Plasma free hemoglobin is an independent predictor of mortality among patients on extracorporeal membrane oxygenation support

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Omar, Hesham R ^a   Mirsaeidi, Mehdi ^b   Socias, Stephanie ^c   Sprenker, Collin ^c   Caldeira, Christiano ^d   Camporesi, Enrico M ^e   Mangar, Devanand ^f  

^a Mercy Medical Center   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c Florida Gulf to Bay Anesthesiology Associates   (United States)

^d Florida Advanced Cardiothoracic Surgery   (United States)

^e UNIVERSITY OF SOUTH FLORIDA   (United States)

^f TAMPA GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; LACTATE DEHYDROGENASE; LACTIC ACID; BIOLOGICAL MARKER;

ACUTE KIDNEY FAILURE; ADULT; AGED; ARTICLE; ATRIAL FIBRILLATION; BIVENTRICULAR ASSIST DEVICE; BLEEDING; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CARDIOGENIC SHOCK; CARDIOMYOPATHY; CENTRIFUGAL PUMP; COMORBIDITY; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DIABETES MELLITUS; ERYTHROCYTE CONCENTRATE; ERYTHROCYTE TRANSFUSION; EXTRACORPOREAL OXYGENATION; FEMALE; HEART ARREST; HEART ARRHYTHMIA; HEART DISEASE; HEART GRAFT; HEART INFARCTION; HEART LEFT VENTRICLE FAILURE; HEART SURGERY; HEMATOTHORAX; HEMOGLOBIN BLOOD LEVEL; HEMOLYSIS; HUMAN; HYPERTENSION; INTRAAORTIC BALLOON PUMP; KIDNEY FAILURE; LEFT VENTRICULAR ASSIST DEVICE; LIVER DYSFUNCTION; LUNG DISEASE; LUNG EMBOLISM; LUNG TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MEDIASTINITIS; MORTALITY; OBSERVATIONAL STUDY; OXYGEN SATURATION; PARTIAL THROMBOPLASTIN TIME; PERICARDIAL EFFUSION; PNEUMONIA; PREDICTOR VARIABLE; PULMONARY HYPERTENSION; PULMONARY VASCULAR DISEASE; RESPIRATORY FAILURE; RETROSPECTIVE STUDY; RISK FACTOR; SEPSIS; SURVIVOR; TERTIARY CARE CENTER; TREATMENT DURATION; BLOOD; BLOOD TRANSFUSION; CARDIOMYOPATHIES; HOSPITAL MORTALITY; METABOLISM; MIDDLE AGED; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; RESPIRATORY INSUFFICIENCY; SHOCK, CARDIOGENIC; SURVIVAL ANALYSIS; TERTIARY HEALTH CARE; TIME FACTOR;

AGED; BIOMARKERS; BLOOD TRANSFUSION; CARDIOMYOPATHIES; EXTRACORPOREAL MEMBRANE OXYGENATION; FEMALE; HEMOGLOBINS; HEMOLYSIS; HOSPITAL MORTALITY; HUMANS; LACTIC ACID; LUNG TRANSPLANTATION; MALE; MIDDLE AGED; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RESPIRATORY INSUFFICIENCY; RETROSPECTIVE STUDIES; SHOCK, CARDIOGENIC; SURVIVAL ANALYSIS; TERTIARY HEALTHCARE; TIME FACTORS;

EID: 84930685930     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0124034     Document Type: Article

References (28)

