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Volumn 6, Issue , 2016, Pages

A common mechanism involving the TORC1 pathway can lead to amphotericin B-persistence in biofilm and planktonic Saccharomyces cerevisiae populations

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ANTIFUNGAL AGENT; ERGOSTEROL; PHOSPHATIDYLINOSITOL 3 KINASE; RAPAMYCIN; RAS PROTEIN; RAS1 PROTEIN, S CEREVISIAE; RAS2 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; TOR1 PROTEIN, S CEREVISIAE; TORC1 PROTEIN COMPLEX, S CEREVISIAE; TRANSCRIPTION FACTOR;

EID: 84959420732     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep21874     Document Type: Article
Times cited : (28)

References (51)
  • 1
    • 24144451315 scopus 로고    scopus 로고
    • Changing patterns and trends in systemic fungal infections
    • Richardson, M. D. Changing patterns and trends in systemic fungal infections. J Antimicrob Chemother 56 Suppl 1, i5-i11 (2005).
    • (2005) J Antimicrob Chemother 56 Suppl , vol.1 , pp. i5-i11
    • Richardson, M.D.1
  • 2
    • 33749986341 scopus 로고    scopus 로고
    • Candida biofilms on implanted biomaterials: A clinically significant problem
    • Ramage, G., Martinez, J. P., Lopez-Ribot, J. L. Candida biofilms on implanted biomaterials: a clinically significant problem. FEMS Yeast Res 6, 979-86 (2006).
    • (2006) FEMS Yeast Res , vol.6 , pp. 979-986
    • Ramage, G.1    Martinez, J.P.2    Lopez-Ribot, J.L.3
  • 3
    • 0036840519 scopus 로고    scopus 로고
    • In vitro activity of caspofungin against Candida albicans biofilms
    • Bachmann, S. P. et al. In vitro activity of caspofungin against Candida albicans biofilms. Antimicrob Agents Chemother 46, 3591-6 (2002).
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 3591-3596
    • Bachmann, S.P.1
  • 4
    • 0036096359 scopus 로고    scopus 로고
    • Antifungal susceptibility of Candida biofilms: Unique efficacy of amphotericin B lipid formulations and echinocandins
    • Kuhn, D. M., George, T., Chandra, J., Mukherjee, P. K., Ghannoum, M. A. Antifungal susceptibility of Candida biofilms: unique efficacy of amphotericin B lipid formulations and echinocandins. Antimicrob Agents Chemother 46, 1773-80 (2002).
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 1773-1780
    • Kuhn, D.M.1    George, T.2    Chandra, J.3    Mukherjee, P.K.4    Ghannoum, M.A.5
  • 5
    • 84875503043 scopus 로고    scopus 로고
    • It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug
    • Mesa-Arango, A. C., Scorzoni, L., Zaragoza, O. It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug. Front Microbiol 3, 286 (2012).
    • (2012) Front Microbiol , vol.3 , pp. 286
    • Mesa-Arango, A.C.1    Scorzoni, L.2    Zaragoza, O.3
  • 6
    • 84907123977 scopus 로고
    • The lipid composition and permeability to azole of an azole-and polyene-resistant mutant of Candida albicans
    • Hitchcock, C. A., Barrett-Bee, K. J., Russell, N. J. The lipid composition and permeability to azole of an azole-and polyene-resistant mutant of Candida albicans. J Med Vet Mycol 25, 29-37 (1987).
    • (1987) J Med Vet Mycol , vol.25 , pp. 29-37
    • Hitchcock, C.A.1    Barrett-Bee, K.J.2    Russell, N.J.3
  • 7
    • 33846579562 scopus 로고    scopus 로고
    • Putative role of beta-1,3 glucans in Candida albicans biofilm resistance
    • Nett, J. et al. Putative role of beta-1,3 glucans in Candida albicans biofilm resistance. Antimicrob Agents Chemother 51, 510-20 (2007).
