Protective effects of niacin against methylmercury-induced genotoxicity and alterations in antioxidant status in rats

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 79, Issue 4, 2016, Pages 174-183

  Silva De Paula, Eloisa ^a   Carneiro, Maria Fernanda Hornos ^a   Grotto, Denise ^b   Hernandes, Lívia Cristina ^a   Antunes, Lusânia Maria Greggi ^a   Barbosa, Fernando ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF SOROCABA   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CATALASE; GLUCOSE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; METHYLMERCURY; NICOTINIC ACID; NITRIC OXIDE; TRIACYLGLYCEROL; ANTIOXIDANT; METHYLMERCURY DERIVATIVE; VITAMIN B COMPLEX;

ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; CHOLESTEROL BLOOD LEVEL; COMET ASSAY; CONTROLLED STUDY; ENZYME ACTIVITY; GENOTOXICITY; GLUCOSE BLOOD LEVEL; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; TRIACYLGLYCEROL BLOOD LEVEL; VITAMIN SUPPLEMENTATION; ANALYSIS; ANIMAL; BLOOD; DIETARY SUPPLEMENT; DRUG EFFECTS; METABOLISM; RANDOMIZED CONTROLLED TRIAL; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; DIETARY SUPPLEMENTS; MALE; METHYLMERCURY COMPOUNDS; NIACIN; OXIDATIVE STRESS; RATS; RATS, WISTAR; VITAMIN B COMPLEX;

EID: 84959053711     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287394.2015.1137264     Document Type: Article

References (72)

1. Aebi, H. 1984. Catalase in vitro. Methods Enzymol. 105: 121-126
2. Ali, E. H., McJunkin, B., Jubelirer, S., and, Hood, W. 2013. Niacin induced coagulopathy as a manifestation of occult liver injury. WV Med. J. 109: 12-14
3. Barbieri, F. L., and, Gardon, J. 2009. Hair mercury levels in Amazonian populations: Spatial distribution and trends. Int. J. Health Geogr. 8: 71
4. Barcelos, G. R., Angeli, J. P., Serpeloni, J. M., Grotto, D., Rocha, B. A., Bastos, J. K., Knasmuller, S., and, Junior, F. B. 2011. Quercetin protects human-derived liver cells against mercury-induced DNA-damage and alterations of the redox status. Mutat. Res. 726: 109-115
5. Barcelos, G. R., Grotto, D., Serpeloni, J. M., Aissa, A. F., Antunes, L. M., Knasmuller, S., and, Barbosa, F., Jr. 2012a. Bixin and norbixin protect against DNA-damage and alterations of redox status induced by methylmercury exposure in vivo. Environ. Mol. Mutagen. 53: 535-541
6. Barcelos, G. R. M., de Marco, K. C., Grotto, D., Valentini, J., Garcia, S. C., Braga, G. U. L., and, Barbosa, F. 2012b. Evaluation of glutathione S-transferase GSTM1 and GSTT1 polymorphisms and methylmercury metabolism in an exposed Amazon population. J. Toxicol. Environ. Health A 75: 960-970
7. Barcelos, G. R. M, Grotto, D., de Marco, K. C., Valentini, J., Lengert, A. V., de Oliveira, A. A. S., Garcia, S. C., Braga, G. U. L., Engströmd, K. S., Cólus, I. C., Broberg, K., and, Barbosa, F., Jr. 2013. Polymorphisms in glutathione-related genes modify mercury concentrations and antioxidant status in subjects environmentally exposed to methylmercury. Sci. Total Environ. 463-464: 319-325
8. Bartleman, A. P., Jacobs, R., and, Kirkland, J. B. 2008. Niacin supplementation decreases the incidence of alkylation-induced nonlymphocytic leukemia in Long-Evans rats. Nutr. Cancer 60: 251-258
9. Batista, B. L., Grotto, D., Rodrigues, J. L., Souza, V. C., and, Barbosa, F., Jr. 2009. Determination of trace elements in biological samples by inductively coupled plasma mass spectrometry with tetramethylammonium hydroxide solubilization at room temperature. Anal. Chim. Acta 646: 23-29
