Systematic review of biochemical biomarkers for neck and upper-extremity musculoskeletal disorders

Scandinavian Journal of Work, Environment and Health

Volumn 42, Issue 2, 2016, Pages 103-124

  Gold, Judith E ^a   Hallman, David M ^a   Hellström, Fredrik ^a   Björklund, Martin ^a,d   Crenshaw, Albert G ^a   Djupsjobacka, Mats ^a   Heiden, Marina ^a   Mathiassen, Svend Erik ^a   Piligian, George ^b   Barbe, Mary F ^c  

^a UNIVERSITY OF GÄVLE   (Sweden)

^b Northwell Health   (United States)

^c TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UMEÅ UNIVERSITY   (Sweden)

Author keywords

Collagen degradation; Collagen repair; Inflammation; Lipid; Muscle injury; Muscle metabolites; Pain; Serotonin; Tendon injury; Triglyceride

Indexed keywords

ALPHA 1 ANTITRYPSIN; BIOLOGICAL MARKER; BRADYKININ; C REACTIVE PROTEIN; GELATINASE A; HEAT SHOCK PROTEIN 70; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 33; INTERLEUKIN 6; INTERLEUKIN 8; INTERSTITIAL COLLAGENASE; KALLIDIN; LEPTIN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MATRIX METALLOPROTEINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUROTRANSMITTER; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PALMIDROL; PYRUVIC ACID; SEROTONIN; TENASCIN; TESTOSTERONE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; TIMP1 PROTEIN, HUMAN;

BIOMARKER; BODY CONDITION; COLLAGEN; DATA QUALITY; DEGRADATION; INJURY; LIPID; METABOLISM; METABOLITE; MUSCLE; SKELETON; SPECTRUM; SYMPTOM;

ARM; ARM DISEASE; COLLAGEN DEGRADATION; COMORBIDITY; DATA EXTRACTION; DISEASE SEVERITY; FIBROPROLIFERATIVE DISORDER; HEAD AND NECK DISEASE; HUMAN; INSULIN RESISTANCE; MUSCLE METABOLISM; MUSCULOSKELETAL DISEASE; MYALGIA; NECK; NONHUMAN; PRIORITY JOURNAL; QUALITY CONTROL; REVIEW; SELECTION BIAS; SHOULDER PAIN; SYSTEMATIC REVIEW; TRAPEZIUS MUSCLE; VIBRATION DISEASE; ADULT; CROSS-SECTIONAL STUDY; MIDDLE AGED; MUSCULOSKELETAL DISEASES; NECK INJURIES; OCCUPATIONAL INJURIES; SEVERITY OF ILLNESS INDEX; UPPER LIMB; YOUNG ADULT;

ADULT; BIOMARKERS; CROSS-SECTIONAL STUDIES; HUMANS; MIDDLE AGED; MUSCULOSKELETAL DISEASES; NECK INJURIES; OCCUPATIONAL INJURIES; SEROTONIN; SEVERITY OF ILLNESS INDEX; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TRIGLYCERIDES; UPPER EXTREMITY; YOUNG ADULT;

EID: 84959483922     PISSN: 03553140     EISSN: 1795990X     Source Type: Journal    
DOI: 10.5271/sjweh.3533     Document Type: Review

References (146)

