Ginger for Prevention of Antituberculosis-induced Gastrointestinal Adverse Reactions Including Hepatotoxicity: A Randomized Pilot Clinical Trial

Phytotherapy Research

Volumn 30, Issue 6, 2016, Pages 1003-1009

  Emrani, Zahra ^a   Shojaei, Esphandiar ^b   Khalili, Hossein ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

antituberculosis; gastrointestinal adverse reactions; ginger; hepatotoxicity

Indexed keywords

HERBACEOUS AGENT; PLACEBO; TUBERCULOSTATIC AGENT; ANTIEMETIC AGENT;

ABDOMINAL PAIN; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; DRUG RESPONSE; DRUG TOLERABILITY; DYSPEPSIA; FEMALE; GASTROINTESTINAL DISEASE; GINGER; HEARTBURN; HUMAN; LIVER TOXICITY; MAJOR CLINICAL STUDY; MALE; NAUSEA; PILOT STUDY; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; TREATMENT OUTCOME; TUBERCULOSIS; VOMITING; ADULT; CHEMISTRY; COMPLICATION; DOUBLE BLIND PROCEDURE; GASTROINTESTINAL DISEASES; LIVER; PATHOLOGY;

ADULT; ANTIEMETICS; ANTITUBERCULAR AGENTS; DOUBLE-BLIND METHOD; FEMALE; GASTROINTESTINAL DISEASES; GINGER; HUMANS; LIVER; MALE; NAUSEA; PILOT PROJECTS; TUBERCULOSIS; VOMITING;

EID: 84960145775     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5607     Document Type: Article

References (39)

