BCL3 Reduces the Sterile Inflammatory Response in Pancreatic and Biliary Tissues

Gastroenterology

Volumn 150, Issue 2, 2016, Pages 499-512.e20

  Song, Liang ^a   Wörmann, Sonja ^a   Ai, Jiaoyu ^a   Neuhöfer, Patrick ^a   Lesina, Marina ^a   Diakopoulos, Kalliope N ^a   Ruess, Dietrich ^a   Treiber, Matthias ^a   Witt, Heiko ^b   Bassermann, Florian ^a   Halangk, Walter ^c   Steiner, Jörg M ^a   Esposito, Irene ^d   Rosendahl, Jonas ^e   Schmid, Roland M ^a   Riemann, Marc ^f   Algül, Hana ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c OTTO VON GUERICKE UNIVERSITY   (Germany)

^d HEINRICH HEINE UNIVERSITY   (Germany)

^e UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^f FRITZ LIPMANN INSTITUTE   (Germany)

Author keywords

Cytokines; Immune Regulation; Mouse Model; TLR

Indexed keywords

I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL 3; PROTEIN P50; TOLL LIKE RECEPTOR; CERULETIDE; MULTIDRUG RESISTANCE PROTEIN; NF-KAPPAB INHIBITOR ALPHA; NFKB1 PROTEIN, MOUSE; ONCOPROTEIN; P-GLYCOPROTEIN 2; PROTEASOME; PROTO-ONCOGENE PROTEIN BCL-3; RELA PROTEIN, HUMAN; RELA PROTEIN, MOUSE; TAUROCHOLIC ACID; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RELA;

ACUTE PANCREATITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CELL SELECTION; COMPARATIVE STUDY; CONTROLLED STUDY; DENDRITIC CELL; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; ENZYME ACTIVITY; FEMALE; GRANULOCYTE; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIMARY SCLEROSING CHOLANGITIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SUPPRESSOR CELL; UBIQUITINATION; UPREGULATION; ACUTE DISEASE; ANIMAL; BILE DUCT; BONE MARROW TRANSPLANTATION; C57BL MOUSE; CHEMICALLY INDUCED; CHOLANGITIS, SCLEROSING; DEFICIENCY; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; PANCREAS; PANCREATITIS; PATHOLOGY; PHOSPHORYLATION; PROTEIN DEGRADATION; PROTEIN MULTIMERIZATION; TIME FACTOR;

ACUTE DISEASE; ANIMALS; BILE DUCTS; BONE MARROW TRANSPLANTATION; CERULETIDE; CHOLANGITIS, SCLEROSING; HUMANS; I-KAPPA B PROTEINS; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-KAPPA B P50 SUBUNIT; P-GLYCOPROTEINS; PANCREAS; PANCREATITIS; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN MULTIMERIZATION; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; TAUROCHOLIC ACID; TIME FACTORS; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTORS; UBIQUITINATION;

EID: 84959482463     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2015.10.017     Document Type: Article

References (34)