10. Bhuvaneswari, V., and, Nagini, S. 2005. Lycopene: A review of its potential as an anticancer agent. Curr. Med. Chem. Anticancer Agents 5: 627-635
11. Carneiro, M. F., Grotto, D., and, Barbosa, F., Jr. 2014. Inorganic and methylmercury levels in plasma are differentially associated with age, gender, and oxidative stress markers in a population exposed to mercury through fish consumption. J. Toxicol. Environ. Health A 77: 69-79
12. Cebulska-Wasilewska, A., Panek, A., Zabinski, Z., Moszczynski, P., and, Au, W. W. 2005. Occupational exposure to mercury vapour on genotoxicity and DNA repair. Mutat. Res. 586: 102-114
13. Cho, K. H., Kim, H. J., Rodriguez-Iturbe, B., and, Vaziri, N. D. 2009. Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failure. Am. J. Physiol. Renal Physiol. 297: F106-F113
14. Clarkson, T. W., and, Magos, L. 2006. The toxicology of mercury and its chemical compounds. Crit. Rev. Toxicol. 36: 609-662
15. da Silva, J., de Freitas, T. R., Heuser, V., Marinho, J. R., and, Erdtmann, B. 2000. Genotoxicity biomonitoring in coal regions using wild rodent Ctenomys torquatus by Comet assay and micronucleus test. Environ. Mol. Mutagen. 35: 270-278
16. da Silva, D. A., Barbosa, F., Jr., and, Scarano, W. R. 2012. Oral exposure to methylmercury modifies the prostatic microenvironment in adult rats. Int. J. Exp. Pathol. 93: 354-360
17. de Marco, K. C., Passos, C. J., Sertorio, J., Tanus-Santos, J. E., and, Barbosa, F. Jr., 2010. Environmental exposure to methylmercury is associated with a decrease in nitric oxide production. Basic Clin. Pharmacol. Toxicol. 106: 411-415
18. de Maria, C. A. B., and, Moreira, R. F. A. 2011. A Intrigante química da Niacina-Uma revisão crítica. Química Nova 34: 1739-1752
19. Dorea, J. G., Marques, R. C., and, Abreu, L. 2014. Milestone achievement and neurodevelopment of rural Amazonian toddlers (12 to 24 months) with different methylmercury and ethylmercury exposure. J. Toxicol. Environ. Health A 77: 1-13
20. Dou, X., Shen, C., Wang, Z., Li, S., Zhang, X., and, Song, Z. 2013. Protection of nicotinic acid against oxidative stress-induced cell death in hepatocytes contributes to its beneficial effect on alcohol-induced liver injury in mice. J. Nutr. Biochem. 24: 1520-1528
21. Ellman, G. L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 82: 70-77
22. Farella, N., Lucotte, M., Davidson, R., and, Daigle, S. 2006. Mercury release from deforested soils triggered by cation enrichment. Sci. Total Environ. 368: 19-29
23. Figueiredo, N. L., Areias, A., Mendes, R., Canário, J., Duarte, A., and, Carvalho, C. 2014. Mercury-resistant bacteria from salt marsh of Tagus Estuary: The influence of plants presence and mercury contamination levels. J. Toxicol. Environ. Health A 77: 959-971
24. Frenedoso, R. S., Missassi, G. S., Santos, C. S., de Paula, E. S., Hornos Carneiro, M. F., Grotto, D., Barbosa, F., and, Kempinas, W. G. 2014. Phytoremediation potential of Maná-Cubiu (Solanum sessiliflorum Dunal) for the deleterious effects of methylmercury on the reproductive system of rats. Biomed Res. Int. 2014: 309631
25. Ganji, S. H., Qin, S., Zhang, L., Kamanna, V. S., and, Kashyap, M. L. 2009. Niacin inhibits vascular oxidative stress, redox-sensitive genes, and monocyte adhesion to human aortic endothelial cells. Atherosclerosi s 202: 68-75
26. Gille, A., Bodor, E. T., Ahmed, K., and, Offermanns, S. 2008. Nicotinic acid: Pharmacological effects and mechanisms of action. Annu. Rev. Pharmacol. Toxicol. 48: 79-106
