Engineering approaches to study fibrosis in 3-D in vitro systems

Current Opinion in Biotechnology

Volumn 40, Issue , 2016, Pages 24-30

  Porras, Ana M ^a   Hutson, Heather N ^a   Berger, Anthony J ^a   Masters, Kristyn S ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTECHNOLOGY;

BIOMIMICRY; EXTRACELLULAR MATRIX REMODELING; FIBROTIC DISEASE; IN-VITRO; KEY FEATURE; SENSOR TECHNIQUES; SYSTEMS BIOLOGY;

BIOMIMETICS;

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; GELATIN; HYALURONIC ACID; MACROGOL; MATRIX METALLOPROTEINASE; PROTEIN LYSINE 6 OXIDASE; TRANSFORMING GROWTH FACTOR BETA1; VERY LATE ACTIVATION ANTIGEN 2; MOLECULAR PROBE;

BIOENGINEERING; CELL DIFFERENTIATION; DISEASE COURSE; EXTRACELLULAR MATRIX; FIBROGENESIS; FLUORESCENCE LIFETIME IMAGING MICROSCOPY; HEART MUSCLE FIBROSIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIVER FIBROSIS; LUNG FIBROSIS; MECHANOTRANSDUCTION; MICROSCOPY; MOLECULAR PROBE; MYOFIBROBLAST; NANOENCAPSULATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REVIEW; SECOND HARMONIC GENERATION MICROSCOPY; SPECTRAL LIFETIME IMAGING MICROSCOPY; UPREGULATION; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; FIBROSIS; METABOLISM; PATHOLOGY; PROCEDURES; TISSUE ENGINEERING; TUMOR MICROENVIRONMENT;

ANIMALS; CELLULAR MICROENVIRONMENT; EXTRACELLULAR MATRIX; FIBROSIS; HUMANS; MODELS, BIOLOGICAL; MOLECULAR PROBES; TISSUE ENGINEERING;

EID: 84959156180     PISSN: 09581669     EISSN: 18790429     Source Type: Journal    
DOI: 10.1016/j.copbio.2016.02.006     Document Type: Review

References (61)

