Polymorphisms in glutathione-related genes modify mercury concentrations and antioxidant status in subjects environmentally exposed to methylmercury

Science of the Total Environment

Volumn 463-464, Issue , 2013, Pages 319-325

  Barcelos, Gustavo Rafael Mazzaron ^a   Grotto, Denise ^a   de Marco, Kátia Cristina ^a   Valentini, Juliana ^a   Lengert, André van Helvoort ^b   Oliveira, Andréia Ávila Soares de ^a   Garcia, Solange Cristina ^c   Braga, Gilberto Úbida Leite ^a   Schläwicke Engström, Karin ^d   Cólus, Ilce Mara de Syllos ^b   Broberg, Karin ^d   Barbosa, Fernando ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b STATE UNIVERSITY OF LONDRINA   (Brazil)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^d LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Antioxidant status; Fish intake; Gene environment interactions; Metabolism; Methylmercury; Polymorphisms

Indexed keywords

ANTIOXIDANT STATUS; EXPERIMENTAL MODELS; FISH INTAKE; GENE-ENVIRONMENT INTERACTION; GENETIC DIFFERENCES; GSH CONCENTRATIONS; MERCURY CONCENTRATIONS; METHYL MERCURY;

ANTIOXIDANTS; FISH; GENES; INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY; METABOLISM; PEPTIDES; PHYSIOLOGY; POLYMORPHISM;

BLOOD;

BIOLOGICAL MARKER; CATALASE; CYTOSINE; DNA; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE P1; METHYLMERCURY; THYMINE;

ANTIOXIDANT; CONCENTRATION (COMPOSITION); FISH; GENE; GENETIC DIFFERENTIATION; MERCURY (ELEMENT); METABOLISM; METHYLMERCURY; POLYMORPHISM; TOXICITY;

ADULT; AGED; ALCOHOL CONSUMPTION; ALLELE; ANTIOXIDANT STATUS; ARTICLE; BLOOD LEVEL; BODY BURDEN; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DNA POLYMORPHISM; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; FEMALE; FISH; FOOD INTAKE; GCLM GENE; GENE; GENE DELETION; GENE FREQUENCY; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; GLUTATHIONE RELATED GENE; GSTM1 0 GENE; GSTM1 GENE; GSTP1 GENE; GSTT1 GENE; HAIR LEVEL; HEALTH STATUS; HEREDITY; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MALE; MASS SPECTROMETRY; METAL METABOLISM; MULTIPLEX POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SMOKING; SPECTROPHOTOMETRY;

ANTIOXIDANT STATUS; FISH INTAKE; GENE-ENVIRONMENT INTERACTIONS; METABOLISM; METHYLMERCURY; POLYMORPHISMS;

ADULT; BRAZIL; CROSS-SECTIONAL STUDIES; ENVIRONMENTAL EXPOSURE; FEMALE; GENOTYPING TECHNIQUES; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE S-TRANSFERASE PI; GLUTATHIONE TRANSFERASE; HAIR; HUMANS; MALE; MERCURY POISONING; METHYLMERCURY COMPOUNDS; MULTIPLEX POLYMERASE CHAIN REACTION; OXIDATION-REDUCTION; POLYMORPHISM, GENETIC;

EID: 84880003315     PISSN: 00489697     EISSN: 18791026     Source Type: Journal    
DOI: 10.1016/j.scitotenv.2013.06.029     Document Type: Article

References (40)

