-
1
-
-
0038464650
-
Regulation of cell death: THe calcium-apoptosis link
-
Orrenius S, Zhivotovsky B, Nicotera P. Regulation of cell death: THe calcium-apoptosis link. Nat Rev Mol Cell Biol 2003;4(7):552-65. http://dx.doi.org/10.1038/nrm1150
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, Issue.7
, pp. 552-565
-
-
Orrenius, S.1
Zhivotovsky, B.2
Nicotera, P.3
-
2
-
-
0025302688
-
Manipulations of cellular iron metabolism for modulating normal and malignant cell proliferation: Achievements and prospects
-
Cazzola M, Bergamaschi G, Dezza L, Arosio P. Manipulations of cellular iron metabolism for modulating normal and malignant cell proliferation: Achievements and prospects. Blood 1990;75(10):1903-19.
-
(1990)
Blood
, vol.75
, Issue.10
, pp. 1903-1919
-
-
Cazzola, M.1
Bergamaschi, G.2
Dezza, L.3
Arosio, P.4
-
3
-
-
0017127835
-
Effect of iron deficiency and desferrioxamine on DNA synthesis in human cells
-
Hoffbrand AV, Ganeshaguru K, Hooton JW, Tattersall MH. Effect of iron deficiency and desferrioxamine on DNA synthesis in human cells. Br J Haematol 1976;33(4):517-26. http://dx.doi.org/10.1111/j.1365-2141.1976.tb03570.x.
-
(1976)
Br J Haematol
, vol.33
, Issue.4
, pp. 517-526
-
-
Hoffbrand, A.V.1
Ganeshaguru, K.2
Hooton, J.W.3
Tattersall, M.H.4
-
4
-
-
84864272758
-
Mechanisms of mammalian iron homeostasis
-
Pantopoulos K, Porwal SK, Tartakoff A, Devireddy L. Mechanisms of mammalian iron homeostasis. Biochemistry 2012;51(29):5705-24. http://dx.doi.org/10.1021/bi300752r.
-
(2012)
Biochemistry
, vol.51
, Issue.29
, pp. 5705-5724
-
-
Pantopoulos, K.1
Porwal, S.K.2
Tartakoff, A.3
Devireddy, L.4
-
5
-
-
84876009407
-
Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents
-
Pogribny IP, Tryndyak VP, Pogribna M, Shpyleva S, Surratt G, Gamboa da Costa G, et al. Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents. Int J Oncol 2013;42(5):1822-32. http://dx.doi.org/10.3892/ijo.2013.1855.
-
(2013)
Int J Oncol
, vol.42
, Issue.5
, pp. 1822-1832
-
-
Pogribny, I.P.1
Tryndyak, V.P.2
Pogribna, M.3
Shpyleva, S.4
Surratt, G.5
Gamboa Da Costa, G.6
-
6
-
-
79952227712
-
Ironing out cancer
-
Torti SV, Torti FM. Ironing out cancer. Cancer Res 2011;71(5):1511-4. http://dx.doi.org/10.1158/0008-5472.CAN-10-3614.
-
(2011)
Cancer Res
, vol.71
, Issue.5
, pp. 1511-1514
-
-
Torti, S.V.1
Torti, F.M.2
-
7
-
-
33847065486
-
The epigenomics of cancer
-
Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007;128(4):683-92. http://dx.doi.org/10.1016/j.cell.2007.01.029.
-
(2007)
Cell
, vol.128
, Issue.4
, pp. 683-692
-
-
Jones, P.A.1
Baylin, S.B.2
-
8
-
-
84876854791
-
Iron and cancer: More ore to be mined
-
Torti SV, Torti FM. Iron and cancer: More ore to be mined. Nat Rev Cancer 2013;13(5):342-55. http://dx.doi.org/10.1038/nrc3495.
-
(2013)
Nat Rev Cancer
, vol.13
, Issue.5
, pp. 342-355
-
-
Torti, S.V.1
Torti, F.M.2
-
9
-
-
0038324398
-
The role of iron chelation in cancer therapy
-
Buss JL, Torti FM, Torti SV. The role of iron chelation in cancer therapy. Curr Med Chem 2003;10(12):1021-34. http://dx.doi.org/10.2174/0929867033457638.
-
(2003)
Curr Med Chem
, vol.10
, Issue.12
, pp. 1021-1034
-
-
Buss, J.L.1
Torti, F.M.2
Torti, S.V.3
-
10
-
-
84861898212
-
Iron chelators for the treatment of cancer
-
Yu Y, Gutierrez E, Kovacevic Z, Saletta F, Obeidy P, Suryo Rahmanto Y, et al. Iron chelators for the treatment of cancer. Curr Med Chem 2012;19(17):2689-702. http://dx.doi.org/10.2174/092986712800609706.
