Neuroprotective effects of a standardized flavonoid extract of safflower against neurotoxin-induced cellular and animal models of Parkinson's disease

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Ren, Rutong ^a,b   Shi, Chunyan ^c,d   Cao, Jing ^b   Sun, Yi ^a,b   Zhao, Xin ^a,b   Guo, Yongfei ^a,b   Wang, Chen ^a,b   Lei, Hui ^a,b   Jiang, Hanjie ^a,b   Ablat, Nuramatjan ^a,b   Xu, Jiamin ^a,b   Li, Wan ^a,b   Ma, Yingcong ^b   Qi, Xianrong ^b   Ye, Min ^b   Pu, Xiaoping ^a,b   Han, Hongbin ^c,d  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b PEKING UNIVERSITY   (China)

^c Key Lab of Magnetic Resonance Imaging Device and Technique   (China)

^d PEKING UNIVERSITY THIRD HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; ANHYDROSAFFLOR YELLOW B; FLAVONOID; KAEMPFEROL DERIVATIVE; KAEMPFEROL-3-O-RUTINOSIDE; NEUROPROTECTIVE AGENT; NEUROTOXIN; OXIDOPAMINE; PIGMENT; PLANT EXTRACT;

ANIMAL; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMICALLY INDUCED; CHEMISTRY; DIAGNOSTIC IMAGING; DISEASE MODEL; DRUG EFFECTS; MALE; METABOLISM; MICROTUBULE; NERVE CELL; NUCLEAR MAGNETIC RESONANCE IMAGING; PARKINSON DISEASE, SECONDARY; PC12 CELL LINE; RAT; SAFFLOWER; SPRAGUE DAWLEY RAT; SUBSTANTIA NIGRA;

ALPHA-SYNUCLEIN; ANIMALS; CARTHAMUS TINCTORIUS; CELL SURVIVAL; DISEASE MODELS, ANIMAL; FLAVONOIDS; KAEMPFEROLS; MAGNETIC RESONANCE IMAGING; MALE; MICROTUBULES; MOLECULAR STRUCTURE; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; OXIDOPAMINE; PARKINSON DISEASE, SECONDARY; PC12 CELLS; PIGMENTS, BIOLOGICAL; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANTIA NIGRA;

EID: 84959221654     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep22135     Document Type: Article

References (55)

