Technical-induced hemolysis in patients with respiratory failure supported with veno- venous ECMO - prevalence and risk factors

PLoS ONE

Volumn 10, Issue 11, 2015, Pages

  Lehle, Karla ^a   Philipp, Alois ^a   Zeman, Florian ^a   Lunz, Dirk ^a   Lubnow, Matthias ^a   Wendel, Hans Peter ^b   Göbölös, Laszlo ^c   Schmid, Christof ^a   Müller, Thomas ^a  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^c UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN;

ACUTE RESPIRATORY FAILURE; ADULT; ARTICLE; BLOOD FLOW; CANNULA; CONTROLLED STUDY; EQUIPMENT DESIGN; ERYTHROCYTE TRANSFUSION; EXTRACORPOREAL OXYGENATION; FEMALE; HEMOGLOBIN BLOOD LEVEL; HEMOLYSIS; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE TRAUMA; PREVALENCE; RENAL REPLACEMENT THERAPY; RETROSPECTIVE STUDY; RISK FACTOR; TECHNICAL INDUCED HEMOLYSIS; THROMBOSIS; TREATMENT DURATION; ADVERSE EFFECTS; COMPLICATION; HEMODIAFILTRATION; HEMODYNAMICS; MIDDLE AGED; MORTALITY; PROCEDURES; RENAL INSUFFICIENCY; RESPIRATORY INSUFFICIENCY; TREATMENT OUTCOME;

ADULT; ERYTHROCYTE TRANSFUSION; EXTRACORPOREAL MEMBRANE OXYGENATION; FEMALE; HEMODIAFILTRATION; HEMODYNAMICS; HEMOLYSIS; HUMANS; MALE; MIDDLE AGED; PREVALENCE; RENAL INSUFFICIENCY; RESPIRATORY INSUFFICIENCY; RETROSPECTIVE STUDIES; RISK FACTORS; THROMBOSIS; TREATMENT OUTCOME;

EID: 84960099005     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0143527     Document Type: Article

References (42)