1. Rosenbloom J., Castro S.V., Jimenez S.A. Narrative review: fibrotic diseases: cellular and molecular mechanisms and novel therapies. Ann Intern Med 2010, 152:159-166.
2. Wynn T.A. Cellular and molecular mechanisms of fibrosis. J Pathol 2008, 214:199-210.
3. Klingberg F., Hinz B., White E.S. The myofibroblast matrix: implications for tissue repair and fibrosis. J Pathol 2013, 229:298-309.
4. Hinz B., Phan S.H., Thannickal V.J., Galli A., Bochaton-Piallat M.L., Gabbiani G. The myofibroblast: one function, multiple origins. Am J Pathol 2007, 170:1807-1816.
5. Schroer A.K., Merryman W.D. Mechanobiology of myofibroblast adhesion in fibrotic cardiac disease. J Cell Sci 2015, 128:1865-1875.
6. Friedman S.L., Sheppard D., Duffield J.S., Violette S. Therapy for fibrotic diseases: nearing the starting line. Sci Transl Med 2013, 5. 167sr161.
7. Chen C.Z., Raghunath M. Focus on collagen: in vitro systems to study fibrogenesis and antifibrosis state of the art. Fibrogenesis Tissue Repair 2009, 2:7.
8. Mabry K.M., Payne S.Z., Anseth K.S. Microarray analyses to quantify advantages of 2D and 3D hydrogel culture systems in maintaining the native valvular interstitial cell phenotype. Biomaterials 2015, 74:31-41.
9. Smithmyer M.E., Sawicki L.A., Kloxin A.M. Hydrogel scaffolds as in vitro models to study fibroblast activation in wound healing and disease. Biomater Sci 2014, 2:634-650.
10. Desrochers T.M., Palma E., Kaplan D.L. Tissue-engineered kidney disease models. Adv Drug Deliv Rev 2014, 69-70:67-80.
11. Kanta J. Collagen matrix as a tool in studying fibroblastic cell behavior. Cell Adhes Migr 2015, 9:308-316.
12. van den Broek L.J., Limandjaja G.C., Niessen F.B., Gibbs S. Human hypertrophic and keloid scar models: principles, limitations and future challenges from a tissue engineering perspective. Exp Dermatol 2014, 23:382-386.
13. Hosoya H., Kadowaki K., Matsusaki M., Cabral H., Nishihara H., Ijichi H., Koike K., Kataoka K., Miyazono K., Akashi M., et al. Engineering fibrotic tissue in pancreatic cancer: a novel three-dimensional model to investigate nanoparticle delivery. Biochem Biophys Res Commun 2012, 419:32-37.
14. Corriveau M.P., Boufaied I., Lessard J., Chabaud S., Senecal J.L., Grodzicky T., Chartier S., Raymond Y., Moulin V.J. The fibrotic phenotype of systemic sclerosis fibroblasts varies with disease duration and severity of skin involvement: reconstitution of skin fibrosis development using a tissue engineering approach. J Pathol 2009, 217:534-542.
15. Hjortnaes J., Camci-Unal G., Hutcheson J.D., Jung S.M., Schoen F.J., Kluin J., Aikawa E., Khademhosseini A. Directing valvular interstitial cell myofibroblast-like differentiation in a hybrid hydrogel platform. Adv Healthc Mater 2015, 4:121-130.
16. Duan B., Hockaday L.A., Kapetanovic E., Kang K.H., Butcher J.T. Stiffness and adhesivity control aortic valve interstitial cell behavior within hyaluronic acid based hydrogels. Acta Biomater 2013, 9:7640-7650.
17. Zhu J. Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering. Biomaterials 2010, 31:4639-4656.
18. Gould S.T., Anseth K.S. Role of cell-matrix interactions on VIC phenotype and tissue deposition in 3D PEG hydrogels. J Tissue Eng Regen Med 2013.
19. Gould S.T., Darling N.J., Anseth K.S. Small peptide functionalized thiol-ene hydrogels as culture substrates for understanding valvular interstitial cell activation and de novo tissue deposition. Acta Biomater 2012, 8:3201-3209.
20. Hinz B. The extracellular matrix and transforming growth factor-beta1: tale of a strained relationship. Matrix Biol 2015, 47:54-65.
21. Masters K.S. Covalent growth factor immobilization strategies for tissue repair and regeneration. Macromol Biosci 2011, 11:1149-1163.
22. Sridhar B.V., Doyle N.R., Randolph M.A., Anseth K.S. Covalently tethered TGF-beta1 with encapsulated chondrocytes in a PEG hydrogel system enhances extracellular matrix production. J Biomed Mater Res A 2014, 102:4464-4472.