1. Reeve, A., Simcox, E., & Turnbull, D. Ageing and Parkinson's disease: why is advancing age the biggest risk factor?. Ageing Res. Rev. 14, 19-30 (2014
2. Dauer, W., & Przedborski, S. Parkinson's disease: mechanisms and models. Neuron. 39, 889-909 (2003
3. Tian, L., et al. No differential regulation of dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2) binding in a primate model of Parkinson disease. PLoS One. 7, e31439 (2012
4. Klusa, V. Z., et al. Neuroprotective properties of mildronate, a small molecule, in a rat model of Parkinson's disease. Int. J. Mol. Sci. 11, 4465-4487 (2010
5. Calou, I., et al. Neuroprotective Properties of a Standardized Extract from Myracrodruon urundeuva Fr. All. (Aroeira-Do-Sertao), as Evaluated by a Parkinson's Disease Model in Rats. Parkinsons Dis. 2014, 519615 (2014
6. Sun, Y. Y., et al. Fasciculation and elongation protein zeta-1 (FEZ1) expression in reactive astrocytes in a rat model of Parkinson's disease. Neuropathol. Appl. Neurobiol. 40, 164-176 (2014
7. Sun, S. Y., An, C. N., & Pu, X. P. DJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats. Brain Res. Bull. 88, 609-616 (2012
8. Aureli, C., et al. 5-S-cysteinyldopamine neurotoxicity: Influence on the expression of alpha-synuclein and ERp57 in cellular and animal models of Parkinson's disease. J. Neurosci. Res. 92, 347-358 (2014
9. Haleagrahara, N., Siew, C. J., & Ponnusamy, K. Effect of quercetin and desferrioxamine on 6-hydroxydopamine (6-OHDA) induced neurotoxicity in striatum of rats. J. Toxicol. Sci. 38, 25-33 (2013
10. Bargiotas, P., & Konitsiotis, S. Levodopa-induced dyskinesias in Parkinson's disease: emerging treatments. Neuropsychiatr. Dis. Treat. 9, 1605-1617 (2013
11. Chen, L. W., Wang, Y. Q., Wei, L. C., Shi, M., & Chan, Y. S. Chinese herbs and herbal extracts for neuroprotection of dopaminergic neurons and potential therapeutic treatment of Parkinson's disease. CNS. Neurol. Disord. Drug Targets. 6, 273-281 (2007
12. Jahromi, S. R., Haddadi, M., Shivanandappa, T., & Ramesh, S. R. Attenuation of neuromotor deficits by natural antioxidants of Decalepis hamiltonii in transgenic Drosophila model of Parkinson's disease. Neuroscience. 293, 136-150 (2015
13. Fan, L., et al. Qualitative evaluation and quantitative determination of 10 major active components in Carthamus tinctorius L. by high-performance liquid chromatography coupled with diode array detector. J. Chromatogr A. 1216, 2063-2070 (2009
14. Qu, W., et al. Kaempferol derivatives prevent oxidative stress-induced cell death in a DJ-1-dependent manner. J. Pharmacol. Sci. 110, 191-200 (2009
15. Yu, L., et al. Neuroprotective effect of kaempferol glycosides against brain injury and neuroinflammation by inhibiting the activation of NF-kappaB and STAT3 in transient focal stroke. PLoS One. 8, e55839 (2013
16. Wang, Y., et al. Antinociceptive and anti-inflammatory activities of extract and two isolated flavonoids of Carthamus tinctorius L. J. Ethnopharmacol. 151, 944-950 (2014
17. Han, B., et al. Neuroprotective effect of hydroxysafflor yellow A on 6-hydroxydopamine-induced Parkinson's disease in rats. Eur. J. Pharmacol. 714, 83-88 (2013
18. Wu, Q., Ye, M., & Pu, X. Neuroprotective effect of CTE, an extract from traditional Chinese medicine, in a mouse model of MPTPinduced Parkinson's disease. Chinese Journal of New Drugs. 20, 355-358 (2011
19. Pu, X., Qu, W., Wu, Q., & Ye, M. The applications for safflower extract in the prevention and treatment of Neurodegenerative diseases. Vol. CN102526157A (Patent, China, 2012
20. Sykova, E., & Nicholson, C. Diffusion in brain extracellular space. Physiol. Rev. 88, 1277-1340 (2008
21. Thorne, R. G., & Nicholson, C. In vivo diffusion analysis with quantum dots and dextrans predicts the width of brain extracellular space. Proc. Natl. Acad. Sci. USA. 103, 5567-5572 (2006
22. Sykova, E., Mazel, T., & Simonova, Z. Diffusion constraints and neuron-glia interaction during aging. Exp. Gerontol. 33, 837-851 (1998
23. Zoli, M., Jansson, A., Sykova, E., Agnati, L. F., & Fuxe, K. Volume transmission in the CNS and its relevance for neuropsychopharmacology. Trends Pharmacol. Sci. 20, 142-150 (1999
24. Sykova, E., Mazel, T., Vargova, L., Vorisek, I., & Prokopova-Kubinova, S. Extracellular space diffusion and pathological states. Prog. Brain Res. 125, 155-178 (2000
25. Jiang, J. S., Lu, L., Yang, Y. J., Zhang, J. L., & Zhang, P. C. New spermidines from the florets of Carthamus tinctorius. J. Asian Nat. Prod. Res. 10, 447-451 (2008
26. Chinese Pharmacopoeia Commission. Part one of Chinese Pharmacopoeia. (ed. Chinese Pharmacopoeia Commission) 372-373; The Appendix of Part one of Chinese Pharmacopoeia. (ed. Chinese Pharmacopoeia Commission) IK and XII A. (China medical science press, Beijing, 2010
27. Han, H., et al. A novel MRI tracer-based method for measuring water diffusion in the extracellular space of the rat brain. IEEE J. Biomed. Health Inform. 18, 978-983 (2014
