Engineering fibrotic tissue in pancreatic cancer: A novel three-dimensional model to investigate nanoparticle delivery

Biochemical and Biophysical Research Communications

Volumn 419, Issue 1, 2012, Pages 32-37

  Hosoya, Hitomi ^a   Kadowaki, Koji ^b   Matsusaki, Michiya ^b   Cabral, Horacio ^a   Nishihara, Hiroshi ^c   Ijichi, Hideaki ^a   Koike, Kazuhiko ^a   Kataoka, Kazunori ^b   Miyazono, Kohei ^a   Akashi, Mitsuru ^b   Kano, Mitsunobu R ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Fibroblasts; Fibrosis; NanoDDS; Pancreatic cancer; Permeability

Indexed keywords

DEXTRAN; NANOPARTICLE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL ENGINEERING; CELL MANIPULATION; FIBROBLAST; FLUORESCENCE; HUMAN; HUMAN CELL; HYDRODYNAMICS; IN VITRO STUDY; MEMBRANE PERMEABILITY; MOLECULAR SIZE; MOLECULAR WEIGHT; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG DELIVERY SYSTEMS; FIBROBLASTS; FIBROSIS; MICE; MODELS, BIOLOGICAL; NANOPARTICLES; NIH 3T3 CELLS; PANCREATIC NEOPLASMS; PERMEABILITY; TISSUE ENGINEERING;

MURINAE;

EID: 84857641985     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.01.117     Document Type: Article

References (30)

