Successful use of posaconazole to treat invasive cutaneous fungal infection in a liver transplant patient on sirolimus

Canadian Journal of Infectious Diseases and Medical Microbiology

Volumn 23, Issue 2, 2012, Pages

  Dahlan, Randah ^a   Patel, Ameen ^b   Haider, Shariq ^b  

^a MCMASTER UNIVERSITY   (Canada)

^b HAMILTON HEALTH SCIENCES   (Canada)

Author keywords

Cutaneous fungal infections; Liver transplantation; Posaconazole; Sirolimus

Indexed keywords

COTRIMOXAZOLE; HYDROCHLOROTHIAZIDE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; POSACONAZOLE; RAPAMYCIN; WARFARIN;

ADULT; ANKLE EDEMA; ARTICLE; BUDD CHIARI SYNDROME; CASE REPORT; DERMATITIS; DERMATOMYCOSIS; DRUG DOSE REDUCTION; FUNGUS CULTURE; FUSARIUM; HEART RATE; HEEL; HUMAN; HUMAN TISSUE; HYPERTENSION; IMMUNOSUPPRESSIVE TREATMENT; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PARAKERATOSIS; PICHIA GUILLIERMONDII; POLYCYTHEMIA VERA; SKIN BIOPSY; TOE; TOE GANGRENE; TREATMENT OUTCOME;

EID: 84864835458     PISSN: 17129532     EISSN: None     Source Type: Journal    
DOI: 10.1155/2012/272197     Document Type: Article

References (17)

1. Paya CV. Fungal infections in solid-organ transplantation. Clin Infect Dis 1993;16:677-88. (Pubitemid 23136568)
2. Hong W, Wen H, Liao W. Fungal infection in organ transplant patients. Chin Med J (Eng) 2003;116:1421-5. (Pubitemid 37184855)
3. Enoch DA, Ludlam HA, Brown NM. Invasive fungal infections: a review of epidemiology and management options. J Med Microbiol 2006;55:809-18. (Pubitemid 43974685)
4. Nucci M, Anaissie E. Fusarium infections in immunocompromised patients. Clin Microbiol Rev 2007;20:695-704. (Pubitemid 47623773)
5. Nucci M, Anaissie E. Cutaneous infection by Fusarium species in healthy and immunocompromised hosts: implications for diagnosis and management. Clin Infects Dis 2002;35:909-20. (Pubitemid 35178307)
6. Halpern M, Balbi E, Carius L, et al. Cellulitis and nodular skin lesions due to Fusarium spp. in liver transplant: Case report. Transplant Proc 2010;42:599-600.
7. Saad A, DePestel D, Carver P. Factors influencing the magnitude and clinical significance of drug interactions between azole antifungals and select immunosuppressants. Pharmacotherapy 2006;26:1730-44. (Pubitemid 44885328)
8. Pfaller MA, Messer SA, Hollis RJ, Jones RN; SENTRY Participants Group. Antifungal activities of posaconazole, ravuconazole, and voriconazole compared to those of itraconazole and amphotericin B against 239 clinical isolates of Aspergillus spp. and other filamentous fungi: Report from SENTRY Antimicrobial Surveillance Program, 2000. Antimicrob Agents Chemother 2002;46:1032-37. (Pubitemid 34260347)
9. Pasqualotto AC, Denning DW. New and emerging treatments for fungal infections. J Antimicrob Chemother 2008;61(Suppl 1)1:119-30.
10. Krieter P, Flannery B, Musick T, Gohdes M, Martinho M, Courtney R. Disposition of posaconazole following single-dose oral administration in healthy subjects. Antimicrob Agents Chemother 2004;48:3543-51. (Pubitemid 39129357)
11. Schiller DS, Fung HB. Posaconazole: An extended-spectrum triazole antifungal agent. Clin Ther 2007;29:1862-86. (Pubitemid 350212806)
12. Sansone-Parsons A, Krishna G, Martinho M, Kantesaria B, Gelone S, Mant TG. Effect of oral posaconazole on the pharmacokinetics of cyclosporine and tacrolimus. Pharmacotherapy 2007;27:825-34. (Pubitemid 46849426)
13. Sadaba B, Campanero MA, Quetglas EG, Azanza JR. Clinical relevance of sirolimus drug interactions in transplant patients. Transplant Proc 2004;36:3226-8. (Pubitemid 41126779)
14. Moton A, Ma L, Krishna G, Martinho M, Seiberling S, McLeod J. Effects of oral posaconazole on the pharmacokinetics of sirolimus. Curr Med Res Opin 2009;25:701-7.
15. Narreddy S, Manavathu E, Chandrasekar P, Alangaden G, Revankar S. In vitro interaction of posaconazole with calcineurin inhibitors and sirolimus against zygomycetes. J Antimicrob Chemother 2010;65:701-3.
16. Marty FM, Lowry CM, Cutler CS, et al. Voriconazole and sirolimus co-administration after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2006;12:552-9. (Pubitemid 43956360)
17. Surowiec D, DePestel D, Carver P. Concurrent administration of sirolimus and voriconazole: A pilot study assessing safety and approaches to appropriate management. Pharmacotherapy 2008;28:719-29. (Pubitemid 351975376)