27. Ginsberg, G., Sonawane, B., Nath, R., and, Lewandowski, P. 2014. Methylmercury-induced inhibition of paraoxonase-1 (PON1)-implications for cardiovascular risk. J. Toxicol. Environ. Health A 77: 1004-1023
28. Grandjean, P. 1995. Individual susceptibility in occupational and environmental toxicology. Toxicol. Lett. 77: 105-108
29. Grotto, D., Santa Maria, L. D., Boeira, S., Valentini, J., Charao, M. F., Moro, A. M., Nascimento, P. C., Pomblum, V. J., and, Garcia, S. C. 2007. Rapid quantification of malondialdehyde in plasma by high performance liquid chromatography-visible detection. J. Pharm. Biomed. Anal. 43: 619-624
30. Grotto, D., Barcelos, G. R., Valentini, J., Antunes, L. M., Angeli, J. P., Garcia, S. C., and, Barbosa, F., Jr. 2009a. Low levels of methylmercury induce DNA damage in rats: protective effects of selenium. Arch. Toxicol. 83: 249-254
31. Grotto, D., Barcelos, G. M., Garcia, S. C., and, Barbosa, F. 2009b. Low level and sub-chronic exposure to methylmercury induces hypertension in rats: Nitric oxide depletion and oxidative damage as possible mechanisms. Arch. Toxicol. 83: 249-254
32. Grotto, D., Valentini, J., Fillion, M., Passos, C. J., Garcia, S. C., Mergler, D., and, Barbosa, F., Jr. 2010. Mercury exposure and oxidative stress in communities of the Brazilian Amazon. Sci. Total Environ. 408: 806-811
33. Grotto, D., Vicentini, J., Angeli, J. P., Latorraca, E. F., Monteiro, P. A., Barcelos, G. R., Somacal, S., Emanuelli, T., and, Barbosa, F., Jr. 2011a. Evaluation of protective effects of fish oil against oxidative damage in rats exposed to methylmercury. Ecotoxicol. Environ. Safety 74: 487-493
34. Grotto, D., Valentini, J., Serpeloni, J. M., Monteiro, P. A., Latorraca, E. F., de Oliveira, R. S., Antunes, L. M., Garcia, S. C., and, Barbosa, F., Jr. 2011b. Evaluation of toxic effects of a diet containing fish contaminated with methylmercury in rats mimicking the exposure in the Amazon riverside population. Environ. Res. 111: 1074-1082
35. Guyton, J. R., and, Bays, H. E. 2007. Safety considerations with niacin therapy. Am. J. Cardiol. 99: 22C-31C
36. Health Canada., 2010. Canadian nutrient file. http://webprod3.hc-sc.gc.ca/cnf-fce/index-eng.jsp (. accessed September 2015)
37. Hintelmann, H. 2010. Organomercurials. Their formation and pathways in the environment. Metal Ions Life Sci. 7: 365-401
38. Huang, P. H., Lin, C. P., Wang, C. H., Chiang, C. H., Tsai, H. Y., Chen, J. S., Lin, F. Y., Leu, H. B., Wu, T. C., Chen, J. W., and, Lin, S. J. 2012. Niacin improves ischemia-induced neovascularization in diabetic mice by enhancement of endothelial progenitor cell functions independent of changes in plasma lipids. Angiogenesi s 15: 377-389
39. Jin, X., Chan, H. M., Lok, E., Kapal, K., Taylor, M., Kubow, S., and, Mehta, R. 2008. Dietary fats modulate methylmercury-mediated systemic oxidative stress and oxidative DNA damage in rats. Food Chem. Toxicol. 46: 1706-1720
40. Kirkland, J. B. 2012. Niacin requirements for genomic stability. Mutat. Res. 733: 14-20
41. Kuban, P., Pelcova, P., Margetinova, J., and, Kuban, V. 2009. Mercury speciation by CE: An update. Electrophoresis 30: 92-99
42. Lando, A. M., Fein, S. B., and, Choiniere, C. J. 2012. Awareness of methylmercury in fish and fish consumption among pregnant and postpartum women and women of childbearing age in the United States. Environ. Res. 116: 85-92
43. Lebel, J., Mergler, D., Branches, F., Lucotte, M., Amorim, M., Larribe, F., and, Dolbec, J. 1998. Neurotoxic effects of low-level methylmercury contamination in the Amazonian Basin. Environ. Res. 79: 20-32