23. Mann B.K., Schmedlen R.H., West J.L. Tethered-TGF-beta increases extracellular matrix production of vascular smooth muscle cells. Biomaterials 2001, 22:439-444.
24. Place E.S., Nair R., Chia H.N., Szulgit G., Lim E.H., Stevens M.M. Latent TGF-beta hydrogels for cartilage tissue engineering. Adv Healthc Mater 2012, 1:480-484.
25. Griffin D.R., Schlosser J.L., Lam S.F., Nguyen T.H., Maynard H.D., Kasko A.M. Synthesis of photodegradable macromers for conjugation and release of bioactive molecules. Biomacromolecules 2013, 14:1199-1207.
26. Grim J.C., Marozas I.A., Anseth K.S. Thiol-ene and photo-cleavage chemistry for controlled presentation of biomolecules in hydrogels. J Control Release 2015.
27. Belair D.G., Le N.N., Murphy W.L. Design of growth factor sequestering biomaterials. Chem Commun (Camb) 2014, 50:15651-15668.
28. Kirschner C.M., Alge D.L., Gould S.T., Anseth K.S. Clickable, photodegradable hydrogels to dynamically modulate valvular interstitial cell phenotype. Adv Healthc Mater 2014, 3:649-657.
29. Wang H., Tibbitt M.W., Langer S.J., Leinwand L.A., Anseth K.S. Hydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K/AKT pathway. Proc Natl Acad Sci U S A 2013, 110:19336-19341.
30. Yip C.Y., Chen J.H., Zhao R., Simmons C.A. Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix. Arterioscler Thromb Vasc Biol 2009, 29:936-942.
31. Engler A.J., Sen S., Sweeney H.L., Discher D.E. Matrix elasticity directs stem cell lineage specification. Cell 2006, 126:677-689.
32. Guvendiren M., Burdick J.A. Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics. Nat Commun 2012, 3:792.
33. Stowers R.S., Allen S.C., Suggs L.J. Dynamic phototuning of 3D hydrogel stiffness. Proc Natl Acad Sci U S A 2015, 112:1953-1958.
34. Rosales A.M., Mabry K.M., Nehls E.M., Anseth K.S. Photoresponsive elastic properties of azobenzene-containing poly(ethylene-glycol)-based hydrogels. Biomacromolecules 2015, 16:798-806.
35. Mabry K.M., Lawrence R.L., Anseth K.S. Dynamic stiffening of poly(ethylene glycol)-based hydrogels to direct valvular interstitial cell phenotype in a three-dimensional environment. Biomaterials 2015, 49:47-56.
36. Duscher D., Maan Z.N., Wong V.W., Rennert R.C., Januszyk M., Rodrigues M., Hu M., Whitmore A.J., Whittam A.J., Longaker M.T., et al. Mechanotransduction and fibrosis. J Biomech 2014, 47:1997-2005.
37. Chia H.N., Vigen M., Kasko A.M. Effect of substrate stiffness on pulmonary fibroblast activation by TGF-beta. Acta Biomater 2012, 8:2602-2611.
38. Pena A., Fabre A., Debarre D., Marchal-Somme J., Crestani B., Martin J., Beaurepaire E., Schanne-Klein M.-C. Three-dimensional investigation and scoring of extracellular matrix remodeling during lung fibrosis using multiphoton microscopy. Microsc Res Techn 2007, 70:162-170.
39. Tilbury K., Hocker J., Wen B.L., Sandbo N., Singh V., Campagnola P.J. Second harmonic generation microscopy analysis of extracellular matrix changes in human idiopathic pulmonary fibrosis. J Biomed Opt 2014, 19:086014.
40. Strupler M., Pena a-M, Hernest M., Tharaux P.-L., Martin J.-L., Beaurepaire E., Schanne-Klein M.-C. Second harmonic imaging and scoring of collagen in fibrotic tissues. Opt Express 2007, 15:4054-4065.
41. Ranjit S., Dvornikov A., Stakic M., Hong S.-H., Levi M., Evans R.M., Gratton E. Imaging fibrosis and separating collagens using second harmonic generation and phasor approach to fluorescence lifetime imaging. Sci Rep 2015, 5:13378.
42. Provenzano P.P., Eliceiri K.W., Keely P.J. Multiphoton microscopy and fluorescence lifetime imaging microscopy (FLIM) to monitor metastasis and the tumor microenvironment. Clin Exp Metastasis 2009, 26:357-370.
