Role of oxidative stress and nitric oxide in the protective effects of α-lipoic acid and aminoguanidine against isoniazid-rifampicin-induced hepatotoxicity in rats

Food and Chemical Toxicology

Volumn 48, Issue 7, 2010, Pages 1869-1875

  Saad, Evan I ^a   El Gowilly, Sahar M ^a   Sherhaa, Mabrouka O ^a   Bistawroos, Azza E ^a  

^a Alexandria University Faculty of Pharmacy   (Egypt)

Author keywords

Lipoic acid; Aminoguanidine; Isoniazid; Nitric oxide; Oxidative stress; Rifampicin

Indexed keywords

ALANINE AMINOTRANSFERASE; AMINOGUANIDINE; ASPARTATE AMINOTRANSFERASE; CATALASE; GLUTATHIONE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ISONIAZID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MYELOPEROXIDASE; NITRIC OXIDE; NITRITE; PROTEIN; RIFAMPICIN; SUPEROXIDE DISMUTASE; THIOCTIC ACID; TRIACYLGLYCEROL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; HISTOPATHOLOGY; LIPID PEROXIDATION; LIVER FUNCTION; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; RAT; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; ANTIOXIDANTS; ANTITUBERCULAR AGENTS; DRUG-INDUCED LIVER INJURY; GLUTATHIONE; GUANIDINES; ISONIAZID; LIPID PEROXIDATION; LIVER; LIVER FUNCTION TESTS; MALE; NITRIC OXIDE; OXIDATIVE STRESS; PEROXIDASE; RATS; RATS, WISTAR; RIFAMPIN; THIOCTIC ACID;

RATTUS;

EID: 77953612005     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2010.04.026     Document Type: Article

References (65)

