Development of a whole blood paper-based device for phenylalanine detection in the context of PKU therapy monitoring

Micromachines

Volumn 7, Issue 2, 2016, Pages

  Robinson, Robert ^a   Wong, Liam ^a   Monnat, Raymond J ^b   Fu, Elain ^a  

^a Oregon State University   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Colorimetric readout; Paper based device; Phenylalanine detection; Phenylketonuria; Whole blood assay

Indexed keywords

AMINO ACIDS;

COLORIMETRIC READOUT; METABOLIC DISEASE; PAPER BASED DEVICES; PHENYLKETONURIA; REPRODUCIBILITIES; THERAPEUTIC MONITORING; THERAPY MONITORING; WHOLE BLOOD;

BLOOD;

EID: 84959553520     PISSN: None     EISSN: 2072666X     Source Type: Journal    
DOI: 10.3390/mi7020028     Document Type: Article

References (32)

1. Fernandes, J.; Saudubray, J.-M.; van den Berghe, G. Inborn Metabolic Diseases: Diagnosis and Treatment; Springer-Verlag: Berlin, Germany, 1990.
2. Bilginsoy, C.; Waitzman, N.; Leonard, C.O.; Ernst, S.L. Living with phenylketonuria: Perspectives of patients and their families. J. Inherit. Metab. Dis. 2005, 28, 639-649.
3. Vockley, J.; Andersson, H.; Antshel, K.; Braverman, N.; Burton, B.; Frazier, D.; Mitchell, J.; Smith, W.; Thompson, B.; Berry, S. Phenylalanine hydroxylase deficiency: Diagnosis and management guideline. Genet. Med. 2014, 16, 188-200.
4. Singh, R.; Rohr, F.; Frazier, D.; Cunningham, A.; Mofidi, S.; Ogata, B.; Splett, P.L.; Moseley, K.; Huntington, K.; Acosta, P.; et al. Recommendations for the nutrition management of phenylalanine hydroxylase deficiency. Genet. Med. 2014, 16, 121-131.
5. Guldberg, P.; Henriksen, K.F.; Lou, H.C.; Guttler, F. Aberrant phenylalanine metabolism in phenylketonuria heterozygotes. J. Inherit. Metab. Dis. 1998, 21, 365-372.
6. Wendel, U.; Langenbeck, U. Towards self-monitoring and self-treatment in phenylketonuria-A way to better diet compliance. Eur. J. Pediatrics 1996, 155, S105-S107.
7. Boyer, S.W.; Barclay, L.J.; Burrage, L.C. Inherited Metabolic Disorders: Aspects of Chronic Nutrition Management. Nutr. Clin. Pract. 2015, 30, 502-510.
8. Feillet, F.; Bonnemains, C. La phénylcétonurie: Nouveaux traitements. Arch. Pédiatr. 2013, 20, 1165-1168. (In French).
9. Blau, N.; Longo, N. Alternative therapies to address the unmet medical needs of patients with phenylketonuria. Expert Opin. Pharmacother. 2015, 16, 791-800.
10. Gregory, C.O.; Yu, C.; Singh, R.H. Blood phenylalanine monitoring for dietary compliance among patients with phenylketonuria: Comparison of methods. Genet. Med. 2007, 9, 761-765.
11. NIH Consensus Development Panel. National Institutes of Health consensus development conference statement. Phenylketonuria: Screening and management, October 16-18, 2000. Pediatrics 2000, 108, 972-982.
12. Seashore, M.R.;Wappner, R.; Cho, S.; de la Cruz, F. Development of guidelines for treatment of children with phenylketonuria: Report of a meeting at the National Institute of Child Health and Human Development. Pediatrics 1999, 104, e67.
13. Wappner, R.; Cho, S.; Kronmal, R.A.; Schuett, V.; Seashore, M.R. Management of phenylketonuria for optimal outcome: A review of guidelines for phenylketonuria management and a report of surveys of parents, patients, and clinic directors. Pediatrics 1999, 104, e68.
14. Martinez, A.W.; Phillips, S.T.; Butte, M.J.; Whitesides, G.M. Patterned paper as a platform for inexpensive, low-volume, portable bioassays. Angew. Chem. Int. Ed. 2007, 46, 1318-1320.
15. Byrnes, S.; Thiessen, G.; Fu, E. Progress in the development of paper-based diagnostics for low-resource point-of-care settings. Bioanalysis 2013, 5, 2821-2836.