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 510-520
    • Nett, J.1
  • 8
    • 77955355113 scopus 로고    scopus 로고
    • Role of Fks1p and matrix glucan in Candida albicans biofilm resistance to an echinocandin, pyrimidine, and polyene
    • Nett, J. E., Crawford, K., Marchillo, K., Andes, D. R. Role of Fks1p and matrix glucan in Candida albicans biofilm resistance to an echinocandin, pyrimidine, and polyene. Antimicrob Agents Chemother 54, 3505-8 (2010).
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 3505-3508
    • Nett, J.E.1    Crawford, K.2    Marchillo, K.3    Andes, D.R.4
  • 9
    • 83655192068 scopus 로고    scopus 로고
    • Addition of DNase improves the in vitro activity of antifungal drugs against Candida albicans biofilms
    • Martins, M., Henriques, M., Lopez-Ribot, J. L., Oliveira, R. Addition of DNase improves the in vitro activity of antifungal drugs against Candida albicans biofilms. Mycoses 55, 80-5 (2012).
    • (2012) Mycoses , vol.55 , pp. 80-85
    • Martins, M.1    Henriques, M.2    Lopez-Ribot, J.L.3    Oliveira, R.4
  • 10
    • 0041764578 scopus 로고    scopus 로고
    • Mechanism of fluconazole resistance in Candida albicans biofilms: Phase-specific role of efflux pumps and membrane sterols
    • Mukherjee, P. K., Chandra, J., Kuhn, D. M., Ghannoum, M. A. Mechanism of fluconazole resistance in Candida albicans biofilms: phase-specific role of efflux pumps and membrane sterols. Infect Immun 71, 4333-40 (2003).
    • (2003) Infect Immun , vol.71 , pp. 4333-4340
    • Mukherjee, P.K.1    Chandra, J.2    Kuhn, D.M.3    Ghannoum, M.A.4
  • 11
    • 33750590848 scopus 로고    scopus 로고
    • A small subpopulation of blastospores in candida albicans biofilms exhibit resistance to amphotericin B associated with differential regulation of ergosterol and beta-1,6-glucan pathway genes
    • Khot, P. D., Suci, P. A., Miller, R. L., Nelson, R. D., Tyler, B. J. A small subpopulation of blastospores in candida albicans biofilms exhibit resistance to amphotericin B associated with differential regulation of ergosterol and beta-1,6-glucan pathway genes. Antimicrob Agents Chemother 50, 3708-16 (2006).
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 3708-3716
    • Khot, P.D.1    Suci, P.A.2    Miller, R.L.3    Nelson, R.D.4    Tyler, B.J.5
  • 12
    • 33750596264 scopus 로고    scopus 로고
    • Candida albicans biofilms produce antifungal-tolerant persister cells
    • LaFleur, M. D., Kumamoto, C. A., Lewis, K. Candida albicans biofilms produce antifungal-tolerant persister cells. Antimicrob Agents Chemother 50, 3839-46 (2006).
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 3839-3846
    • LaFleur, M.D.1    Kumamoto, C.A.2    Lewis, K.3
  • 13
    • 77955628762 scopus 로고    scopus 로고
    • Persister cells
    • Lewis, K. Persister cells. Annu Rev Microbiol 64, 357-72 (2010).
    • (2010) Annu Rev Microbiol , vol.64 , pp. 357-372
    • Lewis, K.1
  • 14
    • 76049117463 scopus 로고    scopus 로고
    • Apoptosis in Candida biofilms exposed to amphotericin B
    • Al-Dhaheri, R. S., Douglas, L. J. Apoptosis in Candida biofilms exposed to amphotericin B. J Med Microbiol 59, 149-57 (2010).