1. Abdel-Zaher O., Randa H., Abdel-Hady H., Madeha M., Farrag M.Y. The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage. Toxicology 2008, 243:261-270.
2. Arafa H.M.M. Carnitine deficiency: a possible risk factor in paracetamol hepatotoxicity. Arch. Toxicol. 2009, 83:139-150.
3. Attri S., Rana S.V., Vaiphei K., Sodhi C.P., Katyal R., Goel R.C., Nain C.K., Singh K. Isoniazid and rifampicin induced oxidative hepatic injury protection by N-acetylcysteine. Hum. Exp. Toxicol. 2000, 19:517-522.
4. Biewenga G.P., Haenen G.R., Bast A. The pharmacology of the antioxidant α-lipoic acid. Gen. Pharmacol. 1997, 29:315-331.
5. Bliska A., Wlodek L. Lipoic acid - the drug of the future?. Pharmacol. Rep. 2005, 57:570-577.
6. Bryk R., Wolff D.J. Mechanism of inducible nitric oxide synthase inactivation by aminoguanidine and l-N6-(1-iminoethyl)lysine. Biochemistry 1998, 37:4844-4852.
7. Burstein M., Scholnick H.R. Precipitation of chylomicron and very low-density lipoprotein from human serum with sodium lauryl sulphate. Life Sci. 1972, 11:177-184.
8. Cetinkaya A., Bulbuloglu E., Kurutas E.B., Kantarceken B. N-acetylcysteine ameliorates methotrexate-induced oxidative liver damage in rats. Med. Sci. Monit. 2006, 12:BR274-BR278.
9. Demarco V.G., Scumpia P.O., Bosanquet J.P., Skimming J.W. Alpha-lipoic acid inhibits endotoxin-stimulated expression of iNOS and nitric oxide independent of the heat shock response in RAW264.7 cells. Free Radical Res. 2004, 38:675-682.
10. Eidelman R.A., Lamas G.S., Hennerkens C.H. The new national education program guidelines. Arch. Intern. Med. 2002, 162:2033-2036.
11. Ellard G.A., Mitchison D.A., Girling D.J., Nunn A.J., Fox W. The hepatic toxicity of isoniazid among rapid and slow acetylators of the drug. Am. Rev. Respir. Dis. 1978, 118:628-629.
12. Gardner C.R., Heck D.E., Yang C.S., Thomas P.E., Zhang X.-J., Degeorge G.L., Laskin J.D., Laskin D.L. Role of nitric oxide in acetaminophen-induced hepatotoxicity in the rat. Hepatology 1998, 26:748-754.
13. Gardner C.R., Laskin J.D., Dambach D.M., Sacco M., Durham S.K., Bruno M.K., Cohen S.D., Gordon M.K., Gerecke D.R., Zhou P., Laskin D.L. Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: potential role of tumor necrosis factor-alpha and interleukin-10. Toxicol. Appl. Pharmacol. 2002, 184:27-36.
14. Georgieva N., Gadjeva V., Tolekova A. New isonicotinyl hydrazones with SSA protect against oxidative-hepatic injury of isoniazid. TJS 2004, 2:37-43.
15. Griffith O.W. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal. Biochem. 1980, 106:207-212.
16. Hagar H.H. The protective effect of taurine against cyclosporine A-induced oxidative stress and hepatotoxicity in rats. Toxicol. Lett. 2004, 151:335-343.
17. Han D., Handelman G., Marcocci L., Sen C.K., Roy S., Kobuchi H., Tritschier H.J., Flohe L., Packer L. Lipoic acid increases de novo synthesis of cellular glutathione by improving cysteine utilization. Biofactors 1997, 6:321-338.
18. Harstad E.B., Klaassen C.D. INOS-null mice are not resistant to cadmium chloride-induced hepatotoxicity. Toxicology 2002, 175:83-90.
19. Hierholzer C., Harbrecht B., Menezes J.M., Kane J., MacMicking J., Nathan C.F., Peitzman A.B., Billiar T.R., Tweardy D.J. Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock. J. Exp. Med. 1998, 187:917-928.
20. 2). Proc. Soc. Exp. Biol. Med. 1978, 158:478-481.
21. Hillegass L.M., Griswold D.E., Brickson B., Albridghtson-Winslow C. Assessment of myeloperoxidase activity in whole rat kidney. J. Pharmacol. Methods 1990, 24:285-295.
22. Hinson J.A., Pike S.L., Pumford N.R., Mayeux P.R. Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice. Chem. Res. Toxicol. 1998, 11:604-607.
23. Hoechst M.R. Rifadin. PDR Physicians' Desk Reference 2000, 1379-1382. Medical Economics Data, Oradell, NJ.
