SHIP-deficient mice develop spontaneous intestinal inflammation and arginase-dependent fibrosis

American Journal of Pathology

Volumn 179, Issue 1, 2011, Pages 180-188

  McLarren, Keith W ^a,b   Cole, Alexandra E ^a,b   Weisser, Shelley B ^a,b   Voglmaier, Nicole S ^a,b   Conlin, Victoria S ^a,b   Jacobson, Kevan ^a,b   Popescu, Oana ^a   Boucher, Jean Luc ^c   Sly, Laura M ^a,b  

^a BC CHILDREN S HOSPITAL   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

(2 BORONOETHYL) LEVO CYSTEINE; ARGINASE 1; COLLAGEN; HYDROLASE INHIBITOR; INTERLEUKIN 17; INTERLEUKIN 2; PHOSPHATASE; SRC HOMOLOGY 2 DOMAIN CONTAINING INOSITOL POLYPHOSPHATE 5' PHOSPHATASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL AGGREGATION; CELL INFILTRATION; CONTROLLED STUDY; CROHN DISEASE; ENTERITIS; ENZYME ACTIVITY; ENZYME INHIBITION; FIBROBLAST; GIANT CELL; ILEUM; IMMUNOCOMPETENT CELL; INTESTINAL FIBROSIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAINING;

ANIMALS; ARGINASE; BORONIC ACIDS; CYTOKINES; FEMALE; FIBROBLASTS; FIBROSIS; HYPERPLASIA; ILEUM; IMMUNOENZYME TECHNIQUES; INFLAMMATION; INTESTINAL DISEASES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SKELETAL; PHOSPHORIC MONOESTER HYDROLASES; RECEPTORS, CHEMOKINE; TH17 CELLS;

EID: 80052478963     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.03.018     Document Type: Article

References (114)