-
(2012)
Curr Med Chem
, vol.19
, Issue.17
, pp. 2689-2702
-
-
Yu, Y.1
Gutierrez, E.2
Kovacevic, Z.3
Saletta, F.4
Obeidy, P.5
Suryo Rahmanto, Y.6
-
11
-
-
59149089078
-
The iron chelator Dp44mT causes DNA damage and selective inhibition of topoisomerase IIalpha in breast cancer cells
-
Rao VA, Klein SR, Agama KK, Toyoda E, Adachi N, Pommier Y, et al. The iron chelator Dp44mT causes DNA damage and selective inhibition of topoisomerase IIalpha in breast cancer cells. Cancer Res 2009;69(3):948-57. http://dx.doi.org/10.1158/0008-5472.CAN-08-1437.
-
(2009)
Cancer Res
, vol.69
, Issue.3
, pp. 948-957
-
-
Rao, V.A.1
Klein, S.R.2
Agama, K.K.3
Toyoda, E.4
Adachi, N.5
Pommier, Y.6
-
12
-
-
61849121336
-
Co-application of arsenic trioxide (As2O3) and cisplatin (CDDP) on human SY-5Y neuroblastoma cells has differential effects on the intracellular calcium concentration ([Ca2]i) and cytotoxicity
-
Günes DA, Florea AM, Splettstoesser F, Büsselberg D. Co-application of arsenic trioxide (As2O3) and cisplatin (CDDP) on human SY-5Y neuroblastoma cells has differential effects on the intracellular calcium concentration ([Ca2]i) and cytotoxicity. Neurotoxicology 2009;30(2):194-202. http://dx.doi.org/10.1016/j.neuro.2008.12.001.
-
(2009)
Neurotoxicology
, vol.30
, Issue.2
, pp. 194-202
-
-
Günes, D.A.1
Florea, A.M.2
Splettstoesser, F.3
Büsselberg, D.4
-
13
-
-
34247157226
-
Does the calcein-AM method assay the total cellular ‘labile iron pool’ or only a fraction of it?
-
Tenopoulou M, Kurz T, Doulias PT, Galaris D, Brunk UT. Does the calcein-AM method assay the total cellular ‘labile iron pool’ or only a fraction of it? Biochem J 2007;403(2):261-6. http://dx.doi.org/10.1042/BJ20061840.
-
(2007)
Biochem J
, vol.403
, Issue.2
, pp. 261-266
-
-
Tenopoulou, M.1
Kurz, T.2
Doulias, P.T.3
Galaris, D.4
Brunk, U.T.5
-
14
-
-
0030008052
-
Superoxide production in rat hippocampal neurons: Selective imaging with hydroethidine
-
Bindokas VP, Jordán J, Lee CC, Miller RJ. Superoxide production in rat hippocampal neurons: Selective imaging with hydroethidine. J Neurosci 1996;16(4):1324-36.
-
(1996)
J Neurosci
, vol.16
, Issue.4
, pp. 1324-1336
-
-
Bindokas, V.P.1
Jordán, J.2
Lee, C.C.3
Miller, R.J.4
-
15
-
-
0037424245
-
Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production
-
Li N, Ragheb K, Lawler G, Sturgis J, Rajwa B, Melendez JA, et al. Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. J Biol Chem 2003;278(10):8516-25. http://dx.doi.org/10.1074/jbc.M210432200.
-
(2003)
J Biol Chem
, vol.278
, Issue.10
, pp. 8516-8525
-
-
Li, N.1
Ragheb, K.2
Lawler, G.3
Sturgis, J.4
Rajwa, B.5
Melendez, J.A.6
-
16
-
-
0021895138
-
A new generation of Ca2+ indicators with greatly improved fluorescence properties
-
Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985;260(6):3440-50.
-
(1985)
J Biol Chem
, vol.260
, Issue.6
, pp. 3440-3450
-
-
Grynkiewicz, G.1
Poenie, M.2
Tsien, R.Y.3
-
17
-
-
21344437787
-
Desferal inhibits breast tumor growth and does not interfere with the tumoricidal activity of doxorubicin
-
Hoke EM, Maylock CA, Shacter E. Desferal inhibits breast tumor growth and does not interfere with the tumoricidal activity of doxorubicin. Free Radic Biol Med 2005;39(3):403-11. http://dx.doi.org/10.1016/j.freeradbiomed.2005.03.029.