1. Ali BH, Blunden G, Tanira MO, Nemmar A,. 2008. Some phytochemical, pharmacological and toxicological properties of ginger: a review of recent research. Food Chem Toxicol 46 (2): 409-420.
2. Altug E, et al., 2013. Effect of ginger extract on liver damage in experimental obstructive jaundice produced by main bile duct ligation. Acta Chir Belg 113 (1): 8-13.
3. Atta AH, Elkoly TA, Mouneir SM, Kamel G, Alwabel NA, Zaher S,. 2010. Hepatoprotective effect of methanol extracts of zingiberofficinale and cichoriumintybus. Indian J Pharm Sci 72 (5): 564-570.
4. Becker DE,. 2010. Nausea, vomiting, and hiccups: a review of mechanisms and treatment. Anesth Prog 57 (4): 150-156.
5. ClarkVetri RJ,. 1999. Management of chemotherapy induced emesis. Pharm Times 65: 7885.
6. Dabaghzadeh F, Khalili H, Dashti-Khavidaki S,. 2014a. Ginger for prevention or treatment of drug-induced nausea and vomiting. Curr Clin Pharmacol 9 (4): 387-394.
7. Dabaghzadeh F, Khalili H, Dashti-Khavidaki S, Abbasian L, Moeinifard A,. 2014b. Ginger for prevention of antiretroviral-induced nausea and vomiting: a randomized clinical trial. Expert Opin Drug Saf 13 (7): 859-866.
8. Danan G, Benichou C,. 1993. Causality assessment of adverse reactions to drugs-I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. J Clin Epidemiol 46: 1323-1330.
9. Ergul Y, Erkan T, Uzun H, Genc H, Altug T, Erginoz E,. 2010. Effect of vitamin C on oxidative liver injury due to isoniazid in rats. Pediatr Int 52: 69-74.
10. Farazi A, Sofian M, Jabbariasl M, Keshavarz S,. 2014. Adverse reactions to antituberculosis drugs in Iranian tuberculosis patients. Tuberc Res Treat 2014: 412893.
11. Haniadka R, Saxena A, Shivashankara AR, Fayad R, Palatty PL,. 2013. Ginger protects the liver against the toxic effects of xenobiotic compounds: preclinical observations. J Nutr Food Sci 3: 226.
12. Hatamkhani S, Khalili H, Karimzadeh I, Dashti-Khavidaki S, Abdollahi A, Jafari S,. 2014. Carnitine for prevention of antituberculosis drug-induced hepatotoxicity: a randomized, clinical trial. J Gastroenterol Hepatol 29 (5): 997-1004.
13. Khalili H, Dashti-khavidaki S, Sajadi S, Hajiabolbaghi M,. 2008. Assessment of adherence to tuberculosis drug regimen. DARU 16 (1): 47-50.
14. Khalili H, Dashti-Khavidaki S, Rasoolinejad M, Rezaie L, Etminani M,. 2009. Anti-tuberculosis drugs related hepatotoxicity; incidence, risk factors, pattern of changes in liver enzymes and outcome. DARU 17 (3): 163-167.
15. Langner E, Greifenberg S, Gruenwald J,. 1998. Ginger: history and use. Adv Ther 15 (1): 25-44.
16. Liu Q, Garner P, Wang Y, Huang B, Smith H,. 2008. Drugs and herbs given to prevent hepatotoxicity of tuberculosis therapy: systematic review of ingredients and evaluation studies. BMC Public Health 8: 365.
17. Maciel EL, Guidoni LM, Favero GL, et al., 2010. Adverse effects of the new tuberculosis treatment regimen recommended by the Brazilian Ministry of Health. J Bras Pneumol 36: 232-238.
18. Mahesh R, Perumal RV, Pandi PV,. 2005. Cancer chemotherapy-induced nausea and vomiting: role of mediators, development of drugs and treatment methods. Pharmazie 60 (2): 83-96.
19. Motawi TK, Hamed MA, Shabana MH, Hashem RM, AboulNaser AF,. 2011. Zingiber officinale acts as a nutraceutical agent against liver fibrosis. Nutr Metab 2011;8:40. 47. Sahebkar A. Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease. World J Gastroenterol 17 (2): 271-272.
20. Naranjo CA, Busto U, Sellers EM, et al., 1981. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 30 (2): 239-245.
21. Pertz HH, Lehmann J, Roth-Ehrang R, Elz S,. 2011. Effects of ginger constituents on the gastrointestinal tract: role of cholinergic M3 and serotonergic 5-HT3 and 5-HT4 receptors. Planta Med 77 (10): 973-978.
22. de Pradier E,. 2006. A trial of a mixture of three essential oils in the treatment of postoperative nausea and vomiting. Int J Aromather 16 (1): 15-20.
23. Qian Q, Yue W, Wang Y, Yang Z, Liu Z, Chen W,. 2009. Gingerol inhibits cisplatin-induced vomiting by down regulating 5-hydroxytryptamine, dopamine and substance P expression in minks. Arch. Pharm. Res. 32 (4): 565-573.
24. Qian Q, Yue W, Chen W, Yang Z, Liu Z, Wang Y,. 2010. Effect of gingerol on substance P and NK1 receptor expression in a vomiting model of mink. Chin Med J 123 (4): 478-484.
25. Ramappa V, Aithal GP,. 2013. Hepatotoxicity related to anti-tuberculosis drugs: mechanisms and management. J Clin Exp Hepatol 3: 37-49.
26. Saad EI, El-Gowilly SM, Sherhaa MO, Bistawroos AE,. 2010. Role of oxidative stress and nitric oxide in the protective effects of alpha-lipoic acid and aminoguanidine against isoniazid-rifampicin-induced hepatotoxicity in rats. Food Chem Toxicol 48 (7): 1869-1875.
27. Saukkonen JJ, Cohn DL, Jasmer RM, et al., 2006. An official ATS statement: hepatotoxicity of antituberculosis therapy. Am J Respir Crit Care Med 174: 935-952.
28. Schmid R, Schick T, Steffen R, Tschopp A, Wilk T,. 1994. Comparison of seven commonly used agents for prophylaxis of seasickness. J Travel Med 1: 203-206.
29. Sistanizad M, Azizi E, Khalili H, Hajiabdolbaghi M, Gholami K, Mahjub R,. 2011. Antituberculosis drug-induced hepatotoxicity in Iranian tuberculosis patients: role of isoniazid metabolic polymorphism. Iran J Pharm Res 10: 633-639.
30. Steele MA, Burk R, DesPrez R,. 1991. Toxic hepatitis with isoniazid and rifampin. A meta-analysis. Chest 99: 465-471.
31. Sukhanov DS,. 2012. Effectiveness of the hepatoprotective activity of reamberine, remaxol, and ademethionine and risk assessment in their use in patients with respiratory tuberculosis and drug-induced liver injury. Ter Arkh 84: 26-29.
32. Swamy AH, Kulkarni RV, Koti BC, Gadad PC, Thippeswamy AH, Gore A,. 2012. Hepatoprotective effect of cissus quadrangularis stem extract against rifampicin-induced hepatotoxicity in rats. Indian J Pharm Sci 74 (2): 183-187.
33. Taramian S, Joukar F, Asgharnezhad M, Biabani A, Mansour GF,. 2012. Side effects of first-line anti tuberculosis drugs. J Guilan Univ Med Sci 85: 42-47.
34. Tasduq SA, Peerzada K, Koul S, Bhat R, Johri RK,. 2005. Biochemical manifestations of anti-tuberculosis drugs induced hepatotoxicity and the effect of silymarin. Hepatol Res 31: 132-135.
35. Thompson NP, Caplin ME, Hamilton MI, et al., 1995. Anti-tuberculosis medication and the liver: dangers and recommendations in management. Eur Respir J 8: 1384-1388.
36. Tostmann A, Boeree MJ, Aarnoutse RE, De Lange WC, Van Der Ven AJ, Dekhuijzen R,. 2008. Antituberculosis drug-induced hepatotoxicity: concise up-to-date review. J Gastroenterol Hepatol 23 (2): 192-202.
37. White B,. 2007. Ginger: an overview. Am Fam Physician 75 (11): 1689-1691.
38. World Health Organization. 2014. World Health Organization. Global tuberculosis report.
39. Xia Y, Zhan S,. 2007. Systematic review of anti-tuberculosis drug induced adverse reactions in China. Chin J Tuberc Respir Dis (Zhonghua Jie He He Hu Xi Za Zhi) 30: 419-423.