MiR-190a inhibits epithelial-mesenchymal transition of hepatoma cells via targeting the long non-coding RNA treRNA

FEBS Letters

Volumn 589, Issue 24, 2015, Pages 4079-4087

  Wang, Xinyu ^a,b   Ren, Yanli ^a   Yang, Xinyu ^a   Xiong, Xiangyu ^a   Han, Sichong ^a   Ge, Yunxia ^a   Pan, Wenting ^a   Zhou, Liqing ^c   Yuan, Qipeng ^a   Yang, Ming ^a  

^a BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY   (China)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Huaian No 2 Hospital   (China)

Author keywords

Epithelial to mesenchymal transition; Hepatoma; Long non coding RNA; miR 190a; Translation regulatory long non coding RNA

Indexed keywords

LONG UNTRANSLATED RNA; MICRORNA; MICRORNA 190A; TRERNA; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; MIRN190 MICRORNA, HUMAN; RNA; RNA, RECOMBINANT; SMALL INTERFERING RNA; TRE LONG NONCODING RNA, HUMAN;

ARTICLE; CANCER THERAPY; CELL ACTIVITY; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION; GENE SILENCING; HEPATOMA CELL; HIGH RISK PATIENT; HUMAN; HUMAN CELL; METASTASIS; PRIORITY JOURNAL; PROTEIN TARGETING; RNA ANALYSIS; RNA BINDING; RNA PROCESSING; ANTAGONISTS AND INHIBITORS; BINDING SITE; CELL MOTION; LIVER; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; MUTATION; PATHOLOGY; REPORTER GENE; RNA INTERFERENCE; TUMOR CELL LINE; TUMOR INVASION;

BINDING SITES; BIOMARKERS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL MOVEMENT; DOWN-REGULATION; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; HUMANS; LIVER; LIVER NEOPLASMS; MICRORNAS; MUTATION; NEOPLASM INVASIVENESS; RNA; RNA INTERFERENCE; RNA, LONG NONCODING; RNA, NEOPLASM; RNA, SMALL INTERFERING;

EID: 84959559501     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2015.11.024     Document Type: Article

References (29)

