ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma

Science Translational Medicine

Volumn 8, Issue 328, 2016, Pages

  Koschmann, Carl ^a   Calinescu, Anda Alexandra ^a   Nunez, Felipe J ^a   Mackay, Alan ^b   Fazal Salom, Janet ^b   Thomas, Daniel ^a   Mendez, Flor ^a   Kamran, Neha ^a   Dzaman, Marta ^a   Mulpuri, Lakshman ^a   Krasinkiewicz, Johnathon ^a   Doherty, Robert ^a   Lemons, Rosemary ^a   Brosnan Cashman, Jaqueline A ^c   Li, Youping ^a   Roh, Soyeon ^a   Zhao, Lili ^a   Appelman, Henry ^a   Ferguson, David ^a   Gorbunova, Vera ^d   Meeker, Alan ^e   Jones, Chris ^b   Lowenstein, Pedro R ^a   Castro, Maria G ^a   more..

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF ROCHESTER   (United States)

^e JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATRX PROTEIN; CHAPERONE; DNA; DOUBLE STRANDED DNA; DOXORUBICIN; IRINOTECAN; LOMUSTINE; SINGLE STRANDED DNA; TEMOZOLOMIDE; TOPOTECAN; TRANSPOSASE; UNCLASSIFIED DRUG; ATRX PROTEIN, HUMAN; ATRX PROTEIN, MOUSE; DNA HELICASE; NUCLEAR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATRX GENE; CANCER RADIOTHERAPY; CHEMOSENSITIVITY; CONTROLLED STUDY; COPY NUMBER VARIATION; DISEASE MODEL; DNA DAMAGE; DNA END JOINING REPAIR; DNA STRAND BREAKAGE; GENE LOSS; GENE MUTATION; GENETIC ANALYSIS; GLIOBLASTOMA; MOUSE; NONHUMAN; OVERALL SURVIVAL; PRIORITY JOURNAL; RADIOSENSITIVITY; SINGLE NUCLEOTIDE POLYMORPHISM; SURVIVAL RATE; ANIMAL; BRAIN TUMOR; CELL PROLIFERATION; CHROMOSOME; DEFICIENCY; GENETICS; GLIOMA; HUMAN; METABOLISM; MICROSATELLITE INSTABILITY; MUTATION; PATHOLOGY; SURVIVAL ANALYSIS; TELOMERE HOMEOSTASIS;

ANIMALS; BRAIN NEOPLASMS; CELL PROLIFERATION; CHROMOSOMES, MAMMALIAN; DISEASE MODELS, ANIMAL; DNA COPY NUMBER VARIATIONS; DNA DAMAGE; DNA END-JOINING REPAIR; DNA HELICASES; GLIOMA; HUMANS; MICE; MICROSATELLITE INSTABILITY; MUTATION; NUCLEAR PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; SURVIVAL ANALYSIS; TELOMERE HOMEOSTASIS; TRANSPOSASES;

EID: 84959523012     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aac8228     Document Type: Article

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