24. Imai T., Hirata Y., Kanno K., Marumo F. Induction of nitric oxide synthase by cyclic AMP in rat vascular smooth muscle cells. J. Clin. Invest. 1994, 93:543-549.
25. Iseman M.D., Madsen L.A. Drug-resistant tuberculosis. Clin. Chest Med. 1989, 10:341-353.
26. Laskin D.L., del Valle Rodriguez M.D., Heck E., Hwang S.M., Ohnishi S.T., Durham S.K., Goller N.L., Laskin J.D. Hepatic nitric oxide production following acute endotoxemia in rats is mediated by increased inducible nitric oxide synthase gene expression. Hepatology 1995, 22:223-234.
27. Li B.-F., Liu Y.-F., Zhang K.-Z., Li T.-M., Zhao T.-M. Protective effect of inducible nitric oxide synthase inhibitor on pancreas transplantation in rats. World J. Gastroenterol. 2007, 13(45):6066-6071.
28. Marklund S., Marklund G. Involvement of superoxide anion radical in autoxidation of pyrogallol and a convenient assay for SOD. Eur. J. Biochem. 1974, 47:469-474.
29. Martinet W., Knaapen M.W., De Meyer G.R., Herman A.G., Kockx M.M. Oxidative DNA damage and repair in experimental atherosclerosis are reversed by dietary lipid lowering. Circ. Res. 2001, 88:733-739.
30. Misko T.P., Moore W.M., Kasten T.P. Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur. J. Pharmacol. 1993, 233:119-125.
31. Moshage H., Kok B., Huizenga J.R., Jansen P.L. Nitrite and nitrate determination in plasma: a critical evaluation. J. Clin. Chem. 1995, 41:892-896.
32. Mythili Y., Sudharsan P.T., Sudhahar V., Varalakshmi P. Protective effect of dl-α-lipoic acid on cyclophosphamide induced hyperlipidemic cardiomyopathy. Eur. J. Pharmacol. 2006, 543:92-96.
33. Nakagawa H., Sumiki E., Ikote N., Matsushima Y., Ozawa T. Endogenous and new synthetic antioxidants for peroxynitrite: selective inhibitory effect of 5-methoxytyptamine and lipoic acid on tyrosine nitration by peroxynitrite. Antioxid. Redox. Signal. 1999, 1:239-244.
34. Nakagawa H., Sumiki E., Takusagawa M., Ikote N., Matsushima Y., Ozawa T. Scavengers for peroxynitrite: inhibition of tyrosine nitration and oxidation with tryptamine derivatives, alpha-lipoic acid synthetic compound. Chem. Pharm. Bull. 2000, 48:261-265.
35. Ohta Y., Kongo-Nishimura M., Imai Y., Matsura T., Kitagawa A., Yamada K. α-Tocopherol protects against α-naphthylisothiocyanate-induced hepatotoxicity in rats less effectively than melatonin. Chem. Biol. Interact. 2006, 161(2):115-124.
36. Packer L. α-Lipoic acid: a metabolic antioxidant which regulates NF-κ signal transduction and protects against oxidative injury. Drug Metab. Rev. 1998, (30):245-275.
37. Pal R., Rana S.V., Vaiphei K., Singh K. Isoniazid-rifampicin induced lipid changes in rats. Clin. Chim. Acta 2008, 389:55-60.
38. Picard F., Kapur S., Perreault M., Marette A., Deshaies Y. Nitric oxide mediates endotoxin-induced hypertriglyceridemia through its action on skeletal muscle lipoprotein lipase. FASEB J. 2001, 15(10):1828-1830.
39. Quan, J., Yin, X., Xu, H., 2009. Boschniakiarossica prevents the carbon tetrachloride-induced hepatotoxicity in rat. Exp. and Toxicol. Pathol., in press. Available online: October 2009.
40. Reitman S., Frankel S. A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminase. Am. J. Clin. Pathol. 1957, 28:56-63.
41. Santhosh S., Sini T.K., Anandan R., Mathew P.T. Effect of chitosan supplementation on antitubercular drugs-induced hepatotoxicity in rats. Toxicology 2006, 219:53-59.
42. Santhosh S., Sini T.K., Anandan R., Mathee P.T. Hepatoprotective activity of chitosan against isoniazid and rifampicin-induced toxicity in experimental rats. Eur. J. Pharmacol. 2007, 572:69-73.
43. Sarich T.C., Adams S.P., Petricca G., Wright J.M. Inhibition of isoniazid-induced hepatotoxicity in rabbits by pretreatment with an amidase inhibitor. J. Pharmacol. Exp. Ther. 1999, 289:695-702.
44. Sass G., Koerber K., Bang R., Guehring H., Tiegs G. Inhibition of endotoxemia-induced nitric oxide synthase expression by cyclosporin A enhances hepatocyte injury in rats: amelioration by NO donors. Int. Immunopharmacol. 2002, 2:117-127.