1. Hassard J, Teoh K, Cox T, Dewe P, Cosmar M, Grundler R, et al. Calculating the cost of work-related stress and psychosocial risks - a literature review. Luxembourg: Publications Office of the European Union: European Agency for Safety and Health at Work; 2014.
2. Huisstede BM, Bierma-Zeinstra SM, Koes BW, Verhaar JA. Incidence and prevalence of upper-extremity musculoskeletal disorders. A systematic appraisal of the literature. BMC Musculoskelet Disord. 2006;7:7. http://dx.doi.org/10.1186/1471-2474-7-7.
3. Health and Safety Executive (V2. Handling injuries). Crown Copyright. Available from: www.hse.gove.uk [accessed January 28, 2013]; 2012.
4. World Health Organization. Physical Inactivity: A Global Public Health Problem. Geneva: WHO; 2014. Available from: http://www.who.int/dietphysicalactivity/factsheet_inactivity/en/. [cited 2014 October 8, 2014].
5. Schneider E, Irastorza X. OSH in figures: Work-related musculoskeletal disorders in the EU — Facts and figures. Luxembourg: Publications Office of the European Union: European Agency for Safety and Health at Work; 2010.
6. Buckle PW, Devereux JJ. The nature of work-related neck and upper limb musculoskeletal disorders. Appl Ergo. 2002;33:207-17. http://dx.doi.org/10.1016/S0003-6870(02)00014-5.
7. National Academy of Sciences. Panel on Musculoskeletal Disorders and the Workplace, Commission on Behavioral and Social Sciences and Education, National Research Council. Musculoskeletal Disorders and the Workplace: Low Back and Upper Extremities. Washington, D.C.: National Academy Press; 2001.
8. Virta L, Joranger P, Brox JI, Eriksson R. Costs of shoulder pain and resource use in primary health care: a cost-of-illness study in Sweden. BMC Musculoskelet Disord. 2012;13:17. http://dx.doi.org/10.1186/1471-2474-13-17.
9. Coyte PC, Asche CV, Croxford R, Chan B. The economic cost of musculoskeletal disorders in Canada. Arthritis Care Res. 1998;11(5):315-25. http://dx.doi.org/10.1002/art.1790110503.
10. Bureau of Labor Statistics. Prevention of work-related musculoskeletal disorders. Washington, DC: Bureau of Labor Statistics; 2014. Available from: http://www.bls.gov/news.release/pdf/osh2.pdf.
11. OSHA. Prevention of work-related musculoskeletal disorders: U.S. Department of Labor, Occupational Safety & Health Administration; 2014 [cited 2014 July 29]. Available from: https://www.osha.gov/pls/oshaweb/owadisp.show_document?p_table=UNIFIED_AGENDA&p_id=4481.
12. Viikari-Juntura E. New avenues in research on musculoskeletal disorders. Scand J Work Environ Health. 1999;26(6):564-68.
13. Punnett L, Gold JE. Work-related upper-extremity disorders: epidemiologic findings and unresolved questions. In: Johansson H, Djupsjöbacka M, Windhorst U, Passatore M, Ljubisavljevic M, Blair SJ, editors. Chronic Work-Related Myalgia: Neuromuscular Mechanisms behind Work-Related Chronic Muscle Pain Syndromes. Umea, Sweden: National Institute for Working Life; 2003.
14. Institute of Medicine. Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease. Micheel CM, Ball JR, editors. Washington, DC: The National Academies Press; 2010.
15. Mayeux R. Biomarkers: potential uses and limitations. NeuroRx. 2004;1(2):182-8. http://dx.doi.org/10.1602/neurorx.1.2.182.
16. Committee on Biological Markers of the National Research Council. Biological markers in environmental health research. Environ Health Persp. 1987;74:3-9.
17. Mastin JP, Henningsen GM, Fine LJ. Use of biomarkers of occupational musculoskeletal disorders in epidemiology and laboratory animal model development. Scand J Work Environ Health. 1992;18 Suppl 2:85-7.
18. Saxton JM. A review of current literature on physiological tests and soft tissue biomarkers applicable to work-related upper limb disorders. Occup Med. 2000;50(2):121-30. http://dx.doi.org/10.1093/occmed/50.2.121.
19. Visser B, van Dieen JH. Pathophysiology of upper-extremity muscle disorders. J Electromyogr Kinesiol. 2006;16(1):1-16. http://dx.doi.org/10.1016/j.jelekin.2005.06.005.
20. Gerdle B, Larsson B. Potential Muscle Biomarkers of Chronic Myalgia in Humans - A Systematic Review of Microdialysis Studies, Biomarker. Khan T, editor. Rijeka: Biomarker: InTech; 2012.
21. Barbe MF, Barr AE. Inflammation and the pathophysiology of work-related musculoskeletal disorders. Brain Behav Immun. 2006;20(5):423-9. http://dx.doi.org/10.1016/j.bbi.2006.03.001.
22. Gerdle B, Ghafouri B, Ernberg M, Larsson B. Chronic musculoskeletal pain: review of mechanisms and biochemical biomarkers as assessed by the microdialysis technique. J Pain Res. 2014;7:313-26. http://dx.doi.org/10.2147/JPR.S59144.
23. Boocock MG, Collier JM, McNair PJ, Simmonds M, Larmer PJ, Armstrong B. A framework for the classification and diagnosis of work-related upper-extremity conditions: systematic review. Semin Arthritis Rheum. 2009;38(4):296-311. http://dx.doi.org/10.1016/j.semarthrit.2007.10.006.