1. Abdel-Rahman S.Z., el-Zein R.A., Anwar W.A., Au W.W. A multiplex PCR procedure for polymorphic analysis of GSTM1 and GSTT1 genes in population studies. Cancer Lett 1996, 107:229-233.
2. Aebi H. Catalase in vitro. Methods Enzymol 1984, 105:121-126.
3. Almar M.M., Dierickx P.J. In vitro interaction of mercury, copper (II) and cadmium with human glutathione transferase pi. Res Commun Chem Pathol 1990, 69:99-102.
4. ATSDR Agency for Toxic Substances and Diseases Control. Toxicological profile for mercury 1999, U.S. Department of Health and Human Services, Public Health Service.
5. Barcelos G.R.M., Angeli J.P.F., Serpeloni J.M., Grotto D., Rocha B.A., Bastos J.K., et al. Quercetin protects human-derived liver cells against mercury-induced DNA-damage and alterations of the redox status. Mutat Res 2011, 726:109-115.
6. Barcelos G.R.M., Grotto D., Serpeloni J.M., Angeli J.P.F., Rocha B.A., de Oliveira Souza V.C., et al. Protective properties of quercetin against DNA damage and oxidative stress induced by methylmercury in rats. Arch Toxicol 2011, 85:1151-1157.
7. Choi A.L., Weihe P., Budtz-Jorgensen E., Jorgensen P.J., Salonen J.T., Tuomainen T.P. Methylmercury exposure and adverse cardiovascular effects in Faroese whaling men. Environ Health Perspect 2009, 117:367-372.
8. Clarkson T.W., Magos L. The toxicology of mercury and its chemical compounds. Crit Rev Toxicol 2006, 36:609-662.
9. Counter S.A., Buchanan L.H. Mercury exposure in children: a review. Toxicol Appl Pharmacol 2004, 198:209-230.
10. Custodio H.M., Broberg K., Wennberg M., Jansson J.H., Vessby B., Hallmans G., et al. Polymorphisms in glutathione-related genes affect methylmercury retention. Arch Environ Health 2004, 59:588-595.
11. De Marco K.C., Passos C.J., Sertorio J., Tanus-Santos J.E., Barbosa F. Environmental exposure to methylmercury is associated with a decrease in nitric oxide production. Basic Clin Pharmacol Toxicol 2010, 106:411-415.
12. Dierickx P.J. In vitro inhibition of the soluble glutathione S-transferases from rat liver by heavy metals. Enzyme 1982, 27:25-32.
13. Ellman G.L. Tissue sulfhydryl groups. Arch Biochem Biophys 1959, 82:70-77.
14. Farina M., Frizzo M.E., Soares F.A., Schwalm F.D., Dietrich M.O., Zeni G., et al. Ebselen protects against methylmercury-induced inhibition of glutamate uptake by cortical slices from adult mice. Toxicol Lett 2003, 144:351-357.
15. Goodrich J.M., Basu N. Variants of glutathione s-transferase pi 1 exhibit differential enzymatic activity and inhibition by heavy metals. Toxicol In Vitro 2012, 26:630-635.
16. Grotto D., Barcelos G.R.M., Valentini J., Antunes L.M.G., Angeli J.P.F., Garcia S.C., et al. Low levels of methylmercury induce DNA damage in rats: protective effects of selenium. Arch Toxicol 2009, 83:249-254.
17. Grotto D., Valentini J., Fillion M., Passos C.J., Garcia S.C., Mergler D., et al. Mercury exposure and oxidative stress in communities of the Brazilian Amazon. Sci Total Environ 2010, 408:806-811.
18. Gundacker C., Komarnicki G., Jagiello P., Gencikova A., Dahmen N., Wittmann K.J., et al. Glutathione-S-transferase polymorphism, metallothionein expression, and mercury levels among students in Austria. Sci Total Environ 2007, 385:37-47.
19. Gundacker C., Wittmann K.J., Kukuckova M., Komarnicki G., Hikkel I., Gencik M. Genetic background of lead and mercury metabolism in a group of medical students in Austria. Environ Res 2009, 109:786-796.
20. Gundacker C., Gencik M., Hengstschlager M. The relevance of the individual genetic background for the toxicokinetics of two significant neurodevelopmental toxicants: mercury and lead. Mutat Res 2010, 705:130-140.
21. Hayes J.D., Flanagan J.U., Jowsey I.R. Glutathione transferases. Annu Rev Pharmacol Toxicol 2005, 45:51-88.
22. Houston M.C. Role of mercury toxicity in hypertension, cardiovascular disease, and stroke. J Clin Hypertens 2011, 13:621-627.