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67. H. Szab, G. Fiorino, A. Spinelli, S. Rovida, A. Repici, A.C. Malesci, and S. Danese Review article: anti-fibrotic agents for the treatment of Crohn's disease - lessons learnt from other diseases Aliment Pharmacol Ther 31 2010 189 201
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70. R.K. Bhogal, C.M. Stoica, T.L. McGaha, and C.A. Bona Molecular aspects of regulation of collagen gene expression in fibrosis J Clin Immunol 25 2005 592 603 (Pubitemid 43011750)
71. M.C. Regan, B.M. Flavin, J.M. Fitzpatrick, and P.R. O'Connell Stricture formation in Crohn's disease: the role of intestinal fibroblasts Ann Surg 231 2000 46 50 (Pubitemid 30043938)
72. A. Mizoguchi, and E. Mizoguchi Animal models of IBD: linkage to human disease Curr Opin Pharmacol 10 2010 578 587
73. S. Nell, S. Suerbaum, and C. Josenhans The impact of the microbiota on the pathogenesis of IBD: lessons from mouse infection models Nat Rev Microbiol 8 2010 564 577
74. S.N. Flier, H. Tanjore, E.G. Kokkotou, H. Sugimoto, M. Zeisberg, and R. Kalluri Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis J Biol Chem 285 2010 20202 20212
75. R.J. Rigby, M.R. Hunt, B.P. Scull, J.G. Simmons, K.E. Speck, M.A. Helmrath, and P.K. Lund A new animal model of postsurgical bowel inflammation and fibrosis: the effect of commensal microflora Gut 58 2009 1104 1112
76. G.A. Grassl, Y. Valdez, K.S. Bergstrom, B.A. Vallance, and B.B. Finlay Chronic enteric salmonella infection in mice leads to severe and persistent intestinal fibrosis Gastroenterology 134 2008 768 780
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83. L.M. Sly, V. Ho, F. Antignano, J. Ruschmann, M. Hamilton, V. Lam, M.J. Rauh, and G. Krystal The role of SHIP in macrophages Front Biosci 12 2007 2836 2848
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85. W.G. Kerr, M.Y. Park, M. Maubert, and R.W. Engelman SHIP deficiency causes Crohn's disease-like ileitis Gut 60 2011 177 188
86. V.W. Ho, and L.M. Sly Derivation and characterization of murine alternatively activated (M2) macrophages Methods Mol Biol 531 2009 173 185
87. N.N. Kim, J.D. Cox, R.F. Baggio, F.A. Emig, S.K. Mistry, S.L. Harper, D.W. Speicher, S.M. Morris Jr, D.E. Ash, A. Traish, and D.W. Christianson Probing erectile function: s-(2-boronoethyl)-l-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum Biochemistry 40 2001 2678 2688 (Pubitemid 32198270)
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90. D.K. Podolsky Inflammatory bowel disease N Engl J Med 347 2002 417 429 (Pubitemid 34851835)
91. J. Cosnes, I. Nion-Larmurier, L. Beaugerie, P. Afchain, E. Tiret, and J.P. Gendre Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery Gut 54 2005 237 241 (Pubitemid 40139240)
92. J.E. Lennard-Jones Classification of inflammatory bowel disease Scand J Gastroenterol 170 Suppl 1989 2 6 (Pubitemid 20015811)
93. S.B. Hanauer Inflammatory bowel disease: epidemiology, pathogenesis, and therapeutic opportunities Inflamm Bowel Dis 12 Suppl 1 2006 S3 S9 (Pubitemid 43068428)
94. R.J. Xavier, and D.K. Podolsky Unravelling the pathogenesis of inflammatory bowel disease Nature 448 2007 427 434 (Pubitemid 47123518)
95. D.O. Adams The granulomatous inflammatory response: a review Am J Pathol 84 1976 164 192
96. S. Fais, and F. Pallone Inability of normal human intestinal macrophages to form multinucleated giant cells in response to cytokines Gut 37 1995 798 801
97. M.F. Graham, R.F. Diegelmann, C.O. Elson, W.J. Lindblad, N. Gotschalk, S. Gay, and R. Gay Collagen content and types in the intestinal strictures of Crohn's disease Gastroenterology 94 1988 257 265 (Pubitemid 18054760)
98. S. Kugathasan, L.J. Saubermann, L. Smith, D. Kou, J. Itoh, D.G. Binion, A.D. Levine, R.S. Blumberg, and C. Fiocchi Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease Gut 56 2007 1696 1705 (Pubitemid 350206296)
99. I.J. Fuss, C. Becker, Z. Yang, C. Groden, R.L. Hornung, F. Heller, M.F. Neurath, W. Strober, and P.J. Mannon Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody Inflamm Bowel Dis 12 2006 9 15 (Pubitemid 43032445)
100. G. Monteleone, F. Trapasso, T. Parrello, L. Biancone, A. Stella, R. Iuliano, F. Luzza, A. Fusco, and F. Pallone Bioactive IL-18 expression is up-regulated in Crohn's disease J Immunol 163 1999 143 147 (Pubitemid 29295835)
101. E. Kuroda, F. Antignano, V.W. Ho, M.R. Hughes, J. Ruschmann, V. Lam, T. Kawakami, W.G. Kerr, K.M. McNagny, L.M. Sly, and G. Krystal SHIP represses Th2 skewing by inhibiting IL-4 production from basophils J Immunol 186 2011 323 332
102. E. Kuroda, V. Ho, J. Ruschmann, F. Antignano, M. Hamilton, M.J. Rauh, A. Antov, R.A. Flavell, L.M. Sly, and G. Krystal SHIP represses the generation of IL-3-induced M2 macrophages by inhibiting IL-4 production from basophils J Immunol 183 2009 3652 3660
103. T.A. Wynn Fibrotic disease and the T(H)1/T(H)2 paradigm Nat Rev Immunol 4 2004 583 594
104. P. Gillery, C. Fertin, J.F. Nicolas, F. Chastang, B. Kalis, J. Banchereau, and F.X. Maquart Interleukin-4 stimulates collagen gene expression in human fibroblast monolayer cultures: potential role in fibrosis FEBS Lett 302 1992 231 234
105. A.E. Postlethwaite, M.A. Holness, H. Katai, and R. Raghow Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4 J Clin Invest 90 1992 1479 1485
106. L. Barron, and T.A. Wynn Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages Am J Physiol Gastrointest Liver Physiol 300 2011 G723 G728
107. S.B. Weisser, K.W. McLarren, N. Voglmaier, C.J. van Netten-Thomas, A. Antov, R.A. Flavell, and Sly LM Alternative activation of macrophages by IL-4 requires SHIP degradation Eur J Immunol 2011 Mar 21 10.1002/eji.201041105
108. J.L. Bishop, L.M. Sly, G. Krystal, and B.B. Finlay The inositol phosphatase SHIP controls Salmonella enterica serovar Typhimurium infection in vivo Infect Immun 76 2008 2913 2922
109. R.A. Casero Jr, and L.J. Marton Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases Nat Rev Drug Discov 6 2007 373 390 (Pubitemid 46705201)
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