Codonopsis lanceolata: A Review of Its Therapeutic Potentials

Phytotherapy Research

Volumn 30, Issue 3, 2016, Pages 347-356

  Hossen, Muhammad Jahangir ^a,b   Kim, Mi Yeon ^c   Kim, Jong Hoon ^d   Cho, Jae Youl ^a  

^a Sungkyunkwan University   (South Korea)

^b PATUAKHALI SCIENCE AND TECHNOLOGY UNIVERSITY   (Bangladesh)

^c Soongsil University   (South Korea)

^d Chonbuk National University   (South Korea)

Author keywords

anticancer activity; Codonopsis lanceolata; molecular mechanisms; phytochemical constituent; therapeutic efficacy

Indexed keywords

ALKALOID; ALPHA SPINASTEROL; BETA CARBOLINE; BUTANOL; CODONOLASIDE; CODONOLASIDE I; CODONOLASIDE II; CODONOLASIDE III; CODONOPSIS LANCEOLATA EXTRACT; ECHINOCYSTIC ACID; FRIEDELIN; LANCEMASIDE A; LANCEMASIDE B; ORGANIC COMPOUND; PHENYLPROPANOID; PLANT EXTRACT; POLYPHENOL; SAPONIN; SCOPOLAMINE; STEROID; SYRINGIN; TANGSHENOSIDE I; TANGSHENOSIDE II; TANGSHENOSIDE III; TANGSHENOSIDE IV; TANGSHENOSIDE VIII; TANNIN DERIVATIVE; TRITERPENE; TRYPTOPHAN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ASIA; BRONCHITIS; CODONOPSIS; CODONOPSIS LANCEOLATA; COLITIS; COUGHING; DERMATITIS; DRUG MECHANISM; EDEMA; HEPATITIS; HERB; HUMAN; HYPERLIPIDEMIA; LUNG INJURY; MUSCLE SPASM; NEOPLASM; NEUROSIS; NONHUMAN; OBESITY; PERENNIAL PLANT; PLANT ROOT; REVIEW; TRADITIONAL MEDICINE; CHEMISTRY; PHYTOTHERAPY;

ALKALOIDS; CODONOPSIS; HUMANS; MEDICINE, TRADITIONAL; PHYTOTHERAPY; PLANT EXTRACTS; POLYPHENOLS; SAPONINS; TRITERPENES;

EID: 84959483918     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5553     Document Type: Review

References (48)

