Immunohistochemical evidence of local production of catecholamines in cells of the muscle origins at the lateral and medial humeral epicondyles: Of importance for the development of tennis and golfer's elbow?

British Journal of Sports Medicine

Volumn 43, Issue 4, 2009, Pages 269-275

  Zeisig, E ^a   Ljung, B O ^b   Alfredson, H ^a   Danielson, P ^a,c  

^a UMEÅ UNIVERSITY   (Sweden)

^b SAHLGRENSKA ACADEMY AT UNIVERSITY OF GOTHENBURG   (Sweden)

^c UMEÅ UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; CATECHOLAMINE; CHOLINE ACETYLTRANSFERASE; COLLAGEN FIBER; PROTEIN ANTIBODY; TYROSINE 3 MONOOXYGENASE;

ADULT; ARTICLE; BIOSYNTHESIS; CATECHOLAMINE SYNTHESIS; CLINICAL ARTICLE; CONNECTIVE TISSUE; CONTROLLED STUDY; ELBOW; ENZYME ANALYSIS; FEMALE; FIBROBLAST; FLEXOR MUSCLE; HUMAN; HUMAN CELL; HUMAN TISSUE; HUMERUS; IMMUNOHISTOCHEMISTRY; MALE; MUSCLE BIOPSY; MUSCLE CELL; NERVE CELL; PATHOGENESIS; SPINDLE CELL; SYMPATHETIC INNERVATION; TENNIS ELBOW;

ACETYLCHOLINE; ADULT; BIOPSY; CASE-CONTROL STUDIES; CATECHOLAMINES; FEMALE; FIBROBLASTS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; TENNIS ELBOW; TYROSINE 3-MONOOXYGENASE; YOUNG ADULT;

EID: 65349175831     PISSN: 03063674     EISSN: 14730480     Source Type: Journal    
DOI: 10.1136/bjsm.2008.054619     Document Type: Article

References (49)