    • (2010) J Med Microbiol , vol.59 , pp. 149-157
    • Al-Dhaheri, R.S.1    Douglas, L.J.2
  • 15
    • 80051804445 scopus 로고    scopus 로고
    • Superoxide dismutases are involved in Candida albicans biofilm persistence against miconazole
    • Bink, A. et al. Superoxide dismutases are involved in Candida albicans biofilm persistence against miconazole. Antimicrob Agents Chemother 55, 4033-7 (2011).
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 4033-4037
    • Bink, A.1
  • 17
    • 84924147113 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae biofilm tolerance towards systemic antifungals depends on growth phase
    • Bojsen, R., Regenberg, B., Folkesson, A. Saccharomyces cerevisiae biofilm tolerance towards systemic antifungals depends on growth phase. BMC Microbiol 14, 305 (2014).
    • (2014) BMC Microbiol , vol.14 , pp. 305
    • Bojsen, R.1    Regenberg, B.2    Folkesson, A.3
  • 18
    • 0035173818 scopus 로고    scopus 로고
    • Biofilms and planktonic cells of Pseudomonas aeruginosa have similar resistance to killing by antimicrobials
    • Spoering, A. L., Lewis, K. Biofilms and planktonic cells of Pseudomonas aeruginosa have similar resistance to killing by antimicrobials. J Bacteriol 183, 6746-51 (2001).
    • (2001) J Bacteriol , vol.183 , pp. 6746-6751
    • Spoering, A.L.1    Lewis, K.2
  • 19
    • 0037378920 scopus 로고    scopus 로고
    • Role of nutrient limitation and stationary-phase existence in Klebsiella pneumoniae biofilm resistance to ampicillin and ciprofloxacin
    • Anderl, J. N., Zahller, J., Roe, F., Stewart, P. S. Role of nutrient limitation and stationary-phase existence in Klebsiella pneumoniae biofilm resistance to ampicillin and ciprofloxacin. Antimicrob Agents Chemother 47, 1251-6 (2003).
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 1251-1256
    • Anderl, J.N.1    Zahller, J.2    Roe, F.3    Stewart, P.S.4
  • 20
    • 0035793383 scopus 로고    scopus 로고
    • Bakers' yeast, a model for fungal biofilm formation
    • Reynolds, T. B., Fink, G. R. Bakers' yeast, a model for fungal biofilm formation. Science 291, 878-81 (2001).
    • (2001) Science , vol.291 , pp. 878-881
    • Reynolds, T.B.1    Fink, G.R.2
  • 21
    • 84866124383 scopus 로고    scopus 로고
    • Global gene deletion analysis exploring yeast filamentous growth
    • Ryan, O. et al. Global gene deletion analysis exploring yeast filamentous growth. Science 337, 1353-6 (2012).
    • (2012) Science , vol.337 , pp. 1353-1356
    • Ryan, O.1
  • 22
    • 84887606590 scopus 로고    scopus 로고
    • Genomewide screening for genes involved in biofilm formation and miconazole susceptibility in Saccharomyces cerevisiae
    • Vandenbosch, D. et al. Genomewide screening for genes involved in biofilm formation and miconazole susceptibility in Saccharomyces cerevisiae. FEMS Yeast Res 13, 720-30 (2013).
    • (2013) FEMS Yeast Res , vol.13 , pp. 720-730
    • Vandenbosch, D.1
  • 23
    • 0037173615 scopus 로고    scopus 로고
    • Functional profiling of the Saccharomyces cerevisiae genome
    • Giaever, G. et al. Functional profiling of the Saccharomyces cerevisiae genome. Nature 418, 387-91 (2002).
    • (2002) Nature , vol.418 , pp. 387-391
    • Giaever, G.1
  • 24
    • 84907914671 scopus 로고    scopus 로고
    • Genetic basis for saccharomyces cerevisiae biofilm in liquid medium
    • Andersen, K. S. et al. Genetic Basis for Saccharomyces cerevisiae Biofilm in Liquid Medium. G3 (Bethesda) 4, 1671-1680 (2014).
