Gingerol inhibits cisplatin-induced vomiting by down regulating 5-hydroxytryptamine, dopamine and substance P expression in minks

Archives of Pharmacal Research

Volumn 32, Issue 4, 2009, Pages 565-573

  Qian, Qiu Hai ^a,b   Yue, Wang ^a   Wang, Yao Xia ^a   Yang, Zhi Hong ^a   Liu, Zhan Tao ^a   Chen, Wen Hui ^b  

^a QINGDAO UNIVERSITY   (China)

^b SHANDONG UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

5 HT; Cisplatin; Dopamine; Gingerol; Mink; Substance P; Vomiting

Indexed keywords

CISPLATIN; DOPAMINE; GINGEROL; ONDANSETRON; SEROTONIN; SUBSTANCE P;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIEMETIC ACTIVITY; AREA POSTREMA; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG MECHANISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ILEUM; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MINK; NONHUMAN; VOMITING;

ANIMALS; ANTIEMETICS; AREA POSTREMA; CATECHOLS; CISPLATIN; DISEASE MODELS, ANIMAL; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FATTY ALCOHOLS; ILEUM; INTESTINAL MUCOSA; MALE; MINK; SEROTONIN; SUBSTANCE P; VOMITING;

EID: 65549095892     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-009-1413-9     Document Type: Article

References (41)

