Dual A1/A2B receptor blockade improves cardiac and renal outcomes in a rat model of heart failure with preserved ejection fraction

Journal of Pharmacology and Experimental Therapeutics

Volumn 356, Issue 2, 2016, Pages 333-340

  Tofovic, Stevan P ^a   Salah, Eman M ^a,c   Smits, Glenn J ^b,d   Whalley, Eric T ^b,e   Ticho, Barry ^b,f   Deykin, Aaron ^b   Jackson, Edwin K ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b BIOGEN   (United States)

^c Sohag University   (Egypt)

^d VivoPharm   (United States)

^e Pfizer Inc ^*  (United States)

^f PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [4 (2,6 DIOXO 1,3 DIPROPYL 7H PURIN 8 YL) 1 BICYCLO[2.2.2]OCTANYL]PROPANOIC ACID; ADENOSINE A2B RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; CHOLESTEROL; CREATININE; RENIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2 RECEPTOR ANTAGONIST; TONAPOFYLLINE; XANTHINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ENZYME INHIBITION; GLOMERULOSCLEROSIS; GLUCOSURIA; HEART FAILURE WITH PRESERVED EJECTION FRACTION; HEART FUNCTION; HEART HEMODYNAMICS; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE NECROSIS; HISTOPATHOLOGY; HYPERLIPIDEMIA; KIDNEY BLOOD FLOW; MALE; METABOLIC SYNDROME X; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; POLYDIPSIA; POLYURIA; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; RENAL PROTECTION; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; TRIACYLGLYCEROL BLOOD LEVEL; VASCULITIS; ANIMAL; DRUG EFFECTS; HEART FAILURE; HEART STROKE VOLUME; KIDNEY; METABOLISM; PHYSIOLOGY; ZUCKER RAT;

ADENOSINE A1 RECEPTOR ANTAGONISTS; ADENOSINE A2 RECEPTOR ANTAGONISTS; ANIMALS; HEART FAILURE; KIDNEY; MALE; RATS; RATS, ZUCKER; RECEPTOR, ADENOSINE A1; RECEPTOR, ADENOSINE A2B; STROKE VOLUME; TREATMENT OUTCOME; XANTHINES;

EID: 84959386473     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.115.228841     Document Type: Article

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