24. World Health Organization. Identification and control of workrelated diseases. Geneva: World Health Organization, 1985 Contract No.: 714.
25. Bruns DE, Huth EJ, Magid E, Young DS. Toward a checklist for reporting of studies of diagnostic accuracy of medical tests. Clin Chem. 2000;46(7):893-5.
26. Whiting P, Rutjes AW, Reitsma JB, Bossuyt PM, Kleijnen J. The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol. 2003;3:25. http://dx.doi.org/10.1186/1471-2288-3-25.
27. von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP, et al. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. BMJ. 2007;335(7624):806-8. http://dx.doi.org/10.1136/bmj.39335.541782.AD.
28. Altman DG. Statistical reviewing for medical journals. Stat Med. 1998;17(23):2661-74. http://dx.doi.org/10.1002/(SICI)1097-0258(19981215)17:23<2661::AIDSIM33>3.0.CO;2-B.
29. Downs SH, Black N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health. 1998;52(6):377-84. http://dx.doi.org/10.1136/jech.52.6.377.
30. Slavin RE. Best evidence synthesis: an intelligent alternative to meta-analysis. J Clin Epidemiol. 1995;48(1):9-18. http://dx.doi.org/10.1016/0895-4356(94)00097-A.
31. Sjogaard G, Rosendal L, Kristiansen J, Blangsted AK, Skotte J, Larsson B, et al. Muscle oxygenation and glycolysis in females with trapezius myalgia during stress and repetitive work using microdialysis and NIRS. Eur J Appl Physiol. 2010;108(4):657-69. http://dx.doi.org/10.1007/s00421-009-1268-2.
32. Andersson HI, Ejlertsson G, Leden I, Rosenberg C. Characteristics of subjects with chronic pain, in relation to local and widespread pain report. A prospective study of symptoms, clinical findings and blood tests in subgroups of a geographically defined population. Scand J Rheumatol. 1996;25(3):146-54. http://dx.doi.org/10.3109/03009749609080005.
33. Gumina S, Carbone S, Perugia D, Vestri AR, Postacchini F. Shoulder adhesive capsulitis in the early freezing phase: correlations between blood exams and Constant Score. Musculoskelet Surg. 2011;95 Suppl 1:S37-42. http://dx.doi.org/10.1007/s12306-011-0121-z.
34. Rechardt M, Shiri R, Karppinen J, Jula A, Heliovaara M, Viikari-Juntura E. Lifestyle and metabolic factors in relation to shoulder pain and rotator cuff tendinitis: a population-based study. BMC Musculoskelet Disord. 2010;11:165. http://dx.doi.org/10.1186/1471-2474-11-165.
35. Bunker TD, Esler CN. Frozen shoulder and lipids. J Bone Joint Surg Br. 1995;77(5):684-6.
36. Ohlsson K, Schutz A, Attewell R, Skerfving S. Selenium status in females with occupational cervico-brachial complaints. Int Arch Occup Environ Health. 1988;61(3):167-9. http://dx.doi.org/10.1007/BF00381014.
37. Kaergaard A, Hansen AM, Rasmussen K, Andersen JH. Association between plasma testosterone and work-related neck and shoulder disorders among female workers. Scand J Work Environ Health. 2000;26(4):292-8. http://dx.doi.org/10.5271/sjweh.545.
38. Akesson I, Schutz A, Horstmann V, Skerfving S, Moritz U. Musculoskeletal symptoms among dental personnel; - lack of association with mercury and selenium status, overweight and smoking. Swed Dent J. 2000;24(1-2):23-38.
39. Bovenzi M, D’Agostin F, Rui F, Ambrosi L, Zefferino R. Salivary endothelin and vascular disorders in vibration-exposed workers. Scand J Work Environ Health. 2008;34(2):133-41. http://dx.doi.org/10.5271/sjweh.1224.
40. Carp SJ, Barbe MF, Winter KA, Amin M, Barr AE. Inflammatory biomarkers increase with severity of upper-extremity overuse disorders. Clin Sci (London). 2007;112(5):305-14. http://dx.doi.org/10.1042/CS20060050.
41. Rechardt M, Shiri R, Lindholm H, Karppinen J, Viikari-Juntura E. Associations of metabolic factors and adipokines with pain in incipient upper-extremity soft tissue disorders: a cross-sectional study. BMJ Open. 2013;3(8):e003036. http://dx.doi.org/10.1136/bmjopen-2013-003036.
42. Rechardt M, Shiri R, Matikainen S, Viikari-Juntura E, Karppinen J, Alenius H. Soluble IL-1RII and Il-18 are associated with incipient upper-extremity soft tissue disorders. Cytokine. 2011;54:149-53. http://dx.doi.org/10.1016/j.cyto.2011.02.003.
43. Abboud JA, Kim JS. The effect of hypercholesterolemia on rotator cuff disease. Clin Orthop Relat Res. 2010;468(6):1493-7. http://dx.doi.org/10.1007/s11999-009-1151-9.
44. Lakemeier S, Braun J, Efe T, Foelsch C, Archontidou- Aprin E, Fuchs-Winkelmann S, et al. Expression of matrix metalloproteinases 1, 3, and 9 in differing extents of tendon retraction in the torn rotator cuff. Knee Surg Sports Traumatol Arthrosc. 2011;19(10):1760-5. http://dx.doi.org/10.1007/s00167-010-1367-y.
45. Lakemeier S, Reichelt JJ, Timmesfeld N, Fuchs-Winkelmann S, Paletta JR, Schofer MD. The relevance of long head biceps degeneration in the presence of rotator cuff tears. BMC Musculoskelet Disord. 2010;11:191. http://dx.doi.org/10.1186/1471-2474-11-191.
46. Longo UG, Franceschi F, Spiezia F, Forriol F, Maffulli N, Denaro V. Triglycerides and total serum cholesterol in rotator cuff tears: do they matter? Br J Sports Med. 2010;44(13):948-51. http://dx.doi.org/10.1136/bjsm.2008.056440.