28. Freeley, M., et al. A high-content analysis toolbox permits dissection of diverse signaling pathways for T lymphocyte polarization. J. Biomol. Screen. 15, 541-555 (2010
29. Wilson, M. S., Graham, J. R., & Ball, A. J. Multiparametric High Content Analysis for assessment of neurotoxicity in differentiated neuronal cell lines and human embryonic stem cell-derived neurons. Neurotoxicology. 42, 33-48 (2014
30. Hongo, H., et al. Glycogen synthase kinase-3beta activation mediates rotenone-induced cytotoxicity with the involvement of microtubule destabilization. Biochem. Biophys. Res. Commun. 426, 94-99 (2012
31. Sheng, C., et al. DJ-1 deficiency perturbs microtubule dynamics and impairs striatal neurite outgrowth. Neurobiol. Aging. 34, 489-498 (2013
32. Tyler, V. E. Phytomedicines: back to the future. J. Nat. Prod. 62, 1589-1592 (1999
33. Kim, T. H., Ku, S. K., & Bae, J. S. Inhibitory effects of kaempferol-3-O-sophoroside on HMGB1-mediated proinflammatory responses. Food Chem. Toxicol. 50, 1118-1123 (2012
34. Khan, M. M., et al. Rutin protects dopaminergic neurons from oxidative stress in an animal model of Parkinson's disease. Neurotox. Res. 22, 1-15 (2012
35. Magalingam, K. B., Radhakrishnan, A., Ramdas, P., & Haleagrahara, N. Quercetin Glycosides Induced Neuroprotection by Changes in the Gene Expression in a Cellular Model of Parkinson's Disease. J. Mol. Neurosci. (2014
36. Xu, S. L., et al. Isorhamnetin, A Flavonol Aglycone from Ginkgo biloba L., Induces Neuronal Differentiation of Cultured PC12 Cells: Potentiating the Effect of Nerve Growth Factor. Evid. Based Complement. Alternat. Med. 2012, 278273 (2012
37. Buttner, S., et al. Spermidine protects against alpha-synuclein neurotoxicity. Cell Cycle. 13, 3903-3908 (2014
38. Valentova, K., Vrba, J., Bancirova, M., Ulrichova, J., & Kren, V. Isoquercitrin: pharmacology, toxicology, and metabolism. Food Chem. Toxicol. 68, 267-282 (2014
39. Jager, A. K., & Saaby, L. Flavonoids and the CNS. Molecules. 16, 1471-1485 (2011
40. Zhou, Y. Q., Chen, Y. J., & Feng, Q. R. Advances of studies on dropping pills. Zhongguo Zhong Yao Za Zhi. 31, 101-105 (2006
41. Zhao, X., et al. Neuroprotective effects of protocatechuic aldehyde against neurotoxin-induced cellular and animal models of Parkinson's disease. PLoS One. 8, e78220 (2013
42. Vekrellis, K., Xilouri, M., Emmanouilidou, E., Rideout, H. J., & Stefanis, L. Pathological roles of alpha-synuclein in neurological disorders. Lancet Neurol. 10, 1015-1025 (2011
43. Satpute, R., Lomash, V., Kaushal, M., & Bhattacharya, R. Neuroprotective effects of alpha-ketoglutarate and ethyl pyruvate against motor dysfunction and oxidative changes caused by repeated 1-methyl-4-phenyl-1, 2, 3, 6 tetrahydropyridine exposure in mice. Hum. Exp. Toxicol. 32, 747-758 (2013
44. Joers, V., Vermilyea, S., Dilley, K., & Emborg, M. E. Systemic administration of 6-OHDA to rhesus monkeys upregulates HLA-DR expression in brain microvasculature. J. Inflamm. Res. 7, 139-149 (2014
45. Catala, M., & Poirier, J. Georges Marinesco (1863-1938): neurologist, neurohistologist and neuropathologist. J. Morphol. Embryol. 53, 869-877 (2012
46. Yao, P. P., et al. Enterovirus 71-induced neurological disorders in young gerbils, Meriones unguiculatus: development and application of a neurological disease model. PLoS One. 7, e51996 (2012
47. Reum, T., et al. Diffusion parameters in the striatum of rats with 6-hydroxydopamine-induced lesions and with fetal mesencephalic grafts. J. Neurosci. Res. 70, 680-693 (2002
48. Xu, F., Han, H., Zhang, H., Pi, J., & Fu, Y. Quantification of Gd-DTPA concentration in neuroimaging using T(1)3D MP-RAGE sequence at 3.0 T. Magn. Reson. Imaging. 29, 827-834 (2011
49. Li, K., et al. Real-Time magnetic resonance imaging visualization and quantitative assessment of diffusion in the cerebral extracellular space of C6 glioma-bearing rats. Neurosci. Lett. 543, 84-89 (2013
50. Roitbak, T., & Sykova, E. Diffusion barriers evoked in the rat cortex by reactive astrogliosis. Glia. 28, 40-48 (1999
51. Nicholson, C. Factors governing diffusing molecular signals in brain extracellular space. J. Neural Transm. 112, 29-44 (2005
52. Vargova, L., Jendelova, P., Chvatal, A., & Sykova, E. Glutamate, NMDA, and AMPA induced changes in extracellular space volume and tortuosity in the rat spinal cord. J. Cereb. Blood Flow. Metab. 21, 1077-1089 (2001
53. El Arfani, A., et al. NMDA receptor antagonism potentiates the L-DOPA-induced extracellular dopamine release in the subthalamic nucleus of hemi-parkinson rats. Neuropharmacology. 85, 198-205 (2014
54. Iliff, J. J., et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci. Transl. Med. 4, 147ra111 (2012
55. Shahaduzzaman, M., et al. Anti-human alpha-synuclein N-Terminal peptide antibody protects against dopaminergic cell death and ameliorates behavioral deficits in an AAV-Alpha-synuclein rat model of Parkinson's disease. PLoS One. 10, e0116841 (2015