1. C.-J. Chen, H. Kono, D. Golenbock, and et al. Identification of a key pathway required for the sterile inflammatory response triggered by dying cells Nat Med 13 2007 851 856
2. K.L. Rock, E. Latz, F. Ontiveros, and et al. The sterile inflammatory response Annu Rev Immunol 28 2010 321 342
3. H. Kono, and L.R. Kenneth How dying cells alert the immune system to danger Nat Rev Immunol 8 2008 279 289
4. A.M. Piccinini, and K.S. Midwood DAMPening inflammation by modulating TLR signalling Mediators Inflamm 2010 2010 672395
5. B. Hoesel, and J.A. Schmid The complexity of NF-κB signaling in inflammation and cancer Mol Cancer 12 2013 86
6. F.G. Wulczyn, M. Naumann, and C. Scheidereit Candidate proto-oncogene BCL3 encodes a subunit-specific inhibitor of transcription factor NF-kappa B Nature 358 1992 597 599
7. V. Bours, G. Franzoso, V. Azarenko, and et al. The oncoprotein BCL3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers Cell 72 1993 729 739
8. R.J. Carmody, Q. Ruan, S. Palmer, and et al. Negative regulation of toll-like receptor signaling by NF-κB p50 ubiquitination blockade Science 317 2007 675 678
9. H. Kuwata, Y. Watanabe, H. Miyoshi, and et al. IL10-inducible BCL3 negatively regulates LPS-induced TNF-α production in macrophages Blood 102 2003 4123 4129
10. P. Neuhöfer, S. Liang, H. Einwächter, and et al. Deletion of IκBα activates RelA to reduce acute pancreatitis in mice through up-regulation of Spi2A Gastroenterology 144 2013 192 201
11. M. Scheibel, B. Klein, H. Merkle, and et al. IκBβ is an essential co-activator for LPS-induced IL1β transcription in vivo J Exp Med 207 2010 2621 2630
12. J.M. Laukkarinen, G.J.D. Van Acker, E.R. Weiss, and et al. A mouse model of acute biliary pancreatitis induced by retrograde pancreatic duct infusion of Na-taurocholate Gut 56 2007 1590 1598
13. H. Zhang, P. Neuhöfer, L. Song, and et al. IL6 trans-signaling promotes pancreatitis-associated lung injury and lethality J Clin Invest 123 2013 1019 1031
14. K. Fransen, M.C. Visschedijk, S. van Sommeren, and et al. Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease Hum Mol Genet 19 2010 3482 3488
15. D. Kreisel, S. Sugimoto, J. Tietjens, and et al. BCL3 prevents acute inflammatory lung injury in mice by restraining emergency granulopoiesis J Clin Invest 121 2011 265 276
16. F. Pène, A. Paun, S.U. Sønder, and et al. The IκB family member BCL3 coordinates the pulmonary defense against Klebsiella pneumoniae infection J Immunol 186 2011 2412 2421
17. I. Tassi, N. Rikhi, E. Claudio, and et al. The NF-κB regulator BCL3 modulates inflammation during contact hypersensitivity reactions in radioresistant cells Eur J Immunol 45 2015 1059 1068
18. C. O'Carroll, G. Moloney, G. Hurley, and et al. BCL3 deficiency protects against dextran-sodium sulphate-induced colitis in the mouse Clin Exp Immunol 173 2013 332 342
19. J. Wessells, M. Baer, H.A. Young, and et al. BCL3 and NF-kappaB p50 attenuate lipopolysaccharide-induced inflammatory responses in macrophages J Biol Chem 279 2004 49995 50003
20. J. Bohuslav, V.V. Kravchenko, G.C.N. Parry, and et al. Regulation of an essential innate immune response by the p50 subunit of NF-κB J Clin Invest 102 1998 1645 1652
21. B. Baumann, M. Wagner, T. Aleksic, and et al. Constitutive IKK2 activation in acinar cells is sufficient to induce pancreatitis in vivo J Clin Invest 117 2007 1502 1513
22. H. Huang, Y. Liu, J. Daniluk, and et al. Activation of nuclear factor-κB in acinar cells increases the severity of pancreatitis in mice Gastroenterology 144 2013 202 210
23. H. Algül, M. Treiber, M. Lesina, and et al. Pancreas-specific RelA / p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis J Clin Invest 117 2007 1490 1501
24. N. Li, X. Wu, R.G. Holzer, and et al. Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice J Clin Invest 123 2013 2231 2243
25. L. Deng, C. Wang, E. Spencer, and et al. Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain Cell 103 2000 351 361
26. T. Maniatis A ubiquitin ligase complex essential for the NF-kB, Wnt/Wingless, and Hedgehog signaling pathways Genes Dev 13 1999 505 510
27. D. Altavilla, C. Famulari, M. Passaniti, and et al. Attenuated cerulein-induced pancreatitis in nuclear factor-κB-deficient mice Lab Invest 83 2003 1723 1732
28. M. Riemann, R. Endres, S. Liptay, and et al. The IkB protein BCL3 negatively regulates transcription of the IL10 gene in macrophages J Immunol 175 2005 3560 3568
29. P. Neuhöfer, S. Liang, H. Einwächter, and et al. Deletion of IκBa activates RelA to reduce acute pancreatitis in mice through up-regulation of Spi2A Gastroenterology 144 2013 192 201
30. H. Algül, M. Treiber, M. Lesina, and et al. Pancreas-specific RelA / p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis J. Clin. Invest 117 2007 1490 1501
31. F. Geisler, H. Algül, M. Riemann, and et al. Questioning current concepts in acute pancreatitis: endotoxin contamination of porcine pancreatic elastase is responsible for experimental pancreatitis-associated distant organ failure J. Immunol 174 2005 6431 6439
32. M. Lesina, M.U. Kurkowski, K. Ludes, and et al. Stat3/Socs3 activation by IL6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer Cancer Cell 19 2011 456 469
33. G. Perides, J.M. Laukkarinen, G. Vassileva, and et al. Biliary acute pancreatitis in mice is mediated by the G-protein-coupled cell surface bile acid receptor Gpbar1 Gastroenterology 138 2010 715 725
34. H. Nawaz, R. Mounzer, D. Yadav, and et al. Revised Atlanta and determinant-based classification: application in a prospective cohort of acute pancreatitis patients Am J Gastroenterol 108 2013 1911 1917