1. A. Jemal, F. Bray, M.M. Center, J. Ferlay, E. Ward, D. Forman, Global cancer statistics. CA Cancer J. Clin., 61, (2011), 69-90.
2. W. Chen, R. Zheng, S. Zhang, P. Zhao, H. Zeng, X. Zou, Report of cancer incidence and mortality in China, 2010. Ann. Transl. Med., 2, (2014), 61 -
3. P.A. Farazi, R.A. DePinho, Hepatocellular carcinoma pathogenesis: from genes to environment. Nat. Rev. Cancer, 6, (2006), 674-687.
4. C. Xie, J. Yuan, H. Li, M. Li, G. Zhao, D. Bu, W. Zhu, W. Wu, R. Chen, Y. Zhao, NONCODEv4: exploring the world of long non-coding RNA genes. Nucleic Acids Res., 42, (2014), D98-D103.
5. M. Esteller, Non-coding RNAs in human disease. Nat. Rev. Genet., 12, (2011), 861-874.
6. J.L. Rinn, H.Y. Chang, Genome regulation by long noncoding RNAs. Annu. Rev. Biochem., 81, (2012), 145-166.
7. U.A. Orom, T. Derrien, M. Beringer, K. Gumireddy, A. Gardini, G. Bussotti, F. Lai, M. Zytnicki, C. Notredame, Q. Huang, R. Guigo, R. Shiekhattar, Long noncoding RNAs with enhancer-like function in human cells. Cell, 143, (2010), 46-58.
8. M.J. Barbera, I. Puig, D. Dominguez, S. Julien-Grille, S. Guaita-Esteruelas, S. Peiro, J. Baulida, C. Franci, S. Dedhar, L. Larue, A. Garcia de Herreros, Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells. Oncogene, 23, (2004), 7345-7354.
9. K.M. Hajra, D.Y. Chen, E.R. Fearon, The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res., 62, (2002), 1613-1618.
10. E. Batlle, E. Sancho, C. Franci, D. Dominguez, M. Monfar, J. Baulida, A. Garcia De Herreros, The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat. Cell Biol., 2, (2000), 84-89.
11. K. Gumireddy, A. Li, J. Yan, T. Setoyama, G.J. Johannes, U.A. Orom, J. Tchou, Q. Liu, L. Zhang, D.W. Speicher, G.A. Calin, Q. Huang, Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step. EMBO J., 32, (2013), 2672-2684.
12. P. Guilford, J. Hopkins, J. Harraway, M. McLeod, N. McLeod, P. Harawira, H. Taite, R. Scoular, A. Miller, A.E. Reeve, E-cadherin germline mutations in familial gastric cancer. Nature, 392, (1998), 402-405.
13. J.R. Graff, J.G. Herman, R.G. Lapidus, H. Chopra, R. Xu, D.F. Jarrard, W.B. Isaacs, P.M. Pitha, N.E. Davidson, S.B. Baylin, E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res., 55, (1995), 5195-5199.
14. M. Takeichi, Cadherin cell adhesion receptors as a morphogenetic regulator. Science, 251, (1991), 1451-1455.
15. F. Loayza-Puch, R. Agami, Lncing protein translation to metastasis. EMBO J., 32, (2013), 2657-2658.
16. A. Jeggari, D.S. Marks, E. Larsson, miRcode: a map of putative microRNA target sites in the long non-coding transcriptome. Bioinformatics, 28, (2012), 2062-2063.
17. J.H. Yang, J.H. Li, P. Shao, H. Zhou, Y.Q. Chen, L.H. Qu, StarBase: a database for exploring microRNA-mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data. Nucleic Acids Res., 39, (2011), D202-D209.
18. S. Jalali, D. Bhartiya, M.K. Lalwani, S. Sivasubbu, V. Scaria, Systematic transcriptome wide analysis of lncRNA-miRNA interactions. PLoS ONE, 8, (2013), e53823 -
19. X. Wang, M. Li, Z. Wang, S. Han, X. Tang, Y. Ge, L. Zhou, C. Zhou, Q. Yuan, M. Yang, Silencing of long noncoding RNA MALAT1 by miR-101 and miR-217 inhibits proliferation, migration, and invasion of esophageal squamous cell carcinoma cells. J. Biol. Chem., 290, (2015), 3925-3935.
20. M. Cesana, D. Cacchiarelli, I. Legnini, T. Santini, O. Sthandier, M. Chinappi, A. Tramontano, I. Bozzoni, A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA. Cell, 147, (2011), 358-369.
21. X. Wang, L. Li, Y. Huang, Q. Wei, Calcineurin subunit B upregulates beta-interferon production by phosphorylation of interferon regulatory factor 3 via Toll-like receptor 4. Cancer Sci., 103, (2012), 515-521.
22. C.A. Gebeshuber, K. Zatloukal, J. Martinez, miR-29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasis. EMBO Rep., 10, (2009), 400-405.
23. U. Wellner, J. Schubert, U.C. Burk, O. Schmalhofer, F. Zhu, A. Sonntag, B. Waldvogel, C. Vannier, D. Darling, A. zur Hausen, V.G. Brunton, J. Morton, O. Sansom, J. Schuler, M.P. Stemmler, C. Herzberger, U. Hopt, T. Keck, S. Brabletz, T. Brabletz, The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat. Cell Biol., 11, (2009), 1487-1495.
24. T. Vincent, E.P. Neve, J.R. Johnson, A. Kukalev, F. Rojo, J. Albanell, K. Pietras, I. Virtanen, L. Philipson, P.L. Leopold, R.G. Crystal, A.G. de Herreros, A. Moustakas, R.F. Pettersson, J. Fuxe, A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition. Nat. Cell Biol., 11, (2009), 943-950.
25. Q. Yu, I. Stamenkovic, Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev., 14, (2000), 163-176.
26. R.A. Gupta, N. Shah, K.C. Wang, J. Kim, H.M. Horlings, D.J. Wong, M.C. Tsai, T. Hung, P. Argani, J.L. Rinn, Y. Wang, P. Brzoska, B. Kong, R. Li, R.B. West, M.J. van de Vijver, S. Sukumar, H.Y. Chang, Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature, 464, (2010), 1071-1076.
27. K. Morita, M. Furuse, K. Fujimoto, S. Tsukita, Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc. Natl. Acad. Sci. U.S.A., 96, (1999), 511-516.
28. K. Vuoriluoto, H. Haugen, S. Kiviluoto, J.P. Mpindi, J. Nevo, C. Gjerdrum, C. Tiron, J.B. Lorens, J. Ivaska, Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer. Oncogene, 30, (2011), 1436-1448.
29. H.W. Chu, C.W. Cheng, W.C. Chou, L.Y. Hu, H.W. Wang, C.N. Hsiung, H.M. Hsu, P.E. Wu, M.F. Hou, C.Y. Shen, J.C. Yu, A novel estrogen receptor-microRNA 190a-PAR-1-pathway regulates breast cancer progression, a finding initially suggested by genome-wide analysis of loci associated with lymph-node metastasis. Hum. Mol. Genet., 23, (2014), 355-367.