47. Iqbal SA, Manning C, Syed F, Kolluru V, Hayton M, Watson S, et al. Identification of mesenchymal stem cells in perinodular fat and skin in Dupuytren’s disease: a potential source of myofibroblasts with implications for pathogenesis and therapy. Stem Cells Dev. 2012;21(4):609-22. http://dx.doi.org/10.1089/scd.2011.0140.
48. Hnanicek J, Cimburova M, Putova I, Svoboda S, Stritesky J, Kratka K, et al. Lack of association of iron metabolism and Dupuytren’s disease. J Eur Acad Dermatol Venereol. 2008;22(4):476-80. http://dx.doi.org/10.1111/j.1468-3083.2007.02506.x.
49. Ulrich D, Hrynyschyn K, Pallua N. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in sera and tissue of patients with Dupuytren’s disease. Plast Reconstr Surg. 2003;112(5):1279-86. http://dx.doi.org/10.1097/01.PRS.0000081462.40448.49.
50. Ulrich D, Ulrich F, Piatkowski A, Pallua N. Expression of matrix metalloproteinases and their inhibitors in cords and nodules of patients with Dupuytren’s disease. Arch Orthop Trauma Surg. 2009;129(11):1453-9. http://dx.doi.org/10.1007/s00402-008-0726-3.
51. Castagna A, Cesari E, Gigante A, Conti M, Garofalo R. Metalloproteases and their inhibitors are altered in both torn and intact rotator cuff tendons. Musculoskelet Surg. 2013;97 Suppl 1:39-47. http://dx.doi.org/10.1007/s12306-013-0264-1.
52. Papalia R, Del Buono A, Leonardi F, Osti L, Maffulli N, Denaro V. Creatinine and nonprotein nitrogen plasma levels: possible etiopathogenetic factors in rotator cuff tears. Phys Sportsmed. 2011;39(2):127-32. http://dx.doi.org/10.3810/psm.2011.05.1903.
53. Dale AM, Novak CB, Mackinnon SE. Utility of vibration thresholds in patients with brachial plexus nerve compression. Ann Plast Surg. 1999;42:613-8. http://dx.doi.org/10.1097/00000637-199906000-00005.
54. Xu Y, Bonar F, Murrell GA. Neoinnervation in rotator cuff tendinopathy. Sports Med Arthrosc. 2011;19(4):354-9. http://dx.doi.org/10.1097/JSA.0b013e318229d7e3.
55. Xu Y, Bonar F, Murrell GA. Enhanced expression of neuronal proteins in idiopathic frozen shoulder. J Shoulder Elbow Surg. 2012;21(10):1391-7. http://dx.doi.org/10.1016/j.jse.2011.08.046.
56. Lubis AM, Lubis VK. Matrix metalloproteinase, tissue inhibitor of metalloproteinase and transforming growth factorbeta 1 in frozen shoulder, and their changes as response to intensive stretching and supervised neglect exercise. J Orthop Sci. 2013;18(4):519-27. http://dx.doi.org/10.1007/s00776-013-0387-0.
57. Riva R, Mork PJ, Westgaard RH, Lundberg U. Comparison of the cortisol awakening response in women with shoulder and neck pain and women with fibromyalgia. Psychoneuroendocrinology. 2012;37(2):299-306. http://dx.doi.org/10.1016/j.psyneuen.2011.06.014.
58. Tsujii M, Hirata H, Yoshida T, Imanaka-Yoshida K, Morita A, Uchida A. Involvement of tenascin-C and PG-M/versican in flexor tenosynovial pathology of idiopathic carpal tunnel syndrome. Histol Histopathol. 2006;21(5):511-8.
59. Kennedy G, Khan F, McLaren M, Belch JJ. Endothelial activation and response in patients with hand arm vibration syndrome. Eur J Clin Invest. 1999;29(7):577-81. http://dx.doi.org/10.1046/j.1365-2362.1999.00502.x.
60. Nakamura H, Matsuzaki I, Hatta K, Nagase H, Nobokuni Y, Kambayashi Y, et al. Blood endothelin-1 and cold-induced vasodilation in patients with primary Raynaud’s phenomenon and workers with vibration-induced white finger. Int Angiol. 2003;22(3):243-9.
61. Flodgren GM, Crenshaw AG, Hellstrom F, Fahlstrom M. Combining microdialysis and near-infrared spectroscopy for studying effects of low-load repetitive work on the intramuscular chemistry in trapezius myalgia. J Biomed Biotechnol. 2010;2010:513803. http://dx.doi.org/10.1155/2010/513803.
62. Hadrevi J, Ghafouri B, Larsson B, Gerdle B, Hellstrom F. Multivariate modeling of proteins related to trapezius myalgia, a comparative study of female cleaners with or without pain. PLoS One. 2013;8(9):e73285. http://dx.doi.org/10.1371/journal.pone.0073285.
63. Lau CS, Bridges AB, Muir A, Scott N, Bancroft A, Belch JJ. Further evidence of increased polymorphonuclear cell activity in patients with Raynaud’s phenomenon. Br J Rheumatol. 1992;31(6):375-80. http://dx.doi.org/10.1093/rheumatology/31.6.375.
64. Ghafouri B, Larsson BK, Sjors A, Leandersson P, Gerdle BU. Interstitial concentration of serotonin is increased in myalgic human trapezius muscle during rest, repetitive work and mental stress - an in vivo microdialysis study. Scand J Clin Lab Invest. 2010;70(7):478-86. http://dx.doi.org/10.3109/00365513.2010.511257.
65. Sjors A, Larsson B, Karlson B, Osterberg K, Dahlman J, Gerdle B. Salivary cortisol response to acute stress and its relation to psychological factors in women with chronic trapezius myalgia- -a pilot study. Psychoneuroendocrinology. 2010;35(5):674-85. http://dx.doi.org/10.1016/j.psyneuen.2009.10.007.