-
(2005)
Free Radic Biol Med
, vol.39
, Issue.3
, pp. 403-411
-
-
Hoke, E.M.1
Maylock, C.A.2
Shacter, E.3
-
18
-
-
33749515083
-
A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics
-
Whitnall M, Howard J, Ponka P, Richardson DR. A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics. Proc Natl Acad Sci U S A 2006;103(40):14901-6. http://dx.doi.org/10.1073/pnas.0604979103.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.40
, pp. 14901-14906
-
-
Whitnall, M.1
Howard, J.2
Ponka, P.3
Richardson, D.R.4
-
19
-
-
77955607931
-
Ferroportin and iron regulation in breast cancer progression and prognosis
-
Pinnix ZK, Miller LD, Wang W, D’Agostino R Jr, Kute T, Willingham MC, et al. Ferroportin and iron regulation in breast cancer progression and prognosis. Sci Transl Med 2010;2(43):43-56. http://dx.doi.org/10.1126/scitranslmed.3001127.
-
(2010)
Sci Transl Med
, vol.2
, Issue.43
, pp. 43-56
-
-
Pinnix, Z.K.1
Miller, L.D.2
Wang, W.3
D’Agostino, R.4
Kute, T.5
Willingham, M.C.6
-
20
-
-
0037009846
-
The role of iron in cell cycle progression and the proliferation of neoplastic cells
-
Le NT, Richardson DR. The role of iron in cell cycle progression and the proliferation of neoplastic cells. Biochim Biophys Acta 2002;1603(1):31-46. http://dx.doi.org/10.1016/s0304-419x0(20)0068-9.
-
(2002)
Biochim Biophys Acta
, vol.1603
, Issue.1
, pp. 31-46
-
-
Le, N.T.1
Richardson, D.R.2
-
21
-
-
0033729838
-
Control of the eukaryotic cell cycle by MAP kinase signaling pathways
-
Wilkinson MG, Millar JB. Control of the eukaryotic cell cycle by MAP kinase signaling pathways. FASEB J 2000;14(14):2147-57. http://dx.doi.org/10.1096/fj.00-0102rev.
-
(2000)
FASEB J
, vol.14
, Issue.14
, pp. 2147-2157
-
-
Wilkinson, M.G.1
Millar, J.B.2
-
22
-
-
77149125234
-
Iron chelator-mediated alterations in gene expression: Identification of novel iron-regulated molecules that are molecular targets of hypoxia-inducible factor-1 alpha and p53
-
Saletta F, Suryo Rahmanto Y, Noulsri E, Richardson DR. Iron chelator-mediated alterations in gene expression: Identification of novel iron-regulated molecules that are molecular targets of hypoxia-inducible factor-1 alpha and p53. Mol Pharmacol 2010;77(3):443-58. http://dx.doi.org/10.1124/mol.109.061028.
-
(2010)
Mol Pharmacol
, vol.77
, Issue.3
, pp. 443-458
-
-
Saletta, F.1
Suryo Rahmanto, Y.2
Noulsri, E.3
Richardson, D.R.4
-
23
-
-
7244239197
-
Richardson DR. Iron chelators with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: A link between iron metabolism and proliferation
-
Le NT, Richardson DR. Iron chelators with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: A link between iron metabolism and proliferation. Blood 2004;104(9):2967-75. http://dx.doi.org/10.1182/blood-2004-05-1866.
-
(2004)
Blood
, vol.104
, Issue.9
, pp. 2967-2975
-
-
Le, N.T.1
-
24
-
-
0028931345
-
Iron chelators induce apoptosis in proliferating cells
-
Hileti D, Panayiotidis P, Hoffbrand AV. Iron chelators induce apoptosis in proliferating cells. Br J Haematol 1995;89(1):181-7. http://dx.doi.org/10.1111/j.1365-2141.1995.tb08927.x.
-
(1995)
Br J Haematol
, vol.89
, Issue.1
, pp. 181-187
-
-
Hileti, D.1
Panayiotidis, P.2
Hoffbrand, A.V.3
-
25
-
-
1642619084
-
Increased GADD153 gene expression during iron chelation-induced apoptosis in Jurkat T-lymphocytes
-
Pan YJ, Hopkins RG, Loo G. Increased GADD153 gene expression during iron chelation-induced apoptosis in Jurkat T-lymphocytes. Biochim Biophys Acta 2004;1691(1):41-50. http://dx.doi.org/10.1016/j.bbamcr.2003.12.003.