1. Sauer CM, Yuh DD, Bonde P. Extracorporeal membrane oxygenation use has increased by 433% in adults in the United States from 2006 to 2011. ASAIO J. 2015; 61: 31-36. doi: 10.1097/MAT. 0000000000000160 PMID: 25303799
2. Abrams D, Brodie D. Extracorporeal circulatory approaches to treat acute respiratory distress syndrome. Clin Chest Med. 2014; 35: 765-779. doi: 10.1016/j.ccm.2014.08.013 PMID: 25453424
3. Guttendorf J, Boujoukos AJ, Ren D, Rosenzweig MQ, Hravnak M. Discharge outcome in adults treated with extracorporeal membrane oxygenation. Am J Crit Care. 2014; 23: 365-377. doi: 10.4037/ajcc2014115 PMID: 25179031
4. Omar HR, Mirsaeidi M, Socias S, Sprenker C, Caldeira C, Camporesi EM, et al. Plasma Free Hemoglobin Is an Independent Predictor of Mortality among Patients on Extracorporeal Membrane Oxygenation Support. PLoS One. 2015; 10(4): E0124034. doi: 10.1371/journal.pone.0124034 PMID: 25902047
5. Lee SG, Son BS, Kang PJ, Cho WH, Kim do H, Lee YS, et al. The feasibility of extracorporeal membrane oxygenation support for inter-hospital transport and as a bridge to lung transplantation. Ann Thorac Cardiovasc Surg. 2014; 20(1): 26-31. PMID: 24807473
6. Lubnow M, Philipp A, Foltan M, Bull Enger T, Lunz D, Bein T, et al. Technical complications during veno-venous extracorporeal membrane oxygenation and their relevance predicting a systemexchange- retrospective analysis of 265 cases. PLoS One 2014; 9(12): E112316. doi: 10.1371/journal.pone.0112316 PMID: 25464516
7. Murphy DA, Hockings LE, Andrews RK, Aubron C, Gardiner EE, Pellegrino VA, et al. Extracorporeal Membrane Oxygenation-Hemostatic Complications. Transfus Med Rev. 2015; 29(2): 90-101. doi: 10. 1016/j.tmrv.2014.12.001 PMID: 25595476
8. Zangrillo A, Landoni G, Biondi-Zoccai G, Greco M, Greco T, Frati G, et al. A meta-analysis of complications and mortality of extracorporeal membrane oxygenation. Crit Care Resusc. 2013; 15(3): 172-178. PMID: 23944202
9. Leverett LB, Hellums JD, Alfrey CP, Lynch EC. Red blood cell damage by shear stress. Biophys J. 1972; 12(3): 257-273. PMID: 5016112
10. Shimono T, Makinouchi K, Nosé Y. Total erythrocyte destruction time: The new index for the hemolytic performance of rotary blood pumps. Artif Organs. 1995; 19(7): 571-575. PMID: 8572954
11. Vercaemst L. Hemolysis in cardiac surgery patients undergoing cardiopulmonary bypass: A review in search of a treatment algorithm. J Extra Corpor Technol. 2008; 40(4): 257-267 PMID: 19192755
12. Green TP, Kriesmer P, Steinhorn RH, Payne NR, Irmiter RJ, Meyer CL. Comparison of pressure-volume-flow relationships in centrifugal and roller pump extracorporeal membrane oxygenation systems for neonates. ASAIO Trans. 1991; 37(4): 572-576. PMID: 1768491
13. Wielogorski JW, Cross DE, Nwadike EV. The effects of subatmospheric pressure on the haemolysis of blood. J Biomech. 1975; 8(5): 321-325. PMID: 1184603
14. Williams DC, Turi JL, Hornik CP, Bonadonna DK, Williford WL, Walczak RJ, et al. Circuit oxygenator contributes to extracorporeal membrane oxygenation-induced hemolysis. ASAIO J. 2015; 61(2): 190-195. doi: 10.1097/MAT.0000000000000173 PMID: 25419829
15. Skogby M, Mellgren K, Adrian K, Friberg LG, Chevalier JY, Mellgren G. Induced cell trauma during in vitro perfusion: A comparison between two different perfusion systems. Artif Organs. 1998; 22(12): 1045-1051. PMID: 9876097
16. Rother RP, Bell L, Hillmen P, Gladwin MT. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: A novel mechanism of human disease. JAMA. 2005; 293(13): 1653-1662. PMID: 15811985
17. Cappellini MD. Coagulation in the pathophysiology of hemolytic anemias. Hematology Am Soc Hematol Educ Program. 2007: 74-78. PMID: 18024612
18. Jeney V, Balla J, Yachie A, Varga Z, Vercellotti GM, Eaton JW, et al: Pro-oxidant and cytotoxic effects of circulating heme. Blood. 2002; 100(3):879-887. PMID: 12130498
19. Schaer DJ, Buehler PW, Alayash AI, Belcher JD, Vercellotti GM. Hemolysis and free hemoglobin revisited: Exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. Blood. 2013; 121(8): 1276-1284. doi: 10.1182/blood-2012-11-451229 PMID: 23264591
20. Betrus C, Remenapp R, Charpie J, Kudelka T, Brophy P, Smoyer WE, et al. Enhanced hemolysis in pediatric patients requiring extracorporeal membrane oxygenation and continuous renal replacement therapy. Ann Thorac Cardiovasc Surg. 2007; 13(6): 378-383. PMID: 18292719
21. Vermeulen Windsant IC, De Wit NC, Sertorio JT, Van Bijnen AA, Ganushchak YM, Heijmans JH, et al. Hemolysis during cardiac surgery is associated with increased intravascular nitric oxide consumption and perioperative kidney and intestinal tissue damage. Front Physiol. 2014; 5: 340. doi: 10.3389/fphys. 2014.00340 PMID: 25249983