    • (2014) G3 (Bethesda) , vol.4 , pp. 1671-1680
    • Andersen, K.S.1
  • 25
    • 70349634435 scopus 로고    scopus 로고
    • Quantitative phenotyping via deep barcode sequencing
    • Smith, A. M. et al. Quantitative phenotyping via deep barcode sequencing. Genome Res 19, 1836-42 (2009).
    • (2009) Genome Res , vol.19 , pp. 1836-1842
    • Smith, A.M.1
  • 27
    • 75249087100 scopus 로고    scopus 로고
    • EdgeR: A Bioconductor package for differential expression analysis of digital gene expression data
    • Robinson, M. D., McCarthy, D. J., Smyth, G. K. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 26, 139-40 (2010).
    • (2010) Bioinformatics , vol.26 , pp. 139-140
    • Robinson, M.D.1    McCarthy, D.J.2    Smyth, G.K.3
  • 28
    • 84858588614 scopus 로고    scopus 로고
    • Saccharomyces Genome Database: The genomics resource of budding yeast
    • Cherry, J. M. et al. Saccharomyces Genome Database: the genomics resource of budding yeast. Nucleic Acids Res 40, D700-5 (2012).
    • (2012) Nucleic Acids Res , vol.40 , pp. D700-D705
    • Cherry, J.M.1
  • 29
    • 77956101405 scopus 로고    scopus 로고
    • A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B
    • Martel, C. M. et al. A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. Antimicrob Agents Chemother 54, 3578-83 (2010).
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 3578-3583
    • Martel, C.M.1
  • 30
    • 0033501047 scopus 로고    scopus 로고
    • The elm1 kinase functions in a mitotic signaling network in budding yeast
    • Sreenivasan, A., Kellogg, D. The elm1 kinase functions in a mitotic signaling network in budding yeast. Mol Cell Biol 19, 7983-94 (1999).
    • (1999) Mol Cell Biol , vol.19 , pp. 7983-7994
    • Sreenivasan, A.1    Kellogg, D.2
  • 31
    • 83455177213 scopus 로고    scopus 로고
    • Target of rapamycin (TOR) in nutrient signaling and growth control
    • Loewith, R., Hall, M. N. Target of rapamycin (TOR) in nutrient signaling and growth control. Genetics 189, 1177-201 (2011).
    • (2011) Genetics , vol.189 , pp. 1177-1201
    • Loewith, R.1    Hall, M.N.2
  • 32
    • 21244448694 scopus 로고    scopus 로고
    • The TOR and EGO protein complexes orchestrate microautophagy in yeast
    • Dubouloz, F., Deloche, O., Wanke, V., Cameroni, E., De Virgilio, C. The TOR and EGO protein complexes orchestrate microautophagy in yeast. Mol Cell 19, 15-26 (2005).
    • (2005) Mol Cell , vol.19 , pp. 15-26
    • Dubouloz, F.1    Deloche, O.2    Wanke, V.3    Cameroni, E.4    De Virgilio, C.5
  • 33
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger, S., Loewith, R., Hall, M. N. TOR signaling in growth and metabolism. Cell 124, 471-84 (2006).
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 34
    • 0030021524 scopus 로고    scopus 로고
    • TOR controls translation initiation and early G1 progression in yeast
    • Barbet, N. C. et al. TOR controls translation initiation and early G1 progression in yeast. Mol Biol Cell 7, 25-42 (1996).
    • (1996) Mol Biol Cell , vol.7 , pp. 25-42
    • Barbet, N.C.1
  • 35
    • 11144273952 scopus 로고    scopus 로고
    • TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1
    • Martin, D. E., Soulard, A., Hall, M. N. TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1. Cell 119, 969-79 (2004).