-
(2004)
Biochim Biophys Acta
, vol.1691
, Issue.1
, pp. 41-50
-
-
Pan, Y.J.1
Hopkins, R.G.2
Loo, G.3
-
26
-
-
79960029703
-
Phosphorylation of SMC1 by ATR is required for desferrioxamine (DFO)-induced apoptosis
-
So EY, Ausman M, Saeki T, Ouchi T. Phosphorylation of SMC1 by ATR is required for desferrioxamine (DFO)-induced apoptosis. Cell Death Dis 2011;2(41):e128. http://dx.doi.org/10.1038/cddis.2011.9.
-
(2011)
Cell Death Dis
, vol.2
, Issue.41
-
-
So, E.Y.1
Ausman, M.2
Saeki, T.3
Ouchi, T.4
-
27
-
-
80053914848
-
Cellular iron depletion and the mechanisms involved in the iron-dependent regulation of the growth arrest and DNA damage family of genes
-
Saletta F, Suryo Rahmanto Y, Siafakas AR, Richardson DR. Cellular iron depletion and the mechanisms involved in the iron-dependent regulation of the growth arrest and DNA damage family of genes. J Biol Chem 2011;286(41):35396-406. http://dx.doi.org/10.1074/jbc.M111.273060.
-
(2011)
J Biol Chem
, vol.286
, Issue.41
, pp. 35396-35406
-
-
Saletta, F.1
Suryo Rahmanto, Y.2
Siafakas, A.R.3
Richardson, D.R.4
-
28
-
-
33644872102
-
The oxidation of 2’,7’-dichlorofluorescin to reactive oxygen species: A self-fulfilling prophesy?
-
Bonini MG, Rota C, Tomasi A, Mason RP. The oxidation of 2’,7’-dichlorofluorescin to reactive oxygen species: A self-fulfilling prophesy? Free Radic Biol Med 2006;40(6):968-75. http://dx.doi.org/10.1016/j.freeradbiomed.2005.10.042.
-
(2006)
Free Radic Biol Med
, vol.40
, Issue.6
, pp. 968-975
-
-
Bonini, M.G.1
Rota, C.2
Tomasi, A.3
Mason, R.P.4
-
29
-
-
0043032860
-
Burkitt MJ. Evidence for the role of a peroxidase compound I-type intermediate in the oxidation of glutathione, NADH, ascorbate, and dichlorofluorescin by cytochrome c/H2O2. Implications for oxidative stress during apoptosis
-
Lawrence A, Jones CM, Wardman P, Burkitt MJ. Evidence for the role of a peroxidase compound I-type intermediate in the oxidation of glutathione, NADH, ascorbate, and dichlorofluorescin by cytochrome c/H2O2. Implications for oxidative stress during apoptosis. J Biol Chem 2003;278(32):29410-9. http://dx.doi.org/10.1074/jbc.M300054200.
-
(2003)
J Biol Chem
, vol.278
, Issue.32
, pp. 29410-29419
-
-
Lawrence, A.1
Jones, C.M.2
Wardman, P.3
-
30
-
-
33750063955
-
Selective fluorescent imaging of superoxide in vivo using ethidium-based probes
-
Robinson KM, Janes MS, Pehar M, Monette JS, Ross MF, Hagen TM, et al. Selective fluorescent imaging of superoxide in vivo using ethidium-based probes. Proc Natl Acad Sci U S A 2006;103(41):15038-43. http://dx.doi.org/10.1073/pnas.0601945103.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.41
, pp. 15038-15043
-
-
Robinson, K.M.1
Janes, M.S.2
Pehar, M.3
Monette, J.S.4
Ross, M.F.5
Hagen, T.M.6
-
31
-
-
79953898190
-
Iron mediates N-methyl-D-aspartate receptor-dependent stimulation of calcium-induced pathways and hippocampal synaptic plasticity
-
Muñoz P, Humeres A, Elgueta C, Kirkwood A, Hidalgo C, Núñez MT. Iron mediates N-methyl-D-aspartate receptor-dependent stimulation of calcium-induced pathways and hippocampal synaptic plasticity. J Biol Chem 2011;286(15):13382-92. http://dx.doi.org/10.1074/jbc.M110.213785.
-
(2011)
J Biol Chem
, vol.286
, Issue.15
, pp. 13382-13392
-
-
Muñoz, P.1
Humeres, A.2
Elgueta, C.3
Kirkwood, A.4
Hidalgo, C.5
Núñez, M.T.6
-
32
-
-
84862022402
-
Effect of hepcidin on intracellular calcium in human osteoblasts
-
Li GF, Xu YJ, He YF, Du BC, Zhang P, Zhao DY, et al. Effect of hepcidin on intracellular calcium in human osteoblasts. Mol Cell Biochem 2012;366(1-2):169-74. http://dx.doi.org/10.1007/s11010-012-1294-y.
