Activity of SHIP, Which Prevents Expression of Interleukin 1β, Is Reduced in Patients with Crohn's Disease

Gastroenterology

Volumn 150, Issue 2, 2016, Pages 465-476

  Ngoh, Eyler N ^a   Weisser, Shelley B ^a   Lo, Young ^a   Kozicky, Lisa K ^a   Jen, Roger ^a   Brugger, Hayley K ^a   Menzies, Susan C ^a   McLarren, Keith W ^a   Nackiewicz, Dominika ^a   Van Rooijen, Nico ^b   Jacobson, Kevan ^a   Ehses, Jan A ^a   Turvey, Stuart E ^a   Sly, Laura M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Inflammatory; Phosphatidylinositol; PI3Kp110 ; Signal Transduction

Indexed keywords

2 (4 HYDROXYPHENYL) 4 MORPHOLINOPYRIDO[3',2':4,5]FURO[3,2 D]PYRIMIDINE; 2 MORPHOLINO 8 PHENYLCHROMONE; CLODRONIC ACID; COLONY STIMULATING FACTOR 1; GAMMA INTERFERON; GLIBENCLAMIDE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INFLAMMASOME; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LIPOSOME; N (2,3 DIHYDRO 7,8 DIMETHOXYIMIDAZO[1,2 C]QUINAZOLIN 5 YL)NICOTINAMIDE; PHOSPHATE BUFFERED SALINE; PROTEIN SH2; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; SH2 DOMAIN CONTAINING INOSITOLPHOSPHATE 5' PHOSPHATASE; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; IL1B PROTEIN, HUMAN; IL1B PROTEIN, MOUSE; INOSITOL-POLYPHOSPHATE 5-PHOSPHATASE; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PIK3CA PROTEIN, MOUSE; PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; COLON BIOPSY; COMPARATIVE STUDY; CONTROL; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HISTOPATHOLOGY; HOMOGENATE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; INTESTINE BIOPSY; MACROPHAGE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; 129 MOUSE; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; DEFICIENCY; DISEASE MODEL; ENZYMOLOGY; GENETIC TRANSCRIPTION; GENETICS; ILEITIS; ILEUM; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; MONONUCLEAR CELL; PATHOLOGY; UPREGULATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; CROHN DISEASE; DISEASE MODELS, ANIMAL; HUMANS; ILEITIS; ILEUM; INTERLEUKIN-18; INTERLEUKIN-1BETA; LEUKOCYTES, MONONUCLEAR; MACROPHAGES; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN KINASE INHIBITORS; RECEPTORS, INTERLEUKIN-1; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 84959525772     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2015.09.049     Document Type: Article

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