1. Piligian G, Herbert R, Hearns, M, et al. Evaluation and management of chronic work- related musculoskeletal disorders of the distal upper extremity. Am J Ind Med 2000;37:75-93.
2. De Smedt T, de Jong A, Van Leemput W, et al. Lateral epicondylitis in tennis: update on aetiology, biomechanics and treatment. Br J Sports Med 2007;41:816-19.
3. Ljung BO, Alfredson H, Forsgren S. Neurokinin 1-receptors and sensory neuropeptides in tendon insertions at the medial and lateral epicondyles of the humerus. Studies on tennis elbow and medial epicondylalgia. J Orthop Res 2004;22:321-7.
4. Ljung BO, Forsgren S, Friden J. Substance P and calcitonin gene-related peptide expression at the extensor carpi radialis brevis muscle origin: implications for the etiology of tennis elbow. J Orthop Res 1999;17:554-9.
5. Ljung BO, Forsgren S, Friden J. Sympathetic and sensory innervations are heterogeneously distributed in relation to the blood vessels at the extensor carpi radialis brevis muscle origin of man. Cells Tissues Organs 1999;165:45-54.
6. Zeisig E, Ohberg L, Alfredson H. Extensor origin vascularity related to pain in patients with Tennis elbow. Knee Surg Sports Traumatol Arthrosc 2006;14:659-63.
7. Cook JL, Malliaras P, De Luca J, et al. Vascularity and pain in the patellar tendon of adult jumping athletes: a 5 month longitudinal study. Br J Sports Med 2005;39:458-61.
8. Alfredson H, Ohberg L. Neovascularisation in chronic painful patellar tendinosis-promising results after sclerosing neovessels outside the tendon challenge the need for surgery. Knee Surg Sports Traumatol Arthrosc 2005;13:74-80.
9. Hoksrud A, Ohberg L, Alfredson H, et al. Ultrasound-guided sclerosis of neovessels in painful chronic patellar tendinopathy: a randomized controlled trial. Am J Sports Med 2006;34:1738-46.
10. Zeisig E, Fahlstrom M, Ohberg L, et al. Pain relief after intratendinous injections in patients with tennis elbow: results of a randomised study. Br J Sports Med 2008;42:267-71.
11. Zeisig E, Ohberg L, Alfredson H. Sclerosing polidocanol injections in chronic painful tennis elbow-promising results in a pilot study. Knee Surg Sports Traumatol Arthrosc 2006;14:1218-24.
12. Wessler I, Kilbinger H, Bittinger F, et al. The biological role of non-neuronal acetylcholine in plants and humans. Jpn J Pharmacol 2001;85:2-10.
13. Oben JA, Diehl AM. Sympathetic nervous system regulation of liver repair. Anat Rec A Discov Mol Cell Evol Biol 2004;280:874-83.
14. Danielson P, Alfredson H, Forsgren S. Immunohistochemical and histochemical findings favoring the occurrence of autocrine/paracrine as well as nerve-related cholinergic effects in chronic painful patellar tendon tendinosis. Microsc Res Tech 2006;69:808-19.
15. Danielson P, Alfredson H, Forsgren S. In situ hybridization studies confirming recent findings of the existence of a local nonneuronal catecholamine production in human patellar tendinosis. Microsc Res Tech 2007;70:908-11.
16. Danielson P, Alfredson H, Forsgren S. Studies on the importance of sympathetic innervation, adrenergic receptors, and a possible local catecholamine production in the development of patellar tendinopathy (tendinosis) in man. Microsc Res Tech 2007;70:310-24.
17. Danielson P, Andersson G, Alfredson H, et al. Extensive expression of markers for acetylcholine synthesis and of M2 receptors in tenocytes in therapy-resistant chronic painful patellar tendon tendinosis - a pilot study. Life Sci 2007;80:2235-8.
18. Bjur D, Danielson P, Alfredson H, et al. Immunohistochemical and in situ hybridization observations favor a local catecholamine production in the human Achilles tendon. Histol Histopathol 2008;23:197-208.
19. Bjur D, Danielson P, Alfredson H, et al. Presence of a non-neuronal cholinergic system and occurrence of up- and down-regulation in expression of M2 muscarinic acetylcholine receptors: new aspects of importance regarding Achilles tendon tendinosis (tendinopathy). Cell Tissue Res 2008;331:385-400.
20. Anesini C, Borda E. Modulatory effect of the adrenergic system upon fibroblast proliferation: participation of beta 3-adrenoceptors. Auton Autacoid Pharmacol 2002;22:177-86.
21. Oben JA, Yang S, Lin H, et al. Acetylcholine promotes the proliferation and collagen gene expression of myofibroblastic hepatic stellate cells. Biochem Biophys Res Commun 2003;300:172-7.
22. Oben JA, Yang S, Lin H, et al. Norepinephrine and neuropeptide Y promote proliferation and collagen gene expression of hepatic myofibroblastic stellate cells. Biochem Biophys Res Commun 2003;302:685-90.