1. Byeon SE, Lee YG, Cho JY,. 2009a. Regulatory effects of Codonopsis lanceolata on gene expression of GM-CSF in macrophage-like cells. J Ethnopharmacol 123: 185-189.
2. Byeon SE, Choi WS, Hong EK, et al., 2009b. Inhibitory effect of saponin fraction from Codonopsis lanceolata on immune cell-mediated inflammatory responses. Arch Pharm Res 32: 813-822.
3. Cha A, Choi Y, Jin Y, et al., 2012. Antilipogenic and anti-inflammatory activities of Codonopsis lanceolata in mice hepatic tissues after chronic ethanol feeding. J Biomed Biotechnol 2012 141395.
4. Chang Y, Kim S, Han B,. 1986. Chemical studies on the alkaloidal constituents of Codonopsis lanceolata. Yakhak Hoeji 30: 1-7.
5. Cho K, Kim SJ, Park SH, Kim S, Park T,. 2009. Protective effect of Codonopsis lanceolata root extract against alcoholic fatty liver in the rat. J Med Food 12: 1293-1301.
6. Choi H-K, Won E-K, Jang YP, Choung S-Y,. 2013. Antiobesity effect of Codonopsis lanceolata in high-calorie/high-fat-diet-induced obese rats. Evid Based Complement Alternat Med 2013 210297.
7. Cragg GM,. 1998. Paclitaxel (Taxol): a success story with valuable lessons for natural product drug discovery and development. Med Res Rev 18: 315-331.
8. Ferrero-Miliani L, Nielsen OH, Andersen PS, Girardin SE,. 2007. Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation. Clin Exp Immunol 147: 227-235.
9. Grivennikov SI, Greten FR, Karin M,. 2010. Immunity, inflammation, and cancer. Cell 140: 883-899.
10. Guo WL, Gong L, Ding ZF, et al., 2006. Genomic instability in phenotypically normal regenerants of medicinal plant Codonopsis lanceolata Benth. et Hook. f., as revealed by ISSR and RAPD markers. Plant Cell Rep 25: 896-906.
11. Han C, Wang D, Yu X, Li L, Piao Y,. 2005. Preventive effect of Codonopsis lanceolata on lipid metabolic disorder in rats and its mechanism. J Jilin Univ (Med Edi) 31: 564-566.
12. Hur GY, Choi GS, Park HJ, Ye YM, Park HS,. 2008. Anaphylactic shock induced by Codonopsis lanceolata, traditional Chinese medicine in a patient with allergic rhinitis. Allergy 63: 1406-1407.
13. Hyam SR, Jang SE, Jeong JJ, Joh EH, Han MJ, Kim DH,. 2013. Echinocystic acid, a metabolite of lancemaside A, inhibits TNBS-induced colitis in mice. Int Immunopharmacol 15: 433-441.
14. Ichikawa M, Ohta S, Komoto N, et al., 2009. Simultaneous determination of seven saponins in the roots of Codonopsis lanceolata by liquid chromatography-mass spectrometry. J Nat Med 63: 52-57.
15. Joh EH, Kim DH,. 2010. Lancemaside A inhibits lipopolysaccharide-induced inflammation by targeting LPS/TLR4 complex. J Cell Biochem 111: 865-871.
16. Joh EH, Lee IA, Han SJ, Chae S, Kim DH,. 2010. Lancemaside A ameliorates colitis by inhibiting NF-kappaB activation in TNBS-induced colitis mice. Int J Colorectal Dis 25: 545-551.
17. Joh EH, Gu W, Kim DH,. 2012. Echinocystic acid ameliorates lung inflammation in mice and alveolar macrophages by inhibiting the binding of LPS to TLR4 in NF-kappaB and MAPK pathways. Biochem Pharmacol 84: 331-340.
18. Joh EH, Jeong JJ, Kim DH,. 2014. Inhibitory effect of echinocystic acid on 12-O-tetradecanoylphorbol-13-acetate-induced dermatitis in mice. Arch Pharm Res 37: 225-231.
19. Jung IH, Jang SE, Joh EH, Chung J, Han MJ, Kim DH,. 2012. Lancemaside A isolated from Codonopsis lanceolata and its metabolite echinocystic acid ameliorate scopolamine-induced memory and learning deficits in mice. Phytomedicine 20: 84-88.
20. Kim MH, Lee J, Yoo DS, et al., 2009. Protective effect of stress-induced liver damage by saponin fraction from Codonopsis lanceolata. Arch Pharm Res 32: 1441-1446.
21. Kim E, Yang WS, Kim JH, et al., 2014. Lancemaside A from Codonopsis lanceolata modulates the inflammatory responses mediated by monocytes and macrophages. Mediators Inflamm 2014: 405158.
22. Lee KT, Choi J, Jung WT, Nam JH, Jung HJ, Park HJ,. 2002. Structure of a new echinocystic acid bisdesmoside isolated from Codonopsis lanceolata roots and the cytotoxic activity of prosapogenins. J Agric Food Chem 50: 4190-4193.
23. Lee KW, Jung HJ, Park HJ, Kim DG, Lee JY, Lee KT,. 2005. Beta-D-xylopyranosyl-(1 - > 3)-beta-D-glucuronopyranosyl echinocystic acid isolated from the roots of Codonopsis lanceolata induces caspase-dependent apoptosis in human acute promyelocytic leukemia HL-60 cells. Biol Pharm Bull 28: 854-859.