    • (2004) Cell , vol.119 , pp. 969-979
    • Martin, D.E.1    Soulard, A.2    Hall, M.N.3
  • 36
    • 73849102829 scopus 로고    scopus 로고
    • Patients with long-term oral carriage harbor high-persister mutants of Candida albicans
    • Lafleur, M. D., Qi, Q., Lewis, K. Patients with long-term oral carriage harbor high-persister mutants of Candida albicans. Antimicrob Agents Chemother 54, 39-44 (2010).
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 39-44
    • Lafleur, M.D.1    Qi, Q.2    Lewis, K.3
  • 37
    • 84874233056 scopus 로고    scopus 로고
    • Fungicidal drugs induce a common oxidative-damage cellular death pathway
    • Belenky, P., Camacho, D., Collins, J. J. Fungicidal drugs induce a common oxidative-damage cellular death pathway. Cell Rep 3, 350-8 (2013).
    • (2013) Cell Rep , vol.3 , pp. 350-358
    • Belenky, P.1    Camacho, D.2    Collins, J.J.3
  • 38
    • 31444450560 scopus 로고    scopus 로고
    • Ras pathway signaling accelerates programmed cell death in the pathogenic fungus Candida albicans
    • Phillips, A. J., Crowe, J. D., Ramsdale, M. Ras pathway signaling accelerates programmed cell death in the pathogenic fungus Candida albicans. Proc Natl Acad Sci USA 103, 726-31 (2006).
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 726-731
    • Phillips, A.J.1    Crowe, J.D.2    Ramsdale, M.3
  • 39
    • 33745623641 scopus 로고    scopus 로고
    • Isolation of quiescent and nonquiescent cells from yeast stationary-phase cultures
    • Allen, C. et al. Isolation of quiescent and nonquiescent cells from yeast stationary-phase cultures. J Cell Biol 174, 89-100 (2006).
    • (2006) J Cell Biol , vol.174 , pp. 89-100
    • Allen, C.1
  • 40
    • 41649110034 scopus 로고    scopus 로고
    • Characterization of differentiated quiescent and nonquiescent cells in yeast stationary-phase cultures
    • Aragon, A. D. et al. Characterization of differentiated quiescent and nonquiescent cells in yeast stationary-phase cultures. Mol Biol Cell 19, 1271-80 (2008).
    • (2008) Mol Biol Cell , vol.19 , pp. 1271-1280
    • Aragon, A.D.1
  • 41
    • 80053906154 scopus 로고    scopus 로고
    • Heterogeneous bacterial persisters and engineering approaches to eliminate them
    • Allison, K. R., Brynildsen, M. P., Collins, J. J. Heterogeneous bacterial persisters and engineering approaches to eliminate them. Curr Opin Microbiol 14, 593-8 (2011).
    • (2011) Curr Opin Microbiol , vol.14 , pp. 593-598
    • Allison, K.R.1    Brynildsen, M.P.2    Collins, J.J.3
  • 42
    • 84873485631 scopus 로고    scopus 로고
    • Pharmacodynamics population dynamics, and the evolution of persistence in Staphylococcus aureus
    • Johnson, P. J., Levin, B. R. Pharmacodynamics, population dynamics, and the evolution of persistence in Staphylococcus aureus. PLoS Genet 9, e1003123 (2013).
    • (2013) PLoS Genet , vol.9 , pp. e1003123
    • Johnson, P.J.1    Levin, B.R.2
  • 43
    • 81555212273 scopus 로고    scopus 로고
    • Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteria
    • Nguyen, D. et al. Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteria. Science 334, 982-6 (2011).
    • (2011) Science , vol.334 , pp. 982-986
    • Nguyen, D.1
  • 44
    • 84893651400 scopus 로고    scopus 로고
    • Strength in numbers: Antifungal strategies against fungal biofilms
    • Ramage, G., Robertson, S. N., Williams, C. Strength in numbers: antifungal strategies against fungal biofilms. Int J Antimicrob Agents 43, 114-20 (2014).