23. Johansson C., Castoldi A.F., Onishchenko N., Manzo L., Vahter M., Ceccatelli S. Neurobehavioural and molecular changes induced by methylmercury exposure during development. Neurotox Res 2007, 11:241-260.
24. Karagas M.R., Choi A.L., Oken E., Horvat M., Schoeny R., Kamai E., et al. Evidence on the human health effects of low-level methylmercury exposure. Environ Health Perspect 2012, 120:799-806.
25. Lee B.E., Hong Y.C., Park H., Ha M., Koo B.S., Chang N., et al. Interaction between GSTM1/GSTT1 polymorphism and blood mercury on birth weight. Environ Health Perspect 2010, 118:437-443.
26. Mo Z., Gao Y., Cao Y., Gao F., Jian L. An updating meta-analysis of the GSTM1, GSTT1, and GSTP1 polymorphisms and prostate cancer: a HuGE review. Prostate 2009, 69:662-688.
27. Nakamura S., Kugiyama K., Sugiyama S., Miyamoto S., Koide S., Fukushima H., et al. Polymorphism in the 5'-flanking region of human glutamate-cysteine ligase modifier subunit gene is associated with myocardial infarction. Circulation 2002, 105:2968-2973.
28. Paglia D.E., Valentine W.N. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967, 70:158-169.
29. Palmer C.D., Lewis M.E., Geraghty C.M., Barbosa F., Parsons P.J. Determination of lead, cadmium and mercury in blood for assessment of environmental exposure: a comparison between inductively coupled plasma-mass spectrometry and atomic absorption spectrometry. Spectrochim Acta B 2006, 61:980-990.
30. Passos C.J., Mergler D. Human mercury exposure and adverse health effects in the Amazon: a review. Cad Saude Publica 2008, 24:S503-S520.
31. Passos C.J., Mergler D., Fillion M., Lemire M., Mertens F., Guimaraes J.R., et al. Epidemiologic confirmation that fruit consumption influences mercury exposure in riparian communities in the Brazilian Amazon. Environ Res 2007, 105:183-193.
32. Passos C.J., Sampaio D.S., Lemire M., Fillion M., Guimarães J.R.D., Lucotte M., et al. Daily mercury intake in fish-eating populations in the Brazilian Amazon. J Exposure Sci Environ Epidemiol 2008, 18:76-87.
33. Pena S.J. Brazilians and the variable mosaic genome paradigm. Fifty years of human genetics: a festschrift and liber amicorum to celebrate the life and work of George Robert Fraser 2007, 98-104. Wakefield Press, Kent Town, S. Aust. O. Mayo, C. Leach (Eds.).
34. Pinheiro M.C., Oikawa T., Vieira J.L., Gomes M.S., Guimarães G.A., Crespo-Lopez M.E., et al. Comparative study of human exposure to mercury in riverside communities in the Amazon region. Braz J Med Biol Res 2006, 39:411-414.
35. Pinheiro M.C., Macchi B.M., Vieira J.L., Oikawa T., Amoras W.W., Guimarães G.A., et al. Mercury exposure and antioxidant defenses in women: a comparative study in the Amazon. Environ Res 2008, 107:53-59.
36. Rodrigues J.L., Batista B.L., Nunes J.A., Passos C.J., Barbosa F. Evaluation of the use of human hair for biomonitoring the deficiency of essential and exposure to toxic elements. Sci Total Environ 2008, 405:370-376.
37. Salonen J.T., Seppanen K., Nyyssonen K., Korpela H., Kauhanen J., Kantola M., et al. Intake of mercury from fish, lipid peroxidation, and the risk of myocardial infarction and coronary, cardiovascular, and any death in eastern Finnish men. Circulation 1995, 91:645-655.
38. Schläwicke Engström K., Stromberg U., Lundh T., Johansson I., Vessby B., Hallmans G., et al. Genetic variation in glutathione-related genes and body burden of methylmercury. Environ Health Perspect 2008, 116:734-739.
39. Tosic M., Ott J., Barral S., Bovet P., Deppen P., Gheorghita F., et al. Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene. Am J Hum Genet 2006, 79:586-592.
40. Usuki F., Yasutake A., Matsumoto M., Higuchi I. Chronic low-dose methylmercury administration decreases mitochondrial enzyme activities and induces myopathic changes in rats. J Health Sci 2001, 47:162-167.