16. Yetisen, A.K.; Akram, M.W.; Lowe, C.R. Paper-based microfluidic point-of-care diagnostic devices. Lab Chip 2013, 13, 2210-2251.
17. Fu, E. Enabling robust quantitative readout in an equipment-free model of device development. Analyst 2014, 139, 4750-4757.
18. Yang, X.; Forouzan, O.; Brown, T.; Shevkoplyas, S. Integrated separation of blood plasma from whole blood for microfluidic paper-based analytical devices. Lab Chip 2012, 12, 274-280.
19. Songjaroen, T.; Dungchai, W.; Chailapakul, O.; Henry, C.; Laiwattanapaisal, W. Blood separation on microfluidic paper-based analytical devices. Lab Chip 2012, 12, 3392-3398.
20. Vella, S.J.; Beattie, P.; Cademartiri, R.; Laromaine, A.; Martinez, A.W.; Phillips, S.T.; Mirica, K.A.; Whitesides, G.M. Measuring Markers of Liver Function Using a Micropatterned Paper Device Designed for Blood from a Fingerstick. Anal. Chem. 2012, 84, 2883-2891.
21. Thiessen, G.; Robinson, R.; de Los Reyes, K.; Monnat, R.; Fu, E. Conversion of a laboratory-based test for phenylalanine detection to a simple paper-based format and implications for PKU screening in low-resource settings. Analyst 2014, 140, 609-615.
22. De Silva, V.; Oldham, C.D.; May, S.W. L-Phenylalanine concentration in blood of phenylketonuria patients: A modified enzyme colorimetric assay compared with amino acid analysis, tandem mass spectrometry, and HPLC methods. Clin. Chem. Lab. Med. 2010, 48, 1271-1279.
23. Campbell, R.S.; Brearley, G.M.; Varsani, H.; Morris, H.C.; Milligan, T.P.; Hall, S.K.; Hammond, P.M.; Price, C.P. Development and validation of a robust specific enzyme mediated assay for phenylalanine in serum. Clin. Chim. Acta 1992, 210, 197-210.
24. Groselj, U.; Murko, S.; Zerjav Tansek, M.; Kovac, J.; Trampus Bakija, A.; Repic Lampret, B.; Battelino, T. Comparison of tandem mass spectrometry and amino acid analyzer for phenylalanine and tyrosine monitoring-Implications for clinical management of patients with hyperphenylalaninemia. Clin. Biochem. 2015, 48, 14-18.
25. Osborn, J. Novel Paper Networks for Point-of-Care Sample Preparation and Indirect IgM Detection; University of Washington: Seattle, WA, USA, 2011.
26. Pollock, N.R.; McGray, S.; Colby, D.J.; Noubary, F.; Nguyen, H.; Nguyen, T.A.; Khormaee, S.; Jain, S.; Hawkins, K.; Kumar, S.; et al. Field Evaluation of a Prototype Paper-Based Point-of-Care Fingerstick Transaminase Test. PLoS ONE 2013, 8, e75616.
27. Passonneau, J.V.L.; Lowry, O.H. Enzymatic Analysis: A Practical Guide; The Humana Press Inc.: Clifton, NJ, USA, 1993.
28. Fu, E.; Liang, T.; Houghtaling, J.; Ramachandran, S.; Ramsey, S.A.; Lutz, B.; Yager, P. Enhanced Sensitivity of Lateral Flow Tests Using a Two-Dimensional Paper Network Format. Anal. Chem. 2011, 83, 7941-7946.
29. Fu, E.; Liang, T.; Spicar-Mihalic, P.; Houghtaling, J.; Ramachandran, S.; Yager, P. Two-Dimensional Paper Network Format That Enables Simple Multistep Assays for Use in Low-Resource Settings in the Context of Malaria Antigen Detection. Anal. Chem. 2012, 84, 4574-4579.
30. Lutz, B.; Liang, T.; Fu, E.; Ramachandran, S.; Kauffman, P.; Yager, P. Dissolvable fluidic time delays for programming multi-step assays in instrument-free paper diagnostics. Lab Chip 2013, 13, 2840-2847.
31. Toley, B.; Wang, J.; Gupta, M.; Buser, J.; Lafleur, L.; Lutz, B.; Fu, E.; Yager, P. A versatile valving toolkit for automating fluidic operations in paper microfluidic devices. Lab Chip 2015, 15, 1432-1444.
32. Mudanyali, O.; Dimitrov, S.; Sikora, U.; Padmanabhan, S.; Navruz, I.; Ozcan, A. Integrated rapiddiagnostic-test reader platform on a cellphone. Lab Chip 2012, 12, 2678-2686.