-
(2012)
Mol Cell Biochem
, vol.366
, Issue.1-2
, pp. 169-174
-
-
Li, G.F.1
Xu, Y.J.2
He, Y.F.3
Du, B.C.4
Zhang, P.5
Zhao, D.Y.6
-
33
-
-
79952284127
-
Weinberg RA. Hallmarks of cancer: THe next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: THe next generation. Cell 2011;144(5):646-74. http://dx.doi.org/10.1016/j.cell.2011.02.013.
-
(2011)
Cell
, vol.144
, Issue.5
, pp. 646-674
-
-
Hanahan, D.1
-
34
-
-
42549164808
-
Ca2+ signalling checkpoints in cancer: Remodelling Ca2+ for cancer cell proliferation and surviva
-
2+ for cancer cell proliferation and survival. Nat Rev Cancer 2008;8(5):361-75.http://dx.doi.org/10.1038/nrc2374.
-
(2008)
Nat Rev Cance
, vol.8
, Issue.5
, pp. 361-367
-
-
Roderick, H.L.1
Cook, S.J.2
-
35
-
-
79960759956
-
Calcium in tumour metastasis: New roles for known actors
-
Prevarskaya N, Skryma R, Shuba Y. Calcium in tumour metastasis: New roles for known actors. Nat Rev Cancer 2011;11(8):609-18. http://dx.doi.org/10.1038/nrc3105.
-
(2011)
Nat Rev Cancer
, vol.11
, Issue.8
, pp. 609-618
-
-
Prevarskaya, N.1
Skryma, R.2
Shuba, Y.3
-
36
-
-
83455208337
-
Ion channels and transporters in cancer 6. Vascularizing the tumor: TRP channels as molecular targets
-
Fiorio Pla A, Avanzato D, Munaron L, Ambudkar IS. Ion channels and transporters in cancer 6. Vascularizing the tumor: TRP channels as molecular targets. Am J Physiol Cell Physiol 2012;302(1):C9-15. http://dx.doi.org/10.1152/ajpcell.00280.2011.
-
(2012)
Am J Physiol Cell Physiol
, vol.302
, Issue.1
-
-
Fiorio Pla, A.1
Avanzato, D.2
Munaron, L.3
Ambudkar, I.S.4
-
37
-
-
0346880483
-
Calcium and apoptosis: Facts and hypotheses
-
Rizzuto R, Pinton P, Ferrari D, Chami M, Szabadkai G, Magalhães PJ, et al. Calcium and apoptosis: Facts and hypotheses. Oncogene 2003;22(53):8619-27. http://dx.doi.org/10.1038/sj.onc.1207105.
-
(2003)
Oncogene
, vol.22
, Issue.53
, pp. 8619-8627
-
-
Rizzuto, R.1
Pinton, P.2
Ferrari, D.3
Chami, M.4
Szabadkai, G.5
Magalhães, P.J.6
-
38
-
-
82455219496
-
Ion channnels and transporters in cancer 5. Ion channels in control of cancer and cell apoptosis
-
Lehen’kyi V, Shapovalov G, Skryma R, Prevarskaya N. Ion channnels and transporters in cancer 5. Ion channels in control of cancer and cell apoptosis. Am J Physiol Cell Physiol 2011;301(6):C1281-9. http://dx.doi.org/10.1152/ajpcell.00249.2011.
-
(2011)
Am J Physiol Cell Physiol
, vol.301
, Issue.6
-
-
Lehen’Kyi, V.1
Shapovalov, G.2
Skryma, R.3
Prevarskaya, N.4
-
39
-
-
33645297168
-
An introduction to TRP channels
-
Ramsey IS, Delling M, Clapham DE. An introduction to TRP channels. Annu Rev Physiol 2006;68:619-47. http://dx.doi.org/10.1146/annurev.physiol.68.040204.100431.
-
(2006)
Annu Rev Physiol
, vol.68
, pp. 619-647
-
-
Ramsey, I.S.1
Delling, M.2
Clapham, D.E.3
-
40
-
-
0030950849
-
Elementary and global aspects of calcium signalling
-
Berridge MJ. Elementary and global aspects of calcium signalling. J Exp Biol 1997;200:315-9. http://dx.doi.org/10.1113/jphysiol.1997.sp021927.
-
(1997)
J Exp Biol
, vol.200
, pp. 315-319
-
-
Berridge, M.J.1
|