Apoptosis and failure of checkpoint kinase 1 activation in human induced pluripotent stem cells under replication stress

Stem Cell Research and Therapy

Volumn 7, Issue 1, 2016, Pages

  Desmarais, Joelle A ^a   Unger, Christian ^a   Damjanov, Ivan ^b   Meuth, Mark ^a   Andrews, Peter ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF KANSAS HOSPITAL   (United States)

Author keywords

Apoptosis; Ataxia telangiectasia and rad3 related; Ataxia telangiectasia mutated; Checkpoint kinase 1; Genomic instability; Induced pluripotent stem cells; Integration free reprogramming; Replication stress

Indexed keywords

ATM PROTEIN; CHECKPOINT KINASE 1; CHEK1 PROTEIN, HUMAN; CHEK1 PROTEIN, MOUSE; PROTEIN KINASE;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL STRESS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CULTURE MEDIUM; DNA CONTENT; DNA REPLICATION; ENZYME ACTIVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; S PHASE CELL CYCLE CHECKPOINT; SIGNAL TRANSDUCTION; ANIMAL; HCT 116 CELL LINE; INDUCED PLURIPOTENT STEM CELL; METABOLISM; MOUSE; PHYSIOLOGY;

ANIMALS; APOPTOSIS; CHECKPOINT KINASE 1; DNA REPLICATION; HCT116 CELLS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MICE; PROTEIN KINASES;

EID: 84959106369     PISSN: None     EISSN: 17576512     Source Type: Journal    
DOI: 10.1186/s13287-016-0279-2     Document Type: Article

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