43. Provenzano P.P., Inman D.R., Eliceiri K.W., Knittel J.G., Yan L., Rueden C.T., White J.G., Keely P.J. Collagen density promotes mammary tumor initiation and progression. BMC Med 2008, 6:11.
44. Biela E., Galas J., Lee B., Johnson G.L., Darzynkiewicz Z., Dobrucki J.W. Col-F, a fluorescent probe for ex vivo confocal imaging of collagen and elastin in animal tissues. Cytometry A 2013, 83:533-539.
45. Aper S.J., van Spreeuwel A.C., van Turnhout M.C., van der Linden A.J., Pieters P.A., van der Zon N.L., de la Rambelje S.L., Bouten C.V., Merkx M. Colorful protein-based fluorescent probes for collagen imaging. PLOS ONE 2014, 9:e114983.
46. Boerboom R.A., Krahn K.N., Megens R.T., van Zandvoort M.A., Merkx M., Bouten C.V. High resolution imaging of collagen organisation and synthesis using a versatile collagen specific probe. J Struct Biol 2007, 159:392-399.
47. Cai Y., Zhu L., Zhang F., Niu G., Lee S., Kimura S., Chen X. Noninvasive monitoring of pulmonary fibrosis by targeting matrix metalloproteinases (MMPs). Mol Pharm 2013, 10:2237-2247.
48. Aslam T., Miele A., Chankeshwara S.V., Megia-Fernandez A., Michels C., Akram A.R., McDonald N., Hirani N., Haslett C., Bradley M., et al. Optical molecular imaging of lysyl oxidase activity - detection of active fibrogenesis in human lung tissue. Chem Sci 2015, 6:4946-4953.
49. Rodriguez C., Rodriguez-Sinovas A., Martinez-Gonzalez J. Lysyl oxidase as a potential therapeutic target. Drug News Perspect 2008, 21:218-224.
50. LaCroix A.S., Rothenberg K.E., Berginski M.E., Urs A.N., Hoffman B.D. Construction, imaging, and analysis of FRET-based tension sensors in living cells. Methods Cell Biol 2015, 125:161-186.
51. Ratner M. Landmark approvals in idiopathic pulmonary fibrosis. Nat Biotechnol 2014, 32:1069-1070.
52. Tseng H., Balaoing L.R., Grigoryan B., Raphael R.M., Killian T.C., Souza G.R., Grande-Allen K.J. A three-dimensional co-culture model of the aortic valve using magnetic levitation. Acta Biomater 2014, 10:173-182.
53. Zhou Q., Patel D., Kwa T., Haque A., Matharu Z., Stybayeva G., Gao Y., Diehl A.M., Revzin A. Liver injury-on-a-chip: microfluidic co-cultures with integrated biosensors for monitoring liver cell signaling during injury. Lab Chip 2015.
54. Gould S.T., Matherly E.E., Smith J.N., Heistad D.D., Anseth K.S. The role of valvular endothelial cell paracrine signaling and matrix elasticity on valvular interstitial cell activation. Biomaterials 2014, 35:3596-3606.
55. Won S., Davies-Venn C., Liu S., Bluemke D.A. Noninvasive imaging of myocardial extracellular matrix for assessment of fibrosis. Curr Opin Cardiol 2013, 28:282-289.
56. Lovisa S., LeBleu V.S., Tampe B., Sugimoto H., Vadnagara K., Carstens J.L., Wu C.C., Hagos Y., Burckhardt B.C., Pentcheva-Hoang T., et al. Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis. Nat Med 2015, 21:998-1009.
57. Kriz W., Kaissling B., Le Hir M. Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?. J Clin Invest 2011, 121:468-474.
58. Montgomery R.L., Yu G., Latimer P.A., Stack C., Robinson K., Dalby C.M., Kaminski N., van Rooij E. MicroRNA mimicry blocks pulmonary fibrosis. EMBO Mol Med 2014, 6:1347-1356.
59. Dutta-Moscato J., Solovyev A., Mi Q., Nishikawa T., Soto-Gutierrez A., Fox I.J., Vodovotz Y. A multiscale agent-based in silico model of liver fibrosis progression. Front Bioeng Biotechnol 2014, 2:18.
60. Schoeberl B., Pace E.A., Fitzgerald J.B., Harms B.D., Xu L., Nie L., Linggi B., Kalra A., Paragas V., Bukhalid R., et al. Therapeutically targeting ErbB3: a key node in ligand-induced activation of the ErbB receptor-PI3K axis. Sci Signal 2009, 2. ra31.
61. Faratian D., Goltsov A., Lebedeva G., Sorokin A., Moodie S., Mullen P., Kay C., Um I.H., Langdon S., Goryanin I., et al. Systems biology reveals new strategies for personalizing cancer medicine and confirms the role of PTEN in resistance to trastuzumab. Cancer Res 2009, 69:6713-6720.