44. Lebiedzinska, A., Majewski, M., and, Szefer, P. 2008. [Butterfish as a source of niacin]. Rocz. Panstw. Zakl. Hig. 59: 197-201
45. Li, Y., Jiang, Y., and, Yan, X.-P. 2006. Probing mercury species-DNA interactions by capillary electrophoresis with on-line electrothermal atomic absorption spectrometric detection. Anal. Chem. 78: 6115-6120
46. Malm, O. 1998. Gold mining as a source of mercury exposure in the Brazilian Amazon. Environ. Res. 77: 73-78
47. McCord, J. M., and, Fridovich, I. 1969. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J. Biol. Chem. 244: 6049-6055
48. McKenney, J., Bays, H., Koren, M., Ballantyne, C. M., Paolini, J. F., Mitchel, Y., Betteridge, A., Kuznetsova, O., Sapre, A., Sisk, C. M., and, Maccubbin, D. 2010. Safety of extended-release niacin/laropiprant in patients with dyslipidemia. J. Clin. Lipidol. 4: 105-112e101
49. Myers, G. J., Davidson, P. W., Cox, C., Shamlaye, C. F., Palumbo, D., Cernichiari, E., Sloane-Reeves, J., Wilding, G. E., Kost, J., Huang, L. S., and, Clarkson, T. W. 2003. Prenatal methylmercury exposure from ocean fish consumption in the Seychelles Child Development Study. Lancet 361: 1686-1692
50. Nunes, E., Cavaco, A., and, Carvalho, C. 2014a. Childrens health risk and benefits of fish consumption: Risk indices based on a dietiary follow-up of two weeks. J. Toxicol. Environ. Health A 77: 103-114
51. Nunes, E., Cavaco, A., and, Carvalho, C. 2014b. Exposure assessment of pregnant Portuguese women to ethylmercury through the ingestion of fish: Cross-sectional survey and biomarker validation. J. Toxicol. Environ. Health A 77: 133-142
52. Paglia, D. E., and, Valentine, W. N. 1967. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 70: 158-169
53. Pal, M., and, Ghosh, M. 2012. Studies on comparative efficacy of alpha-linolenic acid and alpha-eleostearic acid on prevention of organic mercury-induced oxidative stress in kidney and liver of rat. Food Chem. Toxicol. 50: 1066-1072
54. Palmer, C. D., Lewis, M. E., Jr., Geraghty, C. M., Barbosa, F., Jr., and, Parsons, P. J. 2006. Determination of lead, cadmium and mercury in blood for assessment of environmental exposure: A comparison between inductively coupled plasma-mass spectrometry and atomic absorption spectrometry. Spectrochim. Acta B Atom. Spectrosc. 61: 980-990
55. Park, S., and, Johnson, M. A. 2006. Awareness of fish advisories and mercury exposure in women of childbearing age. Nutr. Rev. 64: 250-256
56. Pinheiro, M. C., Macchi, B. M., Vieira, J. L., Oikawa, T., Amoras, W. W., Guimaraes, G. A., Costa, C. A., Crespo-Lopez, M. E., Herculano, A. M., Silveira, L. C., and, do Nascimento, J. L. 2008. Mercury exposure and antioxidant defenses in women: A comparative study in the Amazon. Environ. Res. 107: 53-59
57. Roulet, M., Lucotte, M., Saint-Aubin, A., Tran, S., Rhéault, I., Farella, N., De Jesus Da Silva, E,., Dezencourt, J., Sousa Passos, C. J., Santos Soares, G., Guimarães, J. R. D., Mergler, D., and, Amorim, M. 1998. The geochemistry of mercury in Central Amazonian soils developed on the Alter-do-Chão formation of the lower Tapajós River Valley, Pará state, Brazil. Sci. Total Environ. 223: 1-24
58. Roulet, M., Lucotte, M., Farella, N., Serique, G., Coelho, H., Sousa Passos, C.J., De Jesus Da Silva, E., Scavone De Andrade, P., Mergler, D., Guimarães, J. R. D., and, Amorim, M. 1999. Effects of recent human colonization on the presence of mercury in Amazonian ecosystems. Water Air Soil Pollut. 112: 297-313