66. Moreno-Torres A, Rosset-Llobet J, Pujol J, Fabregas S, Gonzalez-de-Suso JM. Work-related pain in extrinsic finger extensor musculature of instrumentalists is associated with intracellular pH compartmentation during exercise. PLoS One. 2010;5(2):e9091. http://dx.doi.org/10.1371/journal.pone.0009091.
67. Flodgren GM, Crenshaw AG, Alfredson H, Fahlstrom M, Hellstrom FB, Bronemo L, et al. Glutamate and prostaglandin E2 in the trapezius muscle of female subjects with chronic muscle pain and controls determined by microdialysis. Eur J Pain. 2005;9(5):511-5. http://dx.doi.org/10.1016/j.ejpain.2004.11.004.
68. Nilsen KB, Sand T, Westgaard RH, Stovner LJ, White LR, Bang Leistad R, et al. Autonomic activation and pain in response to low-grade mental stress in fibromyalgia and shoulder/neck pain patients. Eur J Pain. 2007;11(7):743-55. http://dx.doi.org/10.1016/j.ejpain.2006.11.004.
69. Teodorczyk-Injeyan JA, Triano JJ, McGregor M, Woodhouse L, Injeyan HS. Elevated production of inflammatory mediators including nociceptive chemokines in patients with neck pain: a cross-sectional evaluation. J Manipulative Physiol Ther. 2011;34(8):498-505. http://dx.doi.org/10.1016/j.jmpt.2011.08.010.
70. Freeland AE, Tucci MA, Barbieri RA, Angel MF, Nick TG. Biochemical evaluation of serum and flexor tenosynovium in carpal tunnel syndrome. Microsurgery. 2002;22(8):378-85. http://dx.doi.org/10.1002/micr.10065.
71. Larsson B, Rosendal L, Kristiansen J, Sjogaard G, Sogaard K, Ghafouri B, et al. Responses of algesic and metabolic substances to 8 h of repetitive manual work in myalgic human trapezius muscle. Pain. 2008;140(3):479-90. http://dx.doi.org/10.1016/j.pain.2008.10.001.
72. Rosendal L, Kristiansen J, Gerdle B, Sogaard K, Peolsson M, Kjaer M, et al. Increased levels of interstitial potassium but normal levels of muscle IL-6 and LDH in patients with trapezius myalgia. Pain. 2005;119(1-3):201-9. http://dx.doi.org/10.1016/j.pain.2005.09.026.
73. Augoff K, Ratajczak K, Gosk J, Tabola R, Rutowski R. Gelatinase A activity in Dupuytren’s disease. J Hand Surg Am. 2006;31(10):1635-9. http://dx.doi.org/10.1016/j.jhsa.2006.08.007.
74. Gerdle B, Hilgenfeldt U, Larsson B, Kristiansen J, Sogaard K, Rosendal L. Bradykinin and kallidin levels in the trapezius muscle in patients with work-related trapezius myalgia, in patients with whiplash associated pain, and in healthy controls - A microdialysis study of women. Pain. 2008;139(3):578-87. http://dx.doi.org/10.1016/j.pain.2008.06.012.
75. Rosendal L, Larsson B, Kristiansen J, Peolsson M, Sogaard K, Kjaer M, et al. Increase in muscle nociceptive substances and anaerobic metabolism in patients with trapezius myalgia: microdialysis in rest and during exercise. Pain. 2004;112(3):324-34. http://dx.doi.org/10.1016/j.pain.2004.09.017.
76. Ghafouri N, Ghafouri B, Larsson B, Stensson N, Fowler CJ, Gerdle B. Palmitoylethanolamide and stearoylethanolamide levels in the interstitium of the trapezius muscle of women with chronic widespread pain and chronic neckshoulder pain correlate with pain intensity and sensitivity. Pain. 2013;154(9):1649-58. http://dx.doi.org/10.1016/j.pain.2013.05.002.
77. Ozgocmen S, Ardicoglu O. Lipid profile in patients with fibromyalgia and myofascial pain syndromes. Yonsei Med J. 2000;41(5):541-5. http://dx.doi.org/10.3349/ymj.2000.41.5.541.
78. Bunker TD, Anthony PP. The pathology of frozen shoulder. A Dupuytren-like disease. J Bone Joint Surg Br. 1995;77(5):677-83.
79. Wynn TA. Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J Clin Invest. 2007;117(3):524-9. http://dx.doi.org/10.1172/JCI31487.
80. Abate M, Schiavone C, Salini V, Andia I. Occurrence of tendon pathologies in metabolic disorders. Rheumatology (Oxford). 2013;52(4):599-608. http://dx.doi.org/10.1093/rheumatology/kes395.
81. Beason DP, Abboud JA, Kuntz AF, Bassora R, Soslowsky LJ. Cumulative effects of hypercholesterolemia on tendon biomechanics in a mouse model. J Orthop Res. 2011;29(3):380-3. http://dx.doi.org/10.1002/jor.21255.
82. Hart DA, Frank CB, Bray RC. Inflammatory processes inrepetitive motion and overuse syndromes: potential role of neurogenic mechanisms in tendons and ligaments. In: Gordon SL, Blair SJ, Fine LJ, editors. Repetitive Motion Disorders of the Upper-extremity. Rosemont, IL: American Academy of Orthopaedic Surgeons; 1994. p. 247-62.
83. Vogel K. Fibrocartilage in tendon: a response to compressive load. In: Gordon SL, Blair SJ, Fine LJ, editors. Repetitive Motion Disorders of the Upper-extremity. Rosemont, IL: American Academy of Orthopaedic Surgeons; 1994.
84. Beamer B, Hettrich C, Lane J. Vascular endothelial growth factor: an essential component of angiogenesis and fracture healing. HSS J. 2010;6(1):85-94. http://dx.doi.org/10.1007/s11420-009-9129-4.
85. Hadjiargyrou M, Lombardo F, Zhao S, Ahrens W, Joo J, Ahn H, et al. Transcriptional profiling of bone regeneration. Insight into the molecular complexity of wound repair. J Biol Chem. 2002;277(33):30177-82. http://dx.doi.org/10.1074/jbc.M203171200.
