Characterization of tumor necrosis factor-α block haplotypes associated with susceptibility to chronic venous leg ulcers in Caucasian patients

Human Immunology

Volumn 71, Issue 12, 2010, Pages 1214-1219

  Tan, Joo Huang ^a   Price, Patricia ^a,b   Gut, Ivo ^c   Stacey, Michael C ^a   Warrington, Nicole M ^a   Wallace, Hilary J ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b ROYAL PERTH HOSPITAL   (Australia)

^c CENTRE NATIONAL DE GÉNOTYPAGE   (France)

Author keywords

Chronic venous leg ulcers; Genetic susceptibility; Haplotype; Major histocompatibility complex; Tumor necrosis factor

Indexed keywords

GENOMIC DNA; HLA B ANTIGEN; HLA DR ANTIGEN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CAUCASIAN; CLINICAL ASSESSMENT; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA EXTRACTION; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HUMAN; LEG ULCER; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; AGED, 80 AND OVER; ALLELES; CHRONIC DISEASE; DISEASE SUSCEPTIBILITY; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; TUMOR NECROSIS FACTOR-ALPHA; VARICOSE ULCER;

EID: 78149406392     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2010.09.001     Document Type: Article

References (25)

1. Valencia I.C., Falabella A., Kirsner R.S., Eaglstein W.H. Chronic venous insufficiency and venous leg ulceration. J Am Acad Dermatol 2001, 44:401-421.
2. Kurz X., Kahn S.R., Abenhaim L., Clement D., Norgren L., Baccaglini U., et al. Chronic venous disorders of the leg: Epidemiology, outcomes, diagnosis and management. Int Angiol 1999, 18:83-102.
3. Abbade L.P.F., Lastoria S. Venous ulcer: Epidemiology, physiopathology, diagnosis and treatment. Int J Dermatol 2005, 44:449-456.
4. Wallace H.J., Stacey M.C. Levels of tumor necrosis factor-alpha (TNF-alpha) and soluble TNF receptors in chronic venous leg ulcers-correlations to healing status. J Invest Dermatol 1998, 110:292-296.
5. Trengove N.J., Bielefeldt-Ohmann H., Stacey M.C. Mitogenic activity and cytokine levels in non-healing and healing chronic leg ulcers. Wound Repair Regen 2000, 8:13-25.
6. Agren M., Eaglstein W., Ferguson M., et al. Causes and effects of the chronic inflammation in venous leg ulcers. Acta Derm Venereol Suppl 2000, 210:3-17.
7. Zamboni P., Gemmati D. Clinical implications of gene polymorphisms in venous leg ulcer: A model in tissue injury and reparative process. Thromb Haemost 2007, 98:131-137.
8. Dawkins R., Leelayuwat C., Gaudieri S., Tay G., Hui J., Cattley S., et al. Genomics of the major histocompatibility complex: Haplotypes, duplication, retroviruses and disease. Immunol Rev 1999, 167:275-304.
9. Wallace H.J., Vandongen Y.K., Stacey M.C. Tumor necrosis factor-alpha gene polymorphism associated with increased susceptibility to venous leg ulceration. J Invest Dermatol 2006, 126:921-925.
10. Wallace H.J., Vandongen Y.K., Stacey M.C. Tumor necrosis factor-α -308 gene polymorphism and venous leg ulceration-comment on possible link with obesity. J Invest Dermatol 2007, 127:1770-1771.
11. Valente F.P., Tan C.R.T., Temple S.E., Phipps M., Witt C.S., Kaur G., et al. The evolution and diversity of TNF block haplotypes in European, Asian and Australian aboriginal populations. Genes Immun 2009, 10:607-615.
12. Witt C.S., Price P., Kaur G., Cheong K., Kanga U., Sayer D., et al. Common HLA-B8-DR3 haplotype in Northern India is different from that found in Europe. Tissue Antigens 2002, 60:474-480.
13. Valente F.P., Tan C., Phipps M., Witt C.S., Kaur G., Gut I., et al. TNF block haplotypes associated with conserved MHC haplotypes in European, Asian and Australian aboriginal donors. Tissue Antigens 2009, 74:57-61.
14. Raymond M., Rousset F. (Version 1.2): Population genetics software for exact tests and ecumenicism. J Hered 1995, 86:248-249. GENEPOP.
15. Stephens M., Donnelly P. A comparison of Bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 2003, 73:1162-1169.
16. Stephens M., Smith N.J., Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001, 68:978-989.
17. Degli-Esposti M.A., Leaver A.L., Christiansen F.T., Witt C.S., Abraham L.J., Dawkins R.L. Ancestral haplotypes: Conserved population MHC haplotypes. Hum Immunol 1992, 34:242-252.
18. Windsor L., Puschendorf M., Allcock R., et al. Does a central MHC gene in linkage disequilibrium with HLA-DRB1*0401 affect susceptibility to type 1 diabetes?. Genes Immun 2005, 6:298-304.
19. Price P., Witt C., Allcock R., Sayer D., Garlepp M., Kok C.C., et al. The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple immunopathological diseases. Immunol Rev 1999, 167:257-274.
20. Margolis D.J., Knauss J., Bilker W. Medical conditions associated with venous leg ulcers. Br J Dermatol 2004, 150:267-273.
21. Price P., Cheong K.Y.M., Boodhoo A., Witt C.S., Mccann V., Christiansen F.T., Allcock R.J. Can MHC class II genes mediate resistance to type 1 diabetes?. Immunol Cell Biol 2001, 79:602-606.
22. Cheong K., Allcock R., Eerligh P., Witt C.S., Christiansen F.T., Mccann V., Price P. Localization of central MHC genes influencing type I diabetes. Hum Immunol 2001, 62:1363.
23. Chen D.F., Kliem V., Endres W., Brunkhorst R., Tillmann H.L., Koch K.M., et al. Relationship between human leukocyte antigen determinants and courses of hepatitis B virus infection in Caucasian patients with end-stage renal disease. Scand J Gastroenterol 1996, 31:1211-1215.
24. Dorak M.T., Shao W., Machulla H.K.G., Lobashevsky E.S., Tang J., Park M.H., Kaslow R.A. Conserved extended haplotypes of the major histocompatibility complex: Further characterization. Genes Immun 2006, 7:450-467.
25. Rubin L.A., Amos C.I., Wade J.A., Martin J.R., Bale S.J., Little A.H., et al. Investigating the genetic basis for ankylosing spondylitis. Linkage studies with the major histocompatibility complex region. Arthritis Rheum 1994, 37:1212-1220.