1. H. Abali I. Celik 2007 Tropisetron, ondansetron, and granisetron for control of chemotherapy-induced emesis in Turkish cancer patients: a comparison of efficacy, side-effect profile, and cost Cancer Invest 25 135 139 (Pubitemid 47164856)
2. 3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum Eur J Pharmacol 530 136 143 (Pubitemid 43040002)
3. P. L. R. Andrews P. Bhandari 1993 Resinferatoxin, an ultrapotent capsaicin analogue, has anti-emetic properties in the ferret Neuropharmacology 32 799 806 (Pubitemid 23227666)
4. P. L. R. Andrews P. Bhandari 1993 The 5-hydroxytryptamine receptor antagonists as antiemetics: preclinical evaluation and mechanism of action EurJ Cancer 29 Suppll S11 S16
5. P. L. R. Andrews F. Okada A. J. Woods H. Hagiwara S. Kakaimoto M. Toyoda N. Matsuki 2000 The emetic and anti-emetic effects of the capsaicin analogue resiniferatoxin in, the Suncus murinus house musk shrew Br J Pharmacol 130 1247 1254 (Pubitemid 30488586)
6. Andrews, P. L. R. and Rudd, J. A., The role of tachykinins and the tachykinin receptor in nausea and emesis. In Holzer, P. (Eds.), Handbook of Experimental Pharmacology. Springer-Verlag Berlin Heidelberg, Germany, pp. 359-440 (2004).
7. 1 receptor antagonist, CP-99,994, in ferrets Eur J. Pharmacol 249 R3 R4 (Pubitemid 23326901)
8. 3 receptors Br J Pharmacol 94 397 412 (Pubitemid 18253566)
9. L. X. Cubeddu 1996 Serotonin mechanisms in chemotherapyinduced emesis in cancer patients Oncology 53 Suppl1 18 25 (Pubitemid 26335145)
10. L. X. Cubeddu I. S. Hoffman N. T. Fuenmayor 1990 Efficacy of ondansetron (GR 38032F) and the role of serotonin in cisplatin-induced nausea and vomiting N Engl J Med 322 810 816 (Pubitemid 20094144)
11. C. M. Ferrier H. H. de Witte H. Straatman 1999 Comparison of immunohistochemistry with immunoassay (ELISA) for the detection of components of the plasminogen activation system in human tumour tissue British Journal of Cancer 79 1534 154 (Pubitemid 29116817)
12. P. Diemunsch L. Grelot 2000 Potential of substance P antagonists as antiemetics Drugs 60 533 546
13. J. J. Fiore R. J. Gralla 1984 Pharmacologic treatment of chemotherapy-induced nausea and vomiting Cancer Invest 2 351
14. S. M. Grunberg P. J. Hesketh 1993 Control of chemotherapy-induced emesis New Engl J Med 329 1790 1796 (Pubitemid 23355554)
15. J. Herrstedt 1996 New perspectives in antiemetic treatment Support Care Cancer 4 416 419
16. P. J. Hesketh S. Van Belle M. Aapro F. D. Tattersall R. J. Naylor R. Hargreaves A. D. Carides J. K. Evans K. J. Horgan 2003 Differential involvement of neurotransmitters through the time course of cisplatin-induced emesis as revealed by therapy with specific receptor antagonists Eur. J. Cancer 39 1074 1080 (Pubitemid 36555864)
17. T. J. Hickok G. R. Morrow 1993 A biobehavioral model of patientreported nausea: implications for clinical practise Adv. Med. Psychother 6 227
18. S. Z. Jiang S. Z. Mi N. S. Wang 2006 Survey of chemical constituents of gingerol Traditional Chinese Drug Research & Clinical Pharmacology (in Chinese) 17 386 389
19. K. Jordan C. Kasper H. Schmoll 2005 Chemotherapy induced nausea and vomiting: current and new standards in the antiemetic prophylaxis and treatment Eur J Cancer 41 199 205 (Pubitemid 40126951)
20. G. J. Kilpatrick B. J. Jones M. B. Tyers 1989 Binding of the 5-HT3 ligand, [3H]GR65630, to rat area postrema, vagus nerve and the brains of several species Eur J Pharmacol 159 157 164 (Pubitemid 19023013)
21. G. L. King M. R. Landauer 1990 Effects of zacopride and BMY25801 (batanopride) on radiation-induced emesis and loco-motor behavior in the ferret J Pharmacol Exp Ther 253 1026 1033 (Pubitemid 20209359)
22. K. Leksowski P. Peryga R. Szyca 2006 Ondansetron, metoclopramid, dexamethason, and their combinations compared for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a prospective randomized study Surg Endosc 20 878 882 (Pubitemid 43825189)
23. R. A. Leslie 1985 Neuroactive substances in the dorsal vagal complex of the medulla oblongata: nucleus of the tractus solitarius, area postrema, and dosal motor nucleus of vagus Neurochem Int. 7 191 211 (Pubitemid 15116198)
24. J. B. Lucot 1989 Blockade of 5-hydroxytryptamine3 receptors prevents cisplatin-induced but not motion- or xylazineinduced emesis in the cat Pharmacol Biochem Behav 32 207 210 (Pubitemid 19125940)
25. M. Minami T. Endo N. Hamaue 2004 Serotonin and anticancer drug-induced emesis Surg Endosc 124 491 507 (Pubitemid 41350475)
26. A. Nagashima Y. Takano K. Tateishi Y. Matsuoka T. Hamaoka H. Kamiya 1989 Cardiovascular roles of tachykinin peptides in the nucleus tractus solitarii of rats Brain Res 487 392 396 (Pubitemid 19127212)
27. B. W. Newton B. Maley H. Traurig 1985 The distribution of substance P, enkephalin and serotonin immunoreactivities in the area postrema of the rat and cat J. Comp. Neurol 234 87 104 (Pubitemid 15146064)
28. 4-receptors in guinea pig ileum Br. J. Pharmacol 111 419 424 (Pubitemid 24146092)
29. Rudd, J. A. and Andrews, P. L. R., Mechanisms of acute, delayed, and anticipatory emesis induced by anticancer therapies, In P.J. Hesketh (Eds.), Management of Nausea and Vomiting in Cancer and Cancer Treatment, Jones and Barlett Publishers, Inc., USA, pp 15-66 (2004).
30. A. Round D. I. Wallis 1986 The depolarizing action of 5-hydroxy-tryptamine on rabbit vagal afferent and sympathetic neurones in vitro and its selective blockade by ICS 205-930 Br J Pharmacol 88 485 494 (Pubitemid 16123114)
31. D. Pongrojpaw 2003 The efficacy of ginger in prevention of post-operative nausea and vomiting after outpatient gynecological laparoscopy J. Med. Assoc. Thai 3 244 250 (Pubitemid 36781946)
32. J. T. Potts I. E. Fuchs J. Li B. Leshnower J. H. Mitchell 1999 Skeletal muscle afferent fibres release substance P in the nucleus tractus solitarii of anaesthetized cats Journal of Physiology 514 829 841 (Pubitemid 29060328)
33. Rudd, J. A. and Andrews, P. L. R., Mechanisms of acute, delayed and anticipatory vomiting in cancer and cancer treatment. In Hesketh, P. (Eds.), Management of Nausea and Vomiting in Cancer and Cancer Treatment. Jones and Barlett Publishers Inc., New York, pp 15-66 (2004).
34. S. S. Sharma 1997 Antie metic effcacy of ginger against cisplatin induced emsis in dogs Ethnonharmacol 2 93 96
35. Y. J. Surh 2002 Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review Food Chem Toxicol 40 1091 1097 (Pubitemid 34626872)
36. F. D. Tattersall W. Rycroft R. G. Hill R. J. Hargreaves 1994 Enantioselective inhibition of apomorphine-induced emesis in the ferret by the neuokinin1 receptor antagonist CP-99,994 Neuropharmacology 33 259 260 (Pubitemid 24104292)
37. S. Van Belle M. R. Lichinitser R. M. Navari 2002 Prevention of cisplatin-induced acute and delayed emesis by the selective neurokinin-1 antagonists, L-758,298 and MK-869 Cancer 94 3032 3041
38. J. W. Watson S. F. Gonsalves A. A. Fossa S. [tmp] McLean T. Seeger S. Obach P. L. R. Andrews 1995 The antiemetic effects of CP-99,994 in the ferret and dog: role of the NK1 receptor Br. J. Pharmacol 115 84 94
39. T. Vutyavanich 2001 Ginger for nausea and vomiting in pregnancy: randomized double-masked placebo-controlled trial Obstetrics and Gynecology 4 577 582 (Pubitemid 32241115)
40. F. Zhang L. Wang Z. H. Yang 2006 Value of mink vomit model in study of anti-emetic drugs World J Gastroenterol 12 1300 1302
41. D.-x. Zhao Z.-h. Yang M. Li M. Xue W. Yue 2006 Anti-emetic effects of ginger on a nausea model of mink Chinese Pharmaceutical Affairs (in Chinese) 10 601 604