Nonstable staphylococcus aureus small-colony variants are induced by low pH and sensitized to antimicrobial therapy by phagolysosomal alkalinization

Journal of Infectious Diseases

Volumn 213, Issue 2, 2016, Pages 305-313

  Leimer, Nadja ^a   Rachmühl, Carole ^a   Palheiros Marques, Miguel ^a   Bahlmann, Anna Sophie ^a   Furrer, Alexandra ^a   Eichenseher, Fritz ^c   Seidl, Kati ^a   Matt, Ulrich ^a   Loessner, Martin J ^c   Schuepbach, Reto A ^b   Zinkernagel, Annelies S ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c ETH ZURICH   (Switzerland)

Author keywords

antimicrobial therapy; intracellular persistence; relapsing infections; small colony variants; Staphylococcus aureus

Indexed keywords

AMMONIUM CHLORIDE; CHLOROQUINE; FLUCLOXACILLIN; ANTIINFECTIVE AGENT; BAFILOMYCIN A1; MACROLIDE;

ALKALINIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMICROBIAL THERAPY; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL GROWTH; BACTERIUM COLONY; COLONY FORMING UNIT; CONFOCAL MICROSCOPY; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; MALE; MOUSE; NONHUMAN; PHAGOLYSOSOME; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; STAINING; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; ANTIBIOTIC RESISTANCE; C57BL MOUSE; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC VARIATION; GROWTH, DEVELOPMENT AND AGING; MICROBIOLOGY; PH; PHAGOSOME; PHYSIOLOGY; TUMOR CELL LINE;

AMMONIUM CHLORIDE; ANIMALS; ANTI-BACTERIAL AGENTS; CELL LINE, TUMOR; CHLOROQUINE; DRUG RESISTANCE, BACTERIAL; GENE EXPRESSION REGULATION, BACTERIAL; GENETIC VARIATION; HUMANS; HYDROGEN-ION CONCENTRATION; MACROLIDES; MICE; MICE, INBRED C57BL; PHAGOSOMES; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 84959879298     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiv388     Document Type: Article

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