Pathological findings in subsynovial connective tissue in idiopathic carpal tunnel syndrome

Clinical Neuropathology

Volumn 28, Issue 2, 2009, Pages 129-135

  Donato, G ^a,c   Galasso, O ^a   Valentino, P ^a   Conforti, F ^a   Zuccala V ^a   Russo, E ^a   Maltese, L ^a   Perrotta, I ^b   Tripepi, S ^b   Amorosi, A ^a  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b UNIVERSITY OF CALABRIA   (Italy)

^c Policlinico Mater Domini   (Italy)

Author keywords

Carpal tunnel syndrome; Fibrosis; Neo angiogenesis; Subsynovial connective tissue; Vascular endothelial growth factor

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BETA CATENIN; CD31 ANTIGEN; CD34 ANTIGEN; COLLAGEN; VASCULOTROPIN; VON WILLEBRAND FACTOR;

ADULT; ANGIOGENESIS; ARTICLE; CARPAL TUNNEL SYNDROME; CELL PROLIFERATION; CELL ULTRASTRUCTURE; CLINICAL ARTICLE; CONNECTIVE TISSUE CELL; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; FIBROSIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NEOVASCULARIZATION (PATHOLOGY); NEUROPATHOLOGY; PATHOGENESIS; PERIPHERAL NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; CONNECTIVE TISSUE; METABOLISM; MIDDLE AGED; PATHOLOGY; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE; VASCULAR ENDOTHELIUM; VASCULARIZATION;

ANTIGENS, CD34; CARPAL TUNNEL SYNDROME; COLLAGEN; CONNECTIVE TISSUE; ENDOTHELIUM, VASCULAR; FEMALE; FIBROSIS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MEDIAN NEUROPATHY; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC;

EID: 65349185104     PISSN: 07225091     EISSN: None     Source Type: Journal    
DOI: 10.5414/npp28129     Document Type: Article

References (32)

1. Akerman M. Benign fibrous lesions masquerading as sarcomas. Clinical and morphological pitfalls. Acta Orthop Scand Suppl. 1997; 273: 37-40.
2. Bazzoni G, Dejana E. Endothelial cell-to-cell junctions: Molecular organization and role in homeostasis. Physiol Rev. 2004; 84: 869-901.
3. Bergers G, Song S. The role of pericytes in blood-vessel formation and maintenance. Neuro Oncol. 2005; 7: 452-464.
4. Bilbao JM, Schmidt R, Hawkins C. Diseases of peripheral nerve. In: Love S, Louis DN, Ellison DW (eds.) Greenfield's Neuropathology. London: Arnold; 2008. pp. 1813-1814.
5. Bland JD. Carpal tunnel syndrome. Curr Opin Neurol. 2005; 18: 581-585.
6. Brown DM, Regillo CD. Anti-VEGF agents in the treatment of neovascular age-related macular degeneration: applying clinical trial results to the treatment of everyday patients. Am J Ophthalmol. 2007; 144: 627-637.
7. Ema M, Yokomizo T, Wakamatsu A, Terunuma T, Yamamoto M, Takahashi S. Primitive erythropoiesis from mesodermal precursors expressing VE-cadherin, PECAM-1, Tie2, endoglin, and CD34 in the mouse embryo. Blood. 2006; 108: 4018-4024.
8. Ettema AM, Amadio PC, Zhao C, Wold LE, An KN. A histological and immunohistochemical study of the subsynovial connective tissue in idiopathic carpal tunnel syndrome. J Bone Joint Surg Am. 2004; 86-A(7): 1458-1466.
9. Ettema AM, Amadio PC, Zhao C,Wold LE, O'ByrneMM, Moran SL, An KN. Changes in the functional structure of the tenosynovium in idiopathic carpal tunnel syndrome: a scanning electron microscope study. Plast Reconstr Surg. 2006; 118: 1413-1422.
10. Freeland AE, Tucci MA, Barbieri RA, Angel MF, Nick TG. Biochemical evaluation of serum and flexor tenosynovium in carpal tunnel syndrome. Microsurgery. 2002; 22: 378-385.
11. Gerwins P, Skoldenberg E, Claesson-Welsh L. Function of fibroblast growth factors and vascular endothelial growth factors and their receptors in angiogenesis. Crit Rev Oncol Hematol. 2000; 34: 185-194.
12. Hirata H, Nagakura T, Tsujii M. Expression to extracellular matrix remodeling of the tenosynovium in the carpal tunnel syndrome. J Pathol. 2006; 204: 605-612.
13. Humphrey CD, Pittman FE. A simple methylene blue-azure II-basic fuchsin stain for epoxy-embedded tissue sections. Stain Technol. 1974; 49: 9-14.
14. Johnson PC. Peripheral nerve. In: Davis RL, Robertson DM (eds.) Textbook of Neuropathology. Baltimore: Williams and Wilkins; 1997. p. 1236.
15. Kajstura J, Zhang X, Reiss K, Szoke E, Li P, Lagrasta C, Cheng W, Darzynkiewicz Z, Olivetti G, Anversa P. Myocyte cellular hyperplasia and myocyte cellular hypertrophy contribute to chronic ventricular remodeling in coronary artery narrowing-induced cardiomyopathy in rats. Circ Res. 1994; 74: 383-400.
16. Kalka C, Takahashi T, Masuda, Asahara T, Isner JM. Vascular endothelial factor (VEGF): therapeutic angiogenesis and vasculogenesis in the treatment of cardiovascular disease. Med Klin. 1999; 94: 193-201.
17. Keedy VL, Sandler AB. Inhibition of angiogenesis in the treatment of non-small cell lung cancer. Cancer Sci. 2007; 98: 1825-1830.
18. Kirsch-Volders M, Tallon I, Tanzarella C, Sgura A, Hermine T, Parry EM, Parry GM. Mitotic non-disjunction as a mechanism for in vitro aneuploidy induction by X-rays in primary human cells. Mutagenesis. 1996; 11: 307-313.
19. Liptak P, Kemeny E, Morvay Z, Szederkenyi E, Szenohradszky P, Marofka F, Toldi J, Exner M, Ivanyi B. Peritubular capillary damage in acute humoral rejection: an ultrastructural study on human renal allografts. Am J Transplant. 2005; 5: 2870-2876.
20. Mackinnon SE. Pathophysiology of nerve compression. Hand Clin. 2002; 18: 231-241.
21. Oberpriller JO, Oberpriller JC, Aafedt BC. Changes in binucleation and cellular dimensions of rat left atrial myocytes after induced left ventricular infarction. Am J Anat. 1987; 179: 285-290.
22. Oh J, Zhao C, Zobitz ME, Wold LE, An KN, Amadio PC. Morphological changes of collagen fibrils in the subsynovial connective tissue in carpal tunnel syndrome. J Bone Joint SurgAm. 2006; 88-A(4): 824-830.
23. Ozerdem U, Stallcup WB. Early contribution of pericytes to angiogenic sprouting and tube formation. Angiogenesis. 2003; 6: 241-249.
24. Peichev M, Naiyer AJ, Pereira D, Zhu Z, Lane WJ, Williams M, Oz MC, Hicklin DJ, Witte L, Moore MAS, Rafii S. Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors. Blood; 2000; 95: 952-958.
25. Pulitzer DR, Martin PC, Reed RJ. Fibroma of tendon sheath. A clinicopathologic study of 32 cases. Am J Surg Pathol; 1989; 13: 472-479.
26. Rehman J, Li J, Orschell CM, March KL. Peripheral blood "endothelial progenitor cells" are derived from monocyte/ macrophages and secrete angiogenic growth factors. Circulation. 2003; 107: 1164-1169.
27. Rengachary SS, Wilkins RH. Principles of Neurosurgery. London: Mosby-Wolf; 1994. pp. 23.4-23.5.
28. Ribero Caetano M. Axonal degeneration in association with carpal tunnel syndrome. Arq Neuropsiquiatr. 2003; 61: 48-50.
29. Richardson EP, De Girolami U. Pathology of the peripheral nerve. Philadelphia: Saunders; 1995. p. 5.
30. Tashiro K, Shimokama T, Haraoka S, Tokunaga O, Watanabe T. Endothelial cell heterogeneity in experimentally- induced rabbit atherosclerosis. Demonstration of multinucleated giant endothelial cells by scanning electron microscopy and cell culture. Virchows Arch. 1994; 425: 521-529.
31. VolpentestaG, Lavano A, DonatoG, Chirchiglia D, Aloisi M, Veltri C, Piragine G, Signorelli CD. Correlazioni cliniche, neurofisiologiche, istopatologiche e chirurgiche su 200 casi di syndrome del tunnel carpale trattati chirurgicamente sia con tecnica open sia con tecnica mininvasiva. 540 Congresso Società Italiana di Neurochirurgia. Milano; 2004. Abstracts; p. 256.
32. Weis J, Alexianu ME, Heide G, Schroder JM. Renaut bodies contain elastic fiber components. J Neuropathol Exp Neurol. 1993; 5: 444-451.