1. Burris H.A., Moore M.J., Andersen J., Green M.R., Rothenberg M.L., Modiano M.R., et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J. Clin. Oncol. 1997, 15:2403-2413.
2. Pan X., Arumugam T., Yamamoto T., Levin P.A., Ramachandran V., Ji B., et al. Nuclear factor-kappaB p65/relA silencing induces apoptosis and increases gemcitabine effectiveness in a subset of pancreatic cancer cells. Clin. Cancer Res. 2008, 14:8143-8151.
3. Maloney E.K., McLaughlin J.L., Dagdigian N.E., Garrett L.M., Connors K.M., Zhou X.-M., et al. An anti-insulin-like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferation. Cancer Res. 2003, 63:5073-5083.
4. Sofuni A., Iijima H., Moriyasu F., Nakayama D., Shimizu M., Nakamura K., et al. Differential diagnosis of pancreatic tumors using ultrasound contrast imaging. J. Gastroenterol. 2005, 40:518-525.
5. Kano M.R., Bae Y., Iwata C., Morishita Y., Yashiro M., Oka M., et al. Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling. Proc. Natl. Acad. Sci. USA 2007, 104:3460-3465.
6. Pietras K., Ostman A. Hallmarks of cancer: interactions with the tumor stroma. Exp. Cell Res. 2010, 316:1324-1331.
7. Kalluri R., Zeisberg M. Fibroblasts in cancer. Nat. Rev. Cancer 2006, 6:392-401.
8. Cirri P., Chiarugi P. Cancer associated fibroblasts: the dark side of the coin. Am. J. Cancer Res. 2011, 1:482-497.
9. Matsumura Y., Kataoka K. Preclinical and clinical studies of anticancer agent-incorporating polymer micelles. Cancer Sci. 2009, 100:572-579.
10. Chrastina A., Massey K.A., Schnitzer J.E. Overcoming in vivo barriers to targeted nanodelivery. Wiley Interdiscip. Rev. Nanomed. Nanobiotech. 2011, 3:421-437.
11. Cooper J.A., Del Vecchio P.J., Minnear F.L., Burhop K.E., Selig W.M., Garcia J.G., et al. Measurement of albumin permeability across endothelial monolayers in vitro. J. Appl. Physiol. 1987, 62:1076-1083.
12. Deli M.A., Abrahám C.S., Kataoka Y., Niwa M. Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharmacology. Cell. Mol. Neurobiol. 2005, 25:59-127.
13. Green J.A., Yamada K.M. Three-dimensional microenvironments modulate fibroblast signaling responses. Adv. Drug Deliv. Rev. 2007, 59:1293-1298.
14. Dolznig H., Rupp C., Puri C., Haslinger C., Schweifer N., Wieser E., et al. Modeling colon adenocarcinomas in vitro a 3D co-culture system induces cancer-relevant pathways upon tumor cell and stromal fibroblast interaction. Am. J. Pathol. 2011, 179:487-501.
15. Li L., Lu Y. Optimizing a 3D culture system to study the interaction between epithelial breast cancer and its surrounding fibroblasts. J. Cancer 2011, 2:458-466.
16. Pageau S.C., Sazonova O.V., Wong J.Y., Soto A.M., Sonnenschein C. The effect of stromal components on the modulation of the phenotype of human bronchial epithelial cells in 3D culture. Biomaterials 2011, 32:7169-7180.
17. Souza G.R., Molina J.R., Raphael R.M., Ozawa M.G., Stark D.J., Levin C.S., et al. Three-dimensional tissue culture based on magnetic cell levitation. Nat. Nanotechnol. 2010, 5:291-296.
18. Matsusaki M., Kadowaki K., Nakahara Y., Akashi M. Fabrication of cellular multilayers with nanometer-sized extracellular matrix films. Angew. Chem. Int. Ed. Engl. 2007, 46:4689-4692.
19. Kadowaki K., Matsusaki M., Akashi M. Control of cell surface and functions by layer-by-layer nanofilms. Langmuir 2010, 26:5670-5678.
20. Kadowaki K., Matsusaki M., Akashi M. Three-dimensional constructs induce high cellular activity: structural stability and the specific production of proteins and cytokines. Biochem. Biophys. Res. Commun. 2010, 402:153-157.
21. Matsusaki M., Kadowaki K., Adachi E., Sakura T., Yokoyama U., Ishikawa Y., et al. Morphological and histological evaluations of 3D-layered blood vessel constructs prepared by hierarchical cell manipulation. J. Biomater. Sci. Polym. Ed. 2012, 23:63-79.
22. Ijichi H., Chytil A., Gorska A.E., Aakre M.E., Fujitani Y., Fujitani S., et al. Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. Genes Dev. 2006, 20:3147-3160.
23. Ijichi H., Chytil A., Gorska A.E., Aakre M.E., Bierie B., Tada M., et al. Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma. J. Clin. Invest. 2011, 121:4106-4117.
24. Kano M.R., Komuta Y., Iwata C., Oka M., Shirai Y.-t., Morishita Y., et al. Comparison of the effects of the kinase inhibitors imatinib, sorafenib, and transforming growth factor-beta receptor inhibitor on extravasation of nanoparticles from neovasculature. Cancer Sci. 2009, 100:173-180.
25. Weinberg R.A. The Biology of Cancer 2006, Garland Science, New York, NY, USA.
26. Cabral H., Matsumoto Y., Mizuno K., Chen Q., Murakami M., Kimura M., et al. Accumulation of sub-100nm polymeric micelles in poorly permeable tumours depends on size. Nat. Nanotechnol. 2011, 6:815-823.
27. Bhabra G., Sood A., Fisher B., Cartwright L., Saunders M., Evans W.H., et al. Nanoparticles can cause DNA damage across a cellular barrier. Nat. Nanotechnol. 2009, 4:876-883.
28. Sood A., Salih S., Roh D., Lacharme-Lora L., Parry M., Hardiman B., et al. Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness. Nat. Nanotechnol. 2011, 6:824-833.
29. Dreher M.R., Liu W., Michelich C.R., Dewhirst M.W., Yuan F., Chilkoti A. Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers. J. Natl. Cancer Inst. 2006, 98:335-344.
30. Rippe B., Haraldsson B. Transport of macromolecules across microvascular walls: the two-pore theory. Physiol. Rev. 1994, 74:163-219.