24. Lee YG, Kim JY, Lee JY, et al., 2007. Regulatory effects of Codonopsis lanceolata on macrophage-mediated immune responses. J Ethnopharmacol 112: 180-188.
25. Lee JS, Kim KJ, Kim YH, et al., 2014. Codonopsis lanceolata extract prevents diet-induced obesity in C57BL/6 mice. Nutrients 6: 4663-4677.
26. Li JP, Liang ZM, Yuan Z,. 2007. Triterpenoid saponins and anti-inflammatory activity of Codonopsis lanceolata. Pharmazie 62: 463-466.
27. Liang Z, Chun-ji H, Lian-ji L,. 2007. Protective effect of Codonopsis lanceolata extract on alcoholic hepatic injury. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu 11: 5742.
28. Mann J,. 2002. Natural products in cancer chemotherapy: past, present and future. Nat Rev Cancer 2: 143-148.
29. Peifen J, Yonghong Y, Zhongjie Z, Wenqing J,. 1992. Aanlysis of the nutritive constituents in the aerial parts of Codonopsis pilosula. Nat Prod Res Dev 3: 005.
30. Pulla RK, Kim YJ, Kim MK, Senthil KS, In JG, Yang DC,. 2008. Isolation of a novel dehydrin gene from Codonopsis lanceolata and analysis of its response to abiotic stresses. BMB Rep 41: 338-343.
31. Purev M, Kim MK, Samdan N, Yang D-C,. 2008. Isolation of a novel fructose-1, 6-bisphosphate aldolase gene from Codonopsis lanceolata and analysis of the response of this gene to abiotic stresses. Mol Biol 42: 179-186.
32. Ren J, Lin Z, Yuan Z,. 2013. Tangshenosides from Codonopsis lanceolata roots. Phytochem Lett 6: 567-569.
33. Reuters T,. 2010. Progress of Clinical and Experimental Nephrology (CEN): CEN is increasing its presence in Web of Science. Nihon Jinzo Gakkai Shi 52: 40-44.
34. Shin JA, Kim JS, Hong IS, Cho SD,. 2012. Bak is a key molecule in apoptosis induced by methanol extracts of Codonopsis lanceolata and Tricholoma matsutake in HSC-2 human oral cancer cells. Oncol Lett 4: 1379-1383.
35. Ushijima M, Komoto N, Sugizono Y, et al., 2008a. Triterpene glycosides from the roots of Codonopsis lanceolata. Chem Pharm Bull 56: 308-314.
36. Ushijima M, Komoto N, Sugizono Y, et al., 2008b. Triterpene glycosides from the roots of Codonopsis lanceolata. Chem Pharm Bull (Tokyo) 56: 308-314.
37. Wang Z-T, Ma G-Y, Tu P-F, Xu G-J, Ng T-B,. 1995. Chemotaxonomic study of Codonopsis (family Campanulaceae) and its related genera. Biochem Syst Ecol 23: 809-812.
38. Wang L, Xu ML, Hu JH, Rasmussen SK, Wang MH,. 2011a. Codonopsis lanceolata extract induces G0/G1 arrest and apoptosis in human colon tumor HT-29 cells-involvement of ROS generation and polyamine depletion. Food Chem Toxicol 49: 149-154.
39. Wang W, Zhao S, Liu D,. 2011b. Study on the chemical constituents of Codonopsis lanceolata. Zhong Yao Cai 34: 553-555.
40. Weon JB, Yun BR, Lee J, et al., 2013. Effect of Codonopsis lanceolata with steamed and fermented process on scopolamine-induced memory impairment in mice. Biomol Ther (Seoul) 21: 405-410.
41. Weon JB, Yun BR, Lee J, et al., 2014. Cognitive-enhancing effect of steamed and fermented Codonopsis lanceolata: a behavioral and biochemical study. Evid Based Complement Alternat Med 2014 319436:.
42. Xu LP, Wang H, Yuan Z,. 2008a. Triterpenoid saponins with anti-inflammatory activity from Codonopsis lanceolata. Planta Med 74: 1412-1415.
43. Xu Q, Chen X, Liu B, et al., 2008b. Studies on invigorating energy, activating blood flow, resolving blood stasis and anti-aging actions of alcohol extracts of Codonopsis lanceolata. Guangxi Med J 30: 1834-1837.
44. Yoo H, Baek S, Park Y, et al., 2002. Quality control of dried roots of Codonopsis lanceolata. Korean J Pharmacogn 33: 85-87.
45. Yu X, Li L, C-j H, Q-g Z,. 2011. Effects of Codonopsis lanceolata total sanponin on apoptosis in HepG-2 cells. J Jilin Univ (Medicine Edition) 6: 041.
46. Yuan Z, Liang Z-M,. 2006. A new triterpenoid saponin from Codonopsis lanceolata. Chin Chem Lett 17: 1460-1462.
47. Zhang L, Ma Y, Yuan Z,. 2009. A new triterpenoid saponin from the roots of Codonopsis lanceolata. Asian J Tradit Med 4: 210-213.
48. Zhao B, Ren J, Yuan Z,. 2013. Isolation of a new cerebroside from Codonopsis lanceolata. Biochem Syst Ecol 46: 26-28.