86. Mulherin SA, Miller WC. Spectrum bias or spectrum effect? Subgroup variation in diagnostic test evaluation. Ann Intern Med. 2002;137(7):598-602. http://dx.doi.org/10.7326/0003-4819-137-7-200210010-00011.
87. Gao HG, Fisher PW, Lambi AG, Wade CK, Barr- Gillespie AE, Popoff SN, et al. Increased serum and musculotendinous fibrogenic proteins following persistent low-grade inflammation in a rat model of long-term upperextremity overuse. PLoS One. 2013;8(8):e71875. http://dx.doi.org/10.1371/journal.pone.0071875.
88. Fedorczyk JM, Barr AE, Rani S, Gao HG, Amin M, Amin S, et al. Exposure-dependent increases in IL-1beta, substance P, CTGF, and tendinosis in flexor digitorum tendons with upper-extremity repetitive strain injury. J Orthop Res. 2010;28(3):298-307.
89. Kietrys DM, Barr-Gillespie AE, Amin M, Wade CK, Popoff SN, Barbe MF. Aging contributes to inflammation in upperextremity tendons and declines in forelimb agility in a rat model of upper-extremity overuse. PLoS One. 2012;7(10):e46954. http://dx.doi.org/10.1371/journal.pone.0046954.
90. Barr AE, Barbe MF. Inflammation reduces physiological tissue tolerance in the development of work-related musculoskeletal disorders. J Electromyogr Kinesiol. 2004;14(1):77-85. http://dx.doi.org/10.1016/j.jelekin.2003.09.008.
91. Dinarello CA. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood. 2011;117(14):3720-32. http://dx.doi.org/10.1182/blood-2010-07-273417.
92. Liuzzo G, Biasucci LM, Gallimore JR, Grillo RL, Rebuzzi AG, Pepys MB, et al. The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina. N Engl J Med. 1994;331(7):417-24. http://dx.doi.org/10.1056/NEJM199408183310701.
93. Malik S, Wong ND, Franklin S, Pio J, Fairchild C, Chen R. Cardiovascular disease in U.S. patients with metabolic syndrome, diabetes, and elevated C-reactive protein. Diabetes Care. 2005;28(3):690-3. http://dx.doi.org/10.2337/diacare.28.3.690.
94. Beckman JA, Preis O, Ridker PM, Gerhard-Herman M. Comparison of usefulness of inflammatory markers in patients with versus without peripheral arterial disease in predicting adverse cardiovascular outcomes (myocardial infarction, stroke, and death). Am J Cardiol. 2005;96(10):1374-8. http://dx.doi.org/10.1016/j.amjcard.2005.07.041.
95. de Koning L, Liptak C, Shkreta A, Bradwin G, Hu FB, Pradhan AD, et al. A multiplex immunoassay gives different results than singleplex immunoassays which may bias epidemiologic associations. Clin Biochem. 2012;45(10-11):848-51. http://dx.doi.org/10.1016/j.clinbiochem.2012.04.006.
96. de Jager W, Bourcier K, Rijkers GT, Prakken BJ, Seyfert-Margolis V. Prerequisites for cytokine measurements in clinical trials with multiplex immunoassays. BMC Immunol. 2009;10:52. http://dx.doi.org/10.1186/1471-2172-10-52.
97. Astrom M, Rausing A. Chronic Achilles tendinopathy: A survey of surgical and histopathologic findings. Clin Orthop. 1995;316:151-64.
98. Andersson G, Danielson P, Alfredson H, Forsgren S. Presence of substance P and the neurokinin-1 receptor in tenocytes of the human Achilles tendon. Regul Pept. 2008;150(1-3):81-7. http://dx.doi.org/10.1016/j.regpep.2008.02.005.
99. Petersen W, Pufe T, Pfrommer S, Tillmann B. [Overload damage to the Achilles tendon: the importance of vascularization and angiogenesis]. Orthopade. 2005;34(6):533-42. http://dx.doi.org/10.1007/s00132-005-0808-7.
100. Saccenti E, Hoelfsloot HC, Smilde AK, Westerhuis JA, Hendriks MM. Reflections on univariate and multivariate analysis of metabolomics data. Metabolomics. 2014;10(3):361-74. http://dx.doi.org/10.1007/s11306-013-0598-6.
101. Brunnekreef JJ, Thijssen DH, Oosterhof J, Hopman MT. Bilateral changes in forearm oxygen consumption at rest and after exercise in patients with unilateral repetitive strain injury: a case-control study. J Orthop Sports Phys Ther. 2012;42(4):371-8. http://dx.doi.org/10.2519/jospt.2012.3751.
102. Piligian GJ, Gold JE. The repetitive strain injury process: alterations in physiology vis-a-vis symptoms. J Orthop Sports Phys Ther. 2012;42(7):660; author reply 1.
103. Novak CB, Mackinnon SE. Multiple nerve entrapment syndromes in office workers. Occup Med. 1999;14(1):39-59.
104. Riva R, Mork Paul Jarle J, Westgaard Rolf Harald H, Lundberg U. Comparison of the cortisol awakening response in women with shoulder and neck pain and women with fibromyalgia. Psychoneuroendocrinology. 2011;37(2):299-306. http://dx.doi.org/10.1016/j.psyneuen.2011.06.014.
105. Sjörs A, Larsson B, Karlson B, Osterberg K, Dahlman J, Gerdle B. Salivary cortisol response to acute stress and its relation to psychological factors in women with chronic trapezius myalgia- -a pilot study. Psychoneuroendocrinology. 2009;35(5):674-85. http://dx.doi.org/10.1016/j.psyneuen.2009.10.007.
106. Sjøgaard G, Zebis MK, Kiilerich K, Saltin B, Pilegaard H. Exercise training and work task induced metabolic and stress-related mrna and protein responses in myalgic muscles. BioMed Res Inter. 2013;2013:984523. http://dx.doi.org/10.1155/2013/984523.
