CENP-C directs a structural transition of CENP-A nucleosomes mainly through sliding of DNA gyres

Nature Structural and Molecular Biology

Volumn 23, Issue 3, 2016, Pages 204-208

  Falk, Samantha J ^a   Lee, Jaehyoun ^b   Sekulic, Nikolina ^a,c   Sennett, Michael A ^b   Lee, Tae Hee ^b   Black, Ben E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CENTROMERE PROTEIN A; CENTROMERE PROTEIN C; DNA; HISTONE H3; NUCLEAR PROTEIN; UNCLASSIFIED DRUG; AUTOANTIGEN; NONHISTONE PROTEIN; NUCLEOSOME;

ARTICLE; CELL FUNCTION; CELL STRUCTURE; CELLULAR DISTRIBUTION; CENTROMERE; CHROMOSOME; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; NUCLEOSOME; PRIORITY JOURNAL; PROTEIN BINDING; BIOLOGICAL MODEL; CHEMISTRY; METABOLISM; MOLECULAR MODEL;

AUTOANTIGENS; CENTROMERE; CHROMOSOMAL PROTEINS, NON-HISTONE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; NUCLEOSOMES;

EID: 84959518850     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.3175     Document Type: Article

References (39)

1. Sekulic, N., & Black, B.E. Molecular underpinnings of centromere identity and maintenance. Trends Biochem. Sci. 37, 220-229 (2012
2. Allshire, R.C., & Karpen, G.H. Epigenetic regulation of centromeric chromatin: old dogs, new tricks? Nat. Rev. Genet. 9, 923-937 (2008
3. Westhorpe, F.G., & Straight, A.F. The centromere: epigenetic control of chromosome segregation during mitosis. Cold Spring Harb. Perspect. Biol. 7, a015818 (2015
4. Warburton P.E., et al. Immunolocalization of CENP-A suggests a distinct nucleosome structure at the inner kinetochore plate of active centromeres. Curr. Biol. 7, 901-904 (1997
5. Amor D.J., et al. Human centromere repositioning in progress. Proc. Natl. Acad. Sci. USA 101, 6542-6547 (2004
6. Bassett E.A., et al. Epigenetic centromere specification directs aurora B accumulation but is insufficient to efficiently correct mitotic errors. J. Cell Biol. 190, 177-185 (2010
7. Earnshaw, W.C., & Migeon, B.R. Three related centromere proteins are absent from the inactive centromere of a stable isodicentric chromosome. Chromosoma 92, 290-296 (1985
8. Barnhart M.C., et al. HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore. J. Cell Biol. 194, 229-243 (2011
9. Hori, T., Shang, W.-H., Takeuchi, K., & Fukagawa, T. The CCAN recruits CENP-A to the centromere and forms the structural core for kinetochore assembly. J. Cell Biol. 200, 45-60 (2013
10. Chen C.-C., et al. CAL1 is the Drosophila CENP-A assembly factor. J. Cell Biol. 204, 313-329 (2014
11. Logsdon G.A., et al. Both tails and the centromere targeting domain of CENP-A are required for centromere establishment. J. Cell Biol. 208, 521-531 (2015
12. Tachiwana H., et al. HJURP involvement in de novo CenH3(CENP-A) and CENP-C recruitment. Cell Rep. 11, 22-32 (2015
13. Mendiburo, M.J., Padeken, J., Fülöp, S., Schepers, A., & Heun, P. Drosophila CENH3 is sufficient for centromere formation. Science 334, 686-690 (2011
14. Guse, A., Carroll, C.W., Moree, B., Fuller, C.J., & Straight, A.F. In vitro centromere and kinetochore assembly on defined chromatin templates. Nature 477, 354-358 (2011
15. Falk S.J., et al. Chromosomes. CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere. Science 348, 699-703 (2015
16. Sekulic, N., Bassett, E.A., Rogers, D.J., & Black, B.E. The structure of (CENP-A-H4)2 reveals physical features that mark centromeres. Nature 467, 347-351 (2010