59. Pal, M., and, Ghosh, M. 2012. Prophylactic effect of α-linolenic acid and α-eleostearic acid against MeHg induced oxidative stress, DNA damage and structural changes in RBC membrane. Food Chem. Toxicol. 50: 2811-2818
60. Salonen, J. T., Seppanen, K., Lakka, T. A., Salonen, R., and, Kaplan, G. A. 2000. Mercury accumulation and accelerated progression of carotid atherosclerosis: A population-based prospective 4-year follow-up study in men in eastern Finland. Atherosclerosis 148: 265-273
61. Silva-Pereira, L. C., da Rocha, C. A., Cunha, L. R., da Costa, E. T., Guimaraes, A. P., Pontes, T. B., Diniz, D. L., Leal, M. F., Moreira-Nunes, C. A., and, Burbano, R. R. 2014. Protective effect of prolactin against methylmercury-induced mutagenicity and cytotoxicity on human lymphocytes. Int. J. Environ. Res. Public Health 11: 9822-9834
62. Silva-Pereira, L. C., Cardoso, P. C. S., Leite, D. S., Bahia, M. O., Bastos, W. R., Smith, M. A., and, Burbano, R. R. 2005. Cytotoxicity and genotoxicity of low doses of mercury chloride and methylmercury chloride on human lymphocytes in vitro. Braz. J. Med. Biol. Res. 38: 901-907
63. Singh, N. P., McCoy, M. T., Tice, R. R., and, Schneider, E. L. 1988. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 175: 184-191
64. Spronck, J. C., and, Kirkland, J. B. 2002. Niacin deficiency increases spontaneous and etoposide-induced chromosomal instability in rat bone marrow cells in vivo. Mutat. Res. 508: 83-97
65. Surjana, D., Halliday, G. M., and, Damian, D. L. 2010. Role of nicotinamide in DNA damage, mutagenesis, and DNA repair. J. Nucleic Acids pii: 157591
66. Tupe, R. S., Tupe, S. G., and, Agte, V. V. 2011. Dietary nicotinic acid supplementation improves hepatic zinc uptake and offers hepatoprotection against oxidative damage. Br. J. Nutr. 105: 1741-1749
67. Warnholtz, A., Wild, P., Ostad, M. A., Elsner, V., Stieber, F., Schinzel, R., Walter, U., Peetz, D., Lackner, K., Blankenberg, S., and, Munzel, T. 2009. Effects of oral niacin on endothelial dysfunction in patients with coronary artery disease: Results of the randomized, double-blind, placebo-controlled INEF study. Atherosclerosis 204: 216-221
68. Wiggers, G. A., Pecanha, F. M., Briones, A. M., Perez-Giron, J. V., Miguel, M., Vassallo, D. V., Cachofeiro, V., Alonso, M. J., and, Salaices, M. 2008. Low mercury concentrations cause oxidative stress and endothelial dysfunction in conductance and resistance arteries. Am. J. Physiol. Heart Circ. Physiol. 295: H1033-H1043
69. Woods, J. S., Heyer, N. J., Russo, J. E., Martin, M. D., Pillai, P. B., Bammler, T. K., and, Farin, F. M. 2014. Genetic polymorphisms of catechol-o-methyltransferase modify the neurobehavioral effects of mercury in children. J. Toxicol. Environ. Health A 77: 293-312
70. Wormser, U., Brodsky, B., Milatovic, D., Finkelstein, Y., Farina, M., Rocha, J. B., and, Aschner, M. 2012. Protective effect of a novel peptide against methylmercury-induced toxicity in rat primary astrocytes. Neurotoxicology. 33: 763-768
71. Zhang, R., Wu, F., Li, H., Guo, G., Feng, C., Giesy, J. P., and, Chang, H. 2013. Toxicity reference values and tissue residue criteria for protecting avian wildlife exposed to methylmercury in China. Rev. Environ. Contam. Toxicol. 223: 53-80
72. Zimmermann, L. T., dos Santos, D. B., Colle, D., dos Santos, A. A., Hort, M. A., Garcia, S. C., Bressan, L. P., Bohrer, D., and, Farina, M. 2014. Methionine stimulates motor impairment and cerebellar mercury deposition in ethylmercury- exposed mice. J. Toxicol. Environ. Health, A 77: 46-56.