Effect of hepcidin on intracellular calcium in human osteoblasts

Molecular and Cellular Biochemistry

Volumn 366, Issue 1-2, 2012, Pages 169-174

  Li, Guang Fei ^a   Xu, You Jia ^a   He, Yin Feng ^a   Du, Ben Cai ^a   Zhang, Peng ^a   Zhao, Dong Yang ^a   Yu, Chen ^a   Qin, Chen Hao ^a   Li, Kai ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

Calcium ion; Hepcidin; Iron overload; Osteoblast

Indexed keywords

CALCIUM; DANTROLENE; FERROPORTIN; HEPCIDIN; IRON; MEMBRANE PROTEIN; NIMODIPINE;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL PROLIFERATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; FLUORESCENCE; HUMAN; HUMAN CELL; IRON TRANSPORT; OSTEOBLAST; OSTEOPOROSIS; SARCOPLASMIC RETICULUM;

ANTIMICROBIAL CATIONIC PEPTIDES; CALCIUM; CELL LINE; CELL PROLIFERATION; HUMANS; INTRACELLULAR FLUID; IRON; OSTEOBLASTS;

EID: 84862022402     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-012-1294-y     Document Type: Article

References (26)

1. Weinberg ED (2006) Iron loading: a risk factor for osteoporosis. Biometals 19:633-635
2. Yamaguchi M (2010) Role of nutritional zinc in the prevention of osteoporosis. Mol Cell Biochem 338:241-254
3. Yamasaki K, Hagiwara H (2009) Excess iron inhibits osteoblast metabolism. Toxicol Lett 191:211-215
4. Liu G, Men P, Kenner GH, Miller SC (2006) Age-associated iron accumulation in bone: implications for postmenopausal osteoporosis and a new target for prevention and treatment by chelation. Biometals 19:245-251 (Pubitemid 43946164)
5. Qu ZH, Zhang XL, Tang TT, Dai KR (2008) Promotion of osteogenesis through beta-catenin signaling by desferrioxamine. Biochem Biophys Res Commun 370:332-337
6. Valenti L, Varenna M, Fracanzani AL, Rossi V, Fargion S, Sinigaglia L (2009) Association between iron overload and osteoporosis in patients with hereditary hemochromatosis. Ostroporos Int 20:549-555
7. Tsay J, Yang Z, Ross FP, Cunningham-Rundles S, Lin H, Coleman R, Mayer-Kuckuk P, Doty SB, Grady RW, Giardina PJ, Boskey AL, Vogiatzi MG (2010) Bone loss caused by iron overload in a murine model: importance of oxidative stress. Blood 116:2582-2589
8. Li GF, Pan YZ, Sirois P, Li K, Xu YJ (2012) Iron homeostasis in osteoporosis and its clinical implications. Osteoporos Int. doi: 10.1007/s00198-012-1982-1
9. Park CH, Valore EV, Waring AJ, Ganz T (2001) Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 276:7806-7810
10. Zhang AS, Enns CA (2009) Molecular mechanisms of normal iron homeostasis. Hematol Am Soc Hematol Educ Program 1:207-214
11. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306:2090-2093 (Pubitemid 40007660)
12. De Domenico I, Ward DM, Langelier C, Vaughn MB, Nemeth E, Sundquist WI, Ganz T, Musci G, Kaplan J (2007) The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol Biol Cell 18:2569-2578 (Pubitemid 47025722)
13. Rivera S, Nemeth E, Gabayan V, Lopez MA, Farshidi D, Ganz T (2005) Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs. Blood 106:2196-2199 (Pubitemid 41291740)
14. 2+ channels. Regul Pept 172:58-61
15. Berridge MJ, Lipp P, Bootman MD (2000) Signal transduction. The calcium entry pas de deux. Science 287:1604-1605 (Pubitemid 30127754)
16. Labelle D, Jumarie C, Moreau R (2007) Capacitative calcium entry and proliferation of human osteoblast-like MG-63 cells. Cell Prolif 40:866-884 (Pubitemid 350135207)
17. Jang HO, Park YS, Lee JH, Seo JB, Koo KI, Jeong SC, Jin SD, Lee YH, Eom HS, Yun I (2007) Effect of extracts from safflower seeds on osteoblast differentiation and intracellular calcium ion concentration in MC3T3-E1 cells. Nat Prod Res 21:787-797
18. Tsay J, Yang Z, Ross FP, Cunningham-Rundles S, Lin H, Coleman R, Mayer-Kuckuk P, Doty SB, Grady RW, Giardina PJ, Boskey AL, Vogiatzi MG (2010) Bone loss caused by iron overload in a murine model: importance of oxidative stress. Blood 116:2582-2589
19. Kudo H, Suzuki S, Watanabe A, Kikuchi H, Sassa S, Sakamoto S (2008) Effects of colloidal iron overload on renal and hepatic siderosis and the femur in male rats. Toxicology 246:143-147
20. Jian J, Pelle E, Huang X (2009) Iron and menopause: does increased iron affect the health of postmenopausal women? Antioxid Redox Signal 11:2939-2943
21. Guggenbuhl P, Filmon R, Mabilleau G, Basle MF, Chappard D (2008) Iron inhibits hydroxyapatite crystal growth in vitro. Metabolism 57:903-910 (Pubitemid 351814682)
22. Lauckner JE, Hille B, Mackie K (2005) The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins. Proc Natl Acad Sci USA 102: 19144-19149 (Pubitemid 43049580)
23. 2+ release in pancreatic islet beta-cells: critical evaluation of the use of endoplasmic reticulum-targeted "cameleons". Endocrinology 145: 4540-4549
24. 2+ channels in pancreatic beta-cells. J Biol Chem 276: 9971-9977
25. Graves TK, Hinkle PM (2003) Ca(2+)-induced Ca(2+) release in the pancreatic beta-cell: direct evidence of endoplasmic reticulum Ca(2+) release. Endocrinology 144:3565-3574 (Pubitemid 36904436)
26. Choi KJ, Cho DS, Kim JY, Kim BJ, Lee KM, Kim SH, Kim DK, Kim SH, Park HS (2011) Ca-induced Ca release from internal stores in INS-1 rat insulinoma cells. Korean J Physiol Pharmacol 15:53-59