Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Shimshek, Derya R ^a   Jacobson, Laura H ^a,c   Kolly, Carine ^a   Zamurovic, Natasa ^a   Balavenkatraman, Kamal Kumar ^a   Morawiec, Laurent ^a   Kreutzer, Robert ^a   Schelle, Juliane ^b   Jucker, Mathias ^b   Bertschi, Barbara ^a   Theil, Diethilde ^a   Heier, Annabelle ^a   Bigot, Karine ^a   Beltz, Karen ^a   Machauer, Rainer ^a   Brzak, Irena ^a   Perrot, Ludovic ^a   Neumann, Ulf ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; ASPARTIC PROTEINASE; BACE1 PROTEIN, MOUSE; BACE2 PROTEIN, MOUSE; MELANIN; MELANOCYTE PROTEIN PMEL 17; MESSENGER RNA; NB-360; PEPTIDE FRAGMENT; PICOLINIC ACID DERIVATIVE; PROTEINASE INHIBITOR; SECRETASE; SI PROTEIN, MOUSE; THIAZINE DERIVATIVE;

ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CYTOLOGY; DRUG EFFECTS; FEMALE; FLUORESCENCE MICROSCOPY; FOREBRAIN; GENETICS; HAIR; HUMAN; KNOCKOUT MOUSE; MALE; MELANOCYTE; METABOLISM; MOUSE; PATHOLOGY; PIGMENTATION; REAL TIME POLYMERASE CHAIN REACTION; TUMOR CELL LINE; UVEA; WESTERN BLOTTING;

AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; BLOTTING, WESTERN; CELL LINE, TUMOR; FEMALE; GP100 MELANOMA ANTIGEN; HAIR; HUMANS; MALE; MELANINS; MELANOCYTES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, FLUORESCENCE; PEPTIDE FRAGMENTS; PICOLINIC ACIDS; PIGMENTATION; PROSENCEPHALON; PROTEASE INHIBITORS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; THIAZINES; UVEA;

EID: 84959450049     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep21917     Document Type: Article

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