45. Shila S., Subathra M., Devi M.A., Panneerselvam C. Arsenic intoxication-induced reduction of glutathione level and the activity of related enzymes in rat brain regions: reversal by dl-alpha-lipoic acid. Arch. Toxicol. 2005, 79:140-146.
46. Somoskovi A., Parsons L.M., Salfinger M. The molecular basis of resistance to isoniazid, rifampin, and pyrazinamide in Mycobacterium tuberculosis. Resp. Res. 2001, 2:164-168.
47. Spitzer J.A., Zheng M., Kolls J.K., Vande Stouwe C., Spitzer J.J. Ethanol and LPS modulate NF-kappaB activation, inducible NO synthase and COX-2 gene expression in rat liver cells in vivo. Front. Biosci. 2002, 7:99-108.
48. Steele M.A., Burk R.F., Des Prez R.M. Toxic hepatitis with isoniazid and rifampicin - a meta analysis. Chest 1991, 99:465-468.
49. Stein E.A., Myers G.L. Lipids, lipoproteins and apolipoproteins. Tietz Textbook of Clinical Chemistry 1994, vol. 23:1002-1093. WB Saunders Company. second ed.
50. Tasduq S.A., Peerzada K., Koul S., Bhat R., Johri R.K. Biochemical manifestations of anti-tuberculosis drugs induced hepatotoxicity and the effect of silymarin. Hepatol. Res. 2005, 31:132-135.
51. Timmins, G.S., Master, S., Rusnak, F., Deretic, V., 2004. Requirements for nitric oxide generation from isoniazid activation in vitro and inhibition of mycobacterial respiration in vivo. J. Bacteriol., 5427-5431.
52. Timmins G.S., Deretic V. Mechanism of action of isoniazid. Mol. Microbiol. 2006, 62:1220-1227.
53. Tojo A., Gross S.S., Zhang L., et al. Immunocytochemical localization of distinct isoforms of nitric oxide synthase in the juxtaglomerular apparatus of normal rat kidney. J. Am. Soc. Nephrol. 1994, 4:1438-1447.
54. Tomonaga I., Jingyan L., Shuji K., Tomonari K., Xiaofei W., Huijun S., et al. Macrophage-derived lipoprotein lipase increases aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 2005, 179:87-95.
55. Trujillo M., Folkes L., Bartesaghi S., Kalyanaraman B., Wardman P., Radi R. Peroxynitrite-derived carbonate and nitrogen dioxide radicals readily react with lipoic and dihydrolipoic acid. Free Radical Biol. Med. 2005, 39:279-288.
56. Uchiyama M., Mihara M. Determination of malonaldehyde precursor in tissue by thiobarbituric acid test. Anal. Biochem. 1978, 86:271-278.
57. Varley H., Gowenlock A.H., Bell M. The plasma proteins. Practical Clinical Biochemistry. General Topics and Commoner Tests 1980, vol. 1:542-548. William Heinemann Medical Books, LTD, London, (Chapter 19). fifth ed.
58. Walubo A., Smith P., Folb P.I. The role of oxygen free radicals in isoniazid-induced hepatotoxicity. Meth. Find. Exp. Clin. Pharmacol. 1998, 20:649-655.
59. Weber L.W., Boll M., Stampfl A. Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit. Rev. Toxicol. 2003, 33:105-136.
60. Weiss S.J., Ward P.A. Immune complex-induced generation of oxygen metabolites by human neutrophils. J. Immunol. 1982, 129:309.
61. WHO report Global Tuberculosis Control: Surveillance, Planning, Financing 2007, World Health Organization, Geneva, Switzerland.
62. Wybenger D.R., Pileggim B.J., Dirstina T.H., Di Cugio J. Direct manual determination of serum total cholesterol with a single stable reagent. Clin. Chem. 1970, 16:980-984.
63. Yanagisawa H., Nodera M., Wada O. Inducible nitric oxide synthase expression in mercury chloride-induced acute tubular necrosis. Ind. Health 1998, 36:324-330.
64. Yuhas Y., Berent L.E., Cohen R., Ashkenazi S. Roles of NF-κB activation and peroxisome proliferators-activated receptor gamma inhibition in the effect of rifampin on inducible nitric oxide synthase transcription in human lung epithelial cells. Antimicrob. Agents Chemother. 2009, 53(4):1539-1545.
65. Zhang C., Walker L.M., Mayeux P.R. Role of nitric oxide in lipopolysaccharide-induced oxidant stress in the rat kidney. Biochem. Pharmacol. 2000, 59:203-209.