agents Chemother. 35, 701-706.
11. Kern, E.R., Palmer, J., Vogt, P.E., Cundy, K.C., Hitchcock, M.J.M., Sommadossi, J.-P., 1995. Efficacy and pharmacokinetics of topical HPMPC in a genital herpes model. Antiviral Res. 26, A341.
12. Korner, P.I., 1963. Renal blood flow, glomerular filtration rate, renal PAH extraction ratio and the role of the vasomotor nerves in the unanesthetized rabbit. Circ. Res. 12, 353.
13. + and TK-HSV-1 keratitis in rabbits. Antiviral Res. 16, 93-100.
14. Okamato, H., Muta, K., Hashida, M., Sezaki, H., 1990. Percutaneous penetration of acyclovir through excised mouse and rat skin: Effect of vehicle and percutaneous penetration enhancer. Pharm. Res. 7, 64-68.
15. Rowland, M., Tozer, T.N., 1989. Clinical Pharmacokinetics: Concepts and Applications. Second edition. Lea and Febiger, Malvern, PA.
16. Shiba, K., Saito, A., Shimada, J., Hori, S., Kaji, M., Miyahara, T., Kusajima, H., Kaneko, S., Saito, S., Ooie, T., Uchida, Y., 1990. Renal handling of fleroxacin in rabbits, dogs and humans. Antimicrob. Agents Chemother. 34, 58-64.
17. Snoeck, R., Andrei, G., De Clercq, E., Gerard, M., Clumeck, N., Tricot, G., Sadzot-Delvaux, C., 1993. A new topical treatment for resistant herpes simplex infections. New Engl. J. Med. 329, 968.
18. Wachsmann, M., Petty, B., Jaffe, H., Cundy, K.C., Fisher, P.E., Lietman, P., 1994. Phase I trial of a new anti-cytomegalovirus agent, (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine (HPMPC) in HIV-infected volunteers. Antiviral Res. 109 (1), 93.