107. Demirkol A, Uludag M, Soran N, Aksoy N, Gun K, Incebiyik S, et al. Total oxidative stress and antioxidant status in patients with carpal tunnel syndrome. Redox Report. 2012;17(6):234-8. http://dx.doi.org/10.1179/1351000212Y.0000000027.
108. Ghafouri N, Ghafouri B, Larsson B, Turkina Maria VV, Karlsson L, Fowler Christopher JJ, et al. High levels of N-palmitoylethanolamide and N-stearoylethanolamide in microdialysate samples from myalgic trapezius muscle in women. PloS One. 2011;6(11):e27257. http://dx.doi.org/10.1371/journal.pone.0027257.
109. Hallgren Hanna CBC, Eliasson P, Aspenberg P, Adolfsson Lars EE. Elevated plasma levels of TIMP-1 in patients with rotator cuff tear. Acta Orthop. 2012;83(5):523-8. http://dx.doi.org/10.3109/17453674.2012.736174.
110. Han SH, An HJ, Song JY, Shin DE, Kwon YD, Shim JS, et al. Effects of corticosteroid on the expressions of neuropeptide and cytokine mRNA and on tenocyte viability in lateral epicondylitis. J Inflam (United Kingdom). 2012 Oct 30;9(1):40. http://dx.doi.org/10.1186/1476-9255-9-40.
111. Hasselhorn HMM, Theorell T, Vingård E, Musculoskeletal Intervention Center N. Endocrine and immunologic parameters indicative of 6-month prognosis after the onset of low back pain or neck/shoulder pain. Spine. 2001;26(3):E24-9. http://dx.doi.org/10.1097/00007632-200102010-00005.
112. Hindocha S, Iqbal SAA, Farhatullah S, Paus R, Bayat A. Characterization of stem cells in Dupuytren’s disease. British J Surg. 2011;98(2):308-15. http://dx.doi.org/10.1002/bjs.7307.
113. Hirata H, Nagakura T, Tsujii M, Morita A, Fujisawa K, Uchida A. The relationship of VEGF and PGE2 expression to extracellular matrix remodelling of the tenosynovium in the carpal tunnel syndrome. J Path. 2004;204(5):605-12. http://dx.doi.org/10.1002/path.1673.
114. Hirata H, Tsujii M, Yoshida T, Yoshida KI, Morita A, Okuyama N, et al. MMP-2 expression is associated with rapidly proliferative arteriosclerosis in the flexor tenosynovium and pain severity in carpal tunnel syndrome. J Path. 2005;205:443-50. http://dx.doi.org/10.1002/path.1709.
115. Kim Yang-Soo S, Kim Jung-Man M, Lee Yun-Gyoung G, Hong Oak-Kee K, Kwon Hyuk-Sang S, Ji Jong-Hoon H. Intercellular adhesion molecule-1 (ICAM-1, CD54) is increased in adhesive capsulitis. J Bone Joint Surg (Amer). 2013;95(4):e181-8. http://dx.doi.org/10.2106/JBJS.K.00525.
116. Lau CSS, O’Dowd A, Belch JJJ. White blood cell activation in Raynaud’s phenomenon of systemic sclerosis and vibration induced white finger syndrome. Ann Rheum Dis. 1992;51(2):249-52. http://dx.doi.org/10.1136/ard.51.2.249.
117. Nakama K, Gotoh M, Yamada T, Mitsui Y, Yasukawa H, Imaizumi T, et al. Interleukin-6-induced activation of signal transducer and acitvator of transcription-3 in ruptured rotator cuff tendon. J Inter Med Res. 2006;34:624-31. http://dx.doi.org/10.1177/147323000603400607.
118. Nilsson PM, Kandell-Collén A, Andersson HI. Blood pressure and metabolic factors in relation to chronic pain. Blood Press. 1997;6:294-8. http://dx.doi.org/10.3109/08037059709062085.
119. Nowak J, Barregård L, Benthin G, Granung G, Wennmalm A. Thromboxane metabolite excretion in patients with handarm vibration syndrome. Clin Physiol (Oxford, England). 1996;16(4):361-7. http://dx.doi.org/10.1111/j.1475-097X.1996.tb00725.x.
120. Sanderson PLL, Morris MAA, Stanley JKK, Fahmy NRR. Lipids and Dupuytren’s disease. J Bone Joint Surg (British). 1992;74(6):923-7.
121. Tajana MS, Murena L, Valli F, Passi A, Grassi FA. Correlations between biochemical markers in the synovial fluid and severity of rotator cuff disease. Chir Organi Mov. 2009;93 Suppl 1:S41-8. http://dx.doi.org/10.1007/s12306-009-0004-8.
122. Zeisig E, Ljung BOO, Alfredson H, Danielson P. Immunohistochemical evidence of local production of catecholamines in cells of the muscle origins at the lateral and medial humeral epicondyles: of importance for the development of tennis and golfer’s elbow? Br J Sports Med. 2009;43(4):269-75. http://dx.doi.org/10.1136/bjsm.2008.054619.
123. Bergenudd H, Lindgärde F, Nilsson BEE. Prevalence of Dupuytren’s contracture and its correlation with degenerative changes of the hands and feet and with criteria of general health. J Hand Surg (Edinburgh, Scotland). 1993;18(2):254-7. http://dx.doi.org/10.1016/0266-7681(93)90123-W.
124. Hyvönen P, Melkko J, Lehto VPP, Jalovaara P. Involvement of the subacromial bursa in impingement syndrome of the shoulder as judged by expression of tenascin-C and histopathology. J Bone Joint Surg (British). 2003;85(2):299-305. http://dx.doi.org/10.1302/0301-620X.85B2.13124.
125. Keniston RCC, Nathan PAA, Leklem JEE, Lockwood RSS. Vitamin B6, vitamin C, and carpal tunnel syndrome. A cross-sectional study of 441 adults. J Occup Environ Med. 1997;39(10):949-59. http://dx.doi.org/10.1097/00043764-199710000-00007.
