Expression of Activated Ras in Gastric Chief Cells of Mice Leads to the Full Spectrum of Metaplastic Lineage Transitions

Gastroenterology

Volumn 150, Issue 4, 2016, Pages 918-930.e13

  Choi, Eunyoung ^a   Hendley, Audrey M ^c   Bailey, Jennifer M ^c   Leach, Steven D ^c   Goldenring, James R ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT INGRAM CANCER CENTER   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Carcinogenesis; Differentiation; MAP Kinase; Signal Transduction

Indexed keywords

CD44V ANTIGEN; CLUSTERIN; GRIFFONIA SIMPLICIFOLIA LECTIN II; INTESTINAL TREFOIL FACTOR; K RAS PROTEIN; MUCIN 2; MUCIN 6; PLANT LECTIN; SELUMETINIB; TAMOXIFEN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MIST1; TREFOIL FACTOR 3; TUMOR MARKER; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; FEMALE; GASTRIC MUCOSA; GASTRIC PROGENITOR CELL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INTESTINE METAPLASIA; MACROPHAGE; MALE; METAPLASIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPASMOLYTIC POLYPEPTIDE EXPRESSING METAPLASIA; STEM CELL; STOMACH; STOMACH CARCINOGENESIS; STOMACH CHIEF CELL; STOMACH FUNDUS GLAND; TUMOR DIFFERENTIATION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL PROLIFERATION; CELL TRANSFORMATION; DISEASE COURSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; METABOLISM; MUTATION; ONCOGENE RAS; PATHOLOGY; PHENOTYPE; STOMACH NEOPLASMS; TIME FACTOR; TRANSCRIPTION INITIATION; TRANSGENIC MOUSE;

ANIMALS; ANTICARCINOGENIC AGENTS; BENZIMIDAZOLES; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CHIEF CELLS, GASTRIC; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, RAS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MACROPHAGES; MALE; METAPLASIA; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MUTATION; PHENOTYPE; PROTEIN KINASE INHIBITORS; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; TIME FACTORS; TRANSCRIPTIONAL ACTIVATION;

EID: 84959125567     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2015.11.049     Document Type: Article

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