Combined effect of pH and concentration on the activities of gentamicin and oxacillin against Staphylococcus aureus in pharmacodynamic models of extracellular and intracellular infections

Journal of Antimicrobial Chemotherapy

Volumn 59, Issue 2, 2007, Pages 246-253

  Baudoux, Pierre ^a   Bles, Nathalie ^a,b   Lemaire, Sandrine ^a   Mingeot Leclercq, Marie Paule ^a   Tulkens, Paul M ^a   Van Bambeke, Françoise ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Acid pH; Aminoglycosides; Antibiotic accumulation; Pharmacodynamics; lactams

Indexed keywords

GENTAMICIN; METICILLIN; OXACILLIN; OXYTETRACYCLINE; ANTIINFECTIVE AGENT;

ACIDITY; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; CELL ASSAY; CELL PH; CELL SHAPE; COLONY FORMING UNIT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG MECHANISM; HUMAN; HUMAN CELL; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NORMAL HUMAN; PH MEASUREMENT; PHAGOLYSOSOME; PHARMACODYNAMICS; STAPHYLOCOCCUS INFECTION; ANTIBIOTIC SENSITIVITY DISK DIFFUSION TEST; BIOLOGICAL MODEL; CELL LINE; DOSE RESPONSE; DRUG EFFECT; MACROPHAGE; MICROBIOLOGY; PH; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; CELL LINE; DISK DIFFUSION ANTIMICROBIAL TESTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENTAMICINS; HUMANS; HYDROGEN-ION CONCENTRATION; MACROPHAGES; MODELS, BIOLOGICAL; OXACILLIN; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 33947507582     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkl489     Document Type: Article

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