    • (2014) Int J Antimicrob Agents , vol.43 , pp. 114-120
    • Ramage, G.1    Robertson, S.N.2    Williams, C.3
  • 45
    • 84864835458 scopus 로고    scopus 로고
    • Successful use of posaconazole to treat invasive cutaneous fungal infection in a liver transplant patient on sirolimus
    • Dahlan, R., Patel, A., Haider, S. Successful use of posaconazole to treat invasive cutaneous fungal infection in a liver transplant patient on sirolimus. Can J Infect Dis Med Microbiol 23, e44-7 (2012).
    • (2012) Can J Infect Dis Med Microbiol , vol.23 , pp. e44-e47
    • Dahlan, R.1    Patel, A.2    Haider, S.3
  • 46
    • 70149099763 scopus 로고    scopus 로고
    • Endogenous Aspergillus endophthalmitis occurring after liver transplantation: A case report
    • Hashemi, S. B. et al. Endogenous Aspergillus endophthalmitis occurring after liver transplantation: a case report. Transplant Proc 41, 2933-5 (2009).
    • (2009) Transplant Proc , vol.41 , pp. 2933-2935
    • Hashemi, S.B.1
  • 47
    • 49549109164 scopus 로고    scopus 로고
    • Combination antifungal therapy involving amphotericin B, rapamycin and 5-fluorocytosine using PEG-phospholipid micelles
    • Vakil, R., Knilans, K., Andes, D., Kwon, G. S. Combination antifungal therapy involving amphotericin B, rapamycin and 5-fluorocytosine using PEG-phospholipid micelles. Pharm Res 25, 2056-64 (2008).
    • (2008) Pharm Res , vol.25 , pp. 2056-2064
    • Vakil, R.1    Knilans, K.2    Andes, D.3    Kwon, G.S.4
  • 48
    • 67749101402 scopus 로고    scopus 로고
    • In vitro interactions between antifungals and immunosuppressive drugs against zygomycetes
    • Dannaoui, E., Schwarz, P., Lortholary, O. In vitro interactions between antifungals and immunosuppressive drugs against zygomycetes. Antimicrob Agents Chemother 53, 3549-51 (2009).
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 3549-3551
    • Dannaoui, E.1    Schwarz, P.2    Lortholary, O.3
  • 49
    • 0036146756 scopus 로고    scopus 로고
    • Rates and extents of antifungal activities of amphotericin B, flucytosine, fluconazole, and voriconazole against Candida lusitaniae determined by microdilution, Etest, and time-kill methods
    • Ernst, E. J., Yodoi, K., Roling, E. E., Klepser, M. E. Rates and extents of antifungal activities of amphotericin B, flucytosine, fluconazole, and voriconazole against Candida lusitaniae determined by microdilution, Etest, and time-kill methods. Antimicrob Agents Chemother 46, 578-81 (2002).
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 578-581
    • Ernst, E.J.1    Yodoi, K.2    Roling, E.E.3    Klepser, M.E.4
  • 50
    • 40549124325 scopus 로고    scopus 로고
    • EUCAST definitive document EDef 7.1: Method for the determination of broth dilution MICs of antifungal agents for fermentative yeasts
    • EUCAST.
    • EUCAST. EUCAST definitive document EDef 7.1: method for the determination of broth dilution MICs of antifungal agents for fermentative yeasts. Clin Microbiol Infect 14, 398-405 (2008).
    • (2008) Clin Microbiol Infect , vol.14 , pp. 398-405
  • 51
    • 84883364264 scopus 로고    scopus 로고
    • Count-based differential expression analysis of RNA sequencing data using R and Bioconductor
    • Anders, S. et al. Count-based differential expression analysis of RNA sequencing data using R and Bioconductor. Nat Protoc 8, 1765-86 (2013).
    • (2013) Nat Protoc , vol.8 , pp. 1765-1786
    • Anders, S.1


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