22. Gbadegesin R, Zhao S, Charpie J, Brophy PD, Smoyer WE, Lin JJ. Significance of hemolysis on extracorporeal life support after cardiac surgery in children. Pediatr Nephrol. 2009; 24(3): 589-595. doi: 10. 1007/s00467-008-1047-z PMID: 19002722
23. Müller T, Bein T, Philipp A, Graf B, Schmid C, Riegger G. Extracorporeal pulmonary support in severe pulmonary failure in adults: A treatment rediscovered. Dtsch Arztebl Int. 2013; 110(10): 159-166. doi: 10.3238/arztebl.2013.0159 PMID: 23533547
24. Enger T, Philipp A, Videm V, Lubnow M, Wahba A, Fischer M, et al. Prediction of mortality in adult patients with severe acute lung failure receiving veno-venous extracorporeal membrane oxygenation: A prospective observational study. Crit Care. 2014; 18(2): R67. doi: 10.1186/cc13824 PMID: 24716510
25. Brodie D, Bacchetta M. Extracorporeal membrane oxygenation for ARDS in adults. N Engl J Med. 2011; 365(20): 1905-1914. doi: 10.1056/NEJMct1103720 PMID: 22087681
26. Pan KC, McKenzie DP, Pellegrino V, Murphy D, Butt W. The meaning of a high plasma free haemoglobin: Retrospective review of the prevalence of haemolysis and circuit thrombosis in an adult ECMO centre over 5 years. Perfusion. 2015 Jul 22 pii: 0267659115595282.
27. Lou S, MacLaren G, Best D, Delzoppo C, Butt W. Hemolysis in pediatric patients receiving centrifugalpump extracorporeal membrane oxygenation: Prevalence, risk factors, and outcomes. Crit Care Med. 2014; 42(5): 1213-1220. doi: 10.1097/CCM.0000000000000128 PMID: 24351369
28. Lehle K, Philipp A, Müller T, Schettler F, Bein T, Schmid C, et al. Flow dynamics of different adult ECMO systems: A clinical evaluation. Artif Organs. 2014; 38(5): 391-398. doi: 10.1111/aor.12180 PMID: 24117454
29. Steinhorn RH, Isham-Schopf B, Smith C, Green TP. Hemolysis during long-term extracorporeal membrane oxygenation. J Pediatr. 1989; 115(4): 625-630. PMID: 2795361
30. Lubnow M, Philipp A, Dornia C, Schroll S, Bein T, Creutzenberg M, et al. D-dimers as an early marker for oxygenator exchange in extracorporeal membrane oxygenation. J Crit Care. 2014; 29(3): 473. e1-5.
31. Dornia C, Philipp A, Bauer S, Stroszczynski C, Schreyer AG, Müller T, et al: D-dimers are a predictor of clot volume inside membrane oxygenators during extracorporeal membrane oxygenation. Artif Organs. 2015; 39(9): 782-787. doi: 10.1111/aor.12460 PMID: 25845704
32. Ricci Z, Pezzella C, Romagnoli S, Iodice F, Haiberger R, Carotti A, et al. High levels of free haemoglobin in neonates and infants undergoing surgery on cardiopulmonary bypass. Interact Cardiovasc Thorac Surg. 2014; 19(2): 183-187. doi: 10.1093/icvts/ivu129 PMID: 24812332
33. Erdmann J: Blood feud: The debate over how long blood lasts. Nat Med. 2014; 20(9): 979-982. doi: 10. 1038/nm0914-979 PMID: 25198042
34. Kawahito S, Maeda T, Motomura T, Ishitoya H, Takano T, Nonaka K, et al: Hemolytic characteristics of oxygenators during clinical extracorporeal membrane oxygenation. ASAIO J. 2002; 48(6): 636-639. PMID: 12455774
35. Palanzo DA, El-Banayosy A, Stephenson E, Brehm C, Kunselman A, Pae WE. Comparison of hemolysis between CentriMag and RotaFlow rotary blood pumps during extracorporeal membrane oxygenation. Artif Organs. 2013; 37(9): E162-166. doi: 10.1111/aor.12158 PMID: 23981131
36. Klaus S, Körfer S, Mottaghy K, Reul H, Glasmacher B. In vitro blood damage by high shear flow: Human versus porcine blood. Int J Artif Organs. 2002; 25(4): 306-312. PMID: 12027141
37. Bakir I, Hoylaerts MF, Kink T, Foubert L, Luyten P, Van Kerckhoven S, et al. Mechanical stress activates platelets at a subhemolysis level: An in vitro study. Artif Organs. 2007; 31(4): 316-323. PMID: 17437501
38. Toomasian JM, Bartlett RH. Hemolysis and ECMO pumps in the 21st Century. Perfusion. 2011; 26(1): 5-6. doi: 10.1177/0267659110396015 PMID: 21177726
39. Bein T, Zonies D, Philipp A, Zimmermann M, Osborn EC, Allan PF, et al. Transportable extracorporeal lung support for rescue of severe respiratory failure in combat casualties. J Trauma Acute Care Surg. 2012; 73(6): 1450-1456 doi: 10.1097/TA.0b013e3182782480 PMID: 23188237
40. Vermeulen Windsant IC, De Wit NC, Sertorio JT, Beckers EA, Tanus-Santos JE, Jacobs MJ, et al: Blood transfusions increase circulating plasma free hemoglobin levels and plasma nitric oxide consumption: A prospective observational pilot study. Crit Care. 2012; 16(3): R95. doi: 10.1186/cc11359 PMID: 22624585
41. Ozment CP, Mamo LB, Campbell ML, Lokhnygina Y, Ghio AJ, Turi JL. Transfusion-related biologic effects and free hemoglobin, heme, and iron. Transfusion. 2013; 53(4): 732-740. doi: 10.1111/j.1537-2995.2012.03837.x PMID: 22882431
42. Adamzik M, Hamburger T, Petrat F, Peters J, De Groot H, Hartmann M. Free hemoglobin concentration in severe sepsis: Methods of measurement and prediction of outcome. Crit Care. 2012; 16(4): R125. doi: 10.1186/cc11425 PMID: 22800762