126. Laskar Shawkatuzzaman MM, Iwamoto M, Nakamoto M, Koshiyama H, Harada N. Heart rate variation and urinary catecholamine excretion in response to acute psychological stress in hand-arm vibration syndrome patients. J Occup Health. 2004;46(2):125-31. http://dx.doi.org/10.1539/joh.46.125.
127. Okumus M, Ceceli E, Tuncay F, Kocaoglu S, Palulu N, Yorgancioglu ZR. The relationship between serum trace elements, vitamin B12, folic acid and clinical parameters in patients with myofascial pain syndrome. J Back Musc Rehab. 2010;23:187-91.
128. Olausson P, Gerdle B, Ghafouri N, Larsson B, Ghafouri B. Identification of Proteins from Interstitium of Trapezius Muscle in Women with Chronic Myalgia Using Microdialysis in Combination with Proteomics. PloS One. 2012;7. http://dx.doi.org/10.1371/journal.pone.0052560.
129. Ratajczak-Wielgomas K, Gosk J, Rabczyński J, Augoff K, Podhorska-Okołów M, Gamian A, et al. Expression of MMP- 2, TIMP-2, TGF-β1, and decorin in Dupuytren’s contracture. Conn Tissue Res. 2012;53:469-77. http://dx.doi.org/10.3109/03008207.2012.686542.
130. Toesca A, Pagnotta A, Zumbo A, Sadun R. Estrogen andprogesterone receptors in carpal tunnel syndrome. Cell Biol Inter. 2008;32:75-9. http://dx.doi.org/10.1016/j.cellbi.2007.08.014.
131. Kang Jong-Won W, Kim H, Cho Soo-Hun H, Lee Myung- Koo K, Kim Yong-Dae D, Nan Hong-Mei M, et al. The association of subjective stress, urinary catecholamine concentrations and PC game room use and musculoskeletal disorders of the upper limbs in young male Koreans. J Korean Med Sci. 2003;18(3):419-24. http://dx.doi.org/10.3346/jkms.2003.18.3.419.
132. Kent PJJ, Williams GAA, Kester RCC. Platelet activation during hand vibration. Brit J Surg. 1994;81(6):815-8. http://dx.doi.org/10.1002/bjs.1800810608.
133. Meek RMM, McLellan S, Crossan JFF. Dupuytren’s disease. A model for the mechanism of fibrosis and its modulation by steroids. J Bone Joint Surg (Brit). 1999;81(4):732-8. http://dx.doi.org/10.1302/0301-620X.81B4.9163.
134. Riondino S, La Farina F, Martini F, Guadagni F, Ferroni P. Functional impairment in video terminal operators is related to low-grade inflammation. Int Arch Occup Environ Health. 2010;84(7):745-51. http://dx.doi.org/10.1007/s00420-010-0605-4.
135. Chambler A, Rawlinson S, Emery R, Pitsillides A. Quantitative cytochemical evidence for local increases in bone turnover at the acromial enthesis of the human coracoacromial ligament. J Rheum. 2004;31(11):2216-25.
136. Greenstein D, Kester RCC. The role of leukocytes in the pathogenesis of vibration-induced white finger. Angiol. 1998;49(11):915-22. http://dx.doi.org/10.1177/000331979804901107.
137. Ljung Björn-Ove O, Alfredson H, Forsgren S. Neurokinin 1-receptors and sensory neuropeptides in tendon insertions at the medial and lateral epicondyles of the humerus. Studies on tennis elbow and medial epicondylalgia. J Orthop Res. 2004;22(2):321-7. http://dx.doi.org/10.1016/S0736-0266(03)00183-9.
138. Osawa T, Shinozaki T, Takagishi K. Multivariate analysis of biochemical markers in synovial fluid from the shoulder joint for diagnosis of rotator cuff tears. Rheumatol Inter. 2005;25(6):436-41. http://dx.doi.org/10.1007/s00296-004-0509-2.
139. Tucci MAA, Barbieri RAA, Freeland AEE. Biochemical and histological analysis of the flexor tenosynovium in patients with carpal tunnel syndrome. Biomed Sci Instru. 1997;33:246-51.
140. Gudmundsson KGG, Arngrímsson R, Arinbjarnarson S, Olafsson A, Jonsson T. T-and B-lymphocyte subsets in patients with Dupuytren’s disease. Correlations with disease severity. J Hand Surg (Edinburgh, Scotland). 1998;23(6):724-7. http://dx.doi.org/10.1016/S0266-7681(98)80083-1.
141. Harada N, Kondo H, Kimura K. Assessment of autonomic nervous function in patients with vibration syndrome using heart rate variation and plasma cyclic nucleotides. Brit J Indus Med. 1990;47(4):263-8. http://dx.doi.org/10.1136/oem.47.4.263.
142. Ljung BOO, Forsgren S, Fridén J. Substance P and calcitonin gene-related peptide expression at the extensor carpi radialis brevis muscle origin: implications for the etiology of tennis elbow. J Orthop Res. 1999;17(4):554-9. http://dx.doi.org/10.1002/jor.1100170414.
143. Yoshihara Y, Hamada K, Nakajima T, Fujikawa K, Fukuda H. Biochemical markers in the synovial fluid of glenohumeral joints from patients with rotator cuff tear. J Orthop Res. 2001;19(4):573-9. http://dx.doi.org/10.1016/S0736-0266(00)00063-2.
144. Donato G, Galasso O, Valentino P, Conforti F, Zuccalà V, Russo E, et al. Pathological findings in subsynovial connective tissue in idiopathic carpal tunnel syndrome. Clin Neuropath. 2009;28(2):129-35. http://dx.doi.org/10.5414/NPP28129.
145. Kohout J, Topolcan O, Bejcková H. The serum level of endothelin in patients with hand-arm vibration syndrome. Cent Eur J Public Health. 1995;3 Suppl:43-4.
146. Santavirta S, Konttinen YTT, Antti-Poika I, Nordström D. Inflammation of the subacromial bursa in chronic shoulder pain. Arch Orthop Trauma Surg. 1992;111(6):336-40. http://dx.doi.org/10.1007/BF00420062.