Effects of Acyclovir, Foscarnet, and Ribonucleotides on Herpes Simplex Virus-1 DNA Polymerase: Mechanistic Insights and a Novel Mechanism for Preventing Stable Incorporation of Ribonucleotides into DNA

Biochemistry

Volumn 55, Issue 7, 2016, Pages 1168-1177

  Vashishtha, Ashwani Kumar ^a   Kuchta, Robert D ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINS; CARBON; DRUG PRODUCTS; MACHINERY; POLYMERIZATION; VIRUSES;

EXONUCLEASE ACTIVITY; HERPES SIMPLEX VIRUS; MINIMAL EFFECTS; PHOSPHODIESTER BONDS; POLYMERASE ACTIVE SITE; REPLICATION MACHINERY; RIBONUCLEOTIDES; SINGLE-STRANDED DNA;

DNA;

ACICLOVIR TRIPHOSPHATE; CARBON; DEOXYNUCLEOSIDE TRIPHOSPHATE; DNA POLYMERASE; ENZYME; EXONUCLEASE; FOSCARNET; GANCICLOVIR; HYDROXYL GROUP; NUCLEOTIDE; PHOSPHONOACETIC ACID; PRIMER DNA; RIBONUCLEOTIDE; SINGLE STRANDED DNA; SUGAR; UNCLASSIFIED DRUG; ACICLOVIR; ANTIVIRUS AGENT; DNA DIRECTED DNA POLYMERASE; DNA POLYMERASE, SIMPLEXVIRUS; EXODEOXYRIBONUCLEASE; NUCLEIC ACID SYNTHESIS INHIBITOR; RECOMBINANT PROTEIN; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; CHEMICAL BOND; COMPLEX FORMATION; DNA DRUG COMPLEX; DRUG EFFECT; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HERPES SIMPLEX VIRUS 1; HYDROLYSIS; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN POLYMERIZATION; VIRUS REPLICATION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM;

ACYCLOVIR; ANTIVIRAL AGENTS; CATALYTIC DOMAIN; DNA, SINGLE-STRANDED; DNA-DIRECTED DNA POLYMERASE; EXODEOXYRIBONUCLEASES; FOSCARNET; HERPESVIRUS 1, HUMAN; HYDROLYSIS; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEIC ACID SYNTHESIS INHIBITORS; RECOMBINANT PROTEINS; RIBONUCLEOTIDES; SUBSTRATE SPECIFICITY; VIRAL PROTEINS;

EID: 84959320645     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.6b00065     Document Type: Article

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