1. Peek GJ, Mugford M, Tiruvoipati R, Wilson A, Allen E, Thalanany MM, et al. Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial. Lancet. 2009 Oct 17; 374(9698):1351-63. doi: 10.1016/S0140-6736(09)61069-2 PMID: 19762075
2. Conrad SA, Rycus PT, Dalton H. Extracorporeal Life Support registry report 2004. ASAIO J.2005; 51:4-10. PMID: 15745126
3. Lin CY, Tsai FC, Tian YC, Jenq CC, Chen YC, Fang JT, et al. Evaluation of outcome scoring systems for patients on extracorporeal membrane oxygenation. Ann Thorac Surg. 2007 Oct; 84(4):1256-62. PMID: 17888979
4. Lin CY, Chen YC, Tsai FC, Tian YC, Jenq CC, et al. RIFLE classification is predictive of short-term prognosis in critically ill patients with acute renal failure supported by extracorporeal membrane oxygenation. Nephrol Dial Transplant.2006; 21:2867-2873. PMID: 16799171
5. Chen YC, Tsai FC, Chang CH, Lin CY, Jenq CC, Juan KC, et al. Prognosis of patients on extracorporeal membrane oxygenation: the impact of acute kidney injury on mortality. Ann Thorac Surg. 2011 Jan; 91(1):137-42. doi: 10.1016/j.athoracsur.2010.08.063 PMID: 21172502
6. Rastan AJ, Dege A, Mohr M, Doll N, Falk V, Walther T, et al. Early and late outcomes of 517 consecutive adult patients treated with extracorporeal membrane oxygenation for refractory postcardiotomy cardiogenic shock. J Thorac Cardiovasc Surg. 2010; 139(2):302-11. doi: 10.1016/j.jtcvs.2009.10.043 PMID: 20106393
7. Aubron C, Cheng AC, Pilcher D, Leong T, Magrin G, Cooper DJ, et al. Factors associated with outcomes of patients on extracorporeal membrane oxygenation support: a 5-year cohort study. Crit Care. 2013; 17(2):R73. doi: 10.1186/cc12681 PMID: 23594433
8. Kielstein JT, Heiden AM, Beutel G, Gottlieb J, Wiesner O, Hafer C, et al. Renal function and survival in 200 patients undergoing ECMO therapy. Nephrol Dial Transplant. 2013; 28(1):86-90. doi: 10.1093/ndt/gfs398 PMID: 23136216
9. Smith A, Hardison D, Bridges B, Pietsch J. Red blood cell transfusion volume among patients receiving extracorporeal membrane oxygenation. Perfusion. 2013; 28(1):54-60. doi: 10.1177/0267659112457969 PMID: 22892295
10. Kawahito S, Maeda T, Motomura T, Ishitoya H, Takano T, Nonaka K, et al. Hemolytic characteristics of oxygenators during clinical extracorporeal membrane oxygenation. ASAIO J. 2002 Nov-Dec; 48(6):636-9. PMID: 12455774
11. Meyer AD, Wiles AA, Rivera O, Wong EC, Freishtat RJ, Rais-Bahrami K, et al.Hemolytic and thrombocytopathic characteristics of extracorporeal membrane oxygenation systems at simulated flow rate for neonates. Pediatr Crit Care Med. 2012; 13(4):e255-61. doi: 10.1097/PCC.0b013e31823c98ef PMID: 22596067
12. Toomasian JM, Bartlett RH. Hemolysis and ECMO pumps in the 21st Century.Perfusion. 2011; 26(1):5-6. doi: 10.1177/0267659110396015 PMID: 21177726
13. Gbadegesin R, Zhao S, Charpie J, Brophy PD, Smoyer WE, Lin JJ. Significance of hemolysis on extracorporeal life support after cardiac surgery in children. Pediatr Nephrol. 2009 Mar; 24(3):589-95. doi: 10.1007/s00467-008-1047-z PMID: 19002722
14. Rother RP, Bell L, Hillmen P, Gladwin MT. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. J Am Med Assoc. 2005; 293:1653-62.
15. Vermeulen Windsant IC, Hanssen SJ, Buurman WA, Jacobs MJ. Cardiovascular surgery and organ damage: time to reconsider the role of hemolysis. J Thorac Cardiovasc Surg. 2011; 142:1-11. doi: 10.1016/j.jtcvs.2011.02.012 PMID: 21570697
16. Cruz-Landeira A, Bal MJ, Lopez-Rivadulla M. Determination of methemoglobin and total hemoglobin in toxicological studies by derivative spectrophotometry. J Anal Toxicol.2002; 26:67-72. PMID: 11916017
17. http://www.elso.med.umich.edu/WordForms/ELSO Guidelines General All ECLS Version1.1.pdf. Accessed 11/5/2014
18. Chen YS, Chao A, Yu HY, Ko WJ, Wu IH, Chen RJ. Analysis and results of prolonged resuscitation in cardiac arrest patients rescued by extracorporeal membrane oxygenation. J Am Coll Cardiol. 2003 Jan 15; 41(2):197-203. PMID: 12535808
19. Wu MY, Lin PJ, Tsai FC, Haung YK, Liu KS, Tsai FC. Impact of preexisting organ dysfunction on extracorporeal life support for non-postcardiotomy cardiopulmonary failure. Resuscitation. 2008 Oct; 79(1):54-60. doi: 10.1016/j.resuscitation.2008.05.002 PMID: 18617313
20. Vercaemst L. Hemolysis in cardiac surgery patients undergoing cardiopulmonary bypass: a review in search of a treatment algorithm. J Extra Corpor Technol. 2008; 40(4):257-67. PMID: 19192755
21. Jeffers A, Gladwin MT, Kim-Shapiro DB. Computation of plasma hemoglobin nitric oxide scavenging in haemolytic anaemias.Free Radic Biol Med. 2006; 41:1557-65. PMID: 17045924
22. Mumby S, Koh TW, Pepper JR, Gutteridge JM. Risk of iron overload is decreased in beating heart coronary artery surgery compared to conventional bypass. Biochim Biophys Acta. 2001 Nov 29; 1537(3):204-10. PMID: 11731222
23. Davis C, Kausz A, Zager R, Kharasch E, Cochran R. Acute renal failure after CPB is related to decreased serum ferritin levels. J Am Soc Nephrol. 1999; 10:2396-402. PMID: 10541300
24. An Y, Xiao YB, Zhong QJ. Hyperbilirubinemia after extracorporeal circulation surgery: a recent and prospective study. World J Gastroenterol. 2006 Nov 7; 12(41):6722-6. PMID: 17075992
25. Watanabe N, Sakota D, Ochuchi K, Takatani S. Deformability of red blood cells and its relation to blood trauma in rotary blood pumps.Artif Organs. 2007; 31:352-8. PMID: 17470204
26. Bennett M, Horton S, Thuys C, Augustin S, Rosenberg M, Brizard C. Pump-induced haemolysis: a comparison of short-term ventricular assist devices. Perfusion. 2004; 19:107-111. PMID: 15162925
27. Bottrell S, Bennett M, Augustin S, Thuys C, Schultz B, Horton A, et al. comparison study of haemolysis production in three contemporary centrifugal pumps. Perfusion. 2014; 29(5):411-6. doi: 10.1177/0267659113509000 PMID: 24406272
28. Lawson DS, Ing R, Cheifetz IM, Walczak R, Craig D, Schulman S, et al. Hemolytic characteristics of three commercially available centrifugal blood pumps. Pediatr Crit Care Med. 2005; 6(5):573-7. PMID: 16148820