Novel indole-based melatonin analogues: Evaluation of antioxidant activity and protective effect against amyloid β-induced damage

Bioorganic and Medicinal Chemistry

Volumn 24, Issue 8, 2016, Pages 1658-1664

  Gurer Orhan, Hande ^a   Karaaslan, Cigdem ^b   Ozcan, Senem ^a   Firuzi, Omidreza ^c   Tavakkoli, Marjan ^c   Saso, Luciano ^d   Suzen, Sibel ^b  

^a EGE UNIVERSITY   (Turkey)

^b ANKARA UNIVERSITY   (Turkey)

^c SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Alzheimer's disease; Amyloid ; Antioxidant activity; Indole; Melatonin

Indexed keywords

2 (4 FLUOROPHENYL) 3 [[2 (2,2 FLUOROPHENYL)HYDRAZONO]METHYL] 1H INDOLE; 2 (4 FLUOROPHENYL) 3 [[2 (3 FLUOROPHENYL)HYDRAZONO]METHYL] 1H INDOLE; 2 (4 FLUOROPHENYL) 3 [[2 (4 FLUOROPHENYL)HYDRAZONO]METHYL] 1H INDOLE; 3 [[2 (2 BROMOPHENYL)HYDRAZONO]METHYL] 2 (4 FLUOROPHENYL) 1H INDOLE; 3 [[2 (2,4 DICHLOROPHENYL)HYDRAZONO]METHYL] 2 (4 FLUOROPHENYL) 1H INDOLE; 3 [[2 (2,4 DIFLUOROPHENYL)HYDRAZONO]METHYL] 2 (4 FLUOROPHENYL) 1H INDOLE; 3 [[2 (2,5 DICHLOROPHENYL)HYDRAZONO]METHYL] 2 (4 FLUOROPHENYL) 1H INDOLE; 3 [[2 (3 BROMOPHENYL)HYDRAZONO]METHYL] 2 (4 FLUOROPHENYL) 1H INDOLE; 3 [[2 (3 CHLOROPHENYL)HYDRAZONO]METHYL] 2 (4 FLUOROPHENYL) 1H INDOLE; 3 [[2 (3,4 DICHLOROPHENYL)HYDRAZONO]METHYL] 2 (4 FLUOROPHENYL) 1H INDOLE; 3 [[2 (3,5 DICHLOROPHENYL)HYDRAZONO]METHYL] 2 (4 FLUOROPHENYL) 1H INDOLE; 3 [[2 (3,5 DIFLUOROPHENYL)HYDRAZONO]METHYL] 2 (4 FLUOROPHENYL) 1H INDOLE; 3 [[2 (4 CHLOROPHENYL)HYDRAZONO]METHYL] 2 (4 FLUOROPHENYL) 1H INDOLE; AMYLOID BETA PROTEIN; INDOLE DERIVATIVE; MELATONIN; N' [[2 (4 FLUOROPHENYL) 1H INDOL 3 YL]METHYLENE] 4 METHOXYBENZOHYDRAZIDE; UNCLASSIFIED DRUG; AMYLOID BETA-PROTEIN (25-35); ANTIOXIDANT; NEUROPROTECTIVE AGENT; PEPTIDE FRAGMENT; REACTIVE OXYGEN METABOLITE;

ALZHEIMER DISEASE; ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; ERYTHROCYTE; FINITE ELEMENT ANALYSIS; HALOGENATION; HUMAN; HUMAN CELL; HYDROXYLATION; NEUROPROTECTION; NONHUMAN; OXIDATION; RAT; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL LINE; CRICETULUS; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; PC12 CELL LINE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMYLOID BETA-PEPTIDES; ANIMALS; ANTIOXIDANTS; CELL SURVIVAL; CHO CELLS; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INDOLES; MELATONIN; MOLECULAR STRUCTURE; NEUROPROTECTIVE AGENTS; PC12 CELLS; PEPTIDE FRAGMENTS; RATS; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84959895775     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2016.02.039     Document Type: Article

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