17. Carroll, C.W., Milks, K.J., & Straight, A.F. Dual recognition of CENP-A nucleosomes is required for centromere assembly. J. Cell Biol. 189, 1143-1155 (2010
18. Kato, H., et al A conserved mechanism for centromeric nucleosome recognition by centromere protein CENP-C. Science 340 1110-1113 2013
19. Luger, K., Mäder, A.W., Richmond, R.K., Sargent, D.F., & Richmond, T.J. Crystal structure of the nucleosome core particle at 2.8 Å resolution. Nature 389, 251-260 (1997
20. Harp J.M., et al. X-ray diffraction analysis of crystals containing twofold symmetric nucleosome core particles. Acta Crystallogr. D Biol. Crystallogr. 52, 283-288 (1996
21. Hasson D., et al. The octamer is the major form of CENP-A nucleosomes at human centromeres. Nat. Struct. Mol. Biol. 20, 687-695 (2013
22. Lee, J.Y., & Lee, T.-H. Effects of DNA methylation on the structure of nucleosomes. J. Am. Chem. Soc. 134, 173-175 (2012
23. Lee, J.Y., Wei, S., & Lee, T.-H. Effects of histone acetylation by Piccolo NuA4 on the structure of a nucleosome and the interactions between two nucleosomes. J. Biol. Chem. 286, 11099-11109 (2011
24. Ngo, T.T.M., & Ha, T. Nucleosomes undergo slow spontaneous gaping. Nucleic Acids Res. 43, 3964-3971 (2015
25. Tachiwana H., et al. Crystal structure of the human centromeric nucleosome containing CENP-A. Nature 476, 232-235 (2011
26. Ong, M.S., Richmond, T.J., & Davey, C.A. DNA stretching and extreme kinking in the nucleosome core. J. Mol. Biol. 368, 1067-1074 (2007
27. Vasudevan, D., Chua, E.Y.D., & Davey, C.A. Crystal structures of nucleosome core particles containing the 601 strong positioning sequence. J. Mol. Biol. 403, 1-10 (2010
28. Tan, S., & Davey, C.A. Nucleosome structural studies. Curr. Opin. Struct. Biol. 21, 128-136 (2011
29. Lacoste N., et al. Mislocalization of the centromeric histone variant CenH3/CENP-A in human cells depends on the chaperone DAXX. Mol. Cell 53, 631-644 (2014
30. Foltz D.R., et al. The human CENP-A centromeric nucleosome-Associated complex. Nat. Cell Biol. 8, 458-469 (2006
31. Okada M., et al. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. Nat. Cell Biol. 8, 446-457 (2006
32. Heun P., et al. Mislocalization of the Drosophila centromere-specific histone CID promotes formation of functional ectopic kinetochores. Dev. Cell 10, 303-315 (2006
33. Van Hooser A.A., et al. Specification of kinetochore-forming chromatin by the histone H3 variant CENP-A. J. Cell Sci. 114, 3529-3542 (2001
34. Gascoigne K.E., et al. Induced ectopic kinetochore assembly bypasses the requirement for CENP-A nucleosomes. Cell 145, 410-422 (2011
35. Warburton, P.E. Chromosomal dynamics of human neocentromere formation. Chromosome Res. 12, 617-626 (2004
36. Wei, S., Falk, S.J., Black, B.E., & Lee, T.-H. A novel hybrid single molecule approach reveals spontaneous DNA motion in the nucleosome. Nucleic Acids Res. 43 e111 2015
37. Brunger, A.T. Version 1.2 of the Crystallography and NMR system. Nat. Protoc. 2, 2728-2733 (2007
38. Davey, G.E., Wu, B., Dong, Y., Surana, U., & Davey, C.A. DNA stretching in the nucleosome facilitates alkylation by an intercalating antitumour agent. Nucleic Acids Res. 38, 2081-2088 (2010
39. Sambrook, J & Russell, D. Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Laboratory Press 2001