Non-antibacterial tetracyclines modulate mediators of periodontitis and atherosclerotic cardiovascular disease: A mechanistic link between local and systemic inflammation

Pharmacological Research

Volumn 64, Issue 6, 2011, Pages 573-579

  Gu, Ying ^a   Lee, Hsi Ming ^a   Sorsa, Timo ^b   Salminen, Aino ^b   Ryan, Maria E ^a   Slepian, Marvin J ^c   Golub, Lorne M ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

Cardiovascular disease; Chronic periodontitis; Inflammatory biomarkers; Tetracyclines

Indexed keywords

APOLIPOPROTEIN A1; C REACTIVE PROTEIN; DOXYCYCLINE; GELATINASE B; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INCYCLINIDE; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; OXIDIZED LOW DENSITY LIPOPROTEIN; PLACEBO; TUMOR NECROSIS FACTOR ALPHA;

ACUTE CORONARY SYNDROME; AGGREGATIBACTER ACTINOMYCETEMCOMITANS; ARTICLE; ATHEROSCLEROTIC CARDIOVASCULAR DISEASE; CHRONIC PERIODONTITIS; DISEASE COURSE; DRUG FORMULATION; DRUG MECHANISM; ENZYME INHIBITION; HUMAN; IN VITRO STUDY; NONHUMAN; PATHOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ATHEROSCLEROSIS; CYTOKINES; DOXYCYCLINE; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; PERIODONTITIS; TETRACYCLINES;

EID: 80054095409     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2011.06.023     Document Type: Article

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