23. Sekhon HS, Keller JA, Proskocil BJ, et al. Maternal nicotine exposure upregulates collagen gene expression in fetal monkey lung. Association with alpha7 nicotinic acetylcholine receptors. Am J Respir Cell Mol Biol 2002;26:31-11.
24. Baron R. Peripheral neuropathic pain: from mechanisms to symptoms. Clin J Pain 2000;16:S12-20.
25. Vogelsang M, Heyer G, Hornstein OP. Acetylcholine induces different cutaneous sensations in atopic and non-atopic subjects. Acta Derm Venereol 1995;75:434-6.
26. Burniston JG, Tan LB, Goldspink DF. beta2-Adrenergic receptor stimulation in vivo induces apoptosis in the rat heart and soleus muscle. J Appl Physiol 2005;98:1379-86.
27. Yun J, Gaivin RJ, McCune DF, et al. Gene expression profile of neurodegeneration induced by alpha1B-adrenergic receptor overactivity: NMDA/GABAA dysregulation and apoptosis. Brain 2003;126:2667-81.
28. Khan KM, Cook JL, Bonar F, et al. Histopathology of common tendinopathies. Update and implications for clinical management. Sports Med 1999;27:393-408.
29. Peers KH, Lysens RJ. Patellar tendinopathy in athletes: current diagnostic and therapeutic recommendations. Sports Med 2005;35:71-87.
30. Riley GP. Gene expression and matrix turnover in overused and damaged tendons. Scand J Med Sci Sports 2005;15:241-51.
31. Yuan J, Wang MX, Murrell GA. Cell death and tendinopathy. Clin Sports Med 2003;22:693-701.
32. Hansson M, Forsgren S. Immunoreactive atrial and brain natriuretic peptides are co- localized in Purkinje fibres but not in the innervation of the bovine heart conduction system. Histochem J 1995;27:222-30.
33. Jonsson M, Norrgard O, Forsgren S. Presence of a marked nonneuronal cholinergic system in human colon: study of normal colon and colon in ulcerative colitis. Inflamm Bowel Dis 2007;13:1347-56.
34. Andersson G, Danielson P, Alfredson H, et al. Presence of substance P and the neurokinin-1 receptor in tenocytes of the human Achilles tendon. Regul Pept 2008;150:81-7
35. Newcomer SC, Leuenberger UA, Hogeman CS, et al. Different vasodilator responses of human arms and legs. J Physiol 2004;556:1001-11.
36. Danielson P, Alfredson H, Forsgren S. Distribution of general (PGP 9.5) and sensory (substance P/CGRP) innervations in the human patellar tendon. Knee Surg Sports Traumatol Arthrosc 2006;14:125-32.
37. Potter HG, Hannafin JA, Morwessel RM, et al. Lateral epicondylitis: correlation of MR imaging, surgical, and histopathologic findings. Radiology 1995;196:43-6.
38. Nagatsu T, Levitt M, Udenfriend S. Tyrosine hydroxylase. The initial step in norepinephrine biosynthesis. J Biol Chem 1964;239:2910-17.
39. Oben JA, Roskams T, Yang S, et al. Hepatic fibrogenesis requires sympathetic neurotransmitters. Gut 2004;53:438-45.
40. Rieske P, Krynska B, Azizi SA. Human fibroblast-derived cell lines have characteristics of embryonic stem cells and cells of neuro-ectodermal origin. Differentiation 2005;73:474-83.
41. Messmer K, Remington MP, Skidmore F, et al. Induction of tyrosine hydroxylase expression by the transcription factor Pitx3. Int J Dev Neurosci 2007;25:29-37.
42. Lebel M, Gauthier Y, Moreau A, et al. Pitx3 activates mouse tyrosine hydroxylase promoter via a high-affinity binding site. J Neurochem 2001;77:558-67.
43. Kim HS, Park JS, Hong SJ, et al. Regulation of the tyrosine hydroxylase gene promoter by histone deacetylase inhibitors. Biochem Biophys Res Commun 2003;312:950-7.
44. Salingcarnboriboon R, Yoshitake H, Tsuji K, et al. Establishment of tendon-derived cell lines exhibiting pluripotent mesenchymal stem cell-like property. Exp Cell Res 2003;287:289-300.
45. Zhang H, Faber JE. Trophic effect of norepinephrine on arterial intima-media and adventitia is augmented by injury and mediated by different alpha1-adrenoceptor subtypes. Circ Res 2001;89:815-22.
46. Zeisig E, Fahlstrom M, Ohberg L, et al. A 2-year sonographic follow-up after intratendinous injection therapy in patients with tennis elbow. Br J Sports Med. Published Online First: 29 July 2008. doi:10.1136/bjsm.2008.049874
47. Smith RW, Papadopolous E, Mani R, et al. Abnormal microvascular responses in a lateral epicondylitis. Br J Rheumatol 1994;33:1166-8.
48. Baron R, Levine JD, Fields HL. Causalgia and reflex sympathetic dystrophy: does the sympathetic nervous system contribute to the generation of pain? Muscle Nerve 1999;22:678-95.
49. Teasell RW, Arnold JM. Alpha-1 adrenoceptor hyperresponsiveness in three neuropathic pain states: complex regional pain syndrome 1, diabetic peripheral neuropathic pain and central pain states following spinal